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Results: 17
COVID-19 and science advice on the 'Grand Stage'
Hannah Baker, Shauna Concannon, Matthias Meller, Katie Cohen, Alice Millington, Samuel Ward, Emily So
Dec 24, 2022
Science advice for governments attracted great scrutiny during the COVID-19 pandemic, with the public spotlight on institutions and individual experts-putting science advice on the 'Grand Stage'. A review of the academic...
COVID-19 and science advice on the 'Grand Stage'
Hannah Baker, Shauna Concannon, Matthias Meller, Katie Cohen, Alice Millington, Samuel Ward, Emily So
Feb 01, 2023
Science advice for governments attracted great scrutiny during the COVID-19 pandemic, with the public spotlight on institutions and individual experts-putting science advice on the 'Grand Stage'. A review of the academic...
Innovative matrix for applying a food systems approach for developing interventions to address nutrient deficiencies in indigenous communities in India
Suparna Ghosh-Jerath, Shauna Downs, Archna Singh, Santanu Paramanik, Gail Goldberg, Jessica Fanzo
Jul 14, 2020
BACKGROUND: Indigenous communities retain knowledge of the land and food resources rooted in historical continuity within their region of residence. Food systems research can be leveraged to identify strategies to encourage...
A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations.
Marina Evangelou, Deborah J Smyth, Mary D Fortune, Oliver S Burren, Neil M Walker, Hui Guo, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick Concannon, Stephen S Rich, John A Todd, Chris Wallace
Oct 02, 2014
The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in BRCA1/BRCA2/PALB2-Negative Women.
Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population
Anne S Reiner, Charles F Lynch, Julia S Sisti, Esther M John, Jennifer D Brooks, Leslie Bernstein, Julia A Knight, Li Hsu, Patrick Concannon, Lene Mellemkjær, Marc Tischkowitz, Robert W Haile, Ronglai Shen, Kathleen E Malone, Meghan Woods, Xiaolin Liang, Monica Morrow, Jonine L Bernstein
Jul 20, 2017
Abstract
Background
Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer...
The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in BRCA1/BRCA2/PALB2 -Negative Women
Alexey Larionov, Eleanor Fewings, James Redman, Mae Goldgraben, Graeme Clark, John Boice, Patrick Concannon, Jonine Bernstein, David V. Conti, the WECARE Study Collaborative Group, Marc Tischkowitz
Feb 03, 2023
Published by: MDPI
Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA.
Genevieve L Wojcik, Poonum Korpe, Chelsea Marie, Alexander J Mentzer, Tommy Carstensen, Josyf Mychaleckyj, Beth D Kirkpatrick, Stephen S Rich, Patrick Concannon, ASG Faruque, Rashidul Haque, William A Petri, Priya Duggal
Mar 10, 2020
Diarrhea is a major cause of both morbidity and mortality worldwide, especially among young children. Cryptosporidiosis is a leading cause of diarrhea in children, particularly in South Asia and sub-Saharan Africa, where it is...
Cryptosporidium Genetics genome analysis Bangladesh Cryptosporidiosis Cryptosporidium Diarrhea Disease Susceptibility Feces Female Genome Human Genome-Wide Association Study Humans Infant Infant Newborn Male Meta-Analysis as Topic Polymorphism Single Nucleotide Prospective Studies Protein Kinase C-alpha Risk Factors
Confirmation of novel type 1 diabetes risk loci in families.
JD Cooper, JMM Howson, D Smyth, NM Walker, H Stevens, JHM Yang, J-X She, GS Eisenbarth, M Rewers, JA Todd, B Akolkar, P Concannon, HA Erlich, C Julier, G Morahan, J Nerup, C Nierras, F Pociot, SS Rich, Type 1 Diabetes Genetics Consortium
Jul 09, 2019
AIMS/HYPOTHESIS: Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were...
Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women
Anne S Reiner, Julia Sisti, Esther M John, Charles F Lynch, Jennifer D Brooks, Lene Mellemkjær, John D Boice, Julia A Knight, Patrick Concannon, Marinela Capanu, Marc Tischkowitz, Mark Robson, Xiaolin Liang, Meghan Woods, David V Conti, David Duggan, Roy Shore, Daniel O Stram, Duncan C Thomas, Kathleen E Malone, Leslie Bernstein, WECARE Study Collaborative Group, Jonine L Bernstein
Dec 07, 2020
Purpose The Women's Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral breast cancer (CBC) risk, even for noncarriers of deleterious...
Adolescent Adult Age Factors BRCA1 Protein BRCA2 Protein Breast Neoplasms Canada Case-Control Studies Checkpoint Kinase 2 Denmark Fanconi Anemia Complementation Group N Protein Female Genetic Predisposition to Disease Genotype Humans Middle Aged Neoplasm Invasiveness Polymorphism Single Nucleotide Risk Factors United States
Hormone receptor status of a first primary breast cancer predicts contralateral breast cancer risk in the WECARE study population.
Anne S Reiner, Charles F Lynch, Julia S Sisti, Esther M John, Jennifer D Brooks, Leslie Bernstein, Julia A Knight, Li Hsu, Patrick Concannon, Lene Mellemkjær, Marc Tischkowitz, Robert W Haile, Ronglai Shen, Kathleen E Malone, Meghan Woods, Xiaolin Liang, Monica Morrow, Jonine L Bernstein, WECARE Study Collaborative Group
Jul 20, 2017
BACKGROUND: Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covariates...
Contralateral breast cancer estrogen receptor Hormone receptor population-based Progesterone receptor Adult Aged BRCA1 Protein BRCA2 Protein Breast Neoplasms Case-Control Studies Female Humans Middle Aged Mutation Neoplasm Grading Neoplasm Staging Population Surveillance Receptors Estrogen Receptors Progesterone Risk Factors SEER Program Tumor Burden
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Suna Onengut-Gumuscu, Wei-Min Chen, Oliver Burren, Nick J Cooper, Aaron R Quinlan, Josyf C Mychaleckyj, Emily Farber, Jessica K Bonnie, Michal Szpak, Ellen Schofield, Premanand Achuthan, Hui Guo, Mary D Fortune, Helen Stevens, Neil M Walker, Lucas D Ward, Anshul Kundaje, Manolis Kellis, Mark J Daly, Jeffrey C Barrett, Jason D Cooper, Panos Deloukas, Type 1 Diabetes Genetics Consortium, John A Todd, Chris Wallace, Patrick Concannon, Stephen S Rich
May 15, 2015
A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study.
Jennifer D Brooks, John D Boice, Roy E Shore, Anne S Reiner, Susan A Smith, Leslie Bernstein, Julia A Knight, Charles F Lynch, Esther M John, Kathleen E Malone, Lene Mellemkjær, Rikke Langballe, Xiaolin Liang, Meghan Woods, Marc Tischkowitz, Patrick Concannon, Daniel O Stram, WECARE Study Collaborative Group
Oct 23, 2020
OBJECTIVE: To examined the impact of reproductive factors on the relationship between radiation treatment (RT) for a first breast cancer and risk of contralateral breast cancer (CBC). METHODS: The Women's Environmental Cancer...
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Steve Eyre, John Bowes, Dorothée Diogo, Annette Lee, Anne Barton, Paul Martin, Alexandra Zhernakova, Eli Stahl, Sebastien Viatte, Kate McAllister, Christopher I Amos, Leonid Padyukov, Rene EM Toes, Tom WJ Huizinga, Cisca Wijmenga, Gosia Trynka, Lude Franke, Harm-Jan Westra, Lars Alfredsson, Xinli Hu, Cynthia Sandor, Paul IW de Bakker, Sonia Davila, Chiea Chuen Khor, Khai Koon Heng, Robert Andrews, Sarah Edkins, Sarah E Hunt, Cordelia Langford, Deborah Symmons, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Wellcome Trust Case Control Consortium, Pat Concannon, Suna Onengut-Gumuscu, Stephen S Rich, Panos Deloukas, Miguel A Gonzalez-Gay, Luis Rodriguez-Rodriguez, Lisbeth Ärlsetig, Javier Martin, Solbritt Rantapää-Dahlqvist, Robert M Plenge, Soumya Raychaudhuri, Lars Klareskog, Peter K Gregersen, Jane Worthington
May 28, 2021
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European...