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Results: 13
Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Ines Alvarez-Rodrigo, Thomas L Steinacker, Saroj Saurya, Paul T Conduit, Janina Baumbach, Zsofia A Novak, Mustafa G Aydogan, Alan Wainman, Jordan W Raff
Oct 31, 2019
Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear...
D. melanogaster Spd-2 Cell Biology centriole Centrosome feedback loop pericentriolar material polo kinase Animals Centrosome Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Feedback Physiological Homeodomain Proteins Mitosis Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases
EMD-Based Semantic User Similarity Using Past Travel Histories
The cost-effective and easy availability of handheld mobile devices and ubiquity of location acquisition services such as GPS and GSM networks has helped expedient logging and sharing of location histories of mobile users. This...
Published by: IGI Global Scientific Publishing
Delirium in ICU due to Hashimoto’s Encephalopathy
A short review of a case of Hashimoto’s encephalopathy in a 59-year-old male patient. The pathophysiology of Hashimoto’s encephalopathy is rather complex and generally makes the diagnosis tricky to arrive at. However prompt...
Published by: IJHS Medical Association
Delirium in ICU due to Hashimoto’s Encephalopathy
A short review of a case of Hashimoto’s encephalopathy in a 59-year-old male patient. The pathophysiology of Hashimoto’s encephalopathy is rather complex and generally makes the diagnosis tricky to arrive at. However prompt...
Published by: IJHS Medical Association
Fine Tuning CNN for COVID-19 Patterns Detection From Chest Radiographs
The COVID-19 pandemic has crumbled health systems all over the world. Quick and accurate detection of coronavirus infection plays an important role in timely referral of physicians and control transmission of the disease. RT-PCR...
Published by: IGI Global Scientific Publishing
Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders.
Markus A Seeger, Anshumali Mittal, Saroj Velamakanni, Michael Hohl, Stefan Schauer, Ihsene Salaa, Markus G Grütter, Hendrik W van Veen
Oct 05, 2020
ABC transporters use the energy from binding and hydrolysis of ATP to import or extrude substrates across the membrane. Using ribosome display, we raised designed ankyrin repeat proteins (DARPins) against detergent solubilized...
ATP-Binding Cassette Transporters Adenosine Triphosphatases Ankyrin Repeat Biological Transport Biophysical Phenomena Cell Membrane Daunorubicin detergents Enzyme-Linked Immunosorbent Assay Epitope Mapping Epitopes Lactococcus lactis Pharmaceutical Preparations Protein Binding Proteolipids Recombinant Proteins Ribosomes Solubility Surface Plasmon Resonance
MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA.
Hong Ting Lin, Vassiliy N Bavro, Nelson P Barrera, Helen M Frankish, Saroj Velamakanni, Hendrik W van Veen, Carol V Robinson, M Inês Borges-Walmsley, Adrian R Walmsley
Oct 06, 2020
Gram-negative bacteria utilize specialized machinery to translocate drugs and protein toxins across the inner and outer membranes, consisting of a tripartite complex composed of an inner membrane secondary or primary active...
Slum Health
Jason Corburn, David Vlahov, Blessing Mberu, Lee Riley, Waleska Teixeira Caiaffa, Sabina Faiz Rashid, Albert Ko, Sheela Patel, Smurti Jukur, Eliana Martínez-Herrera, Saroj Jayasinghe, Siddharth Agarwal, Blaise Nguendo-Yongsi, Jane Weru, Smith Ouma, Katia Edmundo, Tolu Oni, Hany Ayad
Jun 20, 2020
The informal settlements of the Global South are the least prepared for the pandemic of COVID-19 since basic needs such as water, toilets, sewers, drainage, waste collection, and secure and adequate housing are already in short...
Deterministic optical polarisation in nitride quantum dots at thermoelectrically cooled temperatures.
Tong Wang, Tim J Puchtler, Saroj K Patra, Tongtong Zhu, John C Jarman, Rachel A Oliver, Stefan Schulz, Robert A Taylor
Jan 17, 2018
We report the successful realisation of intrinsic optical polarisation control by growth, in solid-state quantum dots in the thermoelectrically cooled temperature regime (≥200 K), using a non-polar InGaN system. With...
Slum Health
Jason Corburn, David Vlahov, Blessing Mberu, Lee Riley, Waleska Teixeira Caiaffa, Sabina Faiz Rashid, Albert Ko, Sheela Patel, Smurti Jukur, Eliana Martínez-Herrera, Saroj Jayasinghe, Siddharth Agarwal, Blaise Nguendo-Yongsi, Jane Weru, Smith Ouma, Katia Edmundo, Tolu Oni, Hany Ayad
May 26, 2020
The informal settlements of the Global South are the least prepared for the pandemic of COVID-19 since basic needs such as water, toilets, sewers, drainage, waste collection, and secure and adequate housing are already in short...
A multidrug ABC transporter with a taste for salt.
Saroj Velamakanni, Calvin HF Lau, Daniel AP Gutmann, Henrietta Venter, Nelson P Barrera, Markus A Seeger, Barbara Woebking, Dijana Matak-Vinkovic, Lekshmy Balakrishnan, Yao Yao, Edmond CY U, Richard A Shilling, Carol V Robinson, Peter Thorn, Hendrik W van Veen
Oct 05, 2020
BACKGROUND: LmrA is a multidrug ATP-binding cassette (ABC) transporter from Lactococcus lactis with no known physiological substrate, which can transport a wide range of chemotherapeutic agents and toxins from the cell. The...
Avoiding high ozone pollution in Delhi, India.
Ying Chen, Gufran Beig, Scott Archer-Nicholls, Will Drysdale, W Joe F Acton, Douglas Lowe, Beth Nelson, James Lee, Liang Ran, Yu Wang, Zhijun Wu, Saroj Kumar Sahu, Ranjeet S Sokhi, Vikas Singh, Ranu Gadi, C Nicholas Hewitt, Eiko Nemitz, Alex Archibald, Gordon McFiggans, Oliver Wild
May 11, 2021
Surface ozone is a major pollutant threatening public health, agricultural production and natural ecosystems. While measures to improve air quality in megacities such as Delhi are typically aimed at reducing levels of...