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Pharmacokinetics of insulin aspart in pregnant women with type 1 diabetes
Rapid-acting insulin analogs are increasingly used during type 1 diabetic pregnancy. They may assist women to safely optimize glucose control (1,2), but little is known about their pharmacokinetics and reproducibility in...
Demons between the Desert Fathers and the Rabbis
Sophie Lunn-Rockliffe
Nov 21, 2018
In recent years, the study of demons in late antique Christianity has taken off; by comparison, the study of late ancient Jewish demonology has arguably lagged behind. In the broader arena, ground-breaking work has been done...
The effect of uncertainty on prediction error in the action perception loop.
Among all their sensations, agents need to distinguish between those caused by themselves and those caused by external causes. The ability to infer agency is particularly challenging under conditions of uncertainty. Within the...
Joining and splitting models with Markov melding.
Analysing multiple evidence sources is often feasible only via a modular approach, with separate submodels specified for smaller components of the available evidence. Here we introduce a generic framework that enables fully...
Education and Pleasure in the Early Church
Early Christian teachers and preachers were often cautious about, if not suspicious of, pleasure, but they also had a lively awareness of the psychological aspects of pedagogy, and of the power of pleasure and delight to...
Rapid model exploration for complex hierarchical data
We consider situations, which are common in medical statistics, where we have a number of sets of response data, from different individuals, say, potentially under different conditions. A parametric model is defined for each set...
Bayesian hierarchical models Markov Chain Monte Carlo Insulin Pharmacokinetics VARIABLE SELECTION Computer Simulation Data Interpretation Statistical Diabetes mellitus Type 1 Female Humans Insulin Aspart Models Biological Monte Carlo Method Pregnancy Pregnancy Complications Reproducibility of Results
Modelling the dynamics of an experimental host-pathogen microcosm within a hierarchical Bayesian framework.
The advantages of Bayesian statistical approaches, such as flexibility and the ability to acknowledge uncertainty in all parameters, have made them the prevailing method for analysing the spread of infectious diseases in human...
The Invention and Demonisation of an Ascetic Heresiarch
In a letter to the monk Patricius, Philoxenus told a cautionary tale about the downfall of the monk Adelphius. He was said to have accepted a Satanic vision of the Holy Spirit, abandoned ascetic labour and become the...
Sophie Lunn-Rockliffe
Sep 29, 2018
Spatial dynamics of pathogen transmission in communally roosting species
Tamika J Lunn, Alison J Peel, Hamish McCallum, Peggy Eby, Maureen K Kessler, Raina K Plowright, Olivier Restif
Jul 05, 2021
The spatial organization of populations determines their pathogen dynamics. This is particularly important for communally roosting species, whose aggregations are often driven by the spatial structure of their environment. We...
Somatic mutation rates scale with lifespan across mammals.
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim HH Coorens, Mathijs A Sanders, Andrew RJ Lawson, Luke MR Harvey, Shriram Bhosle, David Jones, Raul E Alcantara, Timothy M Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan St John Smith, Moritz Gerstung, Peter J Campbell, Elizabeth P Murchison, Michael R Stratton, Iñigo Martincorena
May 15, 2022
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1-7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the...
Somatic mutation rates scale with lifespan across mammals
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim HH Coorens, Mathijs A Sanders, Andrew RJ Lawson, Luke MR Harvey, Shriram Bhosle, David Jones, Raul E Alcantara, Timothy M Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan St John Smith, Moritz Gerstung, Peter J Campbell, Elizabeth P Murchison, Michael R Stratton, Iñigo Martincorena
Apr 20, 2022
Abstract: The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1–7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses...
A Partial C4 Photosynthetic Biochemical Pathway in Rice.
HsiangChun Lin, Stéphanie Arrivault, Robert A Coe, Shanta Karki, Sarah Covshoff, Efren Bagunu, John E Lunn, Mark Stitt, Robert T Furbank, Julian M Hibberd, William Paul Quick
Oct 29, 2020
Introduction of a C4 photosynthetic pathway into C3 rice (Oryza sativa) requires installation of a biochemical pump that concentrates CO2 at the site of carboxylation in modified bundle sheath cells. To investigate the...
Somatic mutation rates scale with lifespan across mammals.
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim HH Coorens, Mathijs A Sanders, Andrew RJ Lawson, Luke MR Harvey, Shriram Bhosle, David Jones, Raul E Alcantara, Timothy M Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan Smith, Moritz Gerstung, Peter J Campbell, Elizabeth Murchison, Michael R Stratton, Iñigo Martincorena
Apr 21, 2022
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1-7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the...
Plasma cell depletion with bortezomib in the treatment of refractory N-methyl-d-aspartate (NMDA) receptor antibody encephalitis. Rational developments in neuroimmunological treatment.
S Keddie, SJ Crisp, J Blackaby, A Cox, A Coles, M Hart, AJ Church, A Vincent, M Zandi, MP Lunn
Sep 20, 2018
Gene transfer corrects acute GM2 gangliosidosis--potential therapeutic contribution of perivascular enzyme flow.
M Begoña Cachón-González, Susan Z Wang, Rosamund McNair, Josephine Bradley, David Lunn, Robin Ziegler, Seng H Cheng, Timothy M Cox
Jun 03, 2019
Measurement delay associated with the Guardian RT continuous glucose monitoring system.
AIMS: Using compartment modelling, we assessed the time delay between blood glucose and sensor glucose measured by the Guardian RT continuous glucose monitoring system in young subjects with Type 1 diabetes (T1D). METHODS...
Establishing causal order in longitudinal studies combining binary and continuous dependent variables
Longitudinal studies with a mix of binary outcomes and continuous variables are common in organizational research. Selecting the dependent variable is often difficult due to conflicting theories and contradictory empirical...
Establishing causal order in longitudinal studies combining binary and continuous dependent variables
Longitudinal studies with a mix of binary outcomes and continuous variables are common in organizational research. Selecting the dependent variable is often difficult due to conflicting theories and contradictory empirical...
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
Tom D Heightman, James F Callahan, Elisabetta Chiarparin, Joseph E Coyle, Charlotte Griffiths-Jones, Ami S Lakdawala, Rachel McMenamin, Paul N Mortenson, David Norton, Torren M Peakman, Sharna J Rich, Caroline Richardson, William L Rumsey, Yolanda Sanchez, Gordon Saxty, Henriëtte MG Willems, Lawrence Wolfe, Alison J-A Woolford, Zining Wu, Hongxing Yan, Jeffrey K Kerns, Thomas G Davies
Dec 20, 2019
The KEAP1-NRF2-mediated cytoprotective response plays a key role in cellular homoeostasis. Insufficient NRF2 signaling during chronic oxidative stress may be associated with the pathophysiology of several diseases with an...
Whole grain cereals for the primary or secondary prevention of cardiovascular disease.
Sarah Am Kelly, Louise Hartley, Emma Loveman, Jill L Colquitt, Helen M Jones, Lena Al-Khudairy, Christine Clar, Roberta Germanò, Hannah R Lunn, Gary Frost, Karen Rees
Apr 10, 2018
BACKGROUND: There is evidence from observational studies that whole grains can have a beneficial effect on risk for cardiovascular disease (CVD). Earlier versions of this review found mainly short-term intervention studies....
Dose-response and transmission
Tamika J Lunn, Olivier Restif, Alison J Peel, Vincent J Munster, Emmie de Wit, Sanna Sokolow, Neeltje van Doremalen, Peter Hudson, Hamish McCallum
May 07, 2019
Ecology, evolution and spillover of coronaviruses from bats.
Manuel Ruiz-Aravena, Clifton McKee, Amandine Gamble, Tamika Lunn, Aaron Morris, Celine E Snedden, Claude Kwe Yinda, Julia R Port, David W Buchholz, Yao Yu Yeo, Christina Faust, Elinor Jax, Lauren Dee, Devin N Jones, Maureen K Kessler, Caylee Falvo, Daniel Crowley, Nita Bharti, Cara E Brook, Hector C Aguilar, Alison J Peel, Olivier Restif, Tony Schountz, Colin R Parrish, Emily S Gurley, James O Lloyd-Smith, Peter J Hudson, Vincent J Munster, Raina K Plowright
Nov 24, 2021
In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first SARS...
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