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Results: 27
Duck Pack Optimization With Deep Transfer Learning-Enabled Oral Squamous Cell Carcinoma Classification on Histopathological Images
Earlier detection and classification of squamous cell carcinoma (OSCC) is a widespread issue for efficient treatment, enhancing survival rate, and reducing the death rate. Thus, it becomes necessary to design effective diagnosis...
Grid & High Performance Computing Computer Science and Information Technology High Performance Computing
Published by: IGI Global Scientific Publishing
Human Stiffness Perception and Learning in Interacting With Compliant Environments.
Humans are capable of adjusting their posture stably when interacting with a compliant surface. Their whole-body motion can be modulated in order to respond to the environment and reach to a stable state. In perceiving an...
An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian.
Achaete-Scute Complex Genome Region Amino Acid Sequence Animals Arthropods Base Sequence Basic Helix-Loop-Helix Transcription Factors Binding Sites Biological Evolution Conserved Sequence Gene Duplication Gene Expression Regulation Developmental Molecular Sequence Data Nervous System Neural Plate Phylogeny Regulatory Elements Transcriptional Sequence Alignment Species Specificity
The relative importance of COVID-19 pandemic impacts on biodiversity conservation globally.
David W Gibbons, Chris Sandbrook, William J Sutherland, Rezvin Akter, Richard Bradbury, Steven Broad, Andy Clements, Humphrey QP Crick, Joanna Elliott, Ngawang Gyeltshen, Melanie Heath, Jonathan Hughes, Richard KB Jenkins, Alastair H Jones, Rocio Lopez de la Lama, Nicholas BW Macfarlane, Mike Maunder, Ravikash Prasad, Alfredo Romero-Muñoz, Noa Steiner, James Tremlett, Rosie Trevelyan, Savita Vijaykumar, Irushinie Wedage, Nancy Ockendon
May 28, 2021
The relative importance of COVID‐19 pandemic impacts on biodiversity conservation globally
David W. Gibbons, Chris Sandbrook, William J. Sutherland, Rezvin Akter, Richard Bradbury, Steven Broad, Andy Clements, Humphrey Q. P. Crick, Joanna Elliott, Ngawang Gyeltshen, Melanie Heath, Jonathan Hughes, Richard K. B. Jenkins, Alastair H. Jones, Rocio Lopez de la Lama, Nicholas B. W. Macfarlane, Mike Maunder, Ravikash Prasad, Alfredo Romero‐Muñoz, Noa Steiner, James Tremlett, Rosie Trevelyan, Savita Vijaykumar, Irushinie Wedage, Nancy Ockendon
Oct 28, 2021
Abstract: The COVID‐19 pandemic has had an enormous impact on almost all aspects of human society and endeavor; the natural world and its conservation have not been spared. Through a process of expert consultation, we identified...
CONTRIBUTED PAPER CONTRIBUTED PAPERS ambiente compendio coronavirus evaluación fauna naturaleza assessment compendium Environment Nature wildlife
Published by: Conservation Biology
An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank.
Ekaterina Yonova-Doing, Claudia Calabrese, Aurora Gomez-Duran, Katherine Schon, Wei Wei, Savita Karthikeyan, Patrick F Chinnery, Joanna MM Howson
Apr 21, 2021
Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly due to a lack of genotype calling and quality-control procedures. Developing an at-scale workflow for mtDNA variant analyses, we show...
Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors
C Mary Schooling, Shan Luo, Shiu Lun Au Yeung, Deborah J Thompson, Savita Karthikeyan, Thomas R Bolton, Amy M Mason, Erik Ingelsson, Stephen Burgess
Sep 08, 2018
BACKGROUND: Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. The causal role of testosterone can be investigated using a Mendelian randomization approach....
causal inference Disease aetiology Genetic epidemiology Mendelian randomization sex hormones Testosterone Adiponectin Aged Anthropometry blood pressure Coronary Artery Disease Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Jumonji Domain-Containing Histone Demethylases Lipids Male Mendelian Randomization Analysis Middle Aged Oxidoreductases N-Demethylating Receptors Cell Surface Risk Factors stroke Testosterone United Kingdom United States
Persistence of haemostatic response following gene therapy with valoctocogene roxaparvovec in severe haemophilia A.
K John Pasi, Michael Laffan, Savita Rangarajan, Tara M Robinson, Nina Mitchell, Will Lester, Emily Symington, Bella Madan, Xinqun Yang, Benjamin Kim, Glenn F Pierce, Wing Yen Wong
Nov 08, 2021
INTRODUCTION: Valoctocogene roxaparvovec is an investigational AAV5-based factor VIII (FVIII) gene therapy that has demonstrated sustained clinical benefit in people with severe haemophilia A. AIM: To report safety...
Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants.
Scott C Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Michael Inouye
Mar 03, 2023
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and...
The influence of rare variants in circulating metabolic biomarkers.
Fernando Riveros-McKay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth, Inês Barroso
Apr 09, 2020
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy...
Published by: PLoS genetics
The influence of rare variants in circulating metabolic biomarkers
Fernando Riveros-McKay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H. Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, INTERVAL Study, Eleanor Wheeler, Eleftheria Zeggini, Adam S. Butterworth, Inês Barroso
Mar 31, 2020
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy...
The influence of rare variants in circulating metabolic biomarkers.
Fernando Riveros-McKay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, INTERVAL Study, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth, Inês Barroso
Jan 31, 2020
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy...
Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants.
Scott C Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Michael Inouye
Jan 31, 2023
Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke.
Lingyan Chen, James E Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J Roberts, Nicholas A Watkins, Willem H Ouwehand, John Danesh, Cathryn M Lewis, Paola G Bronson, Hugh S Markus, Stephen Burgess, Adam S Butterworth, Joanna MM Howson
Oct 18, 2022
Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2)
Thomas P Hellyer, Niall H Anderson, Jennie Parker, Paul Dark, Tina Van Den Broeck, Suveer Singh, Ronan McMullan, Ashley M Agus, Lydia M Emerson, Bronagh Blackwood, Savita Gossain, Tim S Walsh, Gavin D Perkins, Andrew Conway Morris, Daniel F McAuley, A John Simpson
Jul 18, 2018
BACKGROUND: Ventilator-acquired pneumonia (VAP) is a common reason for antimicrobial therapy in the intensive care unit (ICU). Biomarker-based diagnostics could improve antimicrobial stewardship through rapid exclusion of VAP....
Antibiotic stewardship biomarker randomised controlled trial Ventilator-acquired pneumonia Anti-Bacterial Agents Antimicrobial Stewardship Bacteria Biomarkers Bronchoalveolar Lavage Fluid Clinical Protocols Colony Count Microbial Hospital Mortality Humans Interleukin-1beta Interleukin-8 Length of Stay Organ Dysfunction Scores Patient Selection Pneumonia Bacterial Pneumonia Ventilator-Associated Predictive Value of Tests Prospective Studies Research Design Respiration Artificial Time Factors United Kingdom Unnecessary Procedures
Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke.
Lingyan Chen, James E Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J Roberts, Nicholas A Watkins, Willem H Ouwehand, John Danesh, Cathryn M Lewis, Paola G Bronson, Hugh S Markus, Stephen Burgess, Adam S Butterworth, Joanna MM Howson
Nov 17, 2022
The association of circulating amylin with β-amyloid in familial Alzheimer's disease.
Han Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L Abner, Peter T Nelson, Gregory A Jicha, Donna M Wilcock, Larry B Goldstein, Rita Guerreiro, José Brás, Angela J Hanson, Suzanne Craft, Andrew J Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Aesg, Florin Despa
Feb 19, 2021
INTRODUCTION: This study assessed the hypothesis that circulating human amylin (amyloid-forming) cross-seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD). METHODS: Evidence of amylin-AD pathology interaction was...
Assessing the causal association of glycine with risk of cardio-metabolic diseases.
Laura BL Wittemans, Luca A Lotta, Clare Oliver-Williams, Isobel D Stewart, Praveen Surendran, Savita Karthikeyan, Felix R Day, Albert Koulman, Fumiaki Imamura, Lingyao Zeng, Jeanette Erdmann, Heribert Schunkert, Kay-Tee Khaw, Julian L Griffin, Nita G Forouhi, Robert A Scott, Angela M Wood, Stephen Burgess, Joanna MM Howson, John Danesh, Nicholas J Wareham, Adam S Butterworth, Claudia Langenberg
Feb 18, 2019
Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies
Stephen Burgess, Brian A Ference, James R Staley, Daniel F Freitag, Amy M Mason, Sune F Nielsen, Peter Willeit, Robin Young, Praveen Surendran, Savita Karthikeyan, Thomas R Bolton, James E Peters, Pia R Kamstrup, Anne Tybjaerg-Hansen, Marianne Benn, Anne Langsted, Peter Schnohr, Signe Vedel-Krogh, Camilla J Kobylecki, Ian Ford, Chris Packard, Stella Trompet, J Wouter Jukema, Naveed Sattar, Emanuele Di Angelantonio, Danish Saleheen, Joanna MM Howson, Børge G Nordestgaard, Adam S Butterworth, John Danesh, European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium
Sep 27, 2018
IMPORTANCE: Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25%...
The African Genome Variation Project shapes medical genetics in Africa.
Deepti Gurdasani, Tommy Carstensen, Fasil Tekola-Ayele, Luca Pagani, Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Savita Karthikeyan, Louise Iles, Martin O Pollard, Ananyo Choudhury, Graham RS Ritchie, Yali Xue, Jennifer Asimit, Rebecca N Nsubuga, Elizabeth H Young, Cristina Pomilla, Katja Kivinen, Kirk Rockett, Anatoli Kamali, Ayo P Doumatey, Gershim Asiki, Janet Seeley, Fatoumatta Sisay-Joof, Muminatou Jallow, Stephen Tollman, Ephrem Mekonnen, Rosemary Ekong, Tamiru Oljira, Neil Bradman, Kalifa Bojang, Michele Ramsay, Adebowale Adeyemo, Endashaw Bekele, Ayesha Motala, Shane A Norris, Fraser Pirie, Pontiano Kaleebu, Dominic Kwiatkowski, Chris Tyler-Smith, Charles Rotimi, Eleftheria Zeggini, Manjinder S Sandhu
Aug 15, 2018
Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterization of African genetic diversity is needed. The African Genome Variation Project provides a resource with which to...
Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.
Thomas P Hellyer, Andrew Conway Morris, Daniel F McAuley, Timothy S Walsh, Niall H Anderson, Suveer Singh, Paul Dark, Alistair I Roy, Simon V Baudouin, Stephen E Wright, Gavin D Perkins, Kallirroi Kefala, Melinda Jeffels, Ronan McMullan, Cecilia M O'Kane, Craig Spencer, Shondipon Laha, Nicole Robin, Savita Gossain, Kate Gould, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Emma M Browne, James G MacFarlane, Sarah Wiscombe, John D Widdrington, Ian Dimmick, Ian F Laurenson, Frans Nauwelaers, A John Simpson
Jun 26, 2020
BACKGROUND: Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful...
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
Ming-Huei Chen, Laura M Raffield, Abdou Mousas, Saori Sakaue, Jennifer E Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L Bao, Xue Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, Ken Sin Lo, Huijun Qian, Caleb A Lareau, Mélissa Beaudoin, Karen A Hunt, Masato Akiyama, Traci M Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P Bottinger, Jennifer A Brody, Frank JA van Rooij, Kumaraswamynaidu Chitrala, Kelly Cho, Hélène Choquet, Adolfo Correa, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K Evans, James S Floyd, Linda Broer, Niels Grarup, Michael H Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna MM Howson, Qin Qin Huang, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotis Koskeridis, Leslie A Lange, Terho Lehtimäki, Markus M Lerch, Allan Linneberg, Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Hilary C Martin, Koichi Matsuda, Karen L Mohlke, Nina Mononen, Yoshinori Murakami, Girish N Nadkarni, Matthias Nauck, Kjell Nikus, Willem H Ouwehand, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M Psaty, Olli T Raitakari, David J Roberts, Stephen S Rich, Benjamin AT Rodriguez, Jonathan D Rosen, Jerome I Rotter, Petra Schubert, Cassandra N Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Richard C Trembath, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A Watkins, Alan B Zonderman, VA Million Veteran Program, Peter WF Wilson, Yun Li, Adam S Butterworth, Jean-François Gauchat, Charleston WK Chiang, Bingshan Li, Ruth JF Loos, William J Astle, Evangelos Evangelou, David A van Heel, Vijay G Sankaran, Yukinori Okada, Nicole Soranzo, Andrew D Johnson, Alexander P Reiner, Paul L Auer, Guillaume Lettre
Jun 18, 2020
Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified...
SciPy 1.0
Pauli Virtanen, Ralf Gommers, Travis E. Oliphant, Matt Haberland, Tyler Reddy, David Cournapeau, Evgeni Burovski, Pearu Peterson, Warren Weckesser, Jonathan Bright, Stéfan J. van der Walt, Matthew Brett, Joshua Wilson, K. Jarrod Millman, Nikolay Mayorov, Andrew R. J. Nelson, Eric Jones, Robert Kern, Eric Larson, C J Carey, İlhan Polat, Yu Feng, Eric W. Moore, Jake VanderPlas, Denis Laxalde, Josef Perktold, Robert Cimrman, Ian Henriksen, E. A. Quintero, Charles R. Harris, Anne M. Archibald, Antônio H. Ribeiro, Fabian Pedregosa, Paul van Mulbregt, Aditya Vijaykumar, Alessandro Pietro Bardelli, Alex Rothberg, Andreas Hilboll, Andreas Kloeckner, Anthony Scopatz, Antony Lee, Ariel Rokem, C. Nathan Woods, Chad Fulton, Charles Masson, Christian Häggström, Clark Fitzgerald, David A. Nicholson, David R. Hagen, Dmitrii V. Pasechnik, Emanuele Olivetti, Eric Martin, Eric Wieser, Fabrice Silva, Felix Lenders, Florian Wilhelm, G. Young, Gavin A. Price, Gert-Ludwig Ingold, Gregory E. Allen, Gregory R. Lee, Hervé Audren, Irvin Probst, Jörg P. Dietrich, Jacob Silterra, James T Webber, Janko Slavič, Joel Nothman, Johannes Buchner, Johannes Kulick, Johannes L. Schönberger, José Vinícius de Miranda Cardoso, Joscha Reimer, Joseph Harrington, Juan Luis Cano Rodríguez, Juan Nunez-Iglesias, Justin Kuczynski, Kevin Tritz, Martin Thoma, Matthew Newville, Matthias Kümmerer, Maximilian Bolingbroke, Michael Tartre, Mikhail Pak, Nathaniel J. Smith, Nikolai Nowaczyk, Nikolay Shebanov, Oleksandr Pavlyk, Per A. Brodtkorb, Perry Lee, Robert T. McGibbon, Roman Feldbauer, Sam Lewis, Sam Tygier, Scott Sievert, Sebastiano Vigna, Stefan Peterson, Surhud More, Tadeusz Pudlik, Takuya Oshima, Thomas J. Pingel, Thomas P. Robitaille, Thomas Spura, Thouis R. Jones, Tim Cera, Tim Leslie, Tiziano Zito, Tom Krauss, Utkarsh Upadhyay, Yaroslav O. Halchenko, Yoshiki Vázquez-Baeza
Feb 02, 2021
Abstract: SciPy is an open-source scientific computing library for the Python programming language. Since its initial release in 2001, SciPy has become a de facto standard for leveraging scientific algorithms in Python, with...
The Polygenic and Monogenic Basis of Blood Traits and Diseases.
Dragana Vuckovic, Erik L Bao, Parsa Akbari, Caleb A Lareau, Abdou Mousas, Tao Jiang, Ming-Huei Chen, Laura M Raffield, Manuel Tardaguila, Jennifer E Huffman, Scott C Ritchie, Karyn Megy, Hannes Ponstingl, Christopher J Penkett, Patrick K Albers, Emilie M Wigdor, Saori Sakaue, Arden Moscati, Regina Manansala, Ken Sin Lo, Huijun Qian, Masato Akiyama, Traci M Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P Bottinger, Jennifer A Brody, Frank JA van Rooij, Kumaraswamy N Chitrala, Peter WF Wilson, Hélène Choquet, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K Evans, Stephan B Felix, James S Floyd, Linda Broer, Niels Grarup, Michael H Guo, Qi Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna MM Howson, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotios Koskeridis, Leslie A Lange, Terho Lehtimäki, Allan Linneberg, Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Koichi Matsuda, Karen L Mohlke, Nina Mononen, Yoshinori Murakami, Girish N Nadkarni, Kjell Nikus, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M Psaty, Olli T Raitakari, Stephen S Rich, Benjamin AT Rodriguez, Jonathan D Rosen, Jerome I Rotter, Petra Schubert, Cassandra N Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A Watkins, Stefan Weiss, VA Million Veteran Program, Na Cai, Kousik Kundu, Stephen B Watt, Klaudia Walter, Alan B Zonderman, Kelly Cho, Yun Li, Ruth JF Loos, Julian C Knight, Michel Georges, Oliver Stegle, Evangelos Evangelou, Yukinori Okada, David J Roberts, Michael Inouye, Andrew D Johnson, Paul L Auer, William J Astle, Alexander P Reiner, Adam S Butterworth, Willem H Ouwehand, Guillaume Lettre, Vijay G Sankaran, Nicole Soranzo
Nov 04, 2020
Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from...
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Ayush Giri, Jacklyn N Hellwege, Jacob M Keaton, Jihwan Park, Chengxiang Qiu, Helen R Warren, Eric S Torstenson, Csaba P Kovesdy, Yan V Sun, Otis D Wilson, Cassianne Robinson-Cohen, Christianne L Roumie, Cecilia P Chung, Kelly A Birdwell, Scott M Damrauer, Scott L DuVall, Derek Klarin, Kelly Cho, Yu Wang, Evangelos Evangelou, Claudia P Cabrera, Louise V Wain, Rojesh Shrestha, Brian S Mautz, Elvis A Akwo, Muralidharan Sargurupremraj, Stéphanie Debette, Michael Boehnke, Laura J Scott, Jian'an Luan, Jing-Hua Zhao, Sara M Willems, Sébastien Thériault, Nabi Shah, Christopher Oldmeadow, Peter Almgren, Ruifang Li-Gao, Niek Verweij, Thibaud S Boutin, Massimo Mangino, Ioanna Ntalla, Elena Feofanova, Praveen Surendran, James P Cook, Savita Karthikeyan, Najim Lahrouchi, Chunyu Liu, Nuno Sepúlveda, Tom G Richardson, Aldi Kraja, Philippe Amouyel, Martin Farrall, Neil R Poulter, Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Markku Laakso, Eleftheria Zeggini, Peter Sever, Robert A Scott, Claudia Langenberg, Nicholas J Wareham, David Conen, Colin Neil Alexander Palmer, John Attia, Daniel I Chasman, Paul M Ridker, Olle Melander, Dennis Owen Mook-Kanamori, Pim van der Harst, Francesco Cucca, David Schlessinger, Caroline Hayward, Tim D Spector, Marjo-Riitta Jarvelin, Branwen J Hennig, Nicholas J Timpson, Wei-Qi Wei, Joshua C Smith, Yaomin Xu, Michael E Matheny, Edward E Siew, Cecilia Lindgren, Karl-Heinz Herzig, George Dedoussis, Joshua C Denny, Bruce M Psaty, Joanna MM Howson, Patricia B Munroe, Christopher Newton-Cheh, Mark J Caulfield, Paul Elliott, J Michael Gaziano, John Concato, Peter WF Wilson, Philip S Tsao, Digna R Velez Edwards, Katalin Susztak, Million Veteran Program, Christopher J O'Donnell, Adriana M Hung, Todd L Edwards
Feb 01, 2019
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood...
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