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Brain-Penetrating Histone Deacetylase Inhibitor RG2833 Reduces the Viability of Human Malignant Melanoma Cell Lines SK-MEL-5 and SK-MEL-28 in vitro
Lauren Green
Jan 01, 0001
Histone deacetylases (HDACs) play an important role in the epigenetic control of gene expression in both normal and cancer cells. Previous studies have demonstrated that pharmaceutical inhibition of HDACs can kill and/or...
Published by: Winthrop University
Brain-Penetrating Histone Deacetylase Inhibitor RG2833: A Potential Malignant Melanoma Growth Suppressor
Histone deacetylases (HDACs) play an important role in the epigenetic control of gene expression in both normal and cancer cells. Previous studies have demonstrated that pharmaceutical inhibition of HDACs can kill and/or...
Published by: Winthrop University
Supernumerary kidneys
Peter Rehder, Rafael Rehwald, Julia M Böhm, Astrid E Grams, Alexander Loizides, Marco Pedrini, Jannik Stühmeier, Bernhard Glodny
Oct 16, 2020
BACKGROUND: A supernumerary kidney (SK) is an additional kidney with its own capsule and blood supply that is not fused with the ipsilateral kidney (IK). Because individual case reports indicate a high morbidity rate, the aim of...
A RAC-GEF network critical for early intestinal tumourigenesis.
KA Pickering, K Gilroy, JW Cassidy, SK Fey, AK Najumudeen, LB Zeiger, DF Vincent, DM Gay, J Johansson, RP Fordham, B Miller, W Clark, A Hedley, EB Unal, C Kiel, E McGhee, LM Machesky, C Nixon, AE Johnsson, M Bain, D Strathdee, SR van Hoof, JP Medema, KI Anderson, SM Brachmann, VM Stucke, A Malliri, M Drysdale, M Turner, L Serrano, K Myant, AD Campbell, OJ Sansom
Feb 08, 2021
RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we...
Intestines Animals Mice Knockout rac1 GTP-Binding Protein Guanine Nucleotide Exchange Factors Adenomatous Polyposis Coli Protein Signal Transduction Organ Specificity Up-Regulation Homeostasis Phenotype Mutation Proto-Oncogene Proteins p21(ras) Proto-Oncogene Proteins c-vav Wnt Signaling Pathway Carcinogenesis T-Lymphoma Invasion and Metastasis-inducing Protein 1
Issue Information - TOC
SK Williams
Oct 18, 2018
Despite recent scholarship historians still know relatively little about the dynamics of the maintenance of illegitimate children under the old poor law. This article examines the affiliation system in Southwark and Lambeth...
Statistical Signal Properties of the Pressure-Reactivity Index (PRx)
Objectives: The pressure-reactivity index (PRx) is defined in terms of the moving correlation
coefficient between intracranial pressure (ICP) and mean arterial pressure (MAP) and is a
measure of cerebral autoregulation ability....
Does Knowledge Really Help?
Drawing on the self-determination theory, this study explored the effect of three kinds of low-carbon knowledge (LCB), including system knowledge (SK), action-related knowledge (AK), and effectiveness knowledge (EK), on college...
Published by: IGI Global Scientific Publishing
Evaluation of Diagnostic Performance of Machine Learning Algorithms to Classify the Fetal Heart Rate Baseline From Cardiotocograph
Cardiotocography (CTG) is the widely used cost-effective, non-invasive technique to monitor the fetal heart and mother’s uterine contraction pressure to assess the wellbeing of the fetus. The most important parameters of fetal...
Published by: IGI Global Scientific Publishing
LEAP-GWU-2015
As part of the LEAP-GWU-2015 exercise, a dynamic centrifuge test was conducted at the University of Cambridge on a 5° slope of medium dense Ottawa F-65 sand. The model preparation and saturation details are presented in this...
Dynamic and monotonic response of Monopile Foundations for Offshore wind turbines using centrifuge testing
Abstract The seismic response of monopile foundations is a growing area of research as the offshore wind industry expands worldwide, including in earthquake prone regions of the world. This paper...
The global burden of trauma during the COVID-19 pandemic
Purpose; The COVID-19 pandemic has necessitated profound adaptations in the delivery of healthcare to manage a rise in critically unwell patients. In an attempt to slow the spread of the virus nationwide lockdown restrictions...
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