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Dynamic Capacity Planning of Hospital Resources under COVID-19 Uncertainty using Approximate Dynamic Programming
COVID-19 pandemic has resulted in an inflow of patients into the hospitals and overcrowding of healthcare resources. Healthcare managers increased the capacities reactively by utilizing expensive but quick methods. Instead of...
stochastic programming dynamic programming Health Services SIMULATION /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
Dynamic Capacity Planning of Hospital Resources under COVID-19 Uncertainty using Approximate Dynamic Programming
COVID-19 pandemic has resulted in an inflow of patients into the hospitals and overcrowding of healthcare resources. Healthcare managers increased the capacities reactively by utilizing expensive but quick methods. Instead of...
stochastic programming dynamic programming Health Services SIMULATION /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations.
Arooma Maryam, Rana Rehan Khalid, Sundeep Chaitanya Vedithi, Abdulilah Ece, Suleyman Selim Çınaroğlu, Abdul Rauf Siddiqi, Tom L Blundell
Aug 04, 2020
Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and...
Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment
Elise Abboud, Doha Chrayteh, Nadia Boussetta, Héloise Dalle, Mariangela Malerba, Ting Di Wu, Morgane Le Gall, Olivier Reelfs, Charareh Pourzand, Mark Mellett, Florence Assan, Hervé Bachelez, Joël Poupon, Selim Aractingi, Sophie Vaulont, Pierre Sohier, Bénédicte Oules, Zoubida Karim, Carole Peyssonnaux
Aug 07, 2024
Psoriasis is a multifactorial, chronic inflammatory skin disease with unresolved questions on its primary events. Iron overload has been described in the epidermis of psoriasis patients, but its relevance remains unknown. We...
/dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/subjectarea/asjc/3100/3100 name=General Physics and Astronomy /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment
Elise Abboud, Doha Chrayteh, Nadia Boussetta, Héloise Dalle, Mariangela Malerba, Ting Di Wu, Morgane Le Gall, Olivier Reelfs, Charareh Pourzand, Mark Mellett, Florence Assan, Hervé Bachelez, Joël Poupon, Selim Aractingi, Sophie Vaulont, Pierre Sohier, Bénédicte Oules, Zoubida Karim, Carole Peyssonnaux
Aug 07, 2024
Psoriasis is a multifactorial, chronic inflammatory skin disease with unresolved questions on its primary events. Iron overload has been described in the epidermis of psoriasis patients, but its relevance remains unknown. We...
/dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1300/1300 name=General Biochemistry,Genetics and Molecular Biology /dk/atira/pure/subjectarea/asjc/3100/3100 name=General Physics and Astronomy /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Urgent issues and prospects at the intersection of culture, memory, and witness interviews
Lorraine Hope, Nkansah Anakwah, Jan Antfolk, Sonja P Brubacher, Heather Flowe, Fiona Gabbert, Ellen Giebels, Wangu Kanja, Julia Korkman, Akira Kyo, Makiko Naka, Henry Otgaar, Martine B Powell, Hedayat Selim, Jenny Skrifvars, Isaac Kwasi Sorkpah, Emmanuel A Sowatey, Linda C Steele, Laura Stevens, Nathanael EJ Sumampouw, Paul J Taylor, Javier Trevino‐Rangel, Tanja Veldhuizen, Jianqin Wang, Simon Wells
Jan 05, 2022
A versatile drug delivery system targeting senescent cells.
Daniel Muñoz-Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano-Torres, Marta Paez-Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz-Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez-Máñez, Manuel Serrano
Sep 20, 2018
Senescent cells accumulate in multiple aging-associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β-galactosidase activity of...
Chemotherapy Fibrosis nanomedicine palbociclib Senescence Animals Cell Survival Cellular Senescence Cytotoxins Disease Models Animal Drug Compounding Drug Delivery Systems Fluorescent Dyes Galactose Heterografts Lysosomes Mice Neoplasm Transplantation Neoplasms Oligosaccharides Piperazines Pyridines Staining and Labeling beta-Galactosidase
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.
Karin Tuschl, Esther Meyer, Leonardo E Valdivia, Ningning Zhao, Chris Dadswell, Alaa Abdul-Sada, Christina Y Hung, Michael A Simpson, WK Chong, Thomas S Jacques, Randy L Woltjer, Simon Eaton, Allison Gregory, Lynn Sanford, Eleanna Kara, Henry Houlden, Stephan M Cuno, Holger Prokisch, Lorella Valletta, Valeria Tiranti, Rasha Younis, Eamonn R Maher, John Spencer, Ania Straatman-Iwanowska, Paul Gissen, Laila AM Selim, Guillem Pintos-Morell, Wifredo Coroleu-Lletget, Shekeeb S Mohammad, Sangeetha Yoganathan, Russell C Dale, Maya Thomas, Jason Rihel, Olaf A Bodamer, Caroline A Enns, Susan J Hayflick, Peter T Clayton, Philippa B Mills, Manju A Kurian, Stephen W Wilson
Jun 14, 2016
Treatment outcome in early diffuse cutaneous systemic sclerosis
Ariane L Herrick, Xiaoyan Pan, Sébastien Peytrignet, Mark Lunt, Roger Hesselstrand, Luc Mouthon, Alan Silman, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon Vonk, Codrina Ancuţa, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Alison C Jordan, Paresh Jobanputra, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat İnanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susannah Proudman, Anna Rudin, Joanne Sahhar, Brigitte Coppere, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Christopher P Denton
Jul 01, 2017
OBJECTIVES: The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment...
Treatment outcome in early diffuse cutaneous systemic sclerosis
Ariane L Herrick, Xiaoyan Pan, Sébastien Peytrignet, Mark Lunt, Roger Hesselstrand, Luc Mouthon, Alan Silman, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon Vonk, Codrina Ancuţa, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Alison C Jordan, Paresh Jobanputra, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat İnanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susannah Proudman, Anna Rudin, Joanne Sahhar, Brigitte Coppere, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Christopher P Denton
Jul 01, 2017
OBJECTIVES: The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment...
Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.
Guido J Falcone, Elayna Kirsch, Julian N Acosta, Rommell B Noche, Audrey Leasure, Sandro Marini, Jaeyoon Chung, Magdy Selim, James F Meschia, Devin L Brown, Bradford B Worrall, David L Tirschwell, Jeremiasz M Jagiella, Helena Schmidt, Jordi Jimenez-Conde, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Dipender Gill, Michael Holmes, Chia-Ling Phuah, Nils H Petersen, Charles N Matouk Md, Murat Gunel, Lauren Sansing, Derrick Bennett, Zhengming Chen, Luan L Sun, Robert Clarke, Robin G Walters, Thomas M Gill, Alessandro Biffi, Sekar Kathiresan, Carl D Langefeld, Daniel Woo, Jonathan Rosand, Kevin N Sheth, Christopher D Anderson, International Stroke Genetics Consortium
Apr 20, 2020
OBJECTIVE: Observational studies point to an inverse correlation between low-density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We...