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Abstract: Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to...

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Carrier Proteins Cell Cycle Cell Line Tumor Cell Survival DNA Breaks Double-Stranded Endodeoxyribonucleases Green Fluorescent Proteins HEK293 Cells Humans Immunoblotting Microscopy Confocal Nuclear Proteins RNA Interference Recombinational DNA Repair Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination

Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the...

Cell Line Chromatin Humans DNA Damage Adaptor Proteins Signal Transducing Cell Cycle Proteins Histones DNA Repair Amino Acid Motifs DNA Breaks Double-Stranded Tumor Suppressor p53-Binding Protein 1

Antigens Nuclear Cell Line Tumor Crystallography X-Ray DNA Breaks Double-Stranded DNA End-Joining Repair DNA Repair Enzymes DNA-Binding Proteins Humans Ku Autoantigen Protein Structure Secondary RNA Interference

MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism, where Ub is...

Adaptor Proteins Signal Transducing Animals Axons Binding Sites Cysteine Female Gene Knock-In Techniques Humans Lysine Mice Mice Inbred C57BL Mice Transgenic Models Molecular Molecular Conformation Protein Binding Protein Conformation RING Finger Domains Signal Transduction Structure-Activity Relationship Ubiquitin Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination