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Results: 53
Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.
Eunyoung Lee, Emily L Miedzybrodzka, Xilin Zhang, Ryo Hatano, Junki Miyamoto, Ikuo Kimura, Kosuke Fujimoto, Satoshi Uematsu, Sergio Rodriguez-Cuenca, Antonio Vidal-Puig, Fiona M Gribble, Frank Reimann, Takashi Miki
Dec 11, 2019
As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However...
Lepob/ob diet-induced obese (DIO) mice Glucose-dependent insulinotropic polypeptide (GIP) High-fat diet interleukin-1 receptor antagonist (IL-1Ra) Leptin Animals Diet High-Fat Gastric Inhibitory Polypeptide Gene Expression Interleukin 1 Receptor Antagonist Protein Leptin Male Mice Inbred C57BL Mice Obese obesity Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone
Dissecting the Development and Function of C. elegans Glia with Mutations of the mls-2 and vab-3 Genes
Yoshimura Satoshi
Jan 01, 0001
The past decade has produced much evidence that glia, the major cellular component of vertebrate nervous systems, play active integral roles in a variety of processes including neuronal migration, synaptogenesis, and modulation...
Published by: Rockefeller University
RIKEN MetaDatabase
Recently, the number and heterogeneity of life science datasets published on the Web have increased significantly. However, biomedical scientists face numerous serious difficulties finding, using and publishing useful databases....
Published by: IGI Global Scientific Publishing
Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii.
Ui Okada, Eiki Yamashita, Arthur Neuberger, Mayu Morimoto, Hendrik W van Veen, Satoshi Murakami
Jan 24, 2018
The MacA-MacB-TolC tripartite complex is a transmembrane machine that spans both plasma membrane and outer membrane and actively extrudes substrates, including macrolide antibiotics, virulence factors, peptides and cell envelope...
ATP-Binding Cassette Transporters Acinetobacter baumannii Amino Acid Sequence Bacterial Proteins Conserved Sequence Crystallography X-Ray Drug Resistance Multiple Bacterial Escherichia coli Models Molecular Protein Domains Protein Structure Quaternary Recombinant Proteins Sequence Homology Amino Acid
The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells.
Hitoshi Niwa, Akira Nakamura, Makoto Urata, Maki Shirae-Kurabayashi, Shigehiro Kuraku, Steven Russell, Satoshi Ohtsuka
Sep 29, 2016
BACKGROUND: In mouse ES cells, the function of Sox2 is essential for the maintenance of pluripotency. Since the Sox-family of transcription factors are well conserved in the animal kingdom, addressing the evolutionary origin of...
Predicting and Visualizing Lateral Movements Based on ATT&CK and Quantification Theory Type 3
When a cyber incident occurs, organizations need to identify the attack's impacts. They have to investigate potentially infected devices as well as certainly infected devices. However, as an organization's network expands, it is...
Published by: IGI Global Scientific Publishing
Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose
T. Tsuzuki, S. Takano, N. Sakaguchi, T Kudoh, Takashi Murayama, Takashi Sakurai, Haruhiro Higashida, K Weber, A H Guse, T. Kameda, T. Hirokawa, Y. Kumaki, M Arisawa, Barry Potter, Satoshi Shuto
Jun 01, 2015
Here we describe the successful synthesis of cyclic ADP-4-thioribose (cADPtR, 3), designed as a stable mimic of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger, in which the key N1-β-thioribosyladenosine...
Detailed structural analysis of amorphous Pd<sub>40</sub>Cu<sub>40</sub>P<sub>20</sub>
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Mar 01, 2021
To clarify the relationship between the glass-forming ability (GFA) and local atomic structure of Pd-based metallic glasses, the structures of an amorphous Pd40Cu40P20 (PCP) were investigated...
Anomalous X-ray scattering Glass-forming ability Hyper-ordered structures metallic glasses neutron diffraction Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi
Dec 13, 2018
In the case of organ transplantation accompanied by vascular anastomosis, major histocompatibility complex mismatched vascular endothelial cells become a target for graft rejection. Production of a rejection-free, transplantable...
blastocyst complementation hematopoietic cells Pluripotent Stem Cells tissue regeneration vascular endothelial cells aging Animals Blastocyst Chimera Endothelial Cells Hematopoietic Stem Cells Induced Pluripotent Stem Cells Mice Inbred C57BL Mice Knockout Neovascularization Physiologic Pericytes Phenotype Platelet Endothelial Cell Adhesion Molecule-1 Vascular Endothelial Growth Factor Receptor-2
Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem cell rolling.
Karmen AbuZineh, Luay I Joudeh, Bader Al Alwan, Samir M Hamdan, Jasmeen S Merzaban, Satoshi Habuchi
Sep 20, 2018
Hematopoietic stem/progenitor cell (HSPC) homing occurs via cell adhesion mediated by spatiotemporally organized ligand-receptor interactions. Although molecules and biological processes involved in this multistep cellular...
Powering the ABC multidrug exporter LmrA
Kelvin Agboh, Calvin HF Lau, Yvonne SK Khoo, Himansha Singh, Sagar Raturi, Asha V Nair, Julie Howard, Marco Chiapello, Renata Feret, Michael J Deery, Satoshi Murakami, Hendrik W van Veen
Sep 20, 2018
Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae.
Sagar Raturi, Asha V Nair, Keiko Shinoda, Himansha Singh, Boyan Bai, Satoshi Murakami, Hideaki Fujitani, Hendrik W van Veen
Apr 07, 2021
Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae.
Sagar Raturi, Asha V Nair, Keiko Shinoda, Himansha Singh, Boyan Bai, Satoshi Murakami, Hideaki Fujitani, Hendrik W van Veen
Jun 12, 2021
Multidrug and toxic compound extrusion (MATE) transport proteins confer multidrug resistance on pathogenic microorganisms and affect pharmacokinetics in mammals. Our understanding of how MATE transporters work, has mostly relied...
Published by: Communications biology
Partial structure investigation of the traditional bulk metallic glass Pd40Ni40 P20
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Kenji Maruyama, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Aug 28, 2019
Local structures of Pd40Ni40P20 bulk metallic glass were investigated by combining anomalous x-ray scattering close to the Pd and Ni K absorption edges, x-ray diffraction, neutron diffraction, and reverse Monte Carlo...
Relationship between atomic structure and excellent glass forming ability in Pd42.5Ni7.5Cu30P20 metallic glass
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf-Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Nov 15, 2022
To understand the relation of the glass-forming ability (GFA) to the local atomic configurations of a
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Glass-forming ability Icosahedral arrangement Partial structure Persistent homology analysis Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
Aaron Burberry, Naoki Suzuki, Jin-Yuan Wang, Rob Moccia, Daniel A Mordes, Morag H Stewart, Satomi Suzuki-Uematsu, Sulagna Ghosh, Ajay Singh, Florian T Merkle, Kathryn Koszka, Quan-Zhen Li, Leonard Zon, Derrick J Rossi, Jennifer J Trowbridge, Luigi D Notarangelo, Kevin Eggan
Sep 04, 2019
C9ORF72 mutations are found in a significant fraction of patients suffering from amyotrophic lateral sclerosis and frontotemporal dementia, yet the function of the C9ORF72 gene product remains poorly understood. We show that...
Synthesis and Properties of a Lead-Free Hybrid Double Perov-skite
Fengxia Wei, Zeyu Deng, Shijing Sun, Fenghua Zhang, Donald Evans, Gregor Kieslich, Satoshi Tominaka, Michael Carpenter, Jie Zhang, PD Bristowe, Anthony Cheetham
Mar 02, 2018
The discovery of lead-free hybrid double perovskites provides a viable approach in the search for stable and environmentally benign photovoltaic materials as alternatives to the lead-containing systems such as MAPbX3 (X = Cl...
Relationship between atomic structure and excellent glass forming ability in Pd42.5Ni7.5Cu30P20 metallic glass
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf-Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Nov 15, 2022
To understand the relation of the glass-forming ability (GFA) to the local atomic configurations of a
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Glass-forming ability Icosahedral arrangement Partial structure Persistent homology analysis Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Partial structure investigation of the traditional bulk metallic glass Pd40Ni40 P20
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Kenji Maruyama, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Aug 28, 2019
Local structures of Pd40Ni40P20 bulk metallic glass were investigated by combining anomalous x-ray scattering close to the Pd and Ni K absorption edges, x-ray diffraction, neutron diffraction, and reverse Monte Carlo...
Freezing of Aqueous Solutions and Chemical Stability of Amorphous Pharmaceuticals
Evgenyi Shalaev, Alan Soper, J Axel Zeitler, Satoshi Ohtake, Christopher J Roberts, Michael J Pikal, Ke Wu, Elena Boldyreva
Sep 20, 2018
Detailed structural analysis of amorphous Pd<sub>40</sub>Cu<sub>40</sub>P<sub>20</sub>
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Mar 01, 2021
To clarify the relationship between the glass-forming ability (GFA) and local atomic structure of Pd-based metallic glasses, the structures of an amorphous Pd40Cu40P20 (PCP) were investigated...
Anomalous X-ray scattering Glass-forming ability Hyper-ordered structures metallic glasses neutron diffraction Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose
T. Tsuzuki, S. Takano, N. Sakaguchi, T Kudoh, Takashi Murayama, Takashi Sakurai, Haruhiro Higashida, K Weber, A H Guse, T. Kameda, T. Hirokawa, Y. Kumaki, M Arisawa, Barry Potter, Satoshi Shuto
Jun 01, 2015
Here we describe the successful synthesis of cyclic ADP-4-thioribose (cADPtR, 3), designed as a stable mimic of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger, in which the key N1-β-thioribosyladenosine...
Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.
Lake-Ee Quek, James R Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J Fazakerley, Richard Scalzo, Sarah D Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W Locasale, Tomoyoshi Soga, David E James, Shinya Kuroda
Apr 06, 2020
Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient 13C-tracer dynamic metabolic flux analysis...
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