ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
NO Stitziel,
AV Khera,
X Wang,
AJ Bierhals,
AC Vourakis,
AE Sperry,
P Natarajan,
D Klarin,
CA Emdin,
SM Zekavat,
A Nomura,
J Erdmann,
H Schunkert,
NJ Samani,
WE Kraus,
SH Shah,
B Yu,
E Boerwinkle,
DJ Rader,
N Gupta,
PM Frossard,
A Rasheed,
J Danesh,
ES Lander,
S Gabriel,
D Saleheen,
K Musunuru,
S Kathiresan,
PROMIS and Myocardial Infarction Genetics Consortium Investigators
Oct 30, 2017
Background
Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether...