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Results: 39
'The mothers of England object'
Salim Al-Gailani
Jun 29, 2018
Amid wider efforts to improve maternal and infant health in Britain around the First World War, public health officials debated making pregnancy a notifiable condition. Although the policy never entered national legislation, a...
What Will You Do for the Rest of the Day?
Understanding and predicting human mobility is vital to a large number of applications, ranging from recommendations to safety and urban service planning. In some travel applications, the ability to accurately predict...
Dynamics of Mutations and Promotion of Structural Positions of Civil Servants in Malaka Regency
Melkisedek. N.B.C. NEOLAKA, Ajis Salim Adang DJAHA, Alfred Omri Ena MAU, David Wilfrid RIHI
Jan 31, 2023
The purpose of effective transfers and promotions leads to increasing the effectiveness of local government organizations, but the good intentions of the regional leadership of Malacca Regency, in this case the Regent as PPK, to...
Published by: Indonesia Strategic Sustainability
A Dialogue-Like Video Created From a Monologue Lecture Video Provides Better Learning Experience
Video is the most widely used format to deliver a lecture by the tutor/lecturer in electronic distance learning. One of the video presentation styles is a dialogue style where the learning material is presented with a dialogue...
Published by: IGI Global Scientific Publishing
Attainment, attendance, and school difficulties in UK primary schoolchildren with probable ADHD
Felix May, Tamsin Ford, Astrid Janssens, Tamsin Newlove-Delgado, Abigail Emma Russell, Javid Salim, Obioha C Ukoumunne, Rachel Hayes
Aug 07, 2020
Background. Among children aged 6–16, there is a clear association between attention-deficit/hyperactivity disorder (ADHD) symptoms and academic attainment. We wanted to know whether this association was replicated in younger...
Abdominal aortic aneurysm clinical practice guidelines
Kia Hau Matthew Tan, Safa Salim, Matthew Machin, Aurélien Geroult, Sarah Onida, Tristan Lane, AH Davies
Jan 28, 2022
OBJECTIVES: Abdominal aortic aneurysm (AAA) clinical practice guidelines (CPGs) provide evidence-based information on patient management; however, methodological differences exist in the development of CPGs. This study examines...
Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina.
Sabine Seipold, Florian C Priller, Paul Goldsmith, William A Harris, Herwig Baier, Salim Abdelilah-Seyfried
Jun 13, 2011
Organisational-Level Assessment of Cloud Computing Adoption
Cloud Computing (CC) is an emerging technology that can potentially revolutionise the application and delivery of IT. There has been little research, however, into the adoption of CC in Small and Medium-Sized Enterprises (SMEs)....
Published by: IGI Global Scientific Publishing
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.
Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S Butterworth, Joanna MM Howson, Michael Inouye, Martin Dichgans
Jan 10, 2020
Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive power has been modest compared to established stroke risk factors. Here, using a meta-scoring...
Aged blood pressure Body Mass Index Brain Ischemia Comorbidity Datasets as Topic Female Genetic Predisposition to Disease Genome-Wide Association Study Genomics Humans Male Medical History Taking Middle Aged Polymorphism Single Nucleotide Predictive Value of Tests Risk Assessment Smoking United Kingdom
A novel antibody combination to identify KIR2DS2high natural killer cells in KIR2DL3/L2/S2 heterozygous donors.
Matthew D Blunt, Pauline Rettman, Leidy Y Bastidas-Legarda, Rebecca Fulton, Valentina Capizzuto, Mohammed M Naiyer, James A Traherne, Salim I Khakoo
Dec 10, 2018
The killer cell immunoglobulin-like receptor (KIR) KIR2DS2 induces natural killer (NK) cell activation upon ligation and in genetic studies is associated with protection against certain cancers and viral infections. One of the...
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
Kevin Zbuk, Changchun Xie, Robin Young, Mahyar Heydarpour, Guillaume Pare, A Darlene Davis, Ruby Miller, Matthew B Lanktree, Danish Saleheen, John Danesh, Salim Yusuf, James C Engert, Robert A Hegele, Sonia S Anand
Jul 30, 2012
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2020
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.
Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S Butterworth, Joanna M M Howson, Michael Inouye, Martin Dichgans
Jan 27, 2020
Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive power has been modest compared to established stroke risk factors. Here, using a meta-scoring...
Dominant ACO2 mutations are a frequent cause of isolated optic atrophy.
Majida Charif, Naïg Gueguen, Marc Ferré, Zouhair Elkarhat, Salim Khiati, Morgane LeMao, Arnaud Chevrollier, Valerie Desquiret-Dumas, David Goudenège, Céline Bris, Selma Kane, Jennifer Alban, Stéphanie Chupin, Céline Wetterwald, Leonardo Caporali, Francesca Tagliavini, Chiara LaMorgia, Michele Carbonelli, Neringa Jurkute, Abdelhamid Barakat, Philippe Gohier, Christophe Verny, Magalie Barth, Vincent Procaccio, Dominique Bonneau, Xavier Zanlonghi, Isabelle Meunier, Nicole Weisschuh, Simone Schimpf-Linzenbold, Felix Tonagel, Ulrich Kellner, Patrick Yu-Wai-Man, Valerio Carelli, Bernd Wissinger, Patrizia Amati-Bonneau, Pascal Reynier, European ION Group, Guy Lenaers
Jul 02, 2021
Biallelic mutations in ACO2, encoding the mitochondrial aconitase 2, have been identified in individuals with neurodegenerative syndromes, including infantile cerebellar retinal degeneration and recessive optic neuropathies...
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.
Qin Qin Huang, Howard HF Tang, Shu Mei Teo, Danny Mok, Scott C Ritchie, Artika P Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J Holt, Chiea Chuen Khor, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Aug 25, 2020
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid...
Autoimmune Diseases Butyrophilins CD4-Positive T-Lymphocytes Cathepsin H Child Child Development Child Preschool Datasets as Topic Fetal Blood Gene Expression Profiling Gene Expression Regulation Developmental Gene Regulatory Networks Genetic Predisposition to Disease Genome-Wide Association Study HLA-C Antigens Humans Hypersensitivity Infant Infant Newborn Mendelian Randomization Analysis Myeloid Cells Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Prospective Studies Quantitative Trait Loci
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2021
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
Ludimila Dias Almeida, Ali Salim Faraj Silva, Daniel Calixto Mota, Adrielle Ayumi Vasconcelos, Antônio Pedro Camargo, Gabriel Silva Pires, Monique Furlan, Helena Martins Ribeiro da Cunha Freire, Angélica Hollunder Klippel, Suélen Fernandes Silva, Cleslei Fernando Zanelli, Marcelo Falsarella Carazzolle, Stephen G Oliver, Elizabeth Bilsland
Jan 28, 2022
Saccharomyces cerevisiae drug efflux drug transport drug uptake genetic interactions nonessential transporter double-deletion library plasma membrane transporter xenobiotics Yeast ATP-Binding Cassette Transporters Antifungal Agents Biological Transport Gene Deletion Gene Library High-Throughput Screening Assays Monosaccharide Transport Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins xenobiotics
Interpretation of the evidence for the efficacy and safety of statin therapy.
Rory Collins, Christina Reith, Jonathan Emberson, Jane Armitage, Colin Baigent, Lisa Blackwell, Roger Blumenthal, John Danesh, George Davey Smith, David DeMets, Stephen Evans, Malcolm Law, Stephen MacMahon, Seth Martin, Bruce Neal, Neil Poulter, David Preiss, Paul Ridker, Ian Roberts, Anthony Rodgers, Peter Sandercock, Kenneth Schulz, Peter Sever, John Simes, Liam Smeeth, Nicholas Wald, Salim Yusuf, Richard Peto
Nov 22, 2017
This Review is intended to help clinicians, patients, and the public make informed decisions about statin therapy for the prevention of heart attacks and strokes. It explains how the evidence that is available from randomised...
Identifying the immune interactions underlying HLA class I disease associations
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang
May 28, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.
Margaret E Harley, Olga Murina, Andrea Leitch, Martin R Higgs, Louise S Bicknell, Gökhan Yigit, Andrew N Blackford, Anastasia Zlatanou, Karen J Mackenzie, Kaalak Reddy, Mihail Halachev, Sarah McGlasson, Martin AM Reijns, Adeline Fluteau, Carol-Anne Martin, Simone Sabbioneda, Nursel H Elcioglu, Janine Altmüller, Holger Thiele, Lynn Greenhalgh, Luciana Chessa, Mohamad Maghnie, Mahmoud Salim, Michael B Bober, Peter Nürnberg, Stephen P Jackson, Matthew E Hurles, Bernd Wollnik, Grant S Stewart, Andrew P Jackson
Oct 28, 2015
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.
Jeroen Overman, Frank Fontaine, Mehdi Moustaqil, Deepak Mittal, Emma Sierecki, Natalia Sacilotto, Johannes Zuegg, Avril Ab Robertson, Kelly Holmes, Angela A Salim, Sreeman Mamidyala, Mark S Butler, Ashley S Robinson, Emmanuelle Lesieur, Wayne Johnston, Kirill Alexandrov, Brian L Black, Benjamin M Hogan, Sarah De Val, Robert J Capon, Jason S Carroll, Timothy L Bailey, Peter Koopman, Ralf Jauch, Mark J Smyth, Matthew A Cooper, Yann Gambin, Mathias Francois
May 02, 2019
Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have...
Biochemistry developmental biology Gene Expression MOUSE protein protein interactions small molecules Stem Cells Transcription Factors tumour angiogenesis Zebrafish Animals Antineoplastic Agents Biophysical Phenomena blood vessels Breast Neoplasms Disease Models Animal Genomics Mice Proteomics SOXF Transcription Factors Transcription Genetic Treatment Outcome Zebrafish Zebrafish Proteins
Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1.
Lies Boelen, Bisrat Debebe, Marcos Silveira, Arafa Salam, Julia Makinde, Chrissy H Roberts, Eddie CY Wang, John Frater, Jill Gilmour, Katie Twigger, Kristin Ladell, Kelly L Miners, Jyothi Jayaraman, James A Traherne, David A Price, Ying Qi, Maureen P Martin, Derek C Macallan, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Sharyne M Donfield, Susan Buchbinder, Salim I Khakoo, James J Goedert, John Trowsdale, Mary Carrington, Simon Kollnberger, Becca Asquith
Dec 05, 2018
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory KIRs can also...
Identifying the immune interactions underlying HLA class I disease associations.
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith
Jun 19, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
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