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Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach.
Srinand Sundaram, Eun Na Kim, Georgina M Jones, Shamilene Sivagnanam, Monika Tripathi, Ahmad Miremadi, Massimiliano di Pietro, Lisa M Coussens, Rebecca C Fitzgerald, Young Hwan Chang, Lizhe Zhuang
Jun 07, 2022
Esophageal adenocarcinoma (EAC) develops from a chronic inflammatory environment across four stages: intestinal metaplasia, known as Barrett's esophagus, low- and high-grade dysplasia, and adenocarcinoma. Although the genomic...
Barrett’s esophagus Esophageal Adenocarcinoma immune complexity multiplex imaging sparse subspace clustering Adenocarcinoma Antigen-Antibody Complex Barrett Esophagus Cluster Analysis Ecosystem Esophageal Neoplasms Forkhead Transcription Factors Humans Immunohistochemistry Metaplasia Tumor Microenvironment