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Results: 36
The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response
Uzma Zahid, Robert A McCutcheon, Faith Borgan, Sameer Jauhar, Fiona Pepper, Matthew M Nour, Maria Rogdaki, Martin Osugo, Graham K Murray, Pamela Hathway, Robin M Murray, Oliver D Howes
Sep 29, 2022
INTRODUCTION: Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate...
The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response
Uzma Zahid, Robert A McCutcheon, Faith Borgan, Sameer Jauhar, Fiona Pepper, Matthew M Nour, Maria Rogdaki, Martin Osugo, Graham K Murray, Pamela Hathway, Robin M Murray, Oliver D Howes
Aug 25, 2022
Introduction: Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate...
The Viable System Model for Diagnosing and Handling IT-Project Interdependencies in Large Portfolios
Adequately considering project interdependencies has shown to be a determinant of how successful IT/IS project portfolios are managed. However, this can be especially troublesome since there is no universal way to handle many...
Published by: IGI Global Scientific Publishing
The Mongol Invasion of Kashmir
Sameer Ahmad Sofi
Dec 21, 2019
Medieval period of Kashmir history is the most neglected part of Indian History. This paper is an attempt to remove the confusion, with the support of the original contemporary sources, regarding Mongol invasion of Kashmir....
Published by: Department of History, University of Karachi
FALF ConvNets
Obtaining efficient Convolutional Neural Networks (CNNs) are imperative to enable their application for a wide variety of tasks (classification, detection, etc.). While several methods have been proposed to solve this problem...
Effect of Fair Value Based on IFRS 13 on the Qualitative Characteristics of Accounting Information
The aim of the study to investigate the effect and relationship between accounting of fair value according to the standard of (IFRS13) and the qualitative characteristics of accounting information. The fair value made a good...
Published by: IGI Global Scientific Publishing
The Evolving Sanitation Entrepreneurial Ecosystem
The field of sanitation has been extensively discussed in the literature from varied viewpoints. However, a comprehensive approach summarising the entrepreneurial facets of the sanitation industry is still fragmented. This study...
Published by: IGI Global Scientific Publishing
FALF ConvNets
Obtaining efficient Convolutional Neural Networks (CNNs) are imperative to enable their application for a wide variety of tasks (classification, detection, etc.). While several methods have been proposed to solve this problem...
Can artificial intelligence pass the Fellowship of the Royal College of Radiologists examination? Multi-reader diagnostic accuracy study.
Susan Cheng Shelmerdine, Helena Martin, Kapil Shirodkar, Sameer Shamshuddin, Jonathan Richard Weir-McCall, FRCR-AI Study Collaborators
Dec 22, 2022
Co-infection and ICU-acquired infection in COIVD-19 ICU patients
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes.
Sulochana Manandhar, Raphael M Zellweger, Nhukesh Maharjan, Sabina Dongol, Krishna G Prajapati, Guy Thwaites, Buddha Basnyat, Sameer Mani Dixit, Stephen Baker, Abhilasha Karkey
Jan 11, 2021
BACKGROUND: Multi-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and carbapenemases in Gram-negative bacteria are global public health concerns. Data on...
Antimicrobial resistance Carbapenemase ESBL ESKAPE Gram-negative bacilli multi-drug resistance Nepal Acinetobacter Anti-Bacterial Agents Bacterial Proteins Drug Resistance Multiple Bacterial Enterobacter Escherichia coli Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Klebsiella Microbial Sensitivity Tests Nepal prevalence Retrospective Studies Tertiary Care Centers beta-Lactamases
Risk factors for the development of neonatal sepsis in a neonatal intensive care unit of a tertiary care hospital of Nepal
Sulochana Manandhar, Puja Amatya, Imran Ansari, Niva Joshi, Nhukesh Maharjan, Sabina Dongol, Buddha Basnyat, Sameer M. Dixit, Stephen Baker, Abhilasha Karkey
Jun 10, 2021
Abstract: Background: Sepsis is an overwhelming and life-threatening response to bacteria in bloodstream and a major cause of neonatal morbidity and mortality. Understanding the etiology and potential risk factors for neonatal...
Co-infection and ICU-acquired infection in COIVD-19 ICU patients
Andrew Conway Morris, Katharina Kohler, Thomas De Corte, Ari Ercole, Harm-Jan De Grooth, Paul WG Elbers, Pedro Povoa, Rui Morais, Despoina Koulenti, Sameer Jog, Nathan Nielsen, Alasdair Jubb, Maurizio Cecconi, Jan De Waele, ESICM UNITE COVID investigators
Sep 03, 2022
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes
Sulochana Manandhar, Raphael M. Zellweger, Nhukesh Maharjan, Sabina Dongol, Krishna G. Prajapati, Guy Thwaites, Buddha Basnyat, Sameer Mani Dixit, Stephen Baker, Abhilasha Karkey
Oct 21, 2020
Abstract: Background: Multi-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and carbapenemases in Gram-negative bacteria are global public health concerns. Data...
Risk factors for the development of neonatal sepsis in a neonatal intensive care unit of a tertiary care hospital of Nepal.
Sulochana Manandhar, Puja Amatya, Imran Ansari, Niva Joshi, Nhukesh Maharjan, Sabina Dongol, Buddha Basnyat, Sameer M Dixit, Stephen Baker, Abhilasha Karkey
Aug 09, 2021
BACKGROUND: Sepsis is an overwhelming and life-threatening response to bacteria in bloodstream and a major cause of neonatal morbidity and mortality. Understanding the etiology and potential risk factors for neonatal sepsis is...
Genomic epidemiology, antimicrobial resistance and virulence factors of Enterobacter cloacae complex causing potential community-onset bloodstream infections in a tertiary care hospital of Nepal.
Sulochana Manandhar, Quynh Nguyen, To Nguyen Thi Nguyen, Duy Thanh Pham, Maia A Rabaa, Sabina Dongol, Buddha Basnyat, Sameer M Dixit, Stephen Baker, Abhilasha Karkey
Jul 07, 2022
OBJECTIVES: Community-onset bloodstream infections (BSIs) caused by carbapenemase-producing Enterobacter cloacae complex (ECC) species are increasing internationally. This observation suggests that ECC are emerging pathogens...
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes
Sulochana Manandhar, Raphael M. Zellweger, Nhukesh Maharjan, Sabina Dongol, Krishna G. Prajapati, Guy Thwaites, Buddha Basnyat, Sameer Mani Dixit, Stephen Baker, Abhilasha Karkey
Oct 21, 2021
Abstract: Background: Multi-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and carbapenemases in Gram-negative bacteria are global public health concerns. Data...
Co-infection and ICU-acquired infection in COIVD-19 ICU patients
Andrew Conway Morris, Katharina Kohler, Thomas De Corte, Ari Ercole, Harm-Jan De Grooth, Paul WG Elbers, Pedro Povoa, Rui Morais, Despoina Koulenti, Sameer Jog, Nathan Nielsen, Alasdair Jubb, Maurizio Cecconi, Jan De Waele
Aug 03, 2022
Published by: BioMed Central
PEHO syndrome
Manali Chitre, Michael S Nahorski, Kaitlin Stouffer, Bryony Dunning-Davies, Hamish Houston, Emma L Wakeling, Angela F Brady, Sameer M Zuberi, Mohnish Suri, Alasdair PJ Parker, C Geoffrey Woods
Nov 22, 2018
BACKGROUND: Progressive encephalopathy, hypsarrhythmia and optic atrophy (PEHO) has been described as a clinically distinct syndrome. It has been postulated that it is an autosomal recessive condition. However, the aetiology is...
Developmental epilepsy and seizures Genetics Neurology Age Factors Alleles Biomarkers Brain Edema Child Preschool Electroencephalography Epilepsy Facies Female Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Genotype Humans Infant Infant Newborn Magnetic Resonance Imaging Male Mutation Neurodegenerative Diseases Optic Atrophy Pedigree Phenotype Spasms Infantile
International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.
Pablo A Olivera, Stephane Zuily, Paulo G Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C Ng, Alfredo Papa, Tim Raine, Fabio V Teixeira, David T Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Sep 28, 2021
Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available...
Published by: Nature reviews. Gastroenterology & hepatology
International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.
Pablo A Olivera, Stephane Zuily, Paulo G Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C Ng, Alfredo Papa, Tim Raine, Fabio V Teixeira, David T Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Nov 24, 2021
Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available...
Genome3D
Ian Sillitoe, Antonina Andreeva, Tom L Blundell, Daniel WA Buchan, Robert D Finn, Julian Gough, David Jones, Lawrence A Kelley, Typhaine Paysan-Lafosse, Su Datt Lam, Alexey G Murzin, Arun Prasad Pandurangan, Gustavo A Salazar, Marcin J Skwark, Michael JE Sternberg, Sameer Velankar, Christine Orengo
Mar 11, 2021
Genome3D (https://www.genome3d.eu) is a freely available resource that provides consensus structural annotations for representative protein sequences taken from a selection of model organisms. Since the last NAR update in 2015...
Genome3D
Tony E Lewis, Ian Sillitoe, Antonina Andreeva, Tom L Blundell, Daniel WA Buchan, Cyrus Chothia, Domenico Cozzetto, José M Dana, Ioannis Filippis, Julian Gough, David T Jones, Lawrence A Kelley, Gerard J Kleywegt, Federico Minneci, Jaina Mistry, Alexey G Murzin, Bernardo Ochoa-Montaño, Matt E Oates, Marco Punta, Owen JL Rackham, Jonathan Stahlhacke, Michael JE Sternberg, Sameer Velankar, Christine Orengo
Mar 12, 2021
Genome3D (http://www.genome3d.eu) is a collaborative resource that provides predicted domain annotations and structural models for key sequences. Since introducing Genome3D in a previous NAR paper, we have substantially extended...
The Association between Patient Characteristics and the Efficacy and Safety of Selinexor in Diffuse Large B-Cell Lymphoma in the SADAL Study.
Josée M Zijlstra, George Follows, Rene-Olivier Casasnovas, Joost SP Vermaat, Nagesh Kalakonda, Sylvain Choquet, Brian Hill, Catherine Thieblemont, Federica Cavallo, Fatima De la Cruz, John Kuruvilla, Nada Hamad, Ulrich Jaeger, Paolo Caimi, Ronit Gurion, Krzysztof Warzocha, Sameer Bakhshi, Juan-Manuel Sancho, Michael Schuster, Miklos Egyed, Fritz Offner, Theodoros P Vassilakopoulos, Priyanka Samal, Matthew Ku, Jenny Xu, Kelly Corona, Kamal Chamoun, Jatin Shah, Miguel Canales, Marie Maerevoet
Mar 18, 2022
Selinexor, an oral selective inhibitor of nuclear export, was evaluated in the Phase 2b SADAL study in patients with diffuse large B-cell lymphoma (DLBCL) who previously received two to five prior systemic regimens. In post hoc...
The Association between Patient Characteristics and the Efficacy and Safety of Selinexor in Diffuse Large B-Cell Lymphoma in the SADAL Study.
Josée M Zijlstra, George Follows, Rene-Olivier Casasnovas, Joost SP Vermaat, Nagesh Kalakonda, Sylvain Choquet, Brian Hill, Catherine Thieblemont, Federica Cavallo, Fatima De la Cruz, John Kuruvilla, Nada Hamad, Ulrich Jaeger, Paolo Caimi, Ronit Gurion, Krzysztof Warzocha, Sameer Bakhshi, Juan-Manuel Sancho, Michael Schuster, Miklos Egyed, Fritz Offner, Theodoros P Vassilakopoulos, Priyanka Samal, Matthew Ku, Jenny Xu, Kelly Corona, Kamal Chamoun, Jatin Shah, Miguel Canales, Marie Maerevoet
Feb 05, 2022
Selinexor, an oral selective inhibitor of nuclear export, was evaluated in the Phase 2b SADAL study in patients with diffuse large B-cell lymphoma (DLBCL) who previously received two to five prior systemic regimens. In post hoc...
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