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Genetic and Biochemical Studies on Protein Phosphorylation in the Circadian Clock of Drosophila Melanogaster
Saul Kivimae
Jan 01, 0001
Circadian rhythms in physiology and behavior are observed in almost all phyla. Genetically encoded internal clocks generate such rhythms. Identification of gene products required for the generation and maintenance of endogenous...
Published by: Rockefeller University
The Commonwealth and South Africa
Saul Dubow
Sep 08, 2018
The creation of modern South Africa as an independent unitary state within the British Empire (c. 1910) gave birth to the Commonwealth idea. Jan Smuts’s views on Commonwealth were formative and they continued to inform the...
WERE THERE POLITICAL ALTERNATIVES IN THE WAKE OF THE SHARPEVILLE-LANGA VIOLENCE IN SOUTH AFRICA, 1960?
Abstract In many accounts, the Sharpeville emergency of 1960 was a key ‘turning point’ for modern South African history. It persuaded the liberation movements that there was no point in civil...
Saul Dubow
Oct 18, 2018
Image-Based Model Parameter Optimization Using Model-Assisted Generative Adversarial Networks.
We propose and demonstrate the use of a model-assisted generative adversarial network (GAN) to produce fake images that accurately match true images through the variation of the parameters of the model that describes the...
Monoclonal Antibodies of a Diverse Isotype Induced by an O-Antigen Glycoconjugate Vaccine Mediate In Vitro and In Vivo Killing of African Invasive Nontyphoidal Salmonella.
Yun Shan Goh, Simon Clare, Francesca Micoli, Allan Saul, Pietro Mastroeni, Calman A MacLennan
Jul 14, 2015
Multiple Interactions of Glucose with the Extra-Membranous Loops of GLUT1 Aid Transport
Molecular dynamics simulations amounting to ≈8 μs demonstrate that the glucose transporter GLUT1 undergoes structural fluctuations mediated by the fluidity of the lipid bilayer and the proximity to glucose. The fluctuations...
CpPosNeg
Harry O Jackson, Henry N Taunt, Paweł M Mordaka, Sujata Kumari, Alison G Smith, Saul Purton
May 13, 2022
The chloroplast represents an attractive compartment for light-driven biosynthesis of recombinant products, and advanced synthetic biology tools are available for engineering the chloroplast genome ( = plastome) of several algal...
The Algal Chloroplast as a Testbed for Synthetic Biology Designs Aimed at Radically Rewiring Plant Metabolism
Sustainable and economically viable support for an ever-increasing global population requires a paradigm shift in agricultural productivity, including the application of biotechnology to generate future crop plants. Current...
Fundamental shift in vitamin B12 eco-physiology of a model alga demonstrated by experimental evolution.
Katherine E Helliwell, Sinéad Collins, Elena Kazamia, Saul Purton, Glen L Wheeler, Alison G Smith
Nov 20, 2014
Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation.
Hemalvi Patani, Michael D Rushton, Jonathan Higham, Saul A Teijeiro, David Oxley, Pedro Cutillas, Duncan Sproul, Gabriella Ficz
Sep 09, 2020
Epigenetic reprogramming is a cancer hallmark, but how it unfolds during early neoplastic events and its role in carcinogenesis and cancer progression is not fully understood. Here we show that resetting from primed to naïve...
Animals Cell Line Cell Transformation Neoplastic Cellular Reprogramming Coculture Techniques CpG Islands DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A Epigenesis Genetic FIBROBLASTS Gene Expression Regulation Neoplastic Gene Knockdown Techniques HEK293 Cells Histones Human Embryonic Stem Cells Humans Mice Mixed Function Oxygenases Neoplasms Promoter Regions Genetic Proto-Oncogene Proteins RNA Small Interfering
Multiple Interactions of Glucose with the Extra-Membranous Loops of GLUT1 Aid Transport
Molecular dynamics simulations amounting to ≈8 μs demonstrate that the glucose transporter GLUT1 undergoes structural fluctuations mediated by the fluidity of the lipid bilayer and the proximity to glucose. The fluctuations...
Alternative patterns of sex chromosome differentiation in Aedes aegypti (L).
Corey L Campbell, Laura B Dickson, Saul Lozano-Fuentes, Punita Juneja, Francis M Jiggins, William C Black
Jan 24, 2018
BACKGROUND: Some populations of West African Aedes aegypti, the dengue and zika vector, are reproductively incompatible; our earlier study showed that divergence and rearrangements of genes on chromosome 1, which bears the sex...
Salmonella Paratyphi A Outer Membrane Vesicles Displaying Vi Polysaccharide as a Multivalent Vaccine against Enteric Fever.
G Gasperini, R Alfini, V Arato, F Mancini, MG Aruta, P Kanvatirth, D Pickard, F Necchi, A Saul, O Rossi, F Micoli, P Mastroeni
Dec 11, 2020
Carbene metal amide photoemitters
Alexander S Romanov, Saul TE Jones, Qinying Gu, Patrick J Conaghan, Bluebell H Drummond, Jiale Feng, Florian Chotard, Leonardo Buizza, Morgan Foley, Mikko Linnolahti, Dan Credgington, Manfred Bochmann
Apr 19, 2020
Conformationally flexible "Carbene-Metal-Amide" (CMA) complexes of copper and gold have been developed based on a combination of sterically hindered cyclic (alkyl)(amino)carbene (CAAC) and 6- and 7-ring heterocyclic amide...
Lack of attentional retraining effects in cigarette smokers attempting cessation
Rachna Begh, Marcus R Munafò, Saul Shiffman, Stuart G Ferguson, Linda Nichols, Mohammed A Mohammed, Roger L Holder, Stephen Sutton, Paul Aveyard
Jun 15, 2018
BACKGROUND: Observational studies have shown that attentional bias for smoking-related cues is associated with increased craving and relapse. Laboratory experiments have shown that manipulating attentional bias may change...
Efficient Vacuum-Processed Light-Emitting Diodes Based on Carbene-Metal-Amides.
Patrick J Conaghan, S Matthew Menke, Alexander S Romanov, Saul TE Jones, Andrew J Pearson, Emrys W Evans, Manfred Bochmann, Neil C Greenham, Dan Credgington
Oct 10, 2018
Efficient vacuum-processed organic light-emitting diodes are fabricated using a carbene-metal-amide material, CMA1. An electroluminescence (EL) external quantum efficiency of 23% is achieved in a host-free emissive layer...
Droplet-based microfluidic screening and sorting of microalgal populations for strain engineering applications.
Ziyi Yu, Katrin Geisler, Tina Leontidou, Rosanna EB Young, Sofie E Vonlanthen, Saul Purton, Chris Abell, Alison G Smith
Mar 29, 2021
The application of microfluidic technologies to microalgal research is particularly appealing since these approaches allow the precise control of the extracellular environment and offer a high-throughput approach to studying...
Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella.
Francesca Micoli, Simona Rondini, Renzo Alfini, Luisa Lanzilao, Francesca Necchi, Aurel Negrea, Omar Rossi, Cornelia Brandt, Simon Clare, Pietro Mastroeni, Rino Rappuoli, Allan Saul, Calman A MacLennan
Nov 21, 2018
Nontyphoidal Salmonellae cause a devastating burden of invasive disease in sub-Saharan Africa with high levels of antimicrobial resistance. Vaccination has potential for a major global health impact, but no licensed vaccine is...
Highly efficient blue organic light-emitting diodes based on carbene-metal-amides.
Patrick J Conaghan, Campbell SB Matthews, Florian Chotard, Saul TE Jones, Neil C Greenham, Manfred Bochmann, Dan Credgington, Alexander S Romanov
Mar 06, 2020
Carbene-metal-amides are soluble and thermally stable materials which have recently emerged as emitters in high-performance organic light-emitting diodes. Here we synthesise carbene-metal-amide photoemitters with CF3-substituted...
A Simple Molecular Design Strategy for Delayed Fluorescence toward 1000 nm.
Daniel G Congrave, Bluebell H Drummond, Patrick J Conaghan, Haydn Francis, Saul TE Jones, Clare P Grey, Neil C Greenham, Dan Credgington, Hugo Bronstein
Nov 04, 2019
Harnessing the near-infrared (NIR) region of the electromagnetic spectrum is exceedingly important for photovoltaics, telecommunications, and the biomedical sciences. While thermally activated delayed fluorescent (TADF)...
Doris Gangl, Julie AZ Zedler, Priscilla D Rajakumar, Erick M Ramos Martinez, Anthony Riseley, Artur Włodarczyk, Saul Purton, Yumiko Sakuragi, Christopher J Howe, Poul Erik Jensen, Colin Robinson
Sep 07, 2015
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