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Results: 9415
The Diagnosis and Management of Autism Spectrum Disorder (ASD) in Adult Females in the Presence or Absence of an Intellectual Disability.
We review the reasons for the greater male predominance in the diagnosis of autism spectrum disorder in the non-intellectual disabled population and compare it to autism diagnosed in intellectually disabled individuals. Accurate...
The Diagnosis and Management of Autism Spectrum Disorder (ASD) in Adult Females in the Presence or Absence of an Intellectual Disability.
We review the reasons for the greater male predominance in the diagnosis of autism spectrum disorder in the non-intellectual disabled population and compare it to autism diagnosed in intellectually disabled individuals. Accurate...
The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer’s Disease
Tanzil Rujeedawa, Eva Carrillo Félez, Isabel C. H. Clare, Juan Fortea, Andre Strydom, Anne-Sophie Rebillat, Antonia Coppus, Johannes Levin, Shahid H. Zaman
Oct 04, 2021
The purpose of this review is to compare and highlight the clinical and pathological aspects of genetic versus acquired Alzheimer’s disease: Down syndrome-associated Alzheimer’s disease in (DSAD) and Autosomal Dominant...
Multi-Modal Imaging in Down's Syndrome
In recent decades, the field of neuroimaging has experienced a surge of popularity and innovation which has led to significant advancements in the understanding of neurological disease, if not immediate clinical translation. In...
Multi-Modal Imaging in Down's Syndrome
In recent decades, the field of neuroimaging has experienced a surge of popularity and innovation which has led to significant advancements in the understanding of neurological disease, if not immediate clinical translation. In...
A Systematic Review of Unexplained Early Regression in Adolescents and Adults with Down Syndrome
A proportion of young people with Down syndrome (DS) experience unexplained regression that severely impacts on their daily lives. While this condition has been recognised by clinicians, there is a limited understanding of...
A Systematic Review of Unexplained Early Regression in Adolescents and Adults with Down Syndrome.
A proportion of young people with Down syndrome (DS) experience unexplained regression that severely impacts on their daily lives. While this condition has been recognised by clinicians, there is a limited understanding of...
Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.
Liam R Wilson, Deniz Vatansever, Tiina Annus, Guy B Williams, Young T Hong, Tim D Fryer, Peter J Nestor, Anthony J Holland, Shahid H Zaman
Jul 10, 2019
Down's syndrome is a chromosomal disorder that invariably results in both intellectual disability and Alzheimer's disease neuropathology. However, only a limited number of studies to date have investigated intrinsic brain...
Alzheimer's Disease Down's syndrome anti-correlation Default mode network functional connectivity Memory Adult Alzheimer Disease Amyloid Aniline Compounds Carbon Radioisotopes Cerebral Cortex Connectome Cross-Sectional Studies Down Syndrome Female Humans Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals Thiazoles
Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia
Animesh Alexander Raha, Seyedeh Deniz Ghaffari, James Henderson, Subhojit Chakraborty, Kieren Allinson, Robert P. Friedland, Anthony Holland, Shahid H. Zaman, Elizabeta B. Mukaetova-Ladinska, Ruma Raha-Chowdhury
May 20, 2021
The liver-derived hormone hepcidin, a member of the defensin family of antimicrobial peptides, plays an important role in host defense and innate immunity due to its broad antibacterial and antiviral properties. Ferritin, an...
Exploring electrophysiological markers of auditory predictive processes and pathological ageing in adults with Down's syndrome.
Chiara Avancini, Sally Jennings, Srivas Chennu, Valdas Noreika, April Le, Tristan A Bekinschtein, Madeleine J Walpert, Isabel CH Clare, Anthony J Holland, Shahid H Zaman, Howard Ring
Jul 25, 2022
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H Zaman
Aug 02, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer's disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
Iron ferritin Alzheimer’s disease Hepcidin iron homeostasis Choroid Plexus trisomy 21 Olig2 RUNX1 S100β accelerating ageing down syndrome dementia erythroid-megakaryocyte
Published by: Journal of clinical medicine
The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease.
Tanzil Rujeedawa, Eva Carrillo Félez, Isabel CH Clare, Juan Fortea, Andre Strydom, Anne-Sophie Rebillat, Antonia Coppus, Johannes Levin, Shahid H Zaman
Nov 22, 2021
The purpose of this review is to compare and highlight the clinical and pathological aspects of genetic versus acquired Alzheimer's disease: Down syndrome-associated Alzheimer's disease in (DSAD) and Autosomal Dominant...
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H Zaman
Sep 20, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer's disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.
Animesh Alexander Raha, James W Henderson, Simon RW Stott, Romina Vuono, Simona Foscarin, Robert P Friedland, Shahid H Zaman, Ruma Raha-Chowdhury
Sep 22, 2016
Alzheimer’ disease choroid plexus macrophages immunomodulation innate immunity Myelination Neurogenesis Neuroinflammation neuroplasticity neuroprotective soluble TREM2 aging Alzheimer Disease Amyloid beta-Protein Precursor Animals Brain Cells Cultured Humans Lipopolysaccharides MACROPHAGES Membrane Glycoproteins meninges Mice Inbred C57BL Mice Transgenic Microglia Neurogenesis Neurons Neuroprotection Presenilin-1 RNA Messenger Rats Sprague-Dawley Receptors Immunologic
Age-related retinal thickness in Down's syndrome
Madeleine J Walpert, Eduardo M Normando, Tiina Annus, Sally R Jennings, Liam R Wilson, Peter Watson, Shahid H Zaman, M Francesca Cordeiro, Anthony J Holland
Feb 07, 2020
Introduction:People with Down's syndrome (DS) have a high prevalence of early-onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of...
Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer's Disease and in Down Syndrome Dementia.
Ruma Raha-Chowdhury, James W Henderson, Animesh Alexander Raha, Romina Vuono, Anastasia Bickerton, Elizabeth Jones, Robert Fincham, Kieren Allinson, Anthony Holland, Shahid H Zaman
May 28, 2019
Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia
Animesh Alexander Raha, Seyedeh Deniz Ghaffari, James Henderson, Subhojit Chakraborty, Kieren Allinson, Robert P Friedland, Anthony Holland, Shahid H Zaman, Elizabeta B Mukaetova-Ladinska, Ruma Raha-Chowdhury
May 27, 2021
The liver-derived hormone hepcidin, a member of the defensin family of antimicrobial peptides, plays an important role in host defense and innate immunity due to its broad antibacterial and antiviral properties. Ferritin, an...
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H. Zaman
Jul 02, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer’s disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.
Elijah Mak, Concepcion Padilla, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
Mar 07, 2019
Acute Regression in Down Syndrome.
Benjamin Handen, Isabel Clare, Charles Laymon, Melissa Petersen, Shahid Zaman, Sid O'Bryant, Davneet Minhas, Dana Tudorascu, Stephanie Brown, Bradley Christian
Nov 09, 2021
BACKGROUND: Acute regression has been reported in some individuals with Down syndrome (DS), typically occurring between the teenage years and mid to late 20s. Characterized by sudden, and often unexplained, reductions in...
Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology.
Animesh Alexander Raha, Subhojit Chakraborty, James Henderson, Elizabeta Mukaetova-Ladinska, Shahid Zaman, John Trowsdale, Ruma Raha-Chowdhury
Feb 05, 2021
OBJECTIVE: In some individuals, coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to a variety of serious inflammatory symptoms, including blood clotting and acute respiratory distress....
Corona virus COVID-19 Covid-19 biomarker SARS-CoV-2 infection type 2 diabetes mellitus age-related dementia dipeptidyl peptidase 4 (DPP4) Adult Age Factors Aged Aged 80 and over Animals Biomarkers covid-19 Comorbidity Dementia Diabetes mellitus Type 2 Dipeptidyl Peptidase 4 Duodenum Gene Expression Host-Pathogen Interactions Humans Mice Inbred C57BL Middle Aged SARS-CoV-2
Acute Regression in Down Syndrome.
Benjamin Handen, Isabel Clare, Charles Laymon, Melissa Petersen, Shahid Zaman, Sid O'Bryant, Davneet Minhas, Dana Tudorascu, Stephanie Brown, Bradley Christian
Sep 27, 2021
Background
Acute regression has been reported in some individuals with Down syndrome (DS), typically occurring between the teenage years and mid to late 20s. Characterized by sudden, and often unexplained, reductions in...
Published by: Brain sciences
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain
Animesh Alexander Raha, Anwesha Biswas, James Henderson, Subhojit Chakraborty, Anthony Holland, Robert P Friedland, Elizabeta Mukaetova-Ladinska, Shahid Zaman, Ruma Raha-Chowdhury
Mar 18, 2022
Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms...
Alzheimer’s disease (AD) Down syndrome (DS) Parkinson’s disease (PD) basal ganglia ferritin Hepcidin Locus Coeruleus neurodegeneration striosomes/matrix Substantia Nigra Alzheimer Disease Brain Cation Transport Proteins Down Syndrome Ferritins Hepcidins Humans Iron Neurodegenerative Diseases Parkinson Disease Protein Aggregates
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