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Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes.
Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes
Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways.
Ran Joo Choi, Siti Zuraidah Mohamad Zobir, Ben Alexander-Dann, Nitin Sharma, Marcella Kl Ma, Brian YH Lam, Giles SH Yeo, Weidong Zhang, Tai-Ping Fan, Andreas Bender
Feb 24, 2021
Shexiang Baoxin Pill (SBP) is an oral formulation of Chinese materia medica for the treatment of angina pectoris. It displays pleiotropic roles in protecting the cardiovascular system. However, the mode of action of SBP in...
Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis
B Pignon, H Peyre, A Ayrolles, JB Kirkbride, S Jamain, A Ferchiou, JR Richard, G Baudin, S Tosato, H Jongsma, L de Haan, I Tarricone, M Bernardo, E Velthorst, M Braca, C Arango, M Arrojo, J Bobes, CM Del-Ben, M Di Forti, C Gayer-Anderson, PB Jones, C La Cascia, A Lasalvia, PR Menezes, D Quattrone, J Sanjuán, JP Selten, A Tortelli, PM Llorca, J van Os, BPF Rutten, RM Murray, C Morgan, M Leboyer, A Szöke, F Schürhoff
Oct 28, 2022
AIMS: Gene x environment (G×E) interactions, i.e. genetic modulation of the sensitivity to environmental factors and/or environmental control of the gene expression, have not been reliably established regarding aetiology of...
What Are the Determinants of the Attitude of Civil Servants Toward Using e-Public Procurement?
Mohamad Alomar
Jan 01, 2023
Civil servants are the main users of e-public procurement applications. Their attitude toward using the new system is a crucial element for its successful implementation. However, few studies focused on this topic in public...
Published by: IGI Global Scientific Publishing
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis
Diego Quattrone, Ulrich Reininghaus, Alex L Richards, Giada Tripoli, Laura Ferraro, Andrea Quattrone, Paolo Marino, Victoria Rodriguez, Edoardo Spinazzola, Charlotte Gayer-Anderson, Hannah E Jongsma, Peter B Jones, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Elena Bonora, Sarah Tosato, Antonio Lasalvia, Andrei Szöke, Celso Arango, Miquel Bernardo, Julio Bobes, Cristina Marta Del Ben, Paulo Rossi Menezes, Pierre-Michel Llorca, Jose Luis Santos, Julio Sanjuán, Manuel Arrojo, Andrea Tortelli, Eva Velthorst, Steven Berendsen, Lieuwe de Haan, Bart P F Rutten, Michael T Lynskey, Tom P Freeman, James B Kirkbride, Pak C Sham, Michael C O'Donovan, Alastair G Cardno, Evangelos Vassos, Jim van Os, Craig Morgan, Robin M Murray, Cathryn M Lewis, Marta Di Forti
Sep 11, 2021
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on...
Published by: Translational psychiatry
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis
Diego Quattrone, Ulrich Reininghaus, Alex L. Richards, Giada Tripoli, Laura Ferraro, Andrea Quattrone, Paolo Marino, Victoria Rodriguez, Edoardo Spinazzola, Charlotte Gayer-Anderson, Hannah E. Jongsma, Peter B. Jones, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Elena Bonora, Sarah Tosato, Antonio Lasalvia, Andrei Szöke, Celso Arango, Miquel Bernardo, Julio Bobes, Cristina Marta Del Ben, Paulo Rossi Menezes, Pierre-Michel Llorca, Jose Luis Santos, Julio Sanjuán, Manuel Arrojo, Andrea Tortelli, Eva Velthorst, Steven Berendsen, Lieuwe de Haan, Bart P. F. Rutten, Michael T. Lynskey, Tom P. Freeman, James B. Kirkbride, Pak C. Sham, Michael C. O’Donovan, Alastair G. Cardno, Evangelos Vassos, Jim van Os, Craig Morgan, Robin M. Murray, Cathryn M. Lewis, Marta Di Forti, Kathryn Hubbard, Stephanie Beards, Simona A. Stilo, Mara Parellada, David Fraguas, Marta Rapado Castro, Álvaro Andreu-Bernabeu, Gonzalo López, Mario Matteis, Emiliano González, Manuel Durán-Cutilla, Covadonga M. Díaz-Caneja, Pedro Cuadrado, José Juan Rodríguez Solano, Angel Carracedo, Javier Costas, Emilio Sánchez, Silvia Amoretti, Esther Lorente-Rovira, Paz Garcia-Portilla, Estela Jiménez-López, Nathalie Franke, Daniella van Dam, Fabian Termorshuizen, Elsje van der Ven, Elles Messchaart, Marion Leboyer, Franck Schürhoff, Stéphane Jamain, Grégoire Baudin, Aziz Ferchiou, Baptiste Pignon, Jean-Romain Richard, Thomas Charpeaud, Anne-Marie Tronche, Flora Frijda, Giovanna Marrazzo, Lucia Sideli, Crocettarachele Sartorio, Fabio Seminerio, Camila Marcelino Loureiro, Rosana Shuhama, Mirella Ruggeri, Chiara Bonetto, Doriana Cristofalo, Domenico Berardi, Marco Seri, Giuseppe D’Andrea
Aug 11, 2021
Abstract: Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of...
Mango Agribusiness Development Strategy For Sustainable Agriculture In Karanganyar
An agrarian country prioritizes the agricultural sector as its resource because it provides a high and influential contribution to the community, Indonesia is one of a country that has abundant natural resources and its economy...
ANP Analytic network process agribusiness mango farmers Mango agribusiness development mango agribusiness strategy priorities
Published by: Indonesia Strategic Sustainability
Neuregulin 1 Type I Overexpression Is Associated with Reduced NMDA Receptor-Mediated Synaptic Signaling in Hippocampal Interneurons Expressing PV or CCK.
Dimitrios Kotzadimitriou, Wiebke Nissen, Melinda Paizs, Kathryn Newton, Paul J Harrison, Ole Paulsen, Karri Lamsa
May 16, 2018
Hypofunction of N-methyl-d-aspartate receptors (NMDARs) in inhibitory GABAergic interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder with many susceptibility genes. However, it is still...
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years.
Johannes Lieslehto, Erika Jääskeläinen, Vesa Kiviniemi, Marianne Haapea, Peter B Jones, Graham K Murray, Juha Veijola, Udo Dannlowski, Dominik Grotegerd, Susanne Meinert, Tim Hahn, Anne Ruef, Matti Isohanni, Peter Falkai, Jouko Miettunen, Dominic B Dwyer, Nikolaos Koutsouleris
Jul 28, 2021
Age plays a crucial role in the performance of schizophrenia vs. controls (SZ-HC) neuroimaging-based machine learning (ML) models as the accuracy of identifying first-episode psychosis from controls is poor compared to chronic...
Published by: NPJ schizophrenia
Beyond digital shadows
Abstract Current research on Digital Twin (DT) is largely focused on the performance of built assets in their operational phases as well as on urban environment. However, Digital Twin has not been...
Proof of concept for a smart composite orbital debris detector
Mario Emanuele De Simone, Christos Andreades, Amin Mohamad Hilmi, Michele Meo, Francesco Ciampa
Jul 01, 2019
Space debris particles with dimensions smaller than tens of millimetres are not trackable with existing monitoring systems and have sufficient energy to harm orbiting Earth satellites during impact events. This paper presents...
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years
Johannes Lieslehto, Erika Jääskeläinen, Vesa Kiviniemi, Marianne Haapea, Peter B. Jones, Graham K. Murray, Juha Veijola, Udo Dannlowski, Dominik Grotegerd, Susanne Meinert, Tim Hahn, Anne Ruef, Matti Isohanni, Peter Falkai, Jouko Miettunen, Dominic B. Dwyer, Nikolaos Koutsouleris
Jun 14, 2021
Abstract: Age plays a crucial role in the performance of schizophrenia vs. controls (SZ-HC) neuroimaging-based machine learning (ML) models as the accuracy of identifying first-episode psychosis from controls is poor compared to...
The Dilemma of the Copyrights of Artificial Intelligence
Artificial intelligence (AI) and intellectual property (IP) share some key similarities, such as uncertainty in predictions, processing a massive amount of data, and machine learning. Yet, they also differ from each other. This...
Published by: IGI Global Scientific Publishing
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years.
Johannes Lieslehto, Erika Jääskeläinen, Vesa Kiviniemi, Marianne Haapea, Peter B Jones, Graham K Murray, Juha Veijola, Udo Dannlowski, Dominik Grotegerd, Susanne Meinert, Tim Hahn, Anne Ruef, Matti Isohanni, Peter Falkai, Jouko Miettunen, Dominic B Dwyer, Nikolaos Koutsouleris
Jul 21, 2021
Age plays a crucial role in the performance of schizophrenia vs. controls (SZ-HC) neuroimaging-based machine learning (ML) models as the accuracy of identifying first-episode psychosis from controls is poor compared to chronic...
No Evolution in the Half-mass Radius of Milky Way-type Galaxies over the Last 10 Gyr
Abstract
The Milky Way (MW) galaxy is in focus, thanks to new observational data. Here we shed new light on the MW’s past by studying the structural evolution of MW progenitors...
The Effect of the COVID-19 Pandemic on the Mobile Messaging Application Among Millennials in Public Universities in Malaysia
Mobile messaging apps are currently a popular method in Malaysia for communicating while on the go, owing to its convenience, reliability, and contact-free feature of mobile application. Fueled by mobile internet and smartphone...
Published by: IGI Global Scientific Publishing
The Patentability of AI Invention
Artificial intelligence has gained momentum in the recent past due to technological advancements. As a result, it has elicited an endless debate particularly in light of intellectual property laws. Artificial Intelligence is...
Published by: IGI Global Scientific Publishing
Reactive Power Optimization Using New Enhanced Whale Optimization Algorithm
The standard Whale Optimization Algorithm (WOA) involves exploitation and exploration operations which require to be balanced for improved performance. This paper suggests a new enhanced WOA to improve the convergence speed and...
Published by: IGI Global Scientific Publishing
Proof of concept for a smart composite orbital debris detector
Mario Emanuele De Simone, Christos Andreades, Amin Mohamad Hilmi, Michele Meo, Francesco Ciampa
Jul 01, 2019
Space debris particles with dimensions smaller than tens of millimetres are not trackable with existing monitoring systems and have sufficient energy to harm orbiting Earth satellites during impact events. This paper presents...
Supernetwork Representation Formulation of a Multiclass Simultaneous Transportation Equilibrium Model as a Fixed Demand User Equilibrium Problem
A multiclass simultaneous transportation equilibrium model (MSTEM) explicitly distinguishes between different user classes in terms of socioeconomic attributes, trip purpose, pure and combined transportation modes, as well as...
Published by: IGI Global Scientific Publishing
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