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Results: 38
Butler enables rapid cloud-based analysis of thousands of human genomes.
Sergei Yakneen, Sebastian M Waszak, PCAWG Technical Working Group, Michael Gertz, Jan O Korbel, PCAWG Consortium
Feb 04, 2021
We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data...
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure.
The basic and intrinsically disordered C-terminal domain (CTD) of the linker histone (LH) is essential for chromatin compaction. However, its conformation upon nucleosome binding and its impact on chromatin organization remain...
Corrections
We fix a major gap in our 2017 paper, along with related issues.
Corrections
We fix a major gap in our 2017 paper, along with related issues.
Anomalous Stochastic Transport of Particles with Self-Reinforcement and Mittag-Leffler Distributed Rest Times
We introduce a persistent random walk model for the stochastic transport of particles involving self-reinforcement and a rest state with Mittag–Leffler distributed residence times. The model involves a system of...
Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation.
BACKGROUND: Synapse formation and the development of neural networks are known to be controlled by a coordinated program of mRNA synthesis. microRNAs are now recognized to be important regulators of mRNA translation and...
The Wiener-Hopf technique, its generalizations and applications
This paper reviews the modern state of the Wiener-Hopf factorization method and its generalizations. The main constructive results for matrix Wiener-Hopf problems are presented, approximate methods are outlined and the main...
The Wiener-Hopf technique, its generalizations and applications
This paper reviews the modern state of the Wiener-Hopf factorization method and its generalizations. The main constructive results for matrix Wiener-Hopf problems are presented, approximate methods are outlined and the main...
The biological and clinical significance of emerging SARS-CoV-2 variants.
Kaiming Tao, Philip L Tzou, Janin Nouhin, Ravindra K Gupta, Tulio de Oliveira, Sergei L Kosakovsky Pond, Daniela Fera, Robert W Shafer
Oct 19, 2021
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel spike protein mutations that are influencing the epidemiological and clinical aspects of the COVID-19 pandemic. These variants can increase...
The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.
Elisa Laurenti, Sergei Doulatov, Sasan Zandi, Ian Plumb, Jing Chen, Craig April, Jian-Bing Fan, John E Dick
Jan 02, 2019
Understanding how differentiation programs originate from the gene-expression 'landscape' of hematopoietic stem cells (HSCs) is crucial for the development of new clinical therapies. We mapped the transcriptional dynamics...
Improving sample and feature selection with principal covariates regression
Rose K Cersonsky, Benjamin A Helfrecht, Edgar A Engel, Sergei Kliavinek, Michele Ceriotti
Jul 28, 2021
CDK6 levels regulate quiescence exit in human hematopoietic stem cells.
Elisa Laurenti, Catherine Frelin, Stephanie Xie, Robin Ferrari, Cyrille F Dunant, Sasan Zandi, Andrea Neumann, Ian Plumb, Sergei Doulatov, Jing Chen, Craig April, Jian-Bing Fan, Norman Iscove, John E Dick
Apr 29, 2015
The effect of heterogeneity on invasion in spatial epidemics
Franco M Neri, Anne Bates, Winnie S Füchtbauer, Francisco J Pérez-Reche, Sergei N Taraskin, Wilfred Otten, Douglas J Bailey, Christopher A Gilligan
May 29, 2019
Heterogeneity in host populations is an important factor affecting the ability of a pathogen to invade, yet the quantitative investigation of its effects on epidemic spread is still an open problem. In this paper, we test recent...
Assigning and visualizing germline genes in antibody repertoires.
Simon DW Frost, Ben Murrell, AS Md Mukarram Hossain, Gregg J Silverman, Sergei L Kosakovsky Pond
Aug 28, 2015
IgSCUEAL V(D)J rearrangements classification immunoglobulin phylogenetic models Visualization Algorithms Antibody Diversity Computer Simulation Databases Genetic Gene Rearrangement B-Lymphocyte Humans Immunoglobulin Heavy Chains Models Genetic Models Immunological Phylogeny Sequence Alignment V(D)J Recombination
Jinsuk Kang, Matthias Lienhard, William A Pastor, Ashu Chawla, Mark Novotny, Ageliki Tsagaratou, Roger S Lasken, Elizabeth C Thompson, M Azim Surani, Sergei B Koralov, Sundeep Kalantry, Lukas Chavez, Anjana Rao
Sep 15, 2015
5-hydroxymethylcytosine 5hmC DNA Methylation TET methylcytosine oxidases cholesterol biosynthesis 5-Methylcytosine Animals Biomarkers Blastocyst Blastomeres Cell Lineage Cholesterol DNA DNA-Binding Proteins Dioxygenases Down-Regulation Embryo Loss Embryo Mammalian Embryonic Development Gene Deletion Gene Expression Regulation Developmental Genomic Imprinting Hedgehog Proteins Mice Inbred C57BL Mice Knockout Proto-Oncogene Proteins Repetitive Sequences Nucleic Acid Sequence Analysis RNA Signal Transduction Transcriptome
Diversity and Paleodemography of the Addax (<i>Addax nasomaculatus</i>), a Saharan Antelope on the Verge of Extinction.
Elisabeth Hempel, Michael V Westbury, José H Grau, Alexandra Trinks, Johanna L A Paijmans, Sergei Kliver, Axel Barlow, Frieder Mayer, Johannes Müller, Lei Chen, Klaus-Peter Koepfli, Michael Hofreiter, Faysal Bibi
Sep 27, 2021
Since the 19th century, the addax (Addax nasomaculatus) has lost approximately 99% of its former range. Along with its close relatives, the blue antelope (Hippotragus leucophaeus) and the scimitar-horned oryx...
CONSERVATION critically endangered antelope genome assembly museum collections PSMC Addax nasomaculatus bovid archival DNA
Published by: Genes
Creation of a library of induced pluripotent stem cells from Parkinsonian patients.
Staffan Holmqvist, Šárka Lehtonen, Margarita Chumarina, Katja A Puttonen, Carla Azevedo, Olga Lebedeva, Marika Ruponen, Minna Oksanen, Mehdi Djelloul, Anna Collin, Stefano Goldwurm, Morten Meyer, Maria Lagarkova, Sergei Kiselev, Jari Koistinaho, Laurent Roybon
Jun 01, 2020
Induced pluripotent stem cells (iPSCs) are becoming an important source of pre-clinical models for research focusing on neurodegeneration. They offer the possibility for better understanding of common and divergent pathogenic...
Genetics Stem Cell Research - Induced Pluripotent Stem Cell - Human aging ALS Parkinson's Disease Stem Cell Research - Induced Pluripotent Stem Cell Brain Disorders Rare Diseases Acquired Cognitive Impairment Stem Cell Research Neurodegenerative Dementia Neurosciences Clinical Research 2.1 Biological and endogenous factors 2 Aetiology Neurological
Diversity and Paleodemography of the Addax (Addax nasomaculatus), a Saharan Antelope on the Verge of Extinction.
Elisabeth Hempel, Michael V Westbury, José H Grau, Alexandra Trinks, Johanna LA Paijmans, Sergei Kliver, Axel Barlow, Frieder Mayer, Johannes Müller, Lei Chen, Klaus-Peter Koepfli, Michael Hofreiter, Faysal Bibi
Oct 27, 2021
Since the 19th century, the addax (Addax nasomaculatus) has lost approximately 99% of its former range. Along with its close relatives, the blue antelope (Hippotragus leucophaeus) and the scimitar-horned oryx (Oryx dammah), the...
Diversity and Paleodemography of the Addax ( Addax nasomaculatus ), a Saharan Antelope on the Verge of Extinction
Elisabeth Hempel, Michael V. Westbury, José H. Grau, Alexandra Trinks, Johanna L. A. Paijmans, Sergei Kliver, Axel Barlow, Frieder Mayer, Johannes Müller, Lei Chen, Klaus-Peter Koepfli, Michael Hofreiter, Faysal Bibi
Aug 13, 2021
Since the 19th century, the addax (Addax nasomaculatus) has lost approximately 99% of its former range. Along with its close relatives, the blue antelope (Hippotragus leucophaeus) and the scimitar-horned oryx (Oryx dammah), the...
Viral CpG Deficiency Provides No Evidence That Dogs Were Intermediate Hosts for SARS-CoV-2.
David D Pollock, Todd A Castoe, Blair W Perry, Spyros Lytras, Kristen J Wade, David L Robertson, Edward C Holmes, Maciej F Boni, Sergei L Kosakovsky Pond, Rhys Parry, Elizabeth J Carlton, James LN Wood, Pleuni S Pennings, Richard A Goldstein
Jul 21, 2020
Due to the scope and impact of the COVID-19 pandemic there exists a strong desire to understand where the SARS-CoV-2 virus came from and how it jumped species boundaries to humans. Molecular evolutionary analyses can trace viral...
covid-19 CpG deficiency bats Dogs pangolin Alphacoronavirus Animals Betacoronavirus Biological Evolution covid-19 Chiroptera Coronavirus Infections CpG Islands Dogs Eutheria Genome Viral Humans Immune Evasion Pandemics Pneumonia Viral Protein Binding RNA Viral RNA-Binding Proteins Reassortant Viruses SARS-CoV-2 Virus Replication
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