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Latency-associated viral interleukin-10 (IL-10) encoded by human cytomegalovirus modulates cellular IL-10 and CCL8 Secretion during latent infection through changes in the cellular microRNA hsa-miR-92a.
Emma Poole, Selmir Avdic, Jemima Hodkinson, Sarah Jackson, Mark Wills, Barry Slobedman, John Sinclair
Dec 10, 2015
Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state
Miri Shnayder, Aharon Nachshon, Batsheva Rozman, Biana Bernshtein, Michael Lavi, Noam Fein, Emma Poole, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, John Sinclair, Noam Stern-Ginossar, Michal Schwartz
Feb 24, 2020
Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency. Although reactivation from latency can cause life-threatening disease, our molecular understanding of HCMV latency is incomplete. Here we...
Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state.
Miri Shnayder, Aharon Nachshon, Batsheva Rozman, Biana Bernshtein, Michael Lavi, Noam Fein, Emma Poole, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, John Sinclair, Noam Stern-Ginossar, Michal Schwartz
Jan 27, 2020
Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency. Although reactivation from latency can cause life-threatening disease, our molecular understanding of HCMV latency is incomplete. Here we...
Cytomegalovirus hematopoietic stem and progenitor cells herpesvirus human infectious disease latency microbiology reactivation Single-cell RNA-seq Cell Line Cytomegalovirus Hematopoietic Stem Cells Host-Pathogen Interactions Humans Immune Tolerance Monocytes Sequence Analysis RNA Single-Cell Analysis Transcriptome Virus Latency