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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Florian T Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier, Robert E Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A McCarroll, Kevin Eggan
May 01, 2017
Alleles Cell Count Cell Differentiation Cell Division Cell Line DNA DNA Mutational Analysis Exome Genes Dominant Genes p53 Human Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Loss of Heterozygosity Mosaicism Mutation Neoplasms Protein Domains selection Genetic Tumor Suppressor Protein p53
Global economic productivity losses from vision impairment and blindness.
Ana Patricia Marques, Jacqueline Ramke, John Cairns, Thomas Butt, Justine H Zhang, Debbie Muirhead, Iain Jones, Brandon AM Ah Tong, Bonnielin K Swenor, Hannah Faal, Rupert RA Bourne, Kevin D Frick, Matthew J Burton
Jun 17, 2021
BACKGROUND: In the absence of accessible, good quality eye health services and inclusive environments, vision loss can impact individuals, households and communities in many ways, including through increased poverty, reduced...