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Results: 463
Performant implementation of the atomic cluster expansion (PACE) and application to copper and silicon
Yury Lysogorskiy, Cas van der Oord, Anton Bochkarev, Sarath Menon, Matteo Rinaldi, Thomas Hammerschmidt, Matous Mrovec, Aidan Thompson, Gábor Csányi, Christoph Ortner, Ralf Drautz
Jun 28, 2021
Abstract: The atomic cluster expansion is a general polynomial expansion of the atomic energy in multi-atom basis functions. Here we implement the atomic cluster expansion in the performant C++ code PACE that is suitable for use...
Genome-wide analysis of mRNA decay patterns during early Drosophila development.
Animals Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Embryonic Development Gene Expression Regulation Developmental Genome Insect MicroRNAs Oligonucleotide Array Sequence Analysis Ovum Polymerase Chain Reaction RNA Stability RNA Messenger Regulatory Sequences Ribonucleic Acid Transcription Genetic
Doing Radical Things Right
Neil Howard, Nick Langridge, Vibhor Mathur, Leah Hamilton, David Westlake, Nika Soon-Shiong, Miriam Laker-Oketta, Sarath Davala, Aida Martinez Tinaut, Bru Laín, Maria Franchi, Virginia Morrow
Jan 01, 0001
Increasing calls for reform to welfare provision have seen growing support for basic income (BI) - the unconditional provision of cash transfers to all. As a result, recent years have seen an exponential increase in the number...
Published by: Centre for Development Studies
Critical care management of traumatic brain injury.
Traumatic brain injury (TBI) is a growing global problem, which is responsible for a substantial burden of disability and death, and which generates substantial healthcare costs. High-quality intensive care can save lives and...
ICU Structure and Outcomes Following Traumatic Brain Injury.
We read with interest the paper from McCredie et al in Critical Care Medicine. The authors retrospectively analysed data from 9773 patients from 134 intensive care units (ICUs), obtained between 2011 and 2013, extracted from a...
The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
Elisabete M Nascimento, Claire L Cox, Stewart MacArthur, Shobbir Hussain, Matthew Trotter, Sandra Blanco, Menon Suraj, Jennifer Nichols, Bernd Kübler, Salvador Aznar Benitah, Brian Hendrich, Duncan T Odom, Michaela Frye
Jan 31, 2020
How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation...
Animals Epidermal Cells epidermis Feedback Physiological Female Homeostasis Keratinocytes Kruppel-Like Factor 4 Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Primary Cell Culture Proto-Oncogene Proteins c-myc Repressor Proteins Sin3 Histone Deacetylase and Corepressor Complex Transcription Genetic
Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.
James S Ware, Louise V Wain, Sarath K Channavajjhala, Victoria E Jackson, Elizabeth Edwards, Run Lu, Keith Siew, Wenjing Jia, Nick Shrine, Sue Kinnear, Mahli Jalland, Amanda P Henry, Jenny Clayton, Kevin M O'Shaughnessy, Martin D Tobin, Victor L Schuster, Stuart Cook, Ian P Hall, Mark Glover
Sep 03, 2019
Aged Aged 80 and over Aquaporin 1 Aquaporin 2 Cohort Studies Dinoprostone Female Genome-Wide Association Study Humans Hyponatremia Male Middle Aged Nephrons Organic Anion Transporters Pharmacogenetics Phenotype Polymorphism Single Nucleotide Prostaglandins Sodium Chloride Symporter Inhibitors Thiazides United Kingdom water
Robustness and Independent Evidence
Robustness arguments hold that hypotheses are more likely to be true when they are confirmed by diverse kinds of evidence. Robustness arguments require the confirming evidence to be independent. We identify two kinds of...
Withdrawal of treatment after devastating brain injury
Every year in England, cardiopulmonary resuscitation (CPR) is attempted on about 30,000 people suffering an out of hospital cardiac arrest (OHCA) [1]. Return of spontaneous circulation (ROSC) is achieved in approximately 25%...
Moving to human trials for argon neuroprotection in neurological injury
Despite the global burden of brain injury, neuroprotective agents remain elusive. There are no clinically effective therapies which reduce mortality or improve long-term cognitive outcome. Ventilation could be an easily...
Default Mode Contributions to Automated Information Processing
Intrinsic brain dynamics in the Default Mode Network predict involuntary fluctuations of visual awareness
Abstract Brain activity is intrinsically organised into spatiotemporal patterns, but it is still not clear whether these intrinsic patterns are functional or epiphenomenal. Using a simultaneous...
Reactivity of Polycyclic Aromatic Hydrocarbon Soot Precursors
The thermodynamics and kinetics of cross-linking reactions between PAHs of various reactive edge types that are observed in soot precursors are explored using density functional theory. The forward rate constants confirm that...
The Inert Brain
"Neural inertia" is the brain's tendency to resist changes in its arousal state: it is manifested as emergence from anaesthesia occurring at lower drug doses than those required for anaesthetic induction, a phenomenon observed...
Contusion Progression Following Traumatic Brain Injury
Abstract: Secondary injuries remain an important cause of the morbidity and mortality associated with traumatic brain injury (TBI). Progression of cerebral contusions occurs in up to 75% of patients with TBI, and this...
Structural optimality and neurogenetic expression mediate functional dynamics in the human brain.
The human brain exhibits a rich functional repertoire in terms of complex functional connectivity patterns during rest and tasks. However, how this is developed upon a fixed structural anatomy remains poorly understood. Here we...
Changes in resting neural connectivity during propofol sedation.
BACKGROUND: The default mode network consists of a set of functionally connected brain regions (posterior cingulate, medial prefrontal cortex and bilateral parietal cortex) maximally active in functional imaging studies under...
The Inert Brain
“Neural inertia” is the brain’s tendency to resist changes in its arousal state: it is manifested as emergence from anaesthesia occurring at lower drug doses than those required for anaesthetic induction, a phenomenon observed...
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