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Mesenchymal stem cells from Shwachman-Diamond syndrome patients display normal functions and do not contribute to hematological defects.
V André, D Longoni, S Bresolin, C Cappuzzello, E Dander, M Galbiati, C Bugarin, A Di Meglio, E Nicolis, E Maserati, M Serafini, AJ Warren, G Te Kronnie, G Cazzaniga, L Sainati, M Cipolli, A Biondi, G D'Amico
Apr 14, 2020
Shwachman-Diamond syndrome (SDS) is a rare inherited disorder characterized by bone marrow (BM) dysfunction and exocrine pancreatic insufficiency. SDS patients have an increased risk for myelodisplastic syndrome and acute...
Enhancing the performance of decoupled software pipeline through backward slicing
The rapidly increasing number of cores available in multicore processors does not necessarily lead directly to a commensurate increase in performance: programs written in conventional languages such as C, need careful...
Enhancing the performance of decoupled software pipeline through backward slicing
The rapidly increasing number of cores available in multicore processors does not necessarily lead directly to a commensurate increase in performance: programs written in conventional languages such as C, need careful...
International Residency & Career
We're taking a look at the relationships between career fields and the desired location to work internationally. Chosen locations and career fields can help make various inferences about the relationship between the two. Other...
Published by: Harrisburg University of Science and Technology
Structural Classification of Wild Boar (Sus scrofa) Vocalizations.
Maxime Garcia, Bruno Gingras, Daniel L Bowling, Christian T Herbst, Markus Boeckle, Yann Locatelli, W Tecumseh Fitch
Feb 06, 2019
Determining whether a species' vocal communication system is graded or discrete requires definition of its vocal repertoire. In this context, research on domestic pig (Sus scrofa domesticus) vocalizations, for example, has led...
Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA.
Mathilde Gersel Wegmann, Rikke Beck Jensen, Ajay Thankamony, Jan Frystyk, Edna Roche, Hilary Hoey, Jeremy Kirk, Guftar Shaikh, Sten-A Ivarsson, Olle Söder, David B Dunger, Anders Juul
Nov 19, 2019
BACKGROUND: Some children born small for gestational age (SGA) experience supra-physiological insulin-like growth factor-I (IGF-I) concentrations during GH treatment. However, measurements of total IGF-I concentrations may not...
Characterisation of denatured states of sensory rhodopsin II by solution-state NMR.
Sensory rhodopsin II (pSRII), a retinal-binding photophobic receptor from Natronomonas pharaonis, is a novel model system for membrane protein folding studies. Recently, the SDS-denatured states and the kinetics for reversible...
Somatic genetic rescue of a germline ribosome assembly defect
Shengjiang Tan, Laëtitia Kermasson, Christine Hilcenko, Vasileios Kargas, David Traynor, Ahmed Z. Boukerrou, Norberto Escudero-Urquijo, Alexandre Faille, Alexis Bertrand, Maxim Rossmann, Beatriz Goyenechea, Li Jin, Jonathan Moreil, Olivier Alibeu, Blandine Beaupain, Christine Bôle-Feysot, Stefano Fumagalli, Sophie Kaltenbach, Jean-Alain Martignoles, Cécile Masson, Patrick Nitschké, Mélanie Parisot, Aurore Pouliet, Isabelle Radford-Weiss, Frédéric Tores, Jean-Pierre de Villartay, Mohammed Zarhrate, Ai Ling Koh, Kong Boo Phua, Bruno Reversade, Peter J. Bond, Christine Bellanné-Chantelot, Isabelle Callebaut, François Delhommeau, Jean Donadieu, Alan J. Warren, Patrick Revy
Aug 19, 2021
Abstract: Indirect somatic genetic rescue (SGR) of a germline mutation is thought to be rare in inherited Mendelian disorders. Here, we establish that acquired mutations in the EIF6 gene are a frequent mechanism of SGR in...
Feasting on terrestrial organic matter
Boreal lakes are major components of the global carbon cycle, partly because of sediment-bound heterotrophic microorganisms that decompose within-lake and terrestrially derived organic matter (t-OM). The ability for sediment...
Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome.
Joachim Woelfle, Anders Lindberg, Ferah Aydin, Ken K Ong, Cecilia Camacho-Hubner, Bettina Gohlke
Apr 19, 2018
BACKGROUND: Whether children with chromosomal disorders of growth and puberty are affected by secular trends (STs) as observed in the general population remains unanswered, but this question has relevance for expectations of...
Anogenital distance and penile length in infants with hypospadias or cryptorchidism
Ajay Thankamony, Ngee Lek, Dan Carroll, Martyn Williams, David B Dunger, Carlo L Acerini, Ken K Ong, Ieuan A Hughes
Feb 21, 2020
BACKGROUND: Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias...
Conformally-rescaled Schwarzschild metrics do not predict flat galaxy rotation curves
Abstract: For conformally invariant gravity theories defined on Riemannian spacetime and having the Schwarzschild–de-Sitter (SdS) metric as a solution in the Einstein gauge, we consider whether one may conformally rescale this...
Published by: Springer Berlin Heidelberg
Randomised controlled trial of a theory-based behavioural intervention to reduce formula milk intake.
Rajalakshmi Lakshman, Stephen J Sharp, Fiona Whittle, Annie Schiff, Wendy Hardeman, Lisa Irvine, Ed Wilson, Simon J Griffin, Ken K Ong
Aug 03, 2018
OBJECTIVE: To assess the efficacy of a theory-based behavioural intervention to prevent rapid weight gain in formula milk-fed infants. DESIGN: In this single (assessor) blind, randomised controlled trial, 669 healthy full-term...
Increased GLP-1 response to oral glucose in pre-pubertal obese children.
Cosimo Giannini, Nicoletta Pietropaoli, Nella Polidori, Francesco Chiarelli, Maria Loredana Marcovecchio, Angelika Mohn
Aug 24, 2018
BACKGROUND: Gastrointestinal hormones, such as glucagon-like peptide (GLP-1), have been hypothesized to play a role in the pathogenesis of obesity-related complications. However, few data are available in youth. The objective of...
Conformally-rescaled Schwarzschild metrics do not predict flat galaxy rotation curves
Abstract For conformally invariant gravity theories defined on Riemannian spacetime and having the Schwarzschild–de-Sitter (SdS) metric as a solution in the Einstein gauge, we consider whether one...
Bovine Serum Albumin and Fibrinogen Adsorption at the 316L Stainless Steel/Aqueous Interface.
The binding of bovine serum albumin (BSA) to a 316L stainless steel surface from a buffer solution has been characterized using neutron reflectometry and quartz crystal microbalance measurements; coverage at all concentrations...
The Ursinus Weekly, October 29, 1951
Mary Yost, Richard P. Richter, Robert Rosenberger, G. Brandon Donahue, Jonni Graf, Marilyn Engleman, Dick Hector, Sal Fitch, Ed Klein
Jan 01, 0001
Sororities bid upperclassmen during week Lachman named vice-president Henning Prentis delivers Founders Day Address Curtain Club reveals leads for Fall play Y group hears talk; Four at conference Pianist to perform in...
Ursinus College Collegeville Pennsylvania newspaper sororities Charles Lachman YMCA YWCA student government Ruby Henning Prentis Founders Day Curtain Club Natalie Ryshna rules and customs Gerald Donahue fraternities H. Lloyd Jones Student teachers Soccer Football Intramural Sports field hockey Basketball Ed Sella John E. Ryan David Whiteford Debating team cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche.
Simon R Fitch, Chrysa Kapeni, Aikaterini Tsitsopoulou, Nicola K Wilson, Berthold Göttgens, Marella F de Bruijn, Katrin Ottersbach
Oct 18, 2019
Gata3 RUNX1 aorta-gonads-mesonephros haematopoietic stem cells niche Stromal Cells Animals Aorta Core Binding Factor Alpha 2 Subunit Embryo Mammalian Embryonic Development Endothelium Vascular Female GATA3 Transcription Factor Gonads Hematopoiesis Hematopoietic Stem Cells Mesonephros Mice Mice Inbred C57BL
Evolutionary trade-off between vocal tract and testes dimensions in howler monkeys.
Jacob C Dunn, Lauren B Halenar, Thomas G Davies, Jurgi Cristobal-Azkarate, David Reby, Dan Sykes, Sabine Dengg, W Tecumseh Fitch, Leslie A Knapp
Jan 13, 2016
Rapid evolution of the primate larynx?
Daniel L Bowling, Jacob C Dunn, Jeroen B Smaers, Maxime Garcia, Asha Sato, Georg Hantke, Stephan Handschuh, Sabine Dengg, Max Kerney, Andrew C Kitchener, Michaela Gumpenberger, W Tecumseh Fitch
Aug 11, 2020
Tissue vibrations in the larynx produce most sounds that comprise vocal communication in mammals. Larynx morphology is thus predicted to be a key target for selection, particularly in species with highly developed vocal...
First‐mover disadvantage
Abstract: Using 102 sovereigns rated by the three largest credit rating agencies (CRA), S&P, Moody's and Fitch between January 2000 and January 2019, we document that the first‐mover CRA (S&P) in downgrades falls into a...
The Biogenesis of Peroxisomal Catalase in Rat Liver
Paul Bernard Lazarow
Jan 01, 0001
Rat liver peroxisomal catalase was purified to homogeneity. The starting material was purified peroxisomes, The purity of the final preparation was judged by Sephadex G-200 chromatography, SDS gel electrophoresis, spectral...
Published by: Rockefeller University
Early weight gain influences duration of breast feeding
OBJECTIVE: While several studies have shown that milk formula feeding is associated with faster infant weight gain compared with exclusively breast feeding (EBF), we explored the possible reverse association that infant weight...
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