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Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and BioMEMS
Amirhossein Farahani, Abbas Zarei-Hanzaki, Hamid Reza Abedi, Sara Daryoush, Zahra Delbari Ragheb, Fatemeh Mianabadi, Sahar Shahparvar, Mohammad Akrami, Ebrahim Mostafavi, Hamideh Khanbareh, Farhad R. Nezami
Nov 30, 2023
As an FDA-approved biopolymer, silk has been contemplated for a wide range of applications based on its unique merits, such as biocompatibility, biodegradability, and piezoelectricity. As silk, in both crystalline structure...
Bio-MEMS Bio-sensors cancer therapy Diabetic diseases Drug Delivery Systems Electro-active biopolymer Silk fibroin (SF) Tissue Engineering Wearable bioelectronic Wound Healing /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2500/2507 name=Polymers and Plastics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and BioMEMS
Amirhossein Farahani, Abbas Zarei-Hanzaki, Hamid Reza Abedi, Sara Daryoush, Zahra Delbari Ragheb, Fatemeh Mianabadi, Sahar Shahparvar, Mohammad Akrami, Ebrahim Mostafavi, Hamideh Khanbareh, Farhad R. Nezami
Nov 30, 2023
As an FDA-approved biopolymer, silk has been contemplated for a wide range of applications based on its unique merits, such as biocompatibility, biodegradability, and piezoelectricity. As silk, in both crystalline structure...
Bio-MEMS Bio-sensors cancer therapy Diabetic diseases Drug Delivery Systems Electro-active biopolymer Silk fibroin (SF) Tissue Engineering Wearable bioelectronic Wound Healing /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2500/2507 name=Polymers and Plastics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Strain maps characterize the symmetry of convergence and extension patterns during zebrafish gastrulation.
During gastrulation of the zebrafish embryo, the cap of blastoderm cells organizes into the axial body plan of the embryo with left-right symmetry and head-tail, dorsal-ventral polarities. Our labs have been interested in the...
Innovations, Challenges and Future Directions in Nature of Science Research
There has been sustained research interest in the role of early career researchers in advancing the field and the challenges that they face. However, efforts to document lived experiences of researchers working in a specific...
Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam).
Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E Welland, Lobat Tayebi
Oct 28, 2019
BACKGROUND: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating...
DOX PVCL Raft Cancer Drug delivery Lysine Caprolactam Cell Death Doxorubicin Drug Carriers Drug Delivery Systems Drug Liberation Humans Hydrogels Hydrogen-Ion Concentration Lysine MCF-7 Cells Molecular Weight Nanoparticles Phase Transition Polymers Proton Magnetic Resonance Spectroscopy spectroscopy Fourier Transform Infrared Temperature Toxicity Tests
Mitochondrial dysfunction in liver failure requiring transplantation.
Maria Lane, Veronika Boczonadi, Sahar Bachtari, Aurora Gomez-Duran, Thorsten Langer, Alexandra Griffiths, Stephanie Kleinle, Christine Dineiger, Angela Abicht, Elke Holinski-Feder, Ulrike Schara, Patrick Gerner, Rita Horvath
Mar 07, 2019
Liver failure is a heterogeneous condition which may be fatal and the primary cause is frequently unknown. We investigated mitochondrial oxidative phosphorylation in patients undergoing liver transplantation. We studied 45...
Liver Mitochondria Humans Liver Neoplasms Biliary Atresia Liver Failure Liver Cirrhosis Mitochondrial Diseases Electron Transport Complex IV DNA Mitochondrial Liver Transplantation Electron Transport Oxidative Phosphorylation Adolescent Adult Middle Aged Child Child Preschool Infant Female Male Young Adult
Short-term and long-term mate preference in men and women in an Iranian population.
Fatemeh Sadat Mirfazeli, Meng-Chuan Lai, Amirhossein Memari, Armin Rajab, Milad Shafizadeh, Sahar Zarei, Seyed Vahid Shariat, Maryam Haghighi Fashi, Ebrahim Barzegary, Abdol-Hossein Vahabie
Oct 21, 2021
Mate preference in short-term relationships and long-term ones may depend on many physical, psychological, and socio-cultural factors. In this study, 178 students (81 females) in sports and 153 engineering students (64 females)...
Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors.
Zainab M Elsayed, Hadia Almahli, Alessio Nocentini, Andrea Ammara, Claudiu T Supuran, Wagdy M Eldehna, Sahar M Abou-Seri
Apr 17, 2023
As part of our ongoing endeavour to identify novel inhibitors of cancer-associated CA isoforms IX and XII as possible anticancer candidates, here we describe the design and synthesis of small library of 2-aryl-quinazolin-4-yl...
Systematic lymphadenectomy versus sampling of ipsilateral mediastinal lymph-nodes during lobectomy for non-small-cell lung cancer
Sahar Mokhles, Fergus Macbeth, Tom Treasure, Riad N Younes, Robert C Rintoul, Francesca Fiorentino, Ad JJC Bogers, Johanna JM Takkenberg
Sep 08, 2018
OBJECTIVES: To re-examine the evidence for recommendations for complete dissection versus sampling of ipsilateral mediastinal lymph nodes during lobectomy for cancer. METHODS: We searched for randomized trials of systematic...
A Study of Qillatunnaum (Sleep Deprivation)
Mental problems have been recognized from the earliest time in Unani Medicine. The Greek Physician, Hippocrates (460-377 BC) was the first medical man who rejected the idea of demonology and offered a new theory that mental...
Published by: IJHS Medical Association
A Study of Qillatunnaum (Sleep Deprivation)
Mental problems have been recognized from the earliest time in Unani Medicine. The Greek Physician, Hippocrates (460-377 BC) was the first medical man who rejected the idea of demonology and offered a new theory that mental...
Published by: IJHS Medical Association
The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones.
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R Tough, Paulo Watanabe, Eduardo JA Araujo, Sahar D Mohammed, Jean-Marie Delalande, David C Bulmer, S Mark Scott, Helen M Cox, Nicol C Voermans, Qasim Aziz, L Ashley Blackshaw
Sep 20, 2018
KEY POINTS: Tenascin-X (TNX) is an extracellular matrix glycoprotein with anti-adhesive properties in skin and joints. Here we report the novel finding that TNX is expressed in human and mouse gut tissue where it is exclusive to...
meaRtools
Sahar Gelfman, Quanli Wang, Yi-Fan Lu, Diana Hall, Christopher D Bostick, Ryan Dhindsa, Matt Halvorsen, K Melodi McSweeney, Ellese Cotterill, Tom Edinburgh, Michael A Beaumont, Wayne N Frankel, Slavé Petrovski, Andrew S Allen, Michael J Boland, David B Goldstein, Stephen J Eglen
Nov 16, 2018
Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Louise E Docherty, Faisal I Rezwan, Rebecca L Poole, Claire LS Turner, Emma Kivuva, Eamonn R Maher, Sarah F Smithson, Julian P Hamilton-Shield, Michal Patalan, Maria Gizewska, Jaroslaw Peregud-Pogorzelski, Jasmin Beygo, Karin Buiting, Bernhard Horsthemke, Lukas Soellner, Matthias Begemann, Thomas Eggermann, Emma Baple, Sahar Mansour, I Karen Temple, Deborah JG Mackay
Sep 17, 2015
Abortion Spontaneous Adolescent Adult Autistic Disorder Autoantigens Beckwith-Wiedemann syndrome Computer Simulation DNA Copy Number Variations DNA Methylation Diabetes mellitus Epigenesis Genetic Female Genomic Imprinting Humans Hydatidiform Mole Infant Newborn Diseases Infertility female Male Mitochondrial Proteins Mothers Mutation Nuclear Proteins obesity Polymerase Chain Reaction Pregnancy Sequence Analysis DNA Silver-Russell Syndrome Twins Monozygotic Uterine Neoplasms Young Adult
Genetic association analysis of 77,539 genomes reveals rare disease etiologies
Daniel Greene, Daniela Pirri, Karen Frudd, Ege Sackey, Mohammed Al-Owain, Arnaud PJ Giese, Khushnooda Ramzan, Sehar Riaz, Itaru Yamanaka, Nele Boeckx, Chantal Thys, Bruce D Gelb, Paul Brennan, Verity Hartill, Julie Harvengt, Tomoki Kosho, Sahar Mansour, Mitsuo Masuno, Takako Ohata, Helen Stewart, Khalid Taibah, Claire LS Turner, Faiqa Imtiaz, Saima Riazuddin, Takayuki Morisaki, Pia Ostergaard, Bart L Loeys, Hiroko Morisaki, Zubair M Ahmed, Graeme M Birdsey, Kathleen Freson, Andrew Mumford, Ernest Turro
Mar 22, 2023
Clinical and molecular consequences of disease-associated de novo mutations in SATB2.
Hemant Bengani, Mark Handley, Mohsan Alvi, Rita Ibitoye, Melissa Lees, Sally Ann Lynch, Wayne Lam, Madeleine Fannemel, Ann Nordgren, H Malmgren, M Kvarnung, Sarju Mehta, Shane McKee, Margo Whiteford, Fiona Stewart, Fiona Connell, Jill Clayton-Smith, Sahar Mansour, Shehla Mohammed, Alan Fryer, Jenny Morton, UK10K consortium, Detelina Grozeva, Tara Asam, David Moore, Alejandro Sifrim, Jeremy McRae, Matthew E Hurles, Helen V Firth, F Lucy Raymond, Usha Kini, Christoffer Nellåker, DDD Study, David R FitzPatrick
Jun 25, 2018
PURPOSE: To characterize features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability. METHODS: Twenty previously unreported individuals with 19 different...
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Eliana Portilla-Fernández, Shih-Jen Hwang, Rory Wilson, Jane Maddock, W David Hill, Alexander Teumer, Pashupati P Mishra, Jennifer A Brody, Roby Joehanes, Symen Ligthart, Mohsen Ghanbari, Maryam Kavousi, Anton JM Roks, AH Jan Danser, Daniel Levy, Annette Peters, Sahar Ghasemi, Ulf Schminke, Marcus Dörr, Hans J Grabe, Terho Lehtimäki, Mika Kähönen, Mikko A Hurme, Traci M Bartz, Nona Sotoodehnia, Joshua C Bis, Joachim Thiery, Wolfgang Koenig, Kenneth Ong, Jordana T Bell, Christine Meisinger, Joanna M Wardlaw, John M Starr, Jochen Seissler, Cornelia Then, Wolfgang Rathmann, M Arfan Ikram, Bruce M Psaty, Olli T Raitakari, Henry Völzke, Ian J Deary, Andrew Wong, Melanie Waldenberger, Christopher J O'Donnell, Abbas Dehghan
Jun 14, 2021
Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study...
Genetic association analysis of 77,539 genomes reveals rare disease etiologies.
Daniel Greene, Daniela Pirri, Karen Frudd, Ege Sackey, Mohammed Al-Owain, Arnaud P J Giese, Khushnooda Ramzan, Sehar Riaz, Itaru Yamanaka, Nele Boeckx, Chantal Thys, Bruce D Gelb, Paul Brennan, Verity Hartill, Julie Harvengt, Tomoki Kosho, Sahar Mansour, Mitsuo Masuno, Takako Ohata, Helen Stewart, Khalid Taibah, Claire L S Turner, Faiqa Imtiaz, Saima Riazuddin, Takayuki Morisaki, Pia Ostergaard, Bart L Loeys, Hiroko Morisaki, Zubair M Ahmed, Graeme M Birdsey, Kathleen Freson, Andrew Mumford, Ernest Turro
Apr 17, 2023
The genetic etiologies of more than half of rare diseases remain unknown. Standardized genome sequencing and phenotyping of large patient cohorts provide an opportunity for discovering the unknown etiologies, but this depends on...
Humans Rare Diseases Membrane Proteins Bayes Theorem Genotype Phenotype Genome-Wide Association Study
Published by: Nature medicine
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Eliana Portilla-Fernández, Shih-Jen Hwang, Rory Wilson, Jane Maddock, W David Hill, Alexander Teumer, Pashupati P Mishra, Jennifer A Brody, Roby Joehanes, Symen Ligthart, Mohsen Ghanbari, Maryam Kavousi, Anton JM Roks, AH Jan Danser, Daniel Levy, Annette Peters, Sahar Ghasemi, Ulf Schminke, Marcus Dörr, Hans J Grabe, Terho Lehtimäki, Mika Kähönen, Mikko A Hurme, Traci M Bartz, Nona Sotoodehnia, Joshua C Bis, Joachim Thiery, Wolfgang Koenig, Ken K Ong, Jordana T Bell, Christine Meisinger, Joanna M Wardlaw, John M Starr, Jochen Seissler, Cornelia Then, Wolfgang Rathmann, M Arfan Ikram, Bruce M Psaty, Olli T Raitakari, Henry Völzke, Ian J Deary, Andrew Wong, Melanie Waldenberger, Christopher J O'Donnell, Abbas Dehghan
Dec 15, 2021
cardiovascular risk factors Common carotid intima-media thickness DNA Methylation Differentially methylated regions Epigenome-wide association studies Mendelian randomization Vascular outcomes Carotid Intima-Media Thickness Coronary Artery Disease Cross-Sectional Studies epigenome Humans Risk Factors
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Arash Yavari, Claire J Stocker, Sahar Ghaffari, Edward T Wargent, Violetta Steeples, Gabor Czibik, Katalin Pinter, Mohamed Bellahcene, Angela Woods, Pablo B Martínez de Morentin, Céline Cansell, Brian YH Lam, André Chuster, Kasparas Petkevicius, Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Timothy J Pullen, Peter L Oliver, Alexander Stockenhuber, Chinh Nguyen, Merzaka Lazdam, Jacqueline F O'Dowd, Parvathy Harikumar, Mónika Tóth, Craig Beall, Theodosios Kyriakou, Julia Parnis, Dhruv Sarma, George Katritsis, Diana DJ Wortmann, Andrew R Harper, Laurence A Brown, Robin Willows, Silvia Gandra, Victor Poncio, Márcio J de Oliveira Figueiredo, Nathan R Qi, Stuart N Peirson, Rory J McCrimmon, Balázs Gereben, László Tretter, Csaba Fekete, Charles Redwood, Giles SH Yeo, Lora K Heisler, Guy A Rutter, Mark A Smith, Dominic J Withers, David Carling, Eduardo B Sternick, Jonathan RS Arch, Michael A Cawthorne, Hugh Watkins, Houman Ashrafian
Sep 03, 2019
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed...
AMP-Activated Protein Kinases Adiposity Adult aging Agouti-Related Protein Animals Arcuate Nucleus of Hypothalamus Energy Metabolism Enzyme Activation Feeding Behavior Female Heterozygote Humans Hyperphagia Hypothalamus Insulin Insulin-Secreting Cells Male Mice Mitochondria Mutation Neurons obesity Oxidative Phosphorylation Receptors Ghrelin Ribosomes Signal Transduction Transcriptome Up-Regulation
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.
Garan Jones, Katerina Trajanoska, Adam J Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L Atkins, Joshua R Lewis, ThuyVy Duong, Shengjun Hong, Mary L Biggs, Jian'an Luan, Chloe Sarnowski, Kathryn L Lunetta, Toshiko Tanaka, Mary K Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L Ackert-Bicknell, Dan E Arking, B Gwen Windham, Eric Boerwinkle, Megan L Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette CPGM de Groot, Bruce M Psaty, Michelle C Odden, Alison E Fohner, Claudia Langenberg, Nicholas J Wareham, Stefania Bandinelli, Natasja M van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellström, Magnus Karlsson, David A Bennett, Aron S Buchman, Philip L De Jager, Andre G Uitterlinden, Uwe Völker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguéz-Mañas, Francisco J García, José A Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M Murabito, David Melzer, George A Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P Kiel, Luke C Pilling
Feb 01, 2021
Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22...
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian’an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellström, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Völker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguéz-Mañas, Francisco J. García, José A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Jan 28, 2021
Abstract: Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over...
FinnGen provides genetic insights from a well-phenotyped isolated population
Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipilä, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Päivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Rämö, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rüeger, Susanna Lemmelä, Wei Zhou, Sanni Ruotsalainen, Kalle Pärn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setälä, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Färkkilä, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Åsa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kähönen, Risto Kajanne, Lila Kallio, Reetta Kälviäinen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpeläinen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Mägi, Johanna Mäkelä, Antti Mäkitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar V. Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, Christopher J. O´Donnell, Ma´en Obeidat, George Okafo, Hanna M. Ollila, Antti Palomäki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slavé Petrovski, Anne Pitkäranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-Yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tõnu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. Mäkelä, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie
Feb 24, 2023
Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived...
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G Aragam, Johan Ärnlöv, Joshua D Backman, Mary L Biggs, Heather L Bloom, Jeffrey Brandimarto, Michael R Brown, Leonard Buckbinder, David J Carey, Daniel I Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James P Cook, Graciela E Delgado, Spiros Denaxas, Alexander S Doney, Marcus Dörr, Samuel C Dudley, Michael E Dunn, Gunnar Engström, Tõnu Esko, Stephan B Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S Gottdiener, Stefan Gross, Daníel F Guðbjartsson, Rebecca Gutmann, Christopher M Haggerty, Pim van der Harst, Craig L Hyde, Erik Ingelsson, J Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus E Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Barry London, Luca A Lotta, Ruth C Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth B Margulies, Winfried März, Olle Melander, Ify R Mordi, Thomas Morgan, Andrew D Morris, Andrew P Morris, Alanna C Morrison, Michael W Nagle, Christopher P Nelson, Alexander Niessner, Teemu Niiranen, Michelle L O'Donoghue, Anjali T Owens, Colin NA Palmer, Helen M Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce M Psaty, Regeneron Genetics Center, Kenneth M Rice, Paul M Ridker, Simon PR Romaine, Jerome I Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A Shalaby, Diane T Smelser, Nicholas L Smith, Steen Stender, David J Stott, Per Svensson, Mari-Liis Tammesoo, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre G Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan A Voors, Xiaosong Wang, Nicholas J Wareham, Dawn Waterworth, Peter E Weeke, Raul Weiss, Kerri L Wiggins, Heming Xing, Laura M Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Harry Hemingway, Nilesh J Samani, John JV McMurray, Jian Yang, Peter M Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven A Lubitz, Naveed Sattar, Michael V Holmes, Thomas P Cappola, Folkert W Asselbergs, Aroon D Hingorani, Karoline Kuchenbaecker, Patrick T Ellinor, Chim C Lang, Kari Stefansson, J Gustav Smith, Ramachandran S Vasan, Daniel I Swerdlow, R Thomas Lumbers
Jan 29, 2020
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Atrial fibrillation Cardiomyopathies Carrier Proteins Case-Control Studies Coronary Artery Disease Cyclin-Dependent Kinase Inhibitor p21 Genome-Wide Association Study Heart Failure Humans Mendelian Randomization Analysis Microfilament Proteins Muscle Proteins Risk Factors Ventricular Function Left
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