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Results: 72
Is Dementia Screening of Apparently Healthy Individuals Justified?
1117 Public Health and Health Services Clinical Public Health aging Acquired Cognitive Impairment Neurosciences Dementia Clinical Research Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Alzheimer's Disease Brain Disorders Health Services Prevention Neurodegenerative Neurological 4.2 Evaluation of markers and technologies 7.3 Management and decision making
Cell Competition Drives the Growth of Intestinal Adenomas in Drosophila.
Drosophila Hippo signaling JNK signaling Yki/YAP/TAZ adenomatous polyposis coli (APC) Apoptosis Cancer cell competition Cell Death intestinal adenomas posterior midgut Tumor Microenvironment Adenoma Animals Carcinogenesis Cell Proliferation Cell Transformation Neoplastic Disease Models Animal Drosophila melanogaster Humans Intestinal Neoplasms Signal Transduction
Stem cell lineage survival as a noisy competition for niche access.
Bernat Corominas-Murtra, Colinda LGJ Scheele, Kasumi Kishi, Saskia IJ Ellenbroek, Benjamin D Simons, Jacco van Rheenen, Edouard Hannezo
Jun 08, 2020
Phenotype, cancer risk, and surveillance in Beckwith-Wiedemann syndrome depending on molecular genetic subgroups.
Saskia M Maas, Fleur Vansenne, Daniel JM Kadouch, Abdulla Ibrahim, Jet Bliek, Saskia Hopman, Marcel M Mannens, Johannes HM Merks, Eamonn R Maher, Raoul C Hennekam
Sep 05, 2016
Wiedemann-Beckwith syndrome Wilms tumor genotype-phenotype correlation hepatoblastoma Neuroblastoma Adolescent Beckwith-Wiedemann syndrome Child Cohort Studies DNA Methylation Female Genetic Association Studies Genomic Imprinting Hepatoblastoma Humans Insulin-Like Growth Factor II Male Minisatellite Repeats Neoplasms Phenotype Population Surveillance Potassium Channels Voltage-Gated RNA Long Noncoding risk Wilms tumor Young Adult
Systematic review of the characteristics of school-based feasibility cluster randomised trials of interventions for improving the health of pupils in the UK.
Kitty Parker, Saskia Eddy, Michael Nunns, ZhiMin Xiao, Tamsin Ford, Sandra Eldridge, Obioha C Ukoumunne
Jul 02, 2022
Systematic review of the characteristics of school-based feasibility cluster randomised trials of interventions for improving the health of pupils in the UK.
Kitty Parker, Saskia Eddy, Michael Nunns, ZhiMin Xiao, Tamsin Ford, Sandra Eldridge, Obioha C Ukoumunne
Aug 02, 2022
BACKGROUND: The last 20 years have seen a marked increase in the use of cluster randomised trials (CRTs) in schools to evaluate interventions for improving pupil health outcomes. Schools have limited resources and participating...
Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.
Arginase has therapeutic potential as a cytotoxic agent in some cancers, but this is unclear for precursor B acute lymphoblastic leukaemia (pre-B ALL), the commonest form of childhood leukaemia. We compared arginase cytotoxicity...
Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner.
Golnar Kolahgar, Saskia JE Suijkerbuijk, Iwo Kucinski, Enzo Z Poirier, Sarah Mansour, Benjamin D Simons, Eugenia Piddini
Jun 25, 2015
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
The effect of NOTCH3 pathogenic variant position on CADASIL disease severity
Julie W Rutten, Bastian J Van Eijsden, Marco Duering, Eric Jouvent, Christian Opherk, Leonardo Pantoni, Antonio Federico, Martin Dichgans, Hugh S Markus, Hugues Chabriat, Saskia AJ Lesnik Oberstein
Nov 06, 2018
PURPOSE: CADASIL is a small-vessel disease caused by a cysteine-altering pathogenic variant in one of the 34 epidermal growth factor-like repeat (EGFr) domains of the NOTCH3 protein. We recently found that pathogenic variant in...
Discovery of species-wide tool use in the Hawaiian crow
Christian Rutz, Barbara Klump, Lisa Komarczyk, Rosanna Leighton, Joshua Kramer, Saskia Wischnewski, Shoko Sugasawa, Michael Morrissey, Richard James, James St Clair, Richard Switzer, Bryce Masuda
Sep 15, 2016
Only a handful of bird species are known to use foraging tools in the wild1. Amongst them, the New Caledonian crow (Corvus moneduloides) stands out with its sophisticated tool-making skills2,3. Despite considerable speculation...
Active Human and Porcine Serum Induce Competence for Genetic Transformation in the Emerging Zoonotic Pathogen Streptococcus suis.
Maria Laura Ferrando, Alex Gussak, Saskia Mentink, Marcela Fernandez Gutierrez, Peter van Baarlen, Jerry Mark Wells
Apr 16, 2021
The acquisition of novel genetic traits through natural competence is a strategy used by bacteria in microbe-rich environments where microbial competition, antibiotics, and host immune defenses threaten their survival. Here, we...
One Health Approaches to Trace Mycobacterium leprae ’s Zoonotic Potential Through Time
Christian Urban, Alette A. Blom, Saskia Pfrengle, Kathleen Walker-Meikle, Anne C. Stone, Sarah A. Inskip, Verena J. Schuenemann
Nov 04, 2021
Hansen’s disease (leprosy), mainly caused by infection with Mycobacterium leprae, has accompanied humanity for thousands of years. Although currently rare in Europe, there are over 200,000 new infections annually in South East...
Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity.
David A Rafei-Shamsabadi, Saskia van de Poel, Britta Dorn, Stefanie Kunz, Stefan F Martin, Christoph SN Klose, Sebastian J Arnold, Yakup Tanriver, Karolina Ebert, Andreas Diefenbach, Timotheus YF Halim, Andrew NJ McKenzie, Thilo Jakob
Sep 05, 2018
Allergic contact dermatitis and its animal model, contact hypersensitivity, are T-cell-mediated inflammatory skin diseases that require activation of the innate immune system. Here we investigate the role of innate lymphoid...
Factors determining development of researchers within a research network on cancer diagnosis in primary care (CanTest)
Esther de Groot, Debbie Vermond, Valerie A Sills, Saskia SL Mol, Fiona M Walter, Greg Rubin, Niek J de Wit
Mar 17, 2022
OBJECTIVES: Developing connections with other researchers in a network, learning informally through these connections and using them to reach goals, is expected to increase research capacity and strengthen performance. So far...
Discovery of species-wide tool use in the Hawaiian crow
Christian Rutz, Barbara Klump, Lisa Komarczyk, Rosanna Leighton, Joshua Kramer, Saskia Wischnewski, Shoko Sugasawa, Michael Morrissey, Richard James, James St Clair, Richard Switzer, Bryce Masuda
Sep 15, 2016
Only a handful of bird species are known to use foraging tools in the wild1. Amongst them, the New Caledonian crow (Corvus moneduloides) stands out with its sophisticated tool-making skills2,3. Despite considerable speculation...
MS in South Asians in England
Richard S Nicholas, Vassiliki Kostadima, Maya Hanspal, Benjamin R Wakerley, Ruhena Sergeant, Saskia Decuypere, Omar Malik, Rosemary J Boyton, Daniel M Altmann
Sep 29, 2016
BACKGROUND: Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions can...
Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis.
Jeremie Joffre, Stephane Potteaux, Lynda Zeboudj, Xavier Loyer, Amir Boufenzer, Ludivine Laurans, Bruno Esposito, Marie Vandestienne, Saskia CA de Jager, Carole Hénique, Ivana Zlatanova, Soraya Taleb, Patrick Bruneval, Alain Tedgui, Ziad Mallat, Sebastien Gibot, Hafid Ait-Oufella
Jun 21, 2018
BACKGROUND: Innate immune responses activated through myeloid cells contribute to the initiation, progression, and complications of atherosclerosis in experimental models. However, the critical upstream pathways that link innate...
apolipoprotein foam cells Inflammation macrophage Toll-like receptor Animals Apoptosis Carotid Arteries Carotid Artery Diseases Cells Cultured Disease Models Animal Enzyme-Linked Immunosorbent Assay Genetic Therapy Humans Immunity Innate Lauric Acids MACROPHAGES Male Membrane Glycoproteins Mice Mice Inbred C57BL Mice Transgenic Oligopeptides Plaque Atherosclerotic Receptors Immunologic Rhodamines Triggering Receptor Expressed on Myeloid Cells-1
Increasing the availability and utilization of reliable data on population micronutrient (MN) status globally
Kenneth H Brown, Sophie E Moore, Sonja Y Hess, Christine M McDonald, Kerry S Jones, Sarah R Meadows, Mari S Manger, Jennifer Coates, Silvia Alayon, Saskia JM Osendarp
May 31, 2021
Micronutrient (MN) deficiencies can produce a broad array of adverse health and functional outcomes. Young, preschool children and women of reproductive age in low- and middle-income countries are most affected by these...
Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Jun 29, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C. Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 16, 2020
Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification of...
Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Apr 21, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 12, 2020
UNLABELLED: Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk...
Public health impacts of city policies to reduce climate change
Clive E. Sabel, Rosemary Hiscock, Arja Asikainen, Jun Bi, Mike Depledge, Sef Van Den Elshout, Rainer Friedrich, Ganlin Huang, Fintan Hurley, Matti Jantunen, Spyros P. Karakitsios, Menno Keuken, Simon Kingham, Periklis Kontoroupis, Nino Kuenzli, Miaomiao Liu, Marco Martuzzi, Katie Morton, Pierpaolo Mudu, Marjo Niittynen, Laura Perez, Denis Sarigiannis, Will Stahl-Timmins, Myriam Tobollik, Jouni Tuomisto, Saskia Willers
Mar 08, 2016
Background: Climate change is a global threat to health and wellbeing. Here we provide findings of an international research project investigating the health and wellbeing impacts of policies to reduce greenhouse gas...
Air Pollution buildings China Energy Europe Greenhouse gas emission reduction policies HEALTH transport urban Wellbeing /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Public health impacts of city policies to reduce climate change
Clive E. Sabel, Rosemary Hiscock, Arja Asikainen, Jun Bi, Mike Depledge, Sef Van Den Elshout, Rainer Friedrich, Ganlin Huang, Fintan Hurley, Matti Jantunen, Spyros P. Karakitsios, Menno Keuken, Simon Kingham, Periklis Kontoroupis, Nino Kuenzli, Miaomiao Liu, Marco Martuzzi, Katie Morton, Pierpaolo Mudu, Marjo Niittynen, Laura Perez, Denis Sarigiannis, Will Stahl-Timmins, Myriam Tobollik, Jouni Tuomisto, Saskia Willers
Mar 08, 2016
Background: Climate change is a global threat to health and wellbeing. Here we provide findings of an international research project investigating the health and wellbeing impacts of policies to reduce greenhouse gas...
Air Pollution buildings China Energy Europe Greenhouse gas emission reduction policies HEALTH transport urban Wellbeing /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
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