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Results: 1419
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction
OBJECTIVE: To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. DESIGN: Two sample mendelian randomisation study using genetic variants as instrumental...
Adult Aged Biological Specimen Banks Female Genetic Pleiotropy genetic variation Genome-Wide Association Study Heart Failure Humans Male Mendelian Randomization Analysis Middle Aged Myocardial Infarction Odds Ratio Randomized Controlled Trials as Topic Risk Factors Testosterone Thromboembolism United Kingdom White People
Regulation of Chromosome Segregation by the Chromosomal Passenger Complex
Boo Shan Tseng
Jan 01, 0001
Life depends on faithful DNA segregation. The molecular underpinnings controlling this segregation are not fully understood. Here I describe the role of the chromosomal passenger complex (CPC) in the regulation of chromosome...
Chromosome Segregation chromosomal passenger complex Aurora B spindle assembly xenopus egg Life Sciences
Published by: Rockefeller University
Editorial:ViTac
Animals interact with the world through multimodal sensing inputs, especially vision and touch sensing in the case of humans interacting with our physical surroundings. In contrast, artificial systems usually rely on a single...
Editorial:ViTac
Animals interact with the world through multimodal sensing inputs, especially vision and touch sensing in the case of humans interacting with our physical surroundings. In contrast, artificial systems usually rely on a single...
The time course of facial expression recognition using spatial frequency information
We are able to recognize others’ experience of pain from their facial expressions. However, little is known about what makes the recognition of pain possible and whether it is similar or different from core emotions. This study...
The role of spatial frequency information in the recognition of facial expressions of pain
Being able to detect pain from facial expressions is critical for pain communication. Alongside identifying the specific facial codes used in pain recognition, there are other types of more basic perceptual features, such as...
The role of spatial frequency information in the recognition of facial expressions of pain
Being able to detect pain from facial expressions is critical for pain communication. Alongside identifying the specific facial codes used in pain recognition, there are other types of more basic perceptual features, such as...
The time course of facial expression recognition using spatial frequency information
We are able to recognize others’ experience of pain from their facial expressions. However, little is known about what makes the recognition of pain possible and whether it is similar or different from core emotions. This study...
Large Animal Studies to Reduce the Foreign Body Reaction in Brain-Computer Interfaces
Shan Yasin Mian, Jonathan Roy Honey, Alejandro Carnicer-Lombarte, Damiano Giuseppe Barone
Nov 01, 2021
Brain-computer interfaces (BCI) are reliant on the interface between electrodes and neurons to function. The foreign body reaction (FBR) that occurs in response to electrodes in the brain alters this interface and may pollute...
Exploring attentional biases towards facial expressions of pain in men and women
Background: Interpersonal factors may help explain why men and women differ in their perception and expression of pain. Whilst the focus is often on the person in pain, how observers respond to those in pain is important....
Exploring attentional biases towards facial expressions of pain in men and women
Background: Interpersonal factors may help explain why men and women differ in their perception and expression of pain. Whilst the focus is often on the person in pain, how observers respond to those in pain is important....
Large Animal Studies to Reduce the Foreign Body Reaction in Brain–Computer Interfaces
Shan Yasin Mian, Jonathan Roy Honey, Alejandro Carnicer-Lombarte, Damiano Giuseppe Barone
Aug 17, 2021
Brain–computer interfaces (BCI) are reliant on the interface between electrodes and neurons to function. The foreign body reaction (FBR) that occurs in response to electrodes in the brain alters this interface and may pollute...
Impact of Genetically Predicted Red Blood Cell Traits on Venous Thromboembolism
Background Red blood cell (RBC) transfusion and erythropoiesis-stimulating agent administration are cornerstones of clinical practice, yet concerns exist as to potential increased risk of thrombotic events. This study aims to...
Genetic Risk, Muscle Strength, and Incident Stroke
Youngwon Kim, Semi Hwang, Stephen J Sharp, Shan Luo, Shiu Lun Au Yeung, Craig C Teerlink
Jul 12, 2021
OBJECTIVE: To examine the associations of muscle strength and genetic risk for stroke with stroke incidence. PARTICIPANTS AND METHODS: We included 284,767 white British participants of UK Biobank without genetic relatedness and...
Mechanism-based traps enable protease and hydrolase substrate discovery.
Shan Tang, Adam T Beattie, Lucie Kafkova, Gianluca Petris, Nicolas Huguenin-Dezot, Marc Fiedler, Matthew Freeman, Jason Chin
Feb 23, 2022
Hydrolase enzymes, including proteases, are encoded by 2-3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases-especially...
Mechanism-based traps enable protease and hydrolase substrate discovery.
Shan Tang, Adam T Beattie, Lucie Kafkova, Gianluca Petris, Nicolas Huguenin-Dezot, Marc Fiedler, Matthew Freeman, Jason W Chin
Mar 20, 2022
Hydrolase enzymes, including proteases, are encoded by 2-3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases-especially...
Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Guido A Stoll, Shun-Ichiro Oda, Zheng-Shan Chong, Minmin Yu, Stephen H McLaughlin, Yorgo Modis
Jun 19, 2019
Endogenous retrovirus epigenetic silencing transcriptional repressor transposable element ubiquitin E3 ligase Amino Acid Sequence Binding Sites Chromatin Chromatin Assembly and Disassembly Cloning Molecular Crystallography X-Ray Epigenesis Genetic Escherichia coli Gene Expression Gene Silencing Genetic Vectors Humans Models Molecular Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Recombinant Proteins Repressor Proteins Retroelements Sequence Alignment Sequence Homology Amino Acid Transcription Genetic Tripartite Motif-Containing Protein 28
Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility.
Shan Herath, Sonia T Lilly, Natalia R Santos, Robert O Gilbert, Leopold Goetze, Clare E Bryant, John O White, James Cronin, I Martin Sheldon
Jun 16, 2011
Animals Biopsy Cattle Cattle Diseases Cytokines Endometrium Female Fertility Gene Expression Infections Infertility female Leukocyte Common Antigens Lipopolysaccharide Receptors Lymphocyte Antigen 96 Nod1 Signaling Adaptor Protein Postpartum Period Protein Serine-Threonine Kinases Receptor Transforming Growth Factor-beta Type I Receptors Prostaglandin Receptors Transforming Growth Factor beta Toll-Like Receptors Uterine Diseases
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