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Results: 643
Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain
Ayla Mansur, Eugenii A Rabiner, Robert A Comley, Yvonne Lewis, Lefkos T Middleton, Mickael Huiban, Jan Passchier, Hideo Tsukada, Roger N Gunn, MIND-MAPS Consortium
Jan 27, 2020
Mitochondrial complex 1 is involved in maintaining brain bioenergetics; σ-1 receptor responds to neuronal stress; and synaptic vesicle protein 2A reflects synaptic integrity. Expression of each of these proteins is altered in...
Endoplasmic Reticulum Kinetic modeling Mitochondria neurodegeneration Synapses Adult Age Factors Aged aging Brain Endoplasmic Reticulum Female Humans Image Processing Computer-Assisted Kinetics Ligands Male Middle Aged Mitochondria Neurodegenerative Diseases Piperazines Positron-Emission Tomography Pyridazines Pyridines Pyrrolidinones Radiopharmaceuticals Time Factors
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
Katherine A Vousden, Tomas Lundqvist, Bojana Popovic, Brian Naiman, Alan M Carruthers, Philip Newton, Daniel JD Johnson, Anja Pomowski, Trevor Wilkinson, Patrick Dufner, Isabelle de Mendez, Philip R Mallinder, Clare Murray, Martin Strain, Jane Connor, Lynne A Murray, Matthew A Sleeman, David C Lowe, James A Huntington, Tristan J Vaughan
Apr 09, 2019
Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor (serpin) that regulates fibrinolysis, cell adhesion and cell motility via its interactions with plasminogen activators and vitronectin. PAI-1 has been...
Salicylic Acid and Risk of Colorectal Cancer
Aayah Nounu, Rebecca C Richmond, Isobel D Stewart, Praveen Surendran, Nicholas J Wareham, Adam Butterworth, Stephanie J Weinstein, Demetrius Albanes, John A Baron, John L Hopper, Jane C Figueiredo, Polly A Newcomb, Noralane M Lindor, Graham Casey, Elizabeth A Platz, Loïc Le Marchand, Cornelia M Ulrich, Christopher I Li, Fränzel JB van Dujinhoven, Andrea Gsur, Peter T Campbell, Víctor Moreno, Pavel Vodicka, Ludmila Vodickova, Efrat Amitay, Elizabeth Alwers, Jenny Chang-Claude, Lori C Sakoda, Martha L Slattery, Robert E Schoen, Marc J Gunter, Sergi Castellví-Bel, Hyeong-Rok Kim, Sun-Seog Kweon, Andrew T Chan, Li Li, Wei Zheng, D Timothy Bishop, Daniel D Buchanan, Graham G Giles, Stephen B Gruber, Gad Rennert, Zsofia K Stadler, Tabitha A Harrison, Yi Lin, Temitope O Keku, Michael O Woods, Clemens Schafmayer, Bethany Van Guelpen, Steven Gallinger, Heather Hampel, Sonja I Berndt, Paul DP Pharoah, Annika Lindblom, Alicja Wolk, Anna H Wu, Emily White, Ulrike Peters, David A Drew, Dominique Scherer, Justo Lorenzo Bermejo, Hermann Brenner, Michael Hoffmeister, Ann C Williams, Caroline L Relton
Nov 22, 2021
Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a...
Novel Roles for the Tissue Plasminogen Activator System in the Development of Fetal Alcohol Syndrome and the Regulation of Contextual Learning After Stress
Melissa Noel-Castro
Jan 01, 0001
Ethanol exposure during synaptogenesis can result in brain and behavior neurotoxic defects referred to as fetal alcohol syndrome (FAS). Since tissue plasminogen activator (tPA) has been implicated in mediating excitotoxic...
fetal alcohol syndrome Ethanol plasminogen activator inhibitor-1 (PAI-1) tissue plasminogen activator (tPA) Life Sciences
Published by: Rockefeller University
Technical validation studies of a dual-wavelength LED-based photoacoustic and ultrasound imaging system.
Recent advances in high power, pulsed, light emitting diodes (LEDs) have shown potential as fast, robust and relatively inexpensive excitation sources for photoacoustic imaging (PAI), yet systematic characterization of...
Published by: Photoacoustics
Annular versus supra-annular sizing for transcatheter aortic valve replacement in bicuspid aortic valve disease.
Jonathan R Weir-McCall, Adrian Attinger-Toller, Philipp Blanke, Gidon Y Perlman, Stephanie L Sellers, David Wood, John G Webb, Jonathon Leipsic
Sep 28, 2020
BACKGROUND: CT measurement of supra-annular area (SA) has been proposed as an alternative to annular area (AA) for sizing of trancatheter valves in biscuspid aortic valves (BAV). This study examines the reproducibility of SA and...
Aortic stenosis Bicuspid aortic valve Computer tomography Tavr Valvular disease Aged Aged 80 and over Aortic Valve aortic valve stenosis Bicuspid Aortic Valve Disease Computed Tomography Angiography Coronary Angiography Echocardiography Female Heart Valve Diseases Heart valve prosthesis Humans Male Middle Aged Multidetector Computed Tomography Predictive Value of Tests Prosthesis Design Retrospective Studies Severity of Illness Index transcatheter aortic valve replacement Treatment Outcome
Regional variation in weight-for-height z-scores and surface area/body mass ratio of Chilean children from birth to 3 years of age.
OBJECTIVE: The objectives of the study were to see how much of the variation in weight-for-height z-scores (WHZ) and surface area/body mass ratio (SA/mass) were associated with regional (county) differences including mean...
The Role of Awareness for Complex Planning Task Performance
This study introduces the concept of microgames to support situated learning in order to foster situational awareness (SA) of planners in seaport container terminals. In today's complex working environments, it is often...
Published by: IGI Global Scientific Publishing
The Construction of Sodium Alginate/Carboxymethyl Chitosan Microcapsules as the Physical Barrier to Reduce Corn Starch Digestion
To enhance the resistant starch (RS) content of corn starch, in this work, carboxymethyl chitosan/corn starch/sodium alginate microcapsules (CMCS/CS/SA) with varying concentrations of SA in a citric acid (CA) solution were...
carboxymethyl chitosan Citric Acid resistant starch Sodium Alginate /dk/atira/pure/subjectarea/asjc/1100/1106 name=Food Science /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/3600/3601 name=Health Professions (miscellaneous) /dk/atira/pure/subjectarea/asjc/1100/1110 name=Plant Science
An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt
Abigail Emma Russell, Gibran Hemani, Hannah J Jones, Tamsin Ford, David Gunnell, Jon Heron, Carol Joinson, Paul Moran, Caroline Relton, Matthew Suderman, Sarah Watkins, Becky Mars
Apr 23, 2021
Abstract: Background: Empirical evidence supporting the distinction between suicide attempt (SA) and non-suicidal self-harm (NSSH) is lacking. Although NSSH is a risk factor for SA, we do not currently know whether these...
The IPASC data format
Janek Gröhl, Lina Hacker, Ben T Cox, Kris K Dreher, Stefan Morscher, Avotra Rakotondrainibe, François Varray, Lawrence CM Yip, William C Vogt, Sarah E Bohndiek, Members of the International Photoacoustic Standardisation Consortium (IPASC)
Apr 19, 2022
Photoacoustic imaging (PAI) is an emerging modality that has shown promise for improving patient management in a range of applications. Unfortunately, the current lack of uniformity in PAI data formats compromises inter-user...
The Validity of Automatic Methods for Estimating Skeletal Age in Young Athletes
This study examined the validity of two automated methods (BAUSport, BoneXpert software using Fels, Greulich-Pyle, Tanner-Whithouse III protocols) for estimating skeletal age (SA) in young athletes in comparison to a reference...
An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt.
Abigail Emma Russell, Gibran Hemani, Hannah J Jones, Tamsin Ford, David Gunnell, Jon Heron, Carol Joinson, Paul Moran, Caroline Relton, Matthew Suderman, Sarah Watkins, Becky Mars
May 10, 2021
BACKGROUND: Empirical evidence supporting the distinction between suicide attempt (SA) and non-suicidal self-harm (NSSH) is lacking. Although NSSH is a risk factor for SA, we do not currently know whether these behaviours lie on...
The Validity of Automatic Methods for Estimating Skeletal Age in Young Athletes
This study examined the validity of two automated methods (BAUSport, BoneXpert software using Fels, Greulich-Pyle, Tanner-Whithouse III protocols) for estimating skeletal age (SA) in young athletes in comparison to a reference...
The Construction of Sodium Alginate/Carboxymethyl Chitosan Microcapsules as the Physical Barrier to Reduce Corn Starch Digestion
To enhance the resistant starch (RS) content of corn starch, in this work, carboxymethyl chitosan/corn starch/sodium alginate microcapsules (CMCS/CS/SA) with varying concentrations of SA in a citric acid (CA) solution were...
carboxymethyl chitosan Citric Acid resistant starch Sodium Alginate /dk/atira/pure/subjectarea/asjc/1100/1106 name=Food Science /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/3600/3601 name=Health Professions (miscellaneous) /dk/atira/pure/subjectarea/asjc/1100/1110 name=Plant Science
Nanoscale molecular architecture controls calcium diffusion and ER replenishment in dendritic spines.
Kanishka Basnayake, David Mazaud, Lilia Kushnireva, Alexis Bemelmans, Nathalie Rouach, Eduard Korkotian, David Holcman
Oct 18, 2021
Dendritic spines are critical components of neuronal synapses as they receive and transform synaptic inputs into a succession of calcium-regulated biochemical events. The spine apparatus (SA), an extension of smooth endoplasmic...
Cortical thickness, surface area, and folding alterations in male youths with conduct disorder and varying levels of callous-unemotional traits
Graeme Fairchild, Nicola Toschi, Cindy Hagan, Ian Goodyer, Andrew Calder, Luca Passamonti
Apr 30, 2015
PURPOSE: Previous studies have reported changes in gray matter volume in youths with conduct disorder (CD), although these differences are difficult to interpret as they may have been driven by alterations in cortical thickness...
Two‐Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Yuan Guo, Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony D. James, Jian Li, Xi Chen
May 03, 2021
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Maize phenylalanine ammonia-lyases contribute to resistance to Sugarcane mosaic virus infection, most likely through positive regulation of salicylic acid accumulation.
Wen Yuan, Tong Jiang, Kaitong Du, Hui Chen, Yanyong Cao, Jipeng Xie, Mengfei Li, John P Carr, Boming Wu, Zaifeng Fan, Tao Zhou
May 13, 2019
Sugarcane mosaic virus (SCMV) is a pathogen of worldwide importance that causes dwarf mosaic disease on maize (Zea mays). Until now, few maize genes/proteins have been shown to be involved in resistance to SCMV. In this study...
Education and Successful Aging Trajectories
As the population ages, interest is increasing in studying aging well. However, more refined means of examining predictors of biopsychosocial conceptualizations of successful aging (SA) are required. Existing evidence of the...
Identifying the Factors Associated With Inpatient Admissions for Non-COVID-19 Illnesses
Declining inpatient admissions have serious consequences on hospital financial stability as well as the health of patients. Thus, identifying factors associated with inpatient admissions is crucial to properly manage healthcare...
Published by: IGI Global Scientific Publishing
Chitosan-based electroconductive inks without chemical reaction for cost-effective and versatile 3D printing for electromagnetic interference (EMI) shielding and strain-sensing applications
Naresh D. Sanandiya, Avinash R. Pai, Shayan Seyedin, Fengzai Tang, Sabu Thomas, Fengwei Xie
Aug 01, 2024
The burgeoning interest in biopolymer 3D printing arises from its capacity to meticulously engineer tailored, intricate structures, driven by the intrinsic benefits of biopolymers—renewability, chemical functionality, and...
Biopolymer 3D printing Biopolymer composite materials Biopolymer DIW ink Biopolymer ink rheological properties Chitosan silk protein blend EMI shielding material /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/subjectarea/asjc/2500/2507 name=Polymers and Plastics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Two‐Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
Yuan Guo, Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony D. James, Jian Li, Xi Chen
May 03, 2021
The tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation...
THE STRUCTURE OF HUMBLE CAUSATIVES IN JAPANESE
Fusa Katada
Jul 30, 2013
The so-called sa-ire 'sa-insertion' refers to a morphological change in progress in Japanese humble causatives, verbal forms with the causative suffix sase connoting the speaker's humbleness addressed toward a hearer. This...
Published by: Atlantic Provinces Linguistic Association
The importance of implementation strategy in scaling up Xpert MTB/RIF for diagnosis of tuberculosis in the Indian health-care system
Henrik Salje, Jason R Andrews, Sarang Deo, Srinath Satyanarayana, Amanda Y Sun, Madhukar Pai, David W Dowdy
Feb 15, 2021
BACKGROUND: India has announced a goal of universal access to quality tuberculosis (TB) diagnosis and treatment. A number of novel diagnostics could help meet this important goal. The rollout of one such diagnostic, Xpert...
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