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Results: 206
GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism.
Marco Bauzá-Thorbrügge, Sergio Rodríguez-Cuenca, Antonio Vidal-Puig, Bel M Galmés-Pascual, Miquel Sbert-Roig, Magdalena Gianotti, Isabel Lladó, Ana M Proenza
Dec 10, 2018
Obesity is associated with inflammation, dysregulated adipokine secretion, and disrupted adipose tissue mitochondrial function. Estradiol (E2) has been previously reported to increase mitochondrial function and biogenesis in...
17beta-estradiol G protein-coupled oestrogen receptor adipocyte Mitochondrial function Oestrogen receptor alpha PKA 3T3 Cells Adipocytes Animals Cell Line Cyclic AMP-Dependent Protein Kinases Estradiol Estrogen Receptor alpha Estrogen Receptor beta Female Inflammation Interleukin-6 Male Mice Mice Inbred C57BL Mitochondria obesity Rats Rats Wistar Receptors G-Protein-Coupled
Schizophrenia and the problem of suffering in the Ludlul hymn to Marduk
The Babylonian poem ludlul bel nemeqi begins with a "hymn" to the god Marduk which includes puzzlingly discordant praises of his wrath and his mercy, giving him a somewhat "schizophrenic" character. We argue that, in fact, the...
The timing and widespread effects of the largest Holocene volcanic eruption in Antarctica.
Dermot Antoniades, Santiago Giralt, Adelina Geyer, Antonio M Álvarez-Valero, Sergi Pla-Rabes, Ignacio Granados, Emma J Liu, Manuel Toro, John L Smellie, Marc Oliva
Jan 08, 2019
The caldera collapse of Deception Island Volcano, Antarctica, was comparable in scale to some of the largest eruptions on Earth over the last several millennia. Despite its magnitude and potential for far-reaching environmental...
Effects of Cannabis Use on the Protein and Lipid Profile of Olfactory Neuroepithelium Cells from Schizophrenia Patients Studied by Synchrotron-Based FTIR Spectroscopy.
Sergi Saladrigas-Manjón, Tanja Dučić, Liliana Galindo, Cristina Fernández-Avilés, Víctor Pérez, Rafael de la Torre, Patricia Robledo
Feb 20, 2020
Schizophrenia (SCZ) is a neurodevelopmental disorder with a high genetic component, but the presence of environmental stressors can be important for its onset and progression. Cannabis use can be a major risk factor for...
Modafinil augmentation therapy in unipolar and bipolar depression
Alexander J Goss, Muzaffer Kaser, Sergi G Costafreda, Barbara J Sahakian, Cynthia HY Fu
Aug 21, 2017
OBJECTIVE: Current pharmacologic treatments for a depressive episode in unipolar major depressive disorder (MDD) and bipolar depression are limited by low rates of remission. Residual symptoms include a persistent low mood and...
COL4A1-related autosomal recessive encephalopathy in 2 Turkish children.
Ahmet Yaramis, Hanns Lochmüller, Ana Töpf, Ece Sonmezler, Elmasnur Yilmaz, Semra Hiz, Uluc Yis, Serdal Gungor, Ayse Ipek Polat, Pinar Edem, Sergi Beltran, Steven Laurie, Aysenur Yaramis, Rita Horvath, Yavuz Oktay
Mar 13, 2020
Objective:This study presents the neurologic phenotypes of 2 brothers with a novel homozygous COL4A1 mutation that was identified in a large Turkish consanguineous cohort of neurogenetic diseases. Methods:Whole-exome sequencing...
Published by: Neurology. Genetics
The Ursinus Weekly, November 7, 1955
Richard Winchester
Jan 01, 0001
Dr. Wilton Krogman speaks at Forum Wednesday night French collection at Phila. museum Lively discussions highlight Y retreat; Improvements for next semester suggested Ursinus College publishes the Dean's list Freshman class...
Ursinus College Collegeville Pennsylvania newspaper Wilton M. Krogman Philadelphia Museum of Art YMCA YWCA student government Ben Houser Barry Dempsey Rudy Dippl Pauline Reid Curtain Club Robin Blood Belifiore Dillio Paris Football Soccer field hockey Intramural Sports Ruby sororities Alpha Phi Omega rules and customs dress code cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway
Sergi Trias-Llimós, Lisa Pennells, Aage Tverdal, Alexander V. Kudryavtsev, Sofia Malyutina, Laila A. Hopstock, Olena Iakunchykova, Yuri Nikitin, Per Magnus, Stephen Kaptoge, Emanuele Di Angelantonio, David A. Leon
Nov 27, 2020
Abstract: Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an...
Solving unsolved rare neurological diseases-a Solve-RD viewpoint.
Rebecca Schüle, Dagmar Timmann, Corrie E Erasmus, Jennifer Reichbauer, Melanie Wayand, Solve-RD-DITF-RND, Bart van de Warrenburg, Ludger Schöls, Carlo Wilke, Andrea Bevot, Stephan Zuchner, Sergi Beltran, Steven Laurie, Leslie Matalonga, Holm Graessner, Matthis Synofzik, Solve-RD Consortium
Sep 15, 2021
COL4A1-related autosomal recessive encephalopathy in 2 Turkish children.
Ahmet Yaramis, Hanns Lochmüller, Ana Töpf, Ece Sonmezler, Elmasnur Yilmaz, Semra Hiz, Uluc Yis, Serdal Gungor, Ayse Ipek Polat, Pinar Edem, Sergi Beltran, Steven Laurie, Aysenur Yaramis, Rita Horvath, Yavuz Oktay
Apr 21, 2020
OBJECTIVE: This study presents the neurologic phenotypes of 2 brothers with a novel homozygous COL4A1 mutation that was identified in a large Turkish consanguineous cohort of neurogenetic diseases. METHODS: Whole-exome...
Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway.
Sergi Trias-Llimós, Lisa Pennells, Aage Tverdal, Alexander V Kudryavtsev, Sofia Malyutina, Laila A Hopstock, Olena Iakunchykova, Yuri Nikitin, Per Magnus, Stephen Kaptoge, Emanuele Di Angelantonio, David A Leon
Mar 15, 2021
Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an approach to doing...
Behr syndrome and hypertrophic cardiomyopathy in a family with a novel UCHL1 deletion
Grace McMacken, Hanns Lochmüller, Boglarka Bansagi, Angela Pyle, Angela Lochmüller, Patrick F. Chinnery, Steve Laurie, Sergi Beltran, Leslie Matalonga, Rita Horvath
Nov 19, 2020
Behr syndrome and hypertrophic cardiomyopathy in a family with a novel UCHL1 deletion.
Grace McMacken, Hanns Lochmüller, Boglarka Bansagi, Angela Pyle, Angela Lochmüller, Patrick F Chinnery, Steve Laurie, Sergi Beltran, Leslie Matalonga, Rita Horvath
Feb 09, 2021
BACKGROUND: Behr syndrome is a clinically distinct, but genetically heterogeneous disorder characterized by optic atrophy, progressive spastic paraparesis, and motor neuropathy often associated with ataxia. The molecular...
Behr syndrome and hypertrophic cardiomyopathy in a family with a novel UCHL1 deletion
Grace McMacken, Hanns Lochmüller, Boglarka Bansagi, Angela Pyle, Angela Lochmüller, Patrick F. Chinnery, Steve Laurie, Sergi Beltran, Leslie Matalonga, Rita Horvath
Jul 28, 2021
Effectiveness and safety of vedolizumab in inflammatory bowel disease patients aged 60 and over
Hajir Ibraheim, Mark A Samaan, Ashish Srinivasan, Oliver Brain, Jonathan Digby-Bell, Peter M Irving, Irena Norman, Issrah Jawad, Julia Biedermann, Ana Ibarra, Klaartje Bel Kok, Gareth Parkes, Joanna Rimmer, Elisabeta Compot, Miles Parkes, Jonathan Segal, Philip Oppong, Ailsa Hart, Bu'Hussain Hayee, Nick Powell
Feb 03, 2021
BACKGROUND: The GEMINI trials established the efficacy of vedolizumab in moderate-to-severe inflammatory bowel disease (IBD) and demonstrated a favorable safety profile, suggesting it may be advantageous in older patients at...
Appoggio Demystified
Catherine Robbin
Jan 30, 2014
The semantics of vocal technique can be barriers to its comprehension and practice by singers as well as potential stumbling blocks for teachers of singing. Voice teachers use terms such as support, contract, extend, expand...
Published by: Faculty of Education
Appoggio Demystified
Catherine Robbin
Jan 30, 2014
The semantics of vocal technique can be barriers to its comprehension and practice by singers as well as potential stumbling blocks for teachers of singing. Voice teachers use terms such as support, contract, extend, expand...
Published by: Faculty of Education
Remote visualization of large-scale genomic alignments for collaborative clinical research and diagnosis of rare diseases.
Alberto Corvò, Leslie Matalonga, Dylan Spalding, Alexander Senf, Steven Laurie, Daniel Picó-Amador, Marcos Fernandez-Callejo, Ida Paramonov, Anna Foix Romero, Emilio Garcia-Rios, Jorge Izquierdo Ciges, Anand Mohan, Coline Thomas, Andres Felipe Silva Valencia, Csaba Halmagyi, Mallory Ann Freeberg, Ana Töpf, Rita Horvath, Gary Saunders, Ivo Gut, Thomas Keane, Davide Piscia, Sergi Beltran
Mar 26, 2023
The Solve-RD project objectives include solving undiagnosed rare diseases (RD) through collaborative research on shared genome-phenome datasets. The RD-Connect Genome-Phenome Analysis Platform (GPAP), for data collation and...
genome analysis Diagnosis Data sharing standards Data visualization Rare Diseases Exome Analysis Federated Infrastructures Remote Data Access
Published by: Cell genomics
GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm.
Julio Castaño, Sergi Aranda, Clara Bueno, Fernando J Calero-Nieto, Eva Mejia-Ramirez, Jose Luis Mosquera, Enrique Blanco, Xiaonan Wang, Cristina Prieto, Lorea Zabaleta, Elisabetta Mereu, Meritxell Rovira, Senda Jiménez-Delgado, Daniel R Matson, Holger Heyn, Emery H Bresnick, Berthold Göttgens, Luciano Di Croce, Pablo Menendez, Angel Raya, Alessandra Giorgetti
Jul 01, 2019
GATA2 cardiac development Hematopoiesis hemogenic specification human iPSCs mesoderm diversification Cell Differentiation GATA2 Transcription Factor Gene Expression Regulation Hemangioblasts Hematopoiesis Humans Induced Pluripotent Stem Cells Mesoderm Myocytes Cardiac Protein Binding Single-Cell Analysis
Solving patients with rare diseases through programmatic reanalysis of genome-phenome data.
Leslie Matalonga, Carles Hernández-Ferrer, Davide Piscia, Solve-RD SNV-indel working group, Rebecca Schüle, Matthis Synofzik, Ana Töpf, Lisenka ELM Vissers, Richarda de Voer, Solve-RD DITF-GENTURIS, Solve-RD DITF-ITHACA, Solve-RD DITF-euroNMD, Solve-RD DITF-RND, Raul Tonda, Steven Laurie, Marcos Fernandez-Callejo, Daniel Picó, Carles Garcia-Linares, Anastasios Papakonstantinou, Alberto Corvó, Ricky Joshi, Hector Diez, Ivo Gut, Alexander Hoischen, Holm Graessner, Sergi Beltran, Solve-RD Consortia
Sep 15, 2021
Corticosteroid tapering with benralizumab treatment for eosinophilic asthma
Andrew Menzies-Gow, Jonathan Corren, Elisabeth H Bel, Jorge Maspero, Liam G Heaney, Mark Gurnell, Peter Wessman, Ubaldo J Martin, Shahid Siddiqui, Esther Garcia Gil
Dec 16, 2019
Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody approved in several countries for the add-on maintenance treatment of patients with severe eosinophilic asthma aged 12 years and older. In the...
Autosomal recessive variants in TUBGCP2 alter the γ-tubulin ring complex leading to neurodevelopmental disease.
Serdal Gungor, Yavuz Oktay, Semra Hiz, Álvaro Aranguren-Ibáñez, Ipek Kalafatcilar, Ahmet Yaramis, Ezgi Karaca, Uluc Yis, Ece Sonmezler, Burcu Ekinci, Mahmut Aslan, Elmasnur Yilmaz, Bilge Özgör, Sunitha Balaraju, Nora Szabo, Steven Laurie, Sergi Beltran, Daniel G MacArthur, Denisa Hathazi, Ana Töpf, Andreas Roos, Hanns Lochmuller, Isabelle Vernos, Rita Horvath
Feb 09, 2021
Microtubules help building the cytoskeleton of neurons and other cells. Several components of the gamma-tubulin (γ-tubulin) complex have been previously reported in human neurodevelopmental diseases. We describe two siblings...
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