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Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
Stefan Antonowicz, Zsolt Bodai, Tom Wiggins, Sheraz R. Markar, Piers R. Boshier, Yan Mei Goh, Mina E. Adam, Haonan Lu, Hiromi Kudo, Francesca Rosini, Robert Goldin, Daniela Moralli, Catherine M. Green, Chris J. Peters, Nagy Habib, Hani Gabra, Rebecca C. Fitzgerald, Zoltan Takats, George B. Hanna
Mar 05, 2021
Abstract: Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients’ breath and could improve early diagnosis, however the mechanisms of their production are unknown. Here, we show that weak aldehyde...
Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma.
Stefan Antonowicz, Zsolt Bodai, Tom Wiggins, Sheraz R Markar, Piers R Boshier, Yan Mei Goh, Mina E Adam, Haonan Lu, Hiromi Kudo, Francesca Rosini, Robert Goldin, Daniela Moralli, Catherine M Green, Chris J Peters, Nagy Habib, Hani Gabra, Rebecca C Fitzgerald, Zoltan Takats, George B Hanna
Apr 16, 2021
Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients' breath and could improve early diagnosis, however the mechanisms of their production are unknown. Here, we show that weak aldehyde detoxification...
Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed
Magnus Nilsson, Halla Olafsdottir, Gabriella Alexandersson von Döbeln, Fernanda Villegas, Giovanna Gagliardi, Mats Hellström, Qiao-Li Wang, Hemming Johansson, Val Gebski, Jakob Hedberg, Fredrik Klevebro, Sheraz Markar, Elizabeth Smyth, Pernilla Lagergren, Ghazwan Al-Haidari, Lars Cato Rekstad, Eirik Kjus Aahlin, Bengt Wallner, David Edholm, Jan Johansson, Eva Szabo, John V Reynolds, CS Pramesh, Naveen Mummudi, Amit Joshi, Lorenzo Ferri, Rebecca Ks Wong, Chris O'Callaghan, Jelena Lukovic, Kelvin Kw Chan, Trevor Leong, Andrew Barbour, Mark Smithers, Yin Li, Xiaozheng Kang, Feng-Ming Kong, Yin-Kai Chao, Tom Crosby, Christiane Bruns, Hanneke van Laarhoven, Mark van Berge Henegouwen, Richard van Hillegersberg, Riccardo Rosati, Guillaume Piessen, Giovanni de Manzoni, Florian Lordick
Jul 27, 2022
BACKGROUND: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment...
Encoding cortical dynamics in sparse features.
Sheraz Khan, Julien Lefèvre, Sylvain Baillet, Konstantinos P Michmizos, Santosh Ganesan, Manfred G Kitzbichler, Manuel Zetino, Matti S Hämäläinen, Christos Papadelis, Tal Kenet
Jul 14, 2021
Distributed cortical solutions of magnetoencephalography (MEG) and electroencephalography (EEG) exhibit complex spatial and temporal dynamics. The extraction of patterns of interest and dynamic features from these cortical...
Altered Onset Response Dynamics in Somatosensory Processing in Autism Spectrum Disorder.
Sheraz Khan, Javeria A Hashmi, Fahimeh Mamashli, Hari M Bharadwaj, Santosh Ganesan, Konstantinos P Michmizos, Manfred G Kitzbichler, Manuel Zetino, Keri-Lee A Garel, Matti S Hämäläinen, Tal Kenet
Dec 11, 2019
Abnormalities in cortical connectivity and evoked responses have been extensively documented in autism spectrum disorder (ASD). However, specific signatures of these cortical abnormalities remain elusive, with data pointing...
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese, Andrea Bacci, Serena Mero, Filippo M Santorelli, Beatrice Polini, Grazia Chiellini, Daniela Giuliani, Antonietta Vilella, Martina Bodria, Eleonora Daini, Eleonora Vandini, Simon Rudge, Sheraz Gul, Michale OJ Wakelam, Michele Vendruscolo, Simona Rapposelli
Jan 28, 2022
The identification of effective pharmacological tools for Alzheimer's disease (AD) represents one of the main challenges for therapeutic discovery. Due to the variety of pathological processes associated with AD, a promising...
Maturation trajectories of cortical resting-state networks depend on the mediating frequency band.
Sheraz Khan, Javeria A Hashmi, Fahimeh Mamashli, Konstantinos Michmizos, Manfred G Kitzbichler, Hari Bharadwaj, Yousra Bekhti, Santosh Ganesan, Keri-Lee A Garel, Susan Whitfield-Gabrieli, Randy L Gollub, Jian Kong, Lucia M Vaina, Kunjan D Rana, Steven M Stufflebeam, Matti S Hämäläinen, Tal Kenet
Jul 24, 2019
The functional significance of resting state networks and their abnormal manifestations in psychiatric disorders are firmly established, as is the importance of the cortical rhythms in mediating these networks. Resting state...
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese, Andrea Bacci, Serena Mero, Filippo M Santorelli, Beatrice Polini, Grazia Chiellini, Daniela Giuliani, Antonietta Vilella, Martina Bodria, Eleonora Daini, Eleonora Vandini, Simon Rudge, Sheraz Gul, Michale OJ Wakelam, Michele Vendruscolo, Simona Rapposelli
Jan 05, 2022
The identification of effective pharmacological tools for Alzheimer's disease (AD) represents one of the main challenges for therapeutic discovery. Due to the variety of pathological processes associated with AD, a promising...
Co-Design of a Trustworthy AI System in Healthcare
This paper documents how an ethically aligned co-design methodology ensures trustworthiness in the early design phase of an artificial intelligence (AI) system component for healthcare. The system explains decisions made...
Roberto V Zicari, Sheraz Ahmed, Julia Amann, Stephan Alexander Braun, John Brodersen, Frédérick Bruneault, James Brusseau, Erik Campano, Megan Coffee, Andreas Dengel, Boris Düdder, Alessio Gallucci, Thomas Krendl Gilbert, Philippe Gottfrois, Emmanuel Goffi, Christoffer Bjerre Haase, Thilo Hagendorff, Eleanore Hickman, Elisabeth Hildt, Sune Holm, Pedro Kringen, Ulrich Kühne, Adriano Lucieri, Vince I Madai, Pedro A Moreno-Sánchez, Oriana Medlicott, Matiss Ozols, Eberhard Schnebel, Andy Spezzatti, Jesmin Jahan Tithi, Steven Umbrello, Dennis Vetter, Holger Volland, Magnus Westerlund, Renee Wurth
Jul 28, 2021
Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.
John W Cole, Huichun Xu, Kathleen Ryan, Thomas Jaworek, Nicole Dueker, Patrick McArdle, Brady Gaynor, Yu-Ching Cheng, Jeffrey O'Connell, Steve Bevan, Rainer Malik, Naveed Uddin Ahmed, Philippe Amouyel, Sheraz Anjum, Joshua C Bis, David Crosslin, John Danesh, Stefan T Engelter, Myriam Fornage, Philippe Frossard, Christian Gieger, Anne-Katrin Giese, Caspar Grond-Ginsbach, Weang Kee Ho, Elizabeth Holliday, Jemma Hopewell, M Hussain, W Iqbal, S Jabeen, Jim Jannes, Ayeesha Kamal, Yoichiro Kamatani, Sandip Kanse, Manja Kloss, Mark Lathrop, Didier Leys, Arne Lindgren, WT Longstreth, Khalid Mahmood, Christa Meisinger, Tiina M Metso, Thomas Mosley, Martina Müller-Nurasyid, Bo Norrving, Eugenio Parati, Annette Peters, Alessandro Pezzini, I Quereshi, Asif Rasheed, A Rauf, T Salam, Jess Shen, Agnieszka Słowik, Tara Stanne, Konstantin Strauch, Turgut Tatlisumak, Vincent N Thijs, Steffen Tiedt, Matthew Traylor, Melanie Waldenberger, Matthew Walters, Wei Zhao, Giorgio Boncoraglio, Stéphanie Debette, Christina Jern, Christopher Levi, Hugh Markus, James Meschia, Arndt Rolfs, Peter Rothwell, Danish Saleheen, Sudha Seshadri, Pankaj Sharma, Cathie Sudlow, Bradford Worrall, METASTROKE Consortium of the ISGC, WTCCC-2 Consortium, O Colin Stine, Steven J Kittner, Braxton D Mitchell
Dec 11, 2018