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Results: 58
Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury.
Andrea Paolini, Saleh Omairi, Robert Mitchell, Danielle Vaughan, Antonios Matsakas, Sakthivel Vaiyapuri, Thomas Ricketts, David C Rubinsztein, Ketan Patel
Sep 27, 2018
Autophagy has been implicated as a major factor in the development of a number of diseases of skeletal muscle. However, its role in skeletal muscle homeostasis is still evolving. We examined skeletal muscle architecture in a...
Mechanisms Underlying Motivational Dysfunction in Schizophrenia
Negative symptoms are a debilitating feature of schizophrenia which are often resistant to pharmacological intervention. The mechanisms underlying them remain poorly understood, and diagnostic methods rely on phenotyping through...
Empirical Comparison of Energy Efficiency Between 3-Tier and High-Speed 3-Tier Network Topologies
The high levels of energy use for cloud computing affect carbon emissions and climate change. This research thoroughly compares the energy utilisation of conventional and high-speed three-tier data centres (DCs). The green cloud...
Published by: IGI Global Scientific Publishing
Preliminary studies
Muhammad Iqbal, Tai-Ping Fan, David Watson, Samya Alenezi, Khaled Saleh, Muhamad Sahlan
Sep 10, 2019
Several studies have previously reported propolis, or its constituents, to inhibit tumour angiogenesis. The anti-angiogenic activity of two Indonesian stingless bee propolis extracts from Sulawesi Island on vascular cells were...
Reactive Power Optimization Using New Enhanced Whale Optimization Algorithm
The standard Whale Optimization Algorithm (WOA) involves exploitation and exploration operations which require to be balanced for improved performance. This paper suggests a new enhanced WOA to improve the convergence speed and...
Published by: IGI Global Scientific Publishing
Using Causal Inference in Learning Processes to Predict Student Proficiency
The search for causal relations from observational data is an open problem that spans many fields. In the area of learning, this is especially important. The ability to determine the effect of a new teaching strategy or the...
Educational Technologies Education Learning Assessment and Measurement Computer Science and Information Technology Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Empowering All Students
This chapter focuses on innovative teaching strategies for students of determination in UAE. Gamification, project-based learning, and innovative use of technology in special education promise to revolutionize how we educate and...
Educational Technologies Education Educational Technologies Computer Science and Information Technology Library and Information Science
Published by: IGI Global Scientific Publishing
Mechanisms Underlying Motivational Dysfunction in Schizophrenia.
Negative symptoms are a debilitating feature of schizophrenia which are often resistant to pharmacological intervention. The mechanisms underlying them remain poorly understood, and diagnostic methods rely on phenotyping through...
Plasma heat shock protein response to euglycemia in type 2 diabetes.
Alexander S Atkin, Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L Atkin, Alexandra E Butler
Apr 22, 2021
INTRODUCTION: Glucose variability is associated with mortality and macrovascular diabetes complications. The mechanisms through which glucose variability mediates tissue damage are not well understood, although cellular...
Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching.
Mark Moeller, Misa Hirose, Sarah Mueller, Catrin Roolf, Simone Baltrusch, Saleh Ibrahim, Christian Junghanss, Olaf Wolkenhauer, Robert Jaster, Rüdiger Köhling, Manfred Kunz, Markus Tiedge, Paul N Schofield, Georg Fuellen
Aug 08, 2017
Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using longitudinal data sets from the large-scale inbred mouse strain study at the Jackson Laboratory Nathan Shock Center, we describe a...
Enterprise System as Business Intelligence and Knowledge Capabilities for Enhancing Applications and Practices of IT Governance
According to different views in information systems and the socio-technical perspective, many organizations was led to redefine their business with a more focused IT solutions, this study suggested a number of confirmatory...
Published by: IGI Global Scientific Publishing
Personal exposures to fine particulate matter and carbon monoxide in relation to cooking activities in rural Malawi.
Sepeedeh Saleh, Henry Sambakunsi, Debora Makina, Martha Chinouya, Moses Kumwenda, James Chirombo, Sean Semple, Kevin Mortimer, Jamie Rylance
Apr 05, 2023
Background: Air pollution is a major environmental risk factor for cardiorespiratory disease. Exposures to household air pollution from cooking and other activities, are particularly high in Southern Africa. Following an...
Impact of severe hypoglycemia on the heat shock and related protein response.
Alexander S Atkin, Abu Saleh Md Moin, Manjula Nandakumar, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L Atkin, Alexandra E Butler
Aug 26, 2021
Heat shock proteins contribute to diabetes-induced complications and are affected by glycemic control. Our hypothesis was that hypoglycemia-induced heat shock and related protein changes would be amplified in type 2 diabetes...
Adult Aged Diabetes mellitus Type 2 Female HSP70 Heat-Shock Proteins HEAT-SHOCK PROTEINS Heat-Shock Response Humans Hypoglycemia Interferon-gamma Interleukins Intracellular Signaling Peptides and Proteins Male Middle Aged Molecular Chaperones Protein Serine-Threonine Kinases Proteome Receptor EphA2 Smad3 Protein Tumor Necrosis Factor-alpha Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe
Jun 26, 2021
Abstract: MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite implications of involvement in cell cycle regulation and in...
Transcriptomal Insights of Heart Failure from Normality to Recovery.
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y Al-Halees, Maie AlShahid, Kate S Collison, Stephen Westaby, Futwan Al-Mohanna
May 24, 2022
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more...
Informal healthcare provision in Lebanon
Gladys Honein-AbouHaidar, Aya Noubani, Nour El Arnaout, Sharif Ismail, Hana Nimer, Marilyne Menassa, Adam P. Coutts, Diana Rayes, Lamis Jomaa, Shadi Saleh, Fouad M. Fouad
Aug 27, 2020
Abstract: Background: Syrian healthcare workers (HCWs) are among those who fled the Syrian conflict only to face further social and economic challenges in host countries. In Lebanon, this population group cannot formally...
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure
Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe
Jun 26, 2020
Abstract: MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite implications of involvement in cell cycle regulation and in...
Interactions between callose and cellulose revealed through the analysis of biopolymer mixtures.
Radwa H Abou-Saleh, Mercedes C Hernandez-Gomez, Sam Amsbury, Candelas Paniagua, Matthieu Bourdon, Shunsuke Miyashima, Ykä Helariutta, Martin Fuller, Tatiana Budtova, Simon D Connell, Michael E Ries, Yoselin Benitez-Alfonso
Dec 18, 2018
The properties of (1,3)-β-glucans (i.e., callose) remain largely unknown despite their importance in plant development and defence. Here we use mixtures of (1,3)-β-glucan and cellulose, in ionic liquid solution and hydrogels, as...
Identification of factors required for m$^{6}$A mRNA methylation in $\textit{Arabidopsis}$ reveals a role for the conserved E3 ubiquitin ligase HAKAI.
K Růžička, M Zhang, A Campilho, Z Bodi, M Kashif, M Saleh, D Eeckhout, S El-Showk, H Li, S Zhong, GD Jaeger, NP Mongan, J Hejátko, Y Helariutta, RG Fray
Jun 06, 2017
Informal healthcare provision in Lebanon
Gladys Honein-AbouHaidar, Aya Noubani, Nour El Arnaout, Sharif Ismail, Hana Nimer, Marilyne Menassa, Adam P Coutts, Diana Rayes, Lamis Jomaa, Shadi Saleh, Fouad M Fouad
Nov 20, 2020
BACKGROUND: Syrian healthcare workers (HCWs) are among those who fled the Syrian conflict only to face further social and economic challenges in host countries. In Lebanon, this population group cannot formally practice, yet...
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.
Robert E Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L Morris, TJ Ragan, Christos G Savva, Aditya Chandru, Christopher J Millard, Olga V Makarova, Corinne J Smith, Alan M Roseman, Andrew M Fry, Shaun M Cowley, John WR Schwabe
Jul 06, 2020
MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite implications of involvement in cell cycle regulation and in several...
Amino Acid Sequence Animals Cell Line Chromatin Chromosomes Mammalian Embryo Mammalian Embryonic Development FIBROBLASTS Gene Regulatory Networks Heterozygote Histone Deacetylases Homozygote Humans Mice Inbred C57BL Mice Knockout Mitosis Models Molecular Multiprotein Complexes Nuclear Proteins Protein Domains Protein Multimerization
Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.
Yun Song, Lisbeth Dagil, Louise Fairall, Naomi Robertson, Mingxuan Wu, TJ Ragan, Christos G Savva, Almutasem Saleh, Nobuhiro Morone, Micha BA Kunze, Andrew G Jamieson, Philip A Cole, D Flemming Hansen, John WR Schwabe
Feb 28, 2020
The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase...
CoREST complex HDAC1 KDM1A LSD1 RCOR1 Histone deacetylase lysine demethylase nucleosome Acetylation Amino Acid Sequence Animals Co-Repressor Proteins Cryoelectron Microscopy Demethylation HEK293 Cells Histone Deacetylase 1 Histone Demethylases Humans Kinetics Models Molecular Nerve Tissue Proteins Nucleosomes Xenopus
Transcriptomal Insights of Heart Failure from Normality to Recovery.
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y Al-Halees, Maie AlShahid, Kate S Collison, Stephen Westaby, Futwan Al-Mohanna
Jun 29, 2022
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more...
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Marthe HR Ludtmann, Plamena R Angelova, Mathew H Horrocks, Minee L Choi, Margarida Rodrigues, Artyom Y Baev, Alexey V Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T Ranasinghe, Daniel R Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandhi
Oct 10, 2018
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that...
Animals Coculture Techniques Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Lipid Peroxidation Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Mitochondrial Proton-Translocating ATPases Neurons Oxidation-Reduction Parkinson Disease Patch-Clamp Techniques Permeability Proteomics Rats Rats Sprague-Dawley Reactive Oxygen Species ALPHA-SYNUCLEIN
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