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Strain maps characterize the symmetry of convergence and extension patterns during zebrafish gastrulation.
During gastrulation of the zebrafish embryo, the cap of blastoderm cells organizes into the axial body plan of the embryo with left-right symmetry and head-tail, dorsal-ventral polarities. Our labs have been interested in the...
Innovations, Challenges and Future Directions in Nature of Science Research
There has been sustained research interest in the role of early career researchers in advancing the field and the challenges that they face. However, efforts to document lived experiences of researchers working in a specific...
Probing energetic light dark matter with multi-particle tracks signatures at DUNE
The search for relativistic scattering signals of cosmogenic light dark
matter at terrestrial detectors has received increasing attention as an
alternative approach to probe dark-sector physics. Large-volume neutrino
experiments...
Probing energetic light dark matter with multi-particle tracks signatures at DUNE
Albert De Roeck, Doojin Kim, Zahra Gh. Moghaddam, Jong-Chul Park, Seodong Shin, Leigh H. Whitehead
Nov 11, 2020
Abstract: The search for relativistic scattering signals of cosmogenic light dark matter at terrestrial detectors has received increasing attention as an alternative approach to probe dark-sector physics. Large-volume neutrino...
Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam).
Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E Welland, Lobat Tayebi
Oct 28, 2019
BACKGROUND: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating...
DOX PVCL Raft Cancer Drug delivery Lysine Caprolactam Cell Death Doxorubicin Drug Carriers Drug Delivery Systems Drug Liberation Humans Hydrogels Hydrogen-Ion Concentration Lysine MCF-7 Cells Molecular Weight Nanoparticles Phase Transition Polymers Proton Magnetic Resonance Spectroscopy spectroscopy Fourier Transform Infrared Temperature Toxicity Tests
Mitochondrial dysfunction in liver failure requiring transplantation.
Maria Lane, Veronika Boczonadi, Sahar Bachtari, Aurora Gomez-Duran, Thorsten Langer, Alexandra Griffiths, Stephanie Kleinle, Christine Dineiger, Angela Abicht, Elke Holinski-Feder, Ulrike Schara, Patrick Gerner, Rita Horvath
Mar 07, 2019
Liver failure is a heterogeneous condition which may be fatal and the primary cause is frequently unknown. We investigated mitochondrial oxidative phosphorylation in patients undergoing liver transplantation. We studied 45...
Liver Mitochondria Humans Liver Neoplasms Biliary Atresia Liver Failure Liver Cirrhosis Mitochondrial Diseases Electron Transport Complex IV DNA Mitochondrial Liver Transplantation Electron Transport Oxidative Phosphorylation Adolescent Adult Middle Aged Child Child Preschool Infant Female Male Young Adult
Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and BioMEMS
Amirhossein Farahani, Abbas Zarei-Hanzaki, Hamid Reza Abedi, Sara Daryoush, Zahra Delbari Ragheb, Fatemeh Mianabadi, Sahar Shahparvar, Mohammad Akrami, Ebrahim Mostafavi, Hamideh Khanbareh, Farhad R. Nezami
Nov 30, 2023
As an FDA-approved biopolymer, silk has been contemplated for a wide range of applications based on its unique merits, such as biocompatibility, biodegradability, and piezoelectricity. As silk, in both crystalline structure...
Short-term and long-term mate preference in men and women in an Iranian population.
Fatemeh Sadat Mirfazeli, Meng-Chuan Lai, Amirhossein Memari, Armin Rajab, Milad Shafizadeh, Sahar Zarei, Seyed Vahid Shariat, Maryam Haghighi Fashi, Ebrahim Barzegary, Abdol-Hossein Vahabie
Oct 21, 2021
Mate preference in short-term relationships and long-term ones may depend on many physical, psychological, and socio-cultural factors. In this study, 178 students (81 females) in sports and 153 engineering students (64 females)...
Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and BioMEMS
Amirhossein Farahani, Abbas Zarei-Hanzaki, Hamid Reza Abedi, Sara Daryoush, Zahra Delbari Ragheb, Fatemeh Mianabadi, Sahar Shahparvar, Mohammad Akrami, Ebrahim Mostafavi, Hamideh Khanbareh, Farhad R. Nezami
Nov 30, 2023
As an FDA-approved biopolymer, silk has been contemplated for a wide range of applications based on its unique merits, such as biocompatibility, biodegradability, and piezoelectricity. As silk, in both crystalline structure...
Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors.
Zainab M Elsayed, Hadia Almahli, Alessio Nocentini, Andrea Ammara, Claudiu T Supuran, Wagdy M Eldehna, Sahar M Abou-Seri
Apr 17, 2023
As part of our ongoing endeavour to identify novel inhibitors of cancer-associated CA isoforms IX and XII as possible anticancer candidates, here we describe the design and synthesis of small library of 2-aryl-quinazolin-4-yl...
Systematic lymphadenectomy versus sampling of ipsilateral mediastinal lymph-nodes during lobectomy for non-small-cell lung cancer
Sahar Mokhles, Fergus Macbeth, Tom Treasure, Riad N Younes, Robert C Rintoul, Francesca Fiorentino, Ad JJC Bogers, Johanna JM Takkenberg
Sep 08, 2018
OBJECTIVES: To re-examine the evidence for recommendations for complete dissection versus sampling of ipsilateral mediastinal lymph nodes during lobectomy for cancer. METHODS: We searched for randomized trials of systematic...
Bright light-emitting diodes based on organometal halide perovskite.
Determinants of gastroesophageal reflux disease, including hookah smoking and opium use- a cross-sectional analysis of 50,000 individuals.
Farhad Islami, Siavosh Nasseri-Moghaddam, Akram Pourshams, Hossein Poustchi, Shahryar Semnani, Farin Kamangar, Arash Etemadi, Shahin Merat, Masoud Khoshnia, Sanford M Dawsey, Paul D Pharoah, Paul Brennan, Christian C Abnet, Paolo Boffetta, Reza Malekzadeh
Sep 21, 2018
BACKGROUND: Gastroesophageal reflux disease (GERD) is a common cause of discomfort and morbidity worldwide. However, information on determinants of GERD from large-scale studies in low- to medium-income countries is limited. We...
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M Svensson, Michael P Menden, Ulrika SH Simonsson, On Behalf Of The Unite Tb Consortium
Jul 23, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic...
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M Svensson, Michael P Menden, Ulrika SH Simonsson, On Behalf Of The Unite Tb Consortium
Sep 02, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic...
A Study of Qillatunnaum (Sleep Deprivation)
Mental problems have been recognized from the earliest time in Unani Medicine. The Greek Physician, Hippocrates (460-377 BC) was the first medical man who rejected the idea of demonology and offered a new theory that mental...
Published by: IJHS Medical Association
A Study of Qillatunnaum (Sleep Deprivation)
Mental problems have been recognized from the earliest time in Unani Medicine. The Greek Physician, Hippocrates (460-377 BC) was the first medical man who rejected the idea of demonology and offered a new theory that mental...
Published by: IJHS Medical Association
The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones.
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R Tough, Paulo Watanabe, Eduardo JA Araujo, Sahar D Mohammed, Jean-Marie Delalande, David C Bulmer, S Mark Scott, Helen M Cox, Nicol C Voermans, Qasim Aziz, L Ashley Blackshaw
Sep 20, 2018
KEY POINTS: Tenascin-X (TNX) is an extracellular matrix glycoprotein with anti-adhesive properties in skin and joints. Here we report the novel finding that TNX is expressed in human and mouse gut tissue where it is exclusive to...
Household Fuel Use and the Risk of Gastrointestinal Cancers
Mahdi Sheikh, Hossein Poustchi, Akram Pourshams, Masoud Khoshnia, Abdolsamad Gharavi, Mahdi Zahedi, Gholamreza Roshandel, Sadaf G Sepanlou, Abdolreza Fazel, Maryam Hashemian, Behrooz Abaei, Masoud Sotoudeh, Arash Nikmanesh, Shahin Merat, Arash Etemadi, Siavosh Nasseri Moghaddam, Farhad Islami, Farin Kamangar, Paul D Pharoah, Sanford M Dawsey, Christian C Abnet, Paolo Boffetta, Paul Brennan, Reza Malekzadeh
Dec 15, 2020
BACKGROUND: Three billion people burn nonclean fuels for household purposes. Limited evidence suggests a link between household fuel use and gastrointestinal (GI) cancers. OBJECTIVES: We investigated the relationship between...
meaRtools
Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Louise E Docherty, Faisal I Rezwan, Rebecca L Poole, Claire LS Turner, Emma Kivuva, Eamonn R Maher, Sarah F Smithson, Julian P Hamilton-Shield, Michal Patalan, Maria Gizewska, Jaroslaw Peregud-Pogorzelski, Jasmin Beygo, Karin Buiting, Bernhard Horsthemke, Lukas Soellner, Matthias Begemann, Thomas Eggermann, Emma Baple, Sahar Mansour, I Karen Temple, Deborah JG Mackay
Sep 17, 2015
Abortion Spontaneous Adolescent Adult Autistic Disorder Autoantigens Beckwith-Wiedemann syndrome Computer Simulation DNA Copy Number Variations DNA Methylation Diabetes mellitus Epigenesis Genetic Female Genomic Imprinting Humans Hydatidiform Mole Infant Newborn Diseases Infertility female Male Mitochondrial Proteins Mothers Mutation Nuclear Proteins obesity Polymerase Chain Reaction Pregnancy Sequence Analysis DNA Silver-Russell Syndrome Twins Monozygotic Uterine Neoplasms Young Adult
Genetic association analysis of 77,539 genomes reveals rare disease etiologies
Daniel Greene, Daniela Pirri, Karen Frudd, Ege Sackey, Mohammed Al-Owain, Arnaud PJ Giese, Khushnooda Ramzan, Sehar Riaz, Itaru Yamanaka, Nele Boeckx, Chantal Thys, Bruce D Gelb, Paul Brennan, Verity Hartill, Julie Harvengt, Tomoki Kosho, Sahar Mansour, Mitsuo Masuno, Takako Ohata, Helen Stewart, Khalid Taibah, Claire LS Turner, Faiqa Imtiaz, Saima Riazuddin, Takayuki Morisaki, Pia Ostergaard, Bart L Loeys, Hiroko Morisaki, Zubair M Ahmed, Graeme M Birdsey, Kathleen Freson, Andrew Mumford, Ernest Turro
Mar 22, 2023
Clinical and molecular consequences of disease-associated de novo mutations in SATB2.
Hemant Bengani, Mark Handley, Mohsan Alvi, Rita Ibitoye, Melissa Lees, Sally Ann Lynch, Wayne Lam, Madeleine Fannemel, Ann Nordgren, H Malmgren, M Kvarnung, Sarju Mehta, Shane McKee, Margo Whiteford, Fiona Stewart, Fiona Connell, Jill Clayton-Smith, Sahar Mansour, Shehla Mohammed, Alan Fryer, Jenny Morton, UK10K consortium, Detelina Grozeva, Tara Asam, David Moore, Alejandro Sifrim, Jeremy McRae, Matthew E Hurles, Helen V Firth, F Lucy Raymond, Usha Kini, Christoffer Nellåker, DDD Study, David R FitzPatrick
Jun 25, 2018
PURPOSE: To characterize features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability. METHODS: Twenty previously unreported individuals with 19 different...
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