Search
Results: 12
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Florian T Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier, Robert E Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A McCarroll, Kevin Eggan
May 01, 2017
Alleles Cell Count Cell Differentiation Cell Division Cell Line DNA DNA Mutational Analysis Exome Genes Dominant Genes p53 Human Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Loss of Heterozygosity Mosaicism Mutation Neoplasms Protein Domains selection Genetic Tumor Suppressor Protein p53
Neo-Liberalism and Post-Crisis Recovery
Shila Avissa
Dec 12, 2021
Discussions of the causes of the inequitable impacts of the COVID-19 pandemic strike a similar tone as the same discussion of the 2008 financial crisis. In this review of the literature on post-2008 financial crisis and the...
Published by: Memorial University of Newfoundland
Neo-Liberalism and Post-Crisis Recovery
Shila Avissa
Dec 12, 2021
Discussions of the causes of the inequitable impacts of the COVID-19 pandemic strike a similar tone as the same discussion of the 2008 financial crisis. In this review of the literature on post-2008 financial crisis and the...
Published by: Memorial University of Newfoundland
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation.
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C Marioni, Carolina Guibentif, Berthold Göttgens
Jun 23, 2021
BACKGROUND: Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here we apply...
Erythropoiesis Gastrulation Gata1 RNA velocity Animals Cell Differentiation Datasets as Topic Embryo Mammalian Erythroid Cells Erythropoiesis Fetus GATA1 Transcription Factor Gastrula Gene Expression Regulation Developmental Humans Kinetics Liver Mice Organogenesis Proto-Oncogene Proteins Single-Cell Analysis Trans-Activators Transcriptional Activation
Diverse Routes toward Early Somites in the Mouse Embryo.
Carolina Guibentif, Jonathan A Griffiths, Ivan Imaz-Rosshandler, Shila Ghazanfar, Jennifer Nichols, Valerie Wilson, Berthold Göttgens, John C Marioni
Nov 03, 2020
Brachyury cell fate regulation developmental trajectories neuromesodermal progenitors Somites Animals Body Patterning Cell Differentiation Cell Line Chimera Embryo Mammalian Female Fetal Proteins Gene Expression Profiling Gene Expression Regulation Developmental Germ Cells Heterozygote Male Mesoderm Mice Mice Inbred C57BL SOXB1 Transcription Factors Single-Cell Analysis Somites T-Box Domain Proteins Transcriptome
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation.
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C Marioni, Carolina Guibentif, Berthold Göttgens
Aug 11, 2021
Background
Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here we...
Published by: Genome biology
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C. Marioni, Carolina Guibentif, Berthold Göttgens
Oct 28, 2021
Abstract: Background: Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here...
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C. Marioni, Carolina Guibentif, Berthold Göttgens
Jul 07, 2021
Abstract: Background: Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here...
geneBasis
Alsu Missarova, Jaison Jain, Andrew Butler, Shila Ghazanfar, Tim Stuart, Maigan Brusko, Clive Wasserfall, Harry Nick, Todd Brusko, Mark Atkinson, Rahul Satija, John C Marioni
Jan 28, 2022
scRNA-seq datasets are increasingly used to identify gene panels that can be probed using alternative technologies, such as spatial transcriptomics, where choosing the best subset of genes is vital. Existing methods are limited...
The human body at cellular resolution
Shin Lin, Amanda Posgai, Mark Atkinson, Aviv Regev, Jennifer Rood, Orit Rozenblatt-Rosen, Leslie Gaffney, Anna Hupalowska, Rahul Satija, Nils Gehlenborg, Jay Shendure, Julia Laskin, Pehr Harbury, Nicholas A. Nystrom, Jonathan C. Silverstein, Ziv Bar-Joseph, Kun Zhang, Katy Börner, Yiing Lin, Richard Conroy, Dena Procaccini, Ananda L. Roy, Ajay Pillai, Marishka Brown, Zorina S. Galis, Long Cai, Cole Trapnell, Dana Jackson, Michael P. Snyder, Garry Nolan, William James Greenleaf, Sylvia Plevritis, Sara Ahadi, Stephanie A. Nevins, Hayan Lee, Christian Martijn Schuerch, Sarah Black, Vishal Gautham Venkataraaman, Ed Esplin, Aaron Horning, Amir Bahmani, Xin Sun, Sanjay Jain, James Hagood, Gloria Pryhuber, Peter Kharchenko, Bernd Bodenmiller, Todd Brusko, Michael Clare-Salzler, Harry Nick, Kevin Otto, Clive Wasserfall, Marda Jorgensen, Maigan Brusko, Sergio Maffioletti, Richard M. Caprioli, Jeffrey M. Spraggins, Danielle Gutierrez, Nathan Heath Patterson, Elizabeth K. Neumann, Raymond Harris, Mark deCaestecker, Agnes B. Fogo, Raf van de Plas, Ken Lau, Guo-Cheng Yuan, Qian Zhu, Ruben Dries, Peng Yin, Sinem K. Saka, Jocelyn Y. Kishi, Yu Wang, Isabel Goldaracena, DongHye Ye, Kristin E. Burnum-Johnson, Paul D. Piehowski, Charles Ansong, Ying Zhu, Tushar Desai, Jay Mulye, Peter Chou, Monica Nagendran, Sarah A. Teichmann, Benedict Paten, Robert F. Murphy, Jian Ma, Vladimir Yu. Kiselev, Carl Kingsford, Allyson Ricarte, Maria Keays, Sushma A. Akoju, Matthew Ruffalo, Margaret Vella, Chuck McCallum, Leonard E. Cross, Samuel H. Friedman, Randy Heiland, Bruce Herr, Paul Macklin, Ellen M. Quardokus, Lisel Record, James P. Sluka, Griffin M. Weber, Philip D. Blood, Alexander J. Ropelewski, William E. Shirey, Robin M. Scibek, Paula Mabee, W. Christopher Lenhardt, Kimberly Robasky, Stavros Michailidis, John Marioni, Andrew Butler, Tim Stuart, Eyal Fisher, Shila Ghazanfar, Gokcen Eraslan, Tommaso Biancalani, Eeshit D. Vaishnav, Ananda Roy, Zorina Galis, Pothur Srinivas, Aaron Pawlyk, Salvatore Sechi, Elizabeth Wilder, James Anderson
Oct 08, 2020
Abstract: Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular...