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Codon optimality in cancer.
A key characteristic of cancer cells is their increased proliferative capacity, which requires elevated levels of protein synthesis. The process of protein synthesis involves the translation of codons within the mRNA coding...
Book Review Essay: Sarah Wilson, The Origins of Modern Financial Crime
Book review essay on Sarah Wilson's The Origins of Modern Financial Crime: Historical Foundations and Current Problems in Britain.Routledge, 2014.
Published by: Digital Commons @ Texas A&M University-San Antonio
Book Review Essay: Sarah Wilson, The Origins of Modern Financial Crime
Book review essay on Sarah Wilson's The Origins of Modern Financial Crime: Historical Foundations and Current Problems in Britain.Routledge, 2014.
Published by: Digital Commons @ Texas A&M University-San Antonio
Book Review Essay: Sarah Wilson, The Origins of Modern Financial Crime
Book review essay on Sarah Wilson's The Origins of Modern Financial Crime: Historical Foundations and Current Problems in Britain.Routledge, 2014.
Published by: Digital Commons @ Texas A&M University-San Antonio
Single cell transcriptomics comes of age.
Single cell transcriptomics technologies have vast potential in advancing our understanding of biology and disease. Here, Sarah Aldridge and Sarah Teichmann review the last decade of technological advancements in single-cell...
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma
Lydia M Parkinson, Sarah L Gillen, Laura M Woods, Lewis Chaytor, Daniel Marcos, Fahad R Ali, Jason S Carroll, Anna Philpott
Oct 17, 2022
Robot seeks public library websites
UKOLN has been active recently analysing UK Public Library websites. Brian Kelly, Sarah Ormes and Ian Peacock report on their findings.
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
Joseph A Waldron, David C Tack, Laura E Ritchey, Sarah L Gillen, Ania Wilczynska, Ernest Turro, Philip C Bevilacqua, Sarah M Assmann, Martin Bushell, John Le Quesne
Feb 02, 2020
Translation Cancer RNA structure Translation initiation DMS G-Quadruplexes eIF4A Polysome profiling Hippuristanol Structure-seq
Published by: Genome biology, volume 20, issue 1
Robot seeks public library websites
UKOLN has been active recently analysing UK Public Library websites. Brian Kelly, Sarah Ormes and Ian Peacock report on their findings.
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity
Joseph A. Waldron, David C. Tack, Laura E. Ritchey, Sarah L. Gillen, Ania Wilczynska, Ernest Turro, Philip C. Bevilacqua, Sarah M. Assmann, Martin Bushell, John Le Quesne
Dec 29, 2020
Abstract: Background: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1...
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
Joseph A Waldron, David C Tack, Laura E Ritchey, Sarah L Gillen, Ania Wilczynska, Ernest Turro, Philip C Bevilacqua, Sarah M Assmann, Martin Bushell, John Le Quesne
Feb 24, 2020
BACKGROUND: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in...
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
Eugene L. Opie, 1910
The Rockefeller University
Jan 01, 0001
Eugene L. Opie, M.D. Inflammation
Lecture delivered February 10th, 1910
Bacterial Infection inflammation reaction macrophage Lymphatic Vessels polynuclear leucocytes enzyme
Published by: J.B. Lippincott Company
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
‘The Climate Has Always Been Changing’
Sophia Hatzisavvidou
Dec 31, 2021
Celebrity politician Sarah Palin diffused climate denialism, while advocating a version of social and political conservatism. This article scrutinises her rhetoric and argues that she crafted and performed a brand or ethos that...
Floer Simple Manifolds and L-Space Intervals
An oriented three-manifold with torus boundary admits either no L-space Dehn filling, a unique L-space filling, or an interval of L-space fillings. In the latter case, which we call “Floer simple,” we construct an invariant...
L q -spectra of self-affine measures
Abstract: We study L q -spectra of planar self-affine measures generated by diagonal matrices. We introduce a new technique for constructing and understanding examples based on combinatorial estimates for the exponential growth...
Corinna PMG 655 (= P.Oxy. 2370) fr.1 l. 13 κόσμ[εισα λόγυ]ς
L Prauscello
May 02, 2017
0. Fr. 1 of P.Oxy. 2370 (= MP3
249; LDAB 573), published by Lobel in 1956, is so far the only papyrus
fragment among those extant in Boeotian dialect1
whose authorship can be securely ascribed to
Corinna thanks to the overlap...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
Frank L. Horsfall, Jr., 1952
The Rockefeller University
Jan 01, 0001
Frank L. Horsfall, Jr. Experiments on chemical alteration of virus infections.
Lecture delivered November 20, 1952
Posted with permission
Published by: Academic Press Inc., Publishers
A free boundary problem arising from branching Brownian motion with selection
We study a free boundary problem for a parabolic partial differential equation in which the solution is coupled to the moving boundary through an integral constraint. The problem arises as the hydrodynamic limit of an...
‘The Climate Has Always Been Changing’
Sophia Hatzisavvidou
Dec 31, 2021
Celebrity politician Sarah Palin diffused climate denialism, while advocating a version of social and political conservatism. This article scrutinises her rhetoric and argues that she crafted and performed a brand or ethos that...
Rapid sensing of l-leucine by human and murine hypothalamic neurons
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L Evans, Florian T Merkle, Frank Reimann, Fiona M Gribble, Clemence Blouet
Apr 05, 2018
OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
A free boundary problem arising from branching Brownian motion with selection
We study a free boundary problem for a parabolic partial differential equation in which the solution is coupled to the moving boundary through an integral constraint. The problem arises as the hydrodynamic limit of an...
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