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Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism
Mitochondrial ATP-Mg/Pi carriers import adenine nucleotides into the mitochondrial matrix and export phosphate to the cytosol. They are calcium-regulated to control the size of the matrix adenine nucleotide pool in response to...
Neuroanatomical Correlates of Impulsive Action in Excoriation (Skin-Picking) Disorder.
Austin W Blum, Samuel R Chamberlain, Michael D Harries, Brian L Odlaug, Sarah A Redden, Jon E Grant
May 03, 2018
Excoriation (skin-picking) disorder (SPD) has similarities to obsessive-compulsive disorder (OCD) and is included within the obsessive-compulsive and related disorders (OCRD) diagnostic class in DSM-5. Separate neuroimaging and...
Rule makers and rule takers
Charles Lees
Jan 01, 0001
The last three decades has seen a steady electoral decline in the Volksparteien, culminating in the historically low share of the vote garnered by the CDU/CSU and SPD in the 2009 federal election. Despite this low vote share...
Rule makers and rule takers
Charles Lees
Jan 01, 0001
The last three decades has seen a steady electoral decline in the Volksparteien, culminating in the historically low share of the vote garnered by the CDU/CSU and SPD in the 2009 federal election. Despite this low vote share...
Identifying subtypes of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder using mixture modeling in a multicenter sample.
Jon E Grant, Tara S Peris, Emily J Ricketts, Christine Lochner, Dan J Stein, Jan Stochl, Samuel R Chamberlain, Jeremiah M Scharf, Darin D Dougherty, Douglas W Woods, John Piacentini, Nancy J Keuthen
Jan 05, 2021
Body-focused repetitive behavior disorders (BFRBs) include Trichotillomania (TTM; Hair pulling disorder) and Excoriation (Skin Picking) Disorder (SPD). These conditions are prevalent, highly heterogeneous, under-researched, and...
Thermostability Assays
There are very few generic methods to assess the stability and functional properties of membrane proteins solubilized in detergent. For this purpose, a thiol-reactive fluorochrome...
Sensory reactivity, empathizing and systemizing in autism spectrum conditions and sensory processing disorder.
Teresa Tavassoli, Lucy Jane Miller, Sarah A Schoen, Jennifer Jo Brout, Jillian Sullivan, Simon Baron-Cohen
Aug 17, 2017
Although the DSM-5 added sensory symptoms as a criterion for ASC, there is a group of children who display sensory symptoms but do not have ASC; children with sensory processing disorder (SPD). To be able to differentiate these...
Calcium-regulated mitochondrial ATP-Mg/Pi carriers evolved from a fusion of an EF-hand regulatory domain with a mitochondrial ADP/ATP carrier-like domain.
The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of...
evolution metabolic energy generation Mitochondrial carrier Mitochondrion translocase translocator transport Amino Acid Transport Systems Acidic Animals Antiporters Calcium Calcium Signaling Calcium-Binding Proteins Humans Mitochondria Mitochondrial ADP ATP Translocases Mitochondrial Proteins Protein Conformation Protein Domains Saccharomyces cerevisiae
Sleep quality and its clinical associations in trichotillomania and skin picking disorder.
BACKGROUND: Trichotillomania (TTM) is characterized by recurrent hair pulling and associated hair loss. Skin picking disorder (SPD) is characterized by recurrent skin picking and associated scarring or tissue damage. Both...
Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Ines Alvarez-Rodrigo, Thomas L Steinacker, Saroj Saurya, Paul T Conduit, Janina Baumbach, Zsofia A Novak, Mustafa G Aydogan, Alan Wainman, Jordan W Raff
Oct 31, 2019
Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear...
D. melanogaster Spd-2 Cell Biology centriole Centrosome feedback loop pericentriolar material polo kinase Animals Centrosome Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Feedback Physiological Homeodomain Proteins Mitosis Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases
Alternating minimal energy methods for linear systems in higher dimensions
We propose algorithms for the solution of high-dimensional symmetrical positive definite (SPD) linear systems with the matrix and the right-hand side given and the solution sought in a low-rank format. Similarly to density...
The Grand Coalition and the party system
Charles Lees
Sep 01, 2010
This article examines the formation of the Grand Coalition in the context of the German party system and draws upon a synthetic analytical framework derived from formal coalition theory. It argues that both the SPD and CDU/CSU...
The Grand Coalition and the party system
Charles Lees
Sep 01, 2010
This article examines the formation of the Grand Coalition in the context of the German party system and draws upon a synthetic analytical framework derived from formal coalition theory. It argues that both the SPD and CDU/CSU...
Alternating minimal energy methods for linear systems in higher dimensions
We propose algorithms for the solution of high-dimensional symmetrical positive definite (SPD) linear systems with the matrix and the right-hand side given and the solution sought in a low-rank format. Similarly to density...
Chancellor Hegemony
Charlie Lees
Jan 01, 0001
The eighteenth Bundestag elections of 22 September 2013 brought important changes to the Bundestag party system, some of which are contingent but others of which are more systemic and profound. The narrow failure of the FDP to...
Sustainable Supply Chain Management Practices in Ghana
The study assessed the sustainable supply chain management (SSCM) practices of 303 manufacturing firms in Ghana with an annual turnover of not less than $1,000,000, which were purposively selected for the study. A questionnaire...
Published by: Indonesia Strategic Sustainability
Chancellor Hegemony
Charlie Lees
Jan 01, 0001
The eighteenth Bundestag elections of 22 September 2013 brought important changes to the Bundestag party system, some of which are contingent but others of which are more systemic and profound. The narrow failure of the FDP to...
Jon E Grant, Samuel R Chamberlain, Sarah A Redden, Eric W Leppink, Brian L Odlaug, Suck Won Kim
Apr 05, 2016
IMPORTANCE: Excoriation (skin-picking) disorder (SPD) is a disabling, underrecognized condition in which individuals repeatedly pick at their skin, leading to noticeable tissue damage. To date, there has been no clearly...
Mitotic spindles in pam-1 mutant embryos of Caenorhabditis elegans
Jasmine Borie
Jan 01, 0001
Caenorhabditis elegans is a transparent nematode ideal for studying early embryonic mechanisms such as mitosis and meiosis. Mitosis is an important process involving the division of cells, and the spindles in mitosis are...
Published by: Ursinus College
The German party system(s) in 2005
Charles Lees
Jan 01, 0001
The article assesses the socio-structural underpinnings and systemic dynamics of the contemporary German party system and identifies four phenomena: an increased level of fractionalisation that has made it more difficult for...
The German party system(s) in 2005
Charles Lees
Jan 01, 0001
The article assesses the socio-structural underpinnings and systemic dynamics of the contemporary German party system and identifies four phenomena: an increased level of fractionalisation that has made it more difficult for...
A Bayesian approach for fitting and comparing demographic growth models of radiocarbon dates
Large sets of radiocarbon dates are increasingly used as proxies for inferring past population dynamics and the last few years, in particular, saw an increase in the development of new statistical techniques to overcome some of...
Published by: PLOS ONE
A Bayesian approach for fitting and comparing demographic growth models of radiocarbon dates
Large sets of radiocarbon dates are increasingly used as proxies for inferring past population dynamics and the last few years, in particular, saw an increase in the development of new statistical techniques to overcome some of...
Software-defined cloud manufacturing for industry 4.0
Many of the world’s leading industrial nations have invested in national initiatives to foster advanced manufacturing, innovation,and design for the globalized world. Much of this investment has been driven by visions such as...
Approximate Bayesian Computation of radiocarbon and paleoenvironmental record shows population resilience on Rapa Nui (Easter Island)
Abstract: Examining how past human populations responded to environmental and climatic changes is a central focus of the historical sciences. The use of summed probability distributions (SPD) of radiocarbon dates as a proxy for...
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