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Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae.
Sagar Raturi, Asha V Nair, Keiko Shinoda, Himansha Singh, Boyan Bai, Satoshi Murakami, Hideaki Fujitani, Hendrik W van Veen
Jun 12, 2021
Multidrug and toxic compound extrusion (MATE) transport proteins confer multidrug resistance on pathogenic microorganisms and affect pharmacokinetics in mammals. Our understanding of how MATE transporters work, has mostly relied...
Published by: Communications biology
A Role for RAS in V-CRK Transformation
Heidi Greulich
Jan 01, 0001
The v-Crk oncogene product, while possessing no intrinsic tyrosine kinase activity, causes an elevation in levels of cellular phosphotyrosine as it transforms chicken embryo fibroblasts (CEF). Because of this similarity to v-Src...
Published by: Rockefeller University
LITTLE v IN INUKTITUT
Bettina Spreng
Jul 30, 2013
This paper provides an in-depth examination of the distribution of the Antipassive morpheme -si- in Mittimatalik, a dialect of !nuktitut spoken in North Baffin. It is demonstrated that the occurrence of the overt Antipassive...
Published by: Atlantic Provinces Linguistic Association
LITTLE v IN INUKTITUT
Bettina Spreng
Jul 30, 2013
This paper provides an in-depth examination of the distribution of the Antipassive morpheme -si- in Mittimatalik, a dialect of !nuktitut spoken in North Baffin. It is demonstrated that the occurrence of the overt Antipassive...
Published by: Atlantic Provinces Linguistic Association
Structure and metallicity of phase V of hydrogen
B Monserrat, Neil D Drummond, Philip Dalladay-Simpson, Ross T Howie, Pablo Lopez Rios, Eugene Gregoryanz, Chris J Pickard, Richard J Needs
Oct 08, 2018
A new phase V of hydrogen was recently claimed in experiments above 325 GPa and 300 K. Due to the extremely small sample size at such record pressures the measurements were limited to Raman spectroscopy. The experimental data on...
Patel v Mirza
G Virgo
Nov 17, 2016
The decision of the Supreme Court in Patel v Mirza is now the leading case on the application of the defence of illegality to private law claims, which has resolved a controversy among the Justices of the Supreme Court as to...
Comparing Centrosome Behavior in Wild-Type and pam-1 Mutant One-Celled Caenorhabditis elegans Embryos
Devayu A. Parikh
Jan 01, 0001
Polarization occurs in all organisms and is fundamental to specifying various cell fates and achieving functional potential. In one-cell C. elegans embryos, polarization, characterized by a first asymmetric division, establishes...
Published by: Ursinus College
Evaluating the Clinical Feasibility of an Artificial Intelligence-Powered, Web-Based Clinical Decision Support System for the Treatment of Depression in Adults
Christina Popescu, Grace Golden, David Benrimoh, Myriam Tanguay-Sela, Dominique Slowey, Eryn Lundrigan, Jérôme Williams, Bennet Desormeau, Divyesh Kardani, Tamara Perez, Colleen Rollins, Sonia Israel, Kelly Perlman, Caitrin Armstrong, Jacob Baxter, Kate Whitmore, Marie-Jeanne Fradette, Kaelan Felcarek-Hope, Ghassen Soufi, Robert Fratila, Joseph Mehltretter, Karl Looper, Warren Steiner, Soham Rej, Jordan F Karp, Katherine Heller, Sagar V Parikh, Rebecca McGuire-Snieckus, Manuela Ferrari, Howard Margolese, Gustavo Turecki
Jan 06, 2022
BACKGROUND: Approximately two-thirds of patients with major depressive disorder do not achieve remission during their first treatment. There has been increasing interest in the use of digital, artificial intelligence-powered...
Montgomery's legal and practical impact
Isabelle Le Gallez, Jeffrey Skopek, Kathleen Liddell, Isla Kuhn, Andrew Sagar, Zoë Fritz
Sep 09, 2021
RATIONALE, AIMS AND OBJECTIVES: Six years ago, the Supreme Court judgement in Montgomery v Lanarkshire changed medical law. It introduced a new patient-based standard of care for the communication of treatment risks and...
THE STATE WITHOUT SOVEREIGNTY
Paul Sagar
Jun 08, 2015
Sociability, Luxury and Sympathy
Paul Sagar
Jun 08, 2015
Novel rhenium(V) nitride complexes with dithiocarbimate ligands
Joanne Perils, Fernando Cortezon-Tamarit, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Jonathan R Dilworth, Sofia I. Pascu
Apr 24, 2018
The application of rhenium complexes as therapeutic agents in nuclear medicine has propelled research into the chemistry of these compounds. In our effort to develop and investigate new therapeutic radiopharmaceuticals based...
Amphoteric Colloids. V. The Influence of the Valency of Anions Upon the Physical Properties of Gelatin
Jacques Loeb
Jan 01, 0001
Jacques Loeb. Amphoteric colloids. V. The influence of the valency of anions upon the physical properties of gelatin
Reprinted from J. Gen.Physiol., 1919, 1(5):559-580
Published by: Rockefeller University
Professor Steven V Ley CBE FRS FMedSci
Steven V Ley
Sep 10, 2018
Professor Steven Ley is currently Professor of Chemistry and Director of Research at at the University of Cambridge. He is also a Fellow of Trinity College and was BP 1702 Professor of Chemistry for 21 years. Steve obtained his...
Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae.
Sagar Raturi, Asha V Nair, Keiko Shinoda, Himansha Singh, Boyan Bai, Satoshi Murakami, Hideaki Fujitani, Hendrik W van Veen
Apr 07, 2021
Novel rhenium(V) nitride complexes with dithiocarbimate ligands
Joanne Perils, Fernando Cortezon-Tamarit, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Jonathan R Dilworth, Sofia I. Pascu
Apr 24, 2018
The application of rhenium complexes as therapeutic agents in nuclear medicine has propelled research into the chemistry of these compounds. In our effort to develop and investigate new therapeutic radiopharmaceuticals based...
Beyond sympathy
P Sagar
Feb 13, 2017
Adam Smith’s $\textit{Theory of Moral Sentiments}$ (TMS) has long been recognized as importantly influenced by, and in part responding to, David Hume’s earlier ethical theory. With regard to Smith’s account of the foundations of...
Automatic Question Answering From Large ESG Reports
ESG reports contain crucial information about the corporations' environmental impact, social responsibilities, and governance. Many compliance audits rely on answering questions based on these reports. Moreover, for tasks such...
Published by: IGI Global Scientific Publishing
The Effects of Estrogen, BPA, and BPA Structural Analogs on the MCF-7 Breast Cancer Cell Line
Saloni Parikh
Jan 01, 0001
Cancer results from genetic mutations that lead to a harmful uncontrollable cell division and differentiation. Once the cancer cells amass to a large amount, angiogenesis can turn this group of cells into a malignant tumor. The...
Breast Cancer bisphenols metastasis BPA Cathepsins endocrine disrupting compounds (EDCs) Biochemistry Biochemistry, Biophysics, and Structural Biology Chemicals and Drugs Environmental Public Health Enzymes and Coenzymes Hormones, Hormone Substitutes, and Hormone Antagonists Life Sciences Maternal and Child Health Medical Sciences Medicine and Health Sciences Molecular Biology Other Chemicals and Drugs Public Health Women's Health
Published by: Ursinus College
Migratory Metrics of Wound Healing
Metastatic dissemination generates an aggressive disease facilitated by enhanced migratory and invasive properties. Experimental approaches employ several in vitro and in vivo assays toward quantification of these...
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