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Results: 24
Facilitating Neuron-Specific Genetic Manipulations in Drosophila melanogaster Using a Split GAL4 Repressor.
Michael-John Dolan, Haojiang Luan, William C Shropshire, Ben Sutcliffe, Benjamin Cocanougher, Robert L Scott, Shahar Frechter, Marta Zlatic, Gregory SXE Jefferis, Benjamin H White
Oct 03, 2018
Efforts to map neural circuits have been galvanized by the development of genetic technologies that permit the manipulation of targeted sets of neurons in the brains of freely behaving animals. The success of these efforts...
Functional and anatomical specificity in a higher olfactory centre.
Shahar Frechter, Alexander Shakeel Bates, Sina Tootoonian, Michael-John Dolan, James Manton, Arian Rokkum Jamasb, Johannes Kohl, Davi Bock, Gregory Jefferis
Jan 03, 2020
Most sensory systems are organized into parallel neuronal pathways that process distinct aspects of incoming stimuli. In the insect olfactory system, second order projection neurons target both the mushroom body, required for...
Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila.
An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution
Abstract: Background: Vertebrate brain structure is characterised not only by relative consistency in scaling between components, but also by many examples of divergence from these general trends.. Alternative hypotheses explain...
An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.
Background
Vertebrate brain structure is characterised not only by relative consistency in scaling between components, but also by many examples of divergence from these general trends.. Alternative hypotheses explain...
Published by: BMC biology
Affine and topogical structural entropies in granular statistical mechanics
We identify two orthogonal sources of structural entropy in rattler-free granular systems: affine, involving structural changes that only deform the contact network, and topological, corresponding to different topologies of the...
An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.
BACKGROUND: Vertebrate brain structure is characterised not only by relative consistency in scaling between components, but also by many examples of divergence from these general trends.. Alternative hypotheses explain these...
Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.
Michael-John Dolan, Shahar Frechter, Alexander Shakeel Bates, Chuntao Dan, Paavo Huoviala, Ruairí JV Roberts, Philipp Schlegel, Serene Dhawan, Remy Tabano, Heather Dionne, Christina Christoforou, Kari Close, Ben Sutcliffe, Bianca Giuliani, Feng Li, Marta Costa, Gudrun Ihrke, Geoffrey Wilson Meissner, Davi D Bock, Yoshinori Aso, Gerald M Rubin, Gregory SXE Jefferis
May 24, 2019
Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and...
Theory-based design of sintered granular composites triples three-phase boundary in fuel cells.
Solid-oxide fuel cells produce electric current from energy released by a spontaneous electrochemical reaction. The efficiency of these devices depends crucially on the microstructure of their electrodes and in particular on the...
Credit assignment to state-independent task representations and its relationship with model-based decision making.
Nitzan Shahar, Rani Moran, Tobias U Hauser, Rogier A Kievit, Daniel McNamee, Michael Moutoussis, NSPN Consortium, Raymond J Dolan
Sep 28, 2020
Model-free learning enables an agent to make better decisions based on prior experience while representing only minimal knowledge about an environment's structure. It is generally assumed that model-free state representations...
Basic and complex emotion recognition in children with autism
Shimrit Fridenson-Hayo, Steve Berggren, Amandine Lassalle, Shahar Tal, Delia Pigat, Sven Bölte, Simon Baron-Cohen, Ofer Golan
Jan 04, 2017
Autism spectrum condition Basic emotions Complex emotions Cross-cultural research Emotion recognition Acoustic Stimulation Auditory Perception Autism spectrum disorder Case-Control Studies Child Child Preschool Cross-Cultural Comparison Emotions Facial Expression Female Humans Israel Male Photic Stimulation Psychological Tests Sweden United Kingdom Video Recording Visual Perception
The EU-Emotion Voice Database.
Amandine Lassalle, Delia Pigat, Helen O'Reilly, Steve Berggen, Shimrit Fridenson-Hayo, Shahar Tal, Sigrid Elfström, Anna Råde, Ofer Golan, Sven Bölte, Simon Baron-Cohen, Daniel Lundqvist
May 01, 2019
In this study, we report the validation results of the EU-Emotion Voice Database, an emotional voice database available for scientific use, containing a total of 2,159 validated emotional voice stimuli. The EU-Emotion voice...
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer AN Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny
Nov 22, 2021
Cell homeostasis is perturbed when dramatic shifts in the external environment cause the physical-chemical properties inside the cell to change. Experimental approaches for dynamically monitoring these intracellular effects are...
Arabidopsis Arabidopsis Proteins Binding Sites Biosensing Techniques Cell Line Tumor Escherichia coli Fluorescence Resonance Energy Transfer Gene Expression Humans Intrinsically Disordered Proteins Kinetics Models Molecular Molecular Chaperones Osmolar Concentration Osmotic Pressure Osteoblasts Protein Binding Protein Conformation Protein Interaction Domains and Motifs Recombinant Proteins Saccharomyces cerevisiae Thermodynamics water
Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity.
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A N Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny
Oct 18, 2021
Cell Line Tumor Osteoblasts Humans Escherichia coli Saccharomyces cerevisiae Arabidopsis water Molecular Chaperones Arabidopsis Proteins Recombinant Proteins Fluorescence Resonance Energy Transfer Biosensing Techniques Gene Expression Binding Sites Protein Conformation Protein Binding Kinetics Osmolar Concentration Osmotic Pressure Thermodynamics Models Molecular Protein Interaction Domains and Motifs Intrinsically Disordered Proteins
Published by: Nature Communications
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging
Susanne Röhr, Alexander Pabst, Steffi G Riedel-Heller, Frank Jessen, Yuda Turana, Yvonne S Handajani, Carol Brayne, Fiona E Matthews, Blossom CM Stephan, Richard B Lipton, Mindy J Katz, Cuiling Wang, Maëlenn Guerchet, Pierre-Marie Preux, Pascal Mbelesso, Karen Ritchie, Marie-Laure Ancelin, Isabelle Carrière, Antonio Guaita, Annalisa Davin, Roberta Vaccaro, Ki Woong Kim, Ji Won Han, Seung Wan Suh, Suzana Shahar, Normah C Din, Divya Vanoh, Martin van Boxtel, Sebastian Köhler, Mary Ganguli, Erin P Jacobsen, Beth E Snitz, Kaarin J Anstey, Nicolas Cherbuin, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Xinyi Gwee, Henry Brodaty, Nicole A Kochan, Julian Trollor, Antonio Lobo, Raúl López-Antón, Javier Santabárbara, John D Crawford, Darren M Lipnicki, Perminder S Sachdev, for Cohort Studies of Memory in an International Consortium (COSMIC)
Jan 04, 2021
Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging
Susanne Röhr, Alexander Pabst, Steffi G. Riedel-Heller, Frank Jessen, Yuda Turana, Yvonne S. Handajani, Carol Brayne, Fiona E. Matthews, Blossom C. M. Stephan, Richard B. Lipton, Mindy J. Katz, Cuiling Wang, Maëlenn Guerchet, Pierre-Marie Preux, Pascal Mbelesso, Karen Ritchie, Marie-Laure Ancelin, Isabelle Carrière, Antonio Guaita, Annalisa Davin, Roberta Vaccaro, Ki Woong Kim, Ji Won Han, Seung Wan Suh, Suzana Shahar, Normah C. Din, Divya Vanoh, Martin van Boxtel, Sebastian Köhler, Mary Ganguli, Erin P. Jacobsen, Beth E. Snitz, Kaarin J. Anstey, Nicolas Cherbuin, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Xinyi Gwee, Henry Brodaty, Nicole A. Kochan, Julian Trollor, Antonio Lobo, Raúl López-Antón, Javier Santabárbara, John D. Crawford, Darren M. Lipnicki, Perminder S. Sachdev
Dec 22, 2020
Abstract: Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate...