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Molecular Genetic Characteristics of <i>FANCI</i>, a Proposed New Ovarian Cancer Predisposing Gene.
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Mar 28, 2023
FANCI was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of FANCI c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular...
ovarian cancer Hereditary cancer Whole exome sequencing TCGA Fanci Fanconi Anemia Pathway Cancer Predisposing Gene Humans Ovarian Neoplasms Genetic Predisposition to Disease Molecular Biology Mutation Genes BRCA2 Female Fanconi Anemia Complementation Group Proteins
Published by: Genes
Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene.
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia MT Greenwood, Jiannis Ragoussis, Patricia N Tonin
Feb 03, 2023
Standalone sauna vs exercise followed by sauna on cardiovascular function in non-naïve sauna users
Earric Lee, Joel Kostensalo, Peter Willeit, Setor K Kunutsor, Tanjaniina Laukkanen, Francesco Zaccardi, Hassan Khan, Jari A Laukkanen
Oct 01, 2021
BACKGROUND AND AIMS: Sauna bathing and aerobic exercise have each been shown to affect cardiovascular function. However, direct comparisons between standalone sauna bathing and a combination of exercise and sauna on vascular...
Plasma adiponectin levels and type 2 diabetes risk
Yeli Wang, Rui-Wei Meng, Setor K Kunutsor, Rajiv Chowdhury, Jian-Min Yuan, Woon-Puay Koh, An Pan
Jun 04, 2018
Results from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not...
Longitudinal association between CRP levels and risk of psychosis
Emanuele F. Osimo, Luke Baxter, Jan Stochl, Benjamin I. Perry, Stephen A. Metcalf, Setor K. Kunutsor, Jari A. Laukkanen, Marie Kim Wium-Andersen, Peter B. Jones, Golam M. Khandaker
May 28, 2021
Abstract: Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined...
Environmental toxic metal contaminants and risk of cardiovascular disease
Rajiv Chowdhury, Anna Ramond, Linda M O'Keeffe, Sara Shahzad, Setor K Kunutsor, Taulant Muka, John Gregson, Peter Willeit, Samantha Warnakula, Hassan Khan, Susmita Chowdhury, Reeta Gobin, Oscar H Franco, Emanuele Di Angelantonio
Nov 21, 2018
Association of dietary, circulating, and supplement fatty acids with coronary risk
Rajiv Chowdhury, Samantha Warnakula, Setor Kunutsor, Francesca Crowe, Heather A Ward, Laura Johnson, Oscar H Franco, Adam S Butterworth, Nita G Forouhi, Simon G Thompson, Kay-Tee Khaw, Dariush Mozaffarian, John Danesh, Emanuele Di Angelantonio
Apr 14, 2015
Vitamin D and risk of cause specific death
Rajiv Chowdhury, Setor Kunutsor, Anna Vitezova, Clare Oliver-Williams, Susmita Chowdhury, Jessica C Kiefte-de-Jong, Hassan Khan, Cristina P Baena, Dorairaj Prabhakaran, Moshe B Hoshen, Becca S Feldman, An Pan, Laura Johnson, Francesca Crowe, Frank B Hu, Oscar H Franco
Nov 30, 2018
OBJECTIVE: To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances. DESIGN: Systematic review...
Investigation of antihypertensive class, dementia, and cognitive decline
Ruth Peters, Sevil Yasar, Craig S Anderson, Shea Andrews, Riitta Antikainen, Hisatomi Arima, Nigel Beckett, Joanne C Beer, Anne Suzanne Bertens, Andrew Booth, Martin van Boxtel, Carol Brayne, Henry Brodaty, Michelle C Carlson, John Chalmers, Maria Corrada, Steven DeKosky, Carol Derby, Roger A Dixon, Françoise Forette, Mary Ganguli, Willem A van Gool, Antonio Guaita, Ann M Hever, David B Hogan, Carol Jagger, Mindy Katz, Claudia Kawas, Patrick G Kehoe, Sirkka Keinanen-Kiukaanniemi, Rose Ann Kenny, Sebastian Köhler, Setor K Kunutsor, Jari Laukkanen, Colleen Maxwell, G Peggy McFall, Tessa van Middelaar, Eric P Moll van Charante, Tze-Pin Ng, Jean Peters, Iris Rawtaer, Edo Richard, Kenneth Rockwood, Lina Rydén, Perminder S Sachdev, Ingmar Skoog, Johan Skoog, Jan A Staessen, Blossom CM Stephan, Sylvain Sebert, Lutgarde Thijs, Stella Trompet, Phillip J Tully, Christophe Tzourio, Roberta Vaccaro, Eeva Vaaramo, Erin Walsh, Jane Warwick, Kaarin J Anstey
Sep 03, 2019
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight
Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen EL Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul CD Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene CW Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Urszula Stepaniak, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Fabrizio Veglia, Ian Ford, J Wouter Jukema, Rudi GJ Westendorp, Gert Jan de Borst, Pim A de Jong, Ale Algra, Wilko Spiering, Anke H Maitland-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Charles B Eaton, Jennifer G Robinson, David Duggan, DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium, John Kjekshus, John R Downs, Antonio M Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni, Peter S Sever, Neil R Poulter, David D Waters, Terje R Pedersen, Pierre Amarenco, Haruo Nakamura, John JV McMurray, James D Lewsey, Daniel I Chasman, Paul M Ridker, Aldo P Maggioni, Luigi Tavazzi, Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, JoAnn E Manson, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Pamela J Schreiner, Myriam Fornage, David S Siscovick, Mary Cushman, Meena Kumari, Nick J Wareham, WM Monique Verschuren, Susan Redline, Sanjay R Patel, John C Whittaker, Anders Hamsten, Joseph A Delaney, Caroline Dale, Tom R Gaunt, Andrew Wong, Diana Kuh, Rebecca Hardy, Sekar Kathiresan, Berta A Castillo, Pim van der Harst, Eric J Brunner, Anne Tybjaerg-Hansen, Michael G Marmot, Ronald M Krauss, Michael Tsai, Josef Coresh, Ronald C Hoogeveen, Bruce M Psaty, Leslie A Lange, Hakon Hakonarson, Frank Dudbridge, Steve E Humphries, Philippa J Talmud, Mika Kivimäki, Nicholas J Timpson, Claudia Langenberg, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Alex P Reiner, Brendan J Keating, Aroon D Hingorani, Naveed Sattar
Nov 07, 2018
BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug...
Aged Body Mass Index Body Weight Cholesterol HDL Cholesterol LDL Diabetes mellitus Type 2 Female Genetic Testing Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Polymorphism Single Nucleotide Randomized Controlled Trials as Topic Risk Factors
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Tuomas O Kilpeläinen, Jayne F Martin Carli, Alicja A Skowronski, Qi Sun, Jennifer Kriebel, Mary F Feitosa, Åsa K Hedman, Alexander W Drong, James E Hayes, Jinghua Zhao, Tune H Pers, Ursula Schick, Niels Grarup, Zoltán Kutalik, Stella Trompet, Massimo Mangino, Kati Kristiansson, Marian Beekman, Leo-Pekka Lyytikäinen, Joel Eriksson, Peter Henneman, Jari Lahti, Toshiko Tanaka, Jian'an Luan, Fabiola del Greco M, Dorota Pasko, Frida Renström, Sara M Willems, Anubha Mahajan, Lynda M Rose, Xiuqing Guo, Yongmei Liu, Marcus E Kleber, Louis Pérusse, Tom Gaunt, Tarunveer S Ahluwalia, Yun Ju Sung, Yolande F Ramos, Najaf Amin, Antoinette Amuzu, Inês Barroso, Claire Bellis, John Blangero, Brendan M Buckley, Stefan Böhringer, Yii-Der I Chen, Anton JN de Craen, David R Crosslin, Caroline E Dale, Zari Dastani, Felix R Day, Joris Deelen, Graciela E Delgado, Ayse Demirkan, Francis M Finucane, Ian Ford, Melissa E Garcia, Christian Gieger, Stefan Gustafsson, Göran Hallmans, Susan E Hankinson, Aki S Havulinna, Christian Herder, Dena Hernandez, Andrew A Hicks, David J Hunter, Thomas Illig, Erik Ingelsson, Andreea Ioan-Facsinay, John-Olov Jansson, Nancy S Jenny, Marit E Jørgensen, Torben Jørgensen, Magnus Karlsson, Wolfgang Koenig, Peter Kraft, Joanneke Kwekkeboom, Tiina Laatikainen, Karl-Heinz Ladwig, Charles A LeDuc, Gordon Lowe, Yingchang Lu, Pedro Marques-Vidal, Christa Meisinger, Cristina Menni, Andrew P Morris, Richard H Myers, Satu Männistö, Mike A Nalls, Lavinia Paternoster, Annette Peters, Aruna D Pradhan, Tuomo Rankinen, Laura J Rasmussen-Torvik, Wolfgang Rathmann, Treva K Rice, J Brent Richards, Paul M Ridker, Naveed Sattar, David B Savage, Stefan Söderberg, Nicholas J Timpson, Liesbeth Vandenput, Diana van Heemst, Hae-Won Uh, Marie-Claude Vohl, Mark Walker, Heinz-Erich Wichmann, Elisabeth Widén, Andrew R Wood, Jie Yao, Tanja Zeller, Yiying Zhang, Ingrid Meulenbelt, Margreet Kloppenburg, Arne Astrup, Thorkild IA Sørensen, Mark A Sarzynski, DC Rao, Pekka Jousilahti, Erkki Vartiainen, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Eero Kajantie, Clive Osmond, Aarno Palotie, Johan G Eriksson, Markku Heliövaara, Paul B Knekt, Seppo Koskinen, Antti Jula, Markus Perola, Risto K Huupponen, Jorma S Viikari, Mika Kähönen, Terho Lehtimäki, Olli T Raitakari, Dan Mellström, Mattias Lorentzon, Juan P Casas, Stefanie Bandinelli, Winfried März, Aaron Isaacs, Ko W van Dijk, Cornelia M van Duijn, Tamara B Harris, Claude Bouchard, Matthew A Allison, Daniel I Chasman, Claes Ohlsson, Lars Lind, Robert A Scott, Claudia Langenberg, Nicholas J Wareham, Luigi Ferrucci, Timothy M Frayling, Peter P Pramstaller, Ingrid B Borecki, Dawn M Waterworth, Sven Bergmann, Gérard Waeber, Peter Vollenweider, Henrik Vestergaard, Torben Hansen, Oluf Pedersen, Frank B Hu, P Eline Slagboom, Harald Grallert, Tim D Spector, JW Jukema, Robert J Klein, Erik E Schadt, Paul W Franks, Cecilia M Lindgren, Rudolph L Leibel, Ruth JF Loos
Apr 05, 2016