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Conversionless efficient and broadband laser light diffusers for high brightness illumination applications
Fabian Schütt, Maximilian Zapf, Stefano Signetti, Julian Strobel, Helge Krüger, Robert Röder, Jürgen Carstensen, Niklas Wolff, Janik Marx, Tian Carey, Marleen Schweichel, Maik-Ivo Terasa, Leonard Siebert, Hyo-Ki Hong, Sören Kaps, Bodo Fiedler, Yogendra Kumar Mishra, Zonghoon Lee, Nicola M. Pugno, Lorenz Kienle, Andrea C. Ferrari, Felice Torrisi, Carsten Ronning, Rainer Adelung
Mar 18, 2021
The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing.
Sören Diegelmann, Vanessa Nieratschker, Ursula Werner, Jürgen Hoppe, Troy Zars, Erich Buchner
Jun 14, 2011
Conversionless efficient and broadband laser light diffusers for high brightness illumination applications.
Fabian Schütt, Maximilian Zapf, Stefano Signetti, Julian Strobel, Helge Krüger, Robert Röder, Jürgen Carstensen, Niklas Wolff, Janik Marx, Tian Carey, Marleen Schweichel, Maik-Ivo Terasa, Leonard Siebert, Hyo-Ki Hong, Sören Kaps, Bodo Fiedler, Yogendra Kumar Mishra, Zonghoon Lee, Nicola M Pugno, Lorenz Kienle, Andrea C Ferrari, Felice Torrisi, Carsten Ronning, Rainer Adelung
Jan 15, 2021
Laser diodes are efficient light sources. However, state-of-the-art laser diode-based lighting systems rely on light-converting inorganic phosphor materials, which strongly limit the efficiency and lifetime, as well as...
Mentoring and Supervision in Academia
Dear Editor,
We read with interest the article entitled “Great Expectations: Principal Investigator and Trainee Perspectives on Hiring, Supervision, and Mentoring” by Kaps et al. We agree that a good mentor–mentee relationship...
Conversionless efficient and broadband laser light diffusers for high brightness illumination applications.
Fabian Schütt, Maximilian Zapf, Stefano Signetti, Julian Strobel, Helge Krüger, Robert Röder, Jürgen Carstensen, Niklas Wolff, Janik Marx, Tian Carey, Marleen Schweichel, Maik-Ivo Terasa, Leonard Siebert, Hyo-Ki Hong, Sören Kaps, Bodo Fiedler, Yogendra Kumar Mishra, Zonghoon Lee, Nicola M Pugno, Lorenz Kienle, Andrea C Ferrari, Felice Torrisi, Carsten Ronning, Rainer Adelung
Apr 19, 2020
Laser diodes are efficient light sources. However, state-of-the-art laser diode-based lighting systems rely on light-converting inorganic phosphor materials, which strongly limit the efficiency and lifetime, as well as...
Published by: Nature Communications
A Journey to the West
Robert N Spengler, Sören Stark, Xinying Zhou, Daniel Fuks, Li Tang, Basira Mir-Makhamad, Rasmus Bjørn, Hongen Jiang, Luca M Olivieri, Alisher Begmatov, Nicole Boivin
Nov 01, 2021
Rice is one of the most culturally valued and widely grown crops in the world today, and extensive research over the past decade has clarified much of the narrative of its domestication and early spread across East and South...
Changing composition of SARS-CoV-2 lineages and rise of Delta variant in England.
Swapnil Mishra, Sören Mindermann, Mrinank Sharma, Charles Whittaker, Thomas A Mellan, Thomas Wilton, Dimitra Klapsa, Ryan Mate, Martin Fritzsche, Maria Zambon, Janvi Ahuja, Adam Howes, Xenia Miscouridou, Guy P Nason, Oliver Ratmann, Elizaveta Semenova, Gavin Leech, Julia Fabienne Sandkühler, Charlie Rogers-Smith, Michaela Vollmer, H Juliette T Unwin, Yarin Gal, Meera Chand, Axel Gandy, Javier Martin, Erik Volz, Neil M Ferguson, Samir Bhatt, Jan M Brauner, Seth Flaxman, COVID-19 Genomics UK (COG-UK) Consortium
Aug 13, 2021
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian DS Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L Heppner, Roland Eils, Marcus A Mall, J Brent Richards, Leif-Erik Sander, Irina Lehmann, Sören Lukassen, Nicholas J Wareham, Christian Conrad, Claudia Langenberg
Sep 15, 2022
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian DS Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L Heppner, Roland Eils, Marcus A Mall, J Brent Richards, Leif-Erik Sander, Irina Lehmann, Sören Lukassen, Nicholas J Wareham, Christian Conrad, Claudia Langenberg
Aug 15, 2022
Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but...
SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer.
Iswarya Ramu, Sören M Buchholz, Melanie S Patzak, Robert G Goetze, Shiv K Singh, Frances M Richards, Duncan I Jodrell, Bence Sipos, Philipp Ströbel, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse
Oct 29, 2019
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterised by extensive matrix deposition that has been implicated in impaired drug delivery and therapeutic resistance. Secreted protein acidic and rich in cysteine...
A dataset of non-pharmaceutical interventions on SARS-CoV-2 in Europe.
George Altman, Janvi Ahuja, Joshua Teperowski Monrad, Gurpreet Dhaliwal, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Jonas B Sandbrink, Lukas Finnveden, Alexander John Norman, Sebastian B Oehm, Julia Fabienne Sandkühler, Jan Kulveit, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Mrinank Sharma, Sören Mindermann, Jan Markus Brauner
May 09, 2022
During the second half of 2020, many European governments responded to the resurging transmission of SARS-CoV-2 with wide-ranging non-pharmaceutical interventions (NPIs). These efforts were often highly targeted at the regional...
A dataset of non-pharmaceutical interventions on SARS-CoV-2 in Europe.
George Altman, Janvi Ahuja, Joshua Teperowski Monrad, Gurpreet Dhaliwal, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Jonas B Sandbrink, Lukas Finnveden, Alexander John Norman, Sebastian B Oehm, Julia Fabienne Sandkühler, Jan Kulveit, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Mrinank Sharma, Sören Mindermann, Jan Markus Brauner
Apr 01, 2022
During the second half of 2020, many European governments responded to the resurging transmission of SARS-CoV-2 with wide-ranging non-pharmaceutical interventions (NPIs). These efforts were often highly targeted at the regional...
Biochemical Analysis of the Protein-Protein Interactions Involved in Karyopherin-Mediated Transport Across the Nuclear Pore Complex
Jaclyn Tetenbaum-Novatt
Jan 01, 0001
Nucleocytoplasmic transport occurs through the nuclear pore complex (NPC), which in yeast is a highly symmetric ~50 MDa complex consisting of approximately 30 different proteins. Small molecules can freely exchange through the...
Published by: Rockefeller University
Understanding the effectiveness of government interventions against the resurgence of COVID-19 in Europe
Mrinank Sharma, Sören Mindermann, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Janvi Ahuja, Jonas B. Sandbrink, Joshua Teperowski Monrad, George Altman, Gurpreet Dhaliwal, Lukas Finnveden, Alexander John Norman, Sebastian B. Oehm, Julia Fabienne Sandkühler, Laurence Aitchison, Tomáš Gavenčiak, Thomas Mellan, Jan Kulveit, Leonid Chindelevitch, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Jan Markus Brauner
Oct 05, 2021
Understanding the effectiveness of government interventions against the resurgence of COVID-19 in Europe.
Mrinank Sharma, Sören Mindermann, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Janvi Ahuja, Jonas B Sandbrink, Joshua Teperowski Monrad, George Altman, Gurpreet Dhaliwal, Lukas Finnveden, Alexander John Norman, Sebastian B Oehm, Julia Fabienne Sandkühler, Laurence Aitchison, Tomáš Gavenčiak, Thomas Mellan, Jan Kulveit, Leonid Chindelevitch, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Jan Markus Brauner
Nov 06, 2021
European governments use non-pharmaceutical interventions (NPIs) to control resurging waves of COVID-19. However, they only have outdated estimates for how effective individual NPIs were in the first wave. We estimate the...
Understanding the effectiveness of government interventions against the resurgence of COVID-19 in Europe.
Mrinank Sharma, Sören Mindermann, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Janvi Ahuja, Jonas B Sandbrink, Joshua Teperowski Monrad, George Altman, Gurpreet Dhaliwal, Lukas Finnveden, Alexander John Norman, Sebastian B Oehm, Julia Fabienne Sandkühler, Laurence Aitchison, Tomáš Gavenčiak, Thomas Mellan, Jan Kulveit, Leonid Chindelevitch, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Jan Markus Brauner
Dec 15, 2021
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Manuel A Rivas, Daniel Graham, Patrick Sulem, Christine Stevens, A Nicole Desch, Philippe Goyette, Daniel Gudbjartsson, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Frauke Degenhardt, Sören Mucha, Mitja I Kurki, Dalin Li, Mauro D'Amato, Vito Annese, Severine Vermeire, Rinse K Weersma, Jonas Halfvarson, Paulina Paavola-Sakki, Maarit Lappalainen, Monkol Lek, Beryl Cummings, Taru Tukiainen, Talin Haritunians, Leena Halme, Lotta LE Koskinen, Ashwin N Ananthakrishnan, Yang Luo, Graham A Heap, Marijn C Visschedijk, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Daniel G MacArthur, Benjamin M Neale, Tariq Ahmad, Carl A Anderson, Steven R Brant, Richard H Duerr, Mark S Silverberg, Judy H Cho, Aarno Palotie, Päivi Saavalainen, Kimmo Kontula, Martti Färkkilä, Dermot PB McGovern, Andre Franke, Kari Stefansson, John D Rioux, Ramnik J Xavier, Mark J Daly, J Barrett, K de Lane, C Edwards, A Hart, C Hawkey, L Jostins, N Kennedy, C Lamb, J Lee, C Lees, J Mansfield, C Mathew, C Mowatt, B Newman, E Nimmo, M Parkes, M Pollard, N Prescott, J Randall, D Rice, J Satsangi, A Simmons, M Tremelling, H Uhlig, D Wilson, C Abraham, JP Achkar, A Bitton, G Boucher, K Croitoru, P Fleshner, J Glas, S Kugathasan, JV Limbergen, R Milgrom, D Proctor, M Regueiro, PL Schumm, Y Sharma, JM Stempak, SR Targan, MH Wang
Sep 29, 2018
Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating variants conferring protection against...
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.
Sun-Gou Ji, Brian D Juran, Sören Mucha, Trine Folseraas, Luke Jostins, Espen Melum, Natsuhiko Kumasaka, Elizabeth J Atkinson, Erik M Schlicht, Jimmy Z Liu, Tejas Shah, Javier Gutierrez-Achury, Kirsten M Boberg, Annika Bergquist, Severine Vermeire, Bertus Eksteen, Peter R Durie, Martti Farkkila, Tobias Müller, Christoph Schramm, Martina Sterneck, Tobias J Weismüller, Daniel N Gotthardt, David Ellinghaus, Felix Braun, Andreas Teufel, Mattias Laudes, Wolfgang Lieb, Gunnar Jacobs, Ulrich Beuers, Rinse K Weersma, Cisca Wijmenga, Hanns-Ulrich Marschall, Piotr Milkiewicz, Albert Pares, Kimmo Kontula, Olivier Chazouillères, Pietro Invernizzi, Elizabeth Goode, Kelly Spiess, Carmel Moore, Jennifer Sambrook, Willem H Ouwehand, David J Roberts, John Danesh, Annarosa Floreani, Aliya F Gulamhusein, John E Eaton, Stefan Schreiber, Catalina Coltescu, Christopher L Bowlus, Velimir A Luketic, Joseph A Odin, Kapil B Chopra, Kris V Kowdley, Naga Chalasani, Michael P Manns, Brijesh Srivastava, George Mells, Richard N Sandford, Graeme Alexander, Daniel J Gaffney, Roger W Chapman, Gideon M Hirschfield, Mariza de Andrade, UK-PSC Consortium, International IBD Genetics Consortium, International PSC Study Group, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Carl A Anderson
Nov 21, 2017
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC...
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael R Brown, Ben Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel F Gudbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, John Danesh, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kari Stefansson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, Paul S de Vries, Moritz von Scheidt
Dec 08, 2022
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael R Brown, Ben Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel F Gudbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, Biobank Japan, EPIC-CVD, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kari Stefansson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, CARDIoGRAMplusC4D Consortium
Jan 06, 2023
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD)...