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Results: 290
2D coherent charge transport in highly ordered conducting polymers doped by solid state diffusion.
Keehoon Kang, Shun Watanabe, Katharina Broch, Alessandro Sepe, Adam Brown, Iyad Nasrallah, Mark Nikolka, Zhuping Fei, Martin Heeney, Daisuke Matsumoto, Kazuhiro Marumoto, Hisaaki Tanaka, Shin-Ichi Kuroda, Henning Sirringhaus
Apr 13, 2016
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes
Florence Naillat, Heba Saadeh, Joanna Nowacka-Woszuk, Lenka Gahurova, Fatima Santos, Shin-Ichi Tomizawa, Gavin Kelsey
Jun 28, 2021
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes.
Florence Naillat, Heba Saadeh, Joanna Nowacka-Woszuk, Lenka Gahurova, Fatima Santos, Shin-Ichi Tomizawa, Gavin Kelsey
Sep 05, 2021
BACKGROUND: Reproductive biology methods rely on in vitro follicle cultures from mature follicles obtained by hormonal stimulation for generating metaphase II oocytes to be fertilised and developed into a healthy embryo. Such...
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.
Lenka Gahurova, Shin-Ichi Tomizawa, Sébastien A Smallwood, Kathleen R Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R Andrews, Taiping Chen, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as...
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.
Kanto Shozu, Syuzo Kaneko, Norio Shinkai, Ai Dozen, Hirofumi Kosuge, Makoto Nakakido, Hidenori Machino, Ken Takasawa, Ken Asada, Masaaki Komatsu, Kouhei Tsumoto, Shin-Ichi Ohnuma, Ryuji Hamamoto
Dec 13, 2022
BACKGROUND: Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins, which is markedly suppressed in the majority of early-stage...
Virulence Regulation and Innate Host Response in the Pathogenicity of Vibrio cholerae.
Thandavarayan Ramamurthy, Ranjan K Nandy, Asish K Mukhopadhyay, Shanta Dutta, Ankur Mutreja, Keinosuke Okamoto, Shin-Ichi Miyoshi, G Balakrish Nair, Amit Ghosh
Oct 14, 2020
The human pathogen Vibrio cholerae is the causative agent of severe diarrheal disease known as cholera. Of the more than 200 "O" serogroups of this pathogen, O1 and O139 cause cholera outbreaks and epidemics. The rest of the...
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape.
Lenka Veselovska, Sebastien A Smallwood, Heba Saadeh, Kathleen R Stewart, Felix Krueger, Stéphanie Maupetit-Méhouas, Philippe Arnaud, Shin-Ichi Tomizawa, Simon Andrews, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Previously, a role was demonstrated for transcription in the acquisition of DNA methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome by whole genome approaches revealed that the...
Animals Cell Cycle Proteins Chromatin Assembly and Disassembly CpG Islands DNA Methylation DNA Transposable Elements Female Gene Expression Profiling Genes Tumor Suppressor Genomic Imprinting High-Throughput Nucleotide Sequencing Mice Mice Transgenic Oocytes Sequence Analysis RNA Transcription Factors Transcription Initiation Site Transcriptome
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes.
Kathleen R Stewart, Lenka Veselovska, Jeesun Kim, Jiahao Huang, Heba Saadeh, Shin-Ichi Tomizawa, Sébastien A Smallwood, Taiping Chen, Gavin Kelsey
Jun 24, 2019
Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms underlying DNA methylation establishment remain poorly...
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.
Kanto Shozu, Syuzo Kaneko, Norio Shinkai, Ai Dozen, Hirofumi Kosuge, Makoto Nakakido, Hidenori Machino, Ken Takasawa, Ken Asada, Masaaki Komatsu, Kouhei Tsumoto, Shin-Ichi Ohnuma, Ryuji Hamamoto
Nov 15, 2022
BACKGROUND: Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins, which is markedly suppressed in the majority of early-stage...
Local asymptotic power of the Im-Pesaran-Shin panel unit root test and the impact of initial observations
In this note we derive the local asymptotic power function of the standardized averaged Dickey–Fuller panel unit root statistic of Im, Pesaran, and Shin (2003, Journal of Econometrics, 115, 53–74), allowing for heterogeneous...
Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting RB1 and Uncovers a Treatment-Related Mutational Signature.
Helen R Davies, Kevin D Broad, Zerrin Onadim, Elizabeth A Price, Xueqing Zou, Ibrahim Sheriff, Esin Kotiloğlu Karaa, Irene Scheimberg, M Ashwin Reddy, Mandeep S Sagoo, Shin-Ichi Ohnuma, Serena Nik-Zainal
Feb 17, 2021
The development of retinoblastoma is thought to require pathological genetic changes in both alleles of the RB1 gene. However, cases exist where RB1 mutations are undetectable, suggesting alternative pathways to malignancy. We...
Local asymptotic power of the Im-Pesaran-Shin panel unit root test and the impact of initial observations
In this note we derive the local asymptotic power function of the standardized averaged Dickey–Fuller panel unit root statistic of Im, Pesaran, and Shin (2003, Journal of Econometrics, 115, 53–74), allowing for heterogeneous...
Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting RB1 and Uncovers a Treatment-Related Mutational Signature
Helen R. Davies, Kevin D. Broad, Zerrin Onadim, Elizabeth A. Price, Xueqing Zou, Ibrahim Sheriff, Esin Kotiloğlu Karaa, Irene Scheimberg, M. Ashwin Reddy, Mandeep S. Sagoo, Shin-Ichi Ohnuma, Serena Nik-Zainal
Feb 12, 2021
The development of retinoblastoma is thought to require pathological genetic changes in both alleles of the RB1 gene. However, cases exist where RB1 mutations are undetectable, suggesting alternative pathways to malignancy. We...
Two Secreted Proteoglycans, Activators of Urothelial Cell–Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression
Vasiliki Papadaki, Ken Asada, Julie K. Watson, Toshiya Tamura, Alex Leung, Jack Hopkins, Margaret Dellett, Noriaki Sasai, Hongorzul Davaapil, Serena Nik-Zainal, Rebecca Longbottom, Makoto Nakakido, Ryo Torii, Abhi Veerakumarasivam, Syuzo Kaneko, Mandeep S. Sagoo, Gillian Murphy, Akihisa Mitani, Kohei Tsumoto, John D. Kelly, Ryuji Hamamoto, Shin-Ichi Ohnuma
Nov 14, 2020
Osteomodulin (OMD) and proline/arginine-rich end leucine repeat protein (PRELP) are secreted extracellular matrix proteins belonging to the small leucine-rich proteoglycans family. We found that OMD and PRELP were specifically...
Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.
So Jung Park, Heejin Lee, Doo Shin Jo, Yoon Kyung Jo, Ji Hyun Shin, Han Byeol Kim, Hae Mi Seo, David C Rubinsztein, Jae-Young Koh, Eun Kyung Lee, Dong-Hyung Cho
Oct 27, 2015
Drp1 Mitochondria dynamics RNA binding protein hnRNP A1 3' Untranslated Regions Cell Line Tumor Cell Nucleus Cytoplasm Dynamins GTP Phosphohydrolases Gene Expression Regulation Neoplastic Heterogeneous Nuclear Ribonucleoprotein A1 Heterogeneous-Nuclear Ribonucleoprotein Group A-B Humans Microtubule-Associated Proteins Mitochondrial Dynamics Mitochondrial Proteins Neoplasm Proteins Neuroblastoma Protein Binding Protein Transport RNA processing Post-Transcriptional RNA Messenger RNA Neoplasm
Anatomical variation of the Psoas Valley
BACKGROUND: This scoping review aimed to investigate the literature on the anatomy of the psoas valley, an anterior depression on the acetabular rim, and propose a unified definition of the anatomical structure, describe its...
The role of iliocapsularis in hip pathology
The iliocapsularis is a relatively unheard-of muscle, located deep in the hip covering the anteromedial capsule of the hip joint. Little is known about this constant muscle despite its clinical relevance. The aims of this...
Why are patients dissatisfied following a total knee replacement? A systematic review.
Naoki Nakano, Haitham Shoman, Fernando Olavarria, Tomoyuki Matsumoto, Ryosuke Kuroda, Vikas Khanduja
Nov 26, 2020
BACKGROUND: Although total knee replacement (TKR) is an effective intervention for end-stage arthritis of the knee, a significant number of patients remain dissatisfied following this procedure. Our aim was to identify and...
Anatomical variation of the Psoas Valley
BACKGROUND:This scoping review aimed to investigate the literature on the anatomy of the psoas valley, an anterior depression on the acetabular rim, and propose a unified definition of the anatomical structure, describe its...
Published by: BMC musculoskeletal disorders
Two Secreted Proteoglycans, Activators of Urothelial Cell-Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression.
Vasiliki Papadaki, Ken Asada, Julie K Watson, Toshiya Tamura, Alex Leung, Jack Hopkins, Margaret Dellett, Noriaki Sasai, Hongorzul Davaapil, Serena Nik-Zainal, Rebecca Longbottom, Makoto Nakakido, Ryo Torii, Abhi Veerakumarasivam, Syuzo Kaneko, Mandeep S Sagoo, Gillian Murphy, Akihisa Mitani, Kohei Tsumoto, John D Kelly, Ryuji Hamamoto, Shin-Ichi Ohnuma
Dec 17, 2020
Osteomodulin (OMD) and proline/arginine-rich end leucine repeat protein (PRELP) are secreted extracellular matrix proteins belonging to the small leucine-rich proteoglycans family. We found that OMD and PRELP were specifically...
Decoding the regulatory network of early blood development from single-cell gene expression measurements.
Victoria Moignard, Steven Woodhouse, Laleh Haghverdi, Andrew J Lilly, Yosuke Tanaka, Adam C Wilkinson, Florian Buettner, Iain C Macaulay, Wajid Jawaid, Evangelia Diamanti, Shin-Ichi Nishikawa, Nir Piterman, Valerie Kouskoff, Fabian J Theis, Jasmin Fisher, Berthold Göttgens
Apr 02, 2015
Anatomical variation of the Psoas Valley
Abstract: Background: This scoping review aimed to investigate the literature on the anatomy of the psoas valley, an anterior depression on the acetabular rim, and propose a unified definition of the anatomical structure...
Anatomical variation of the Psoas Valley
Abstract: Background: This scoping review aimed to investigate the literature on the anatomy of the psoas valley, an anterior depression on the acetabular rim, and propose a unified definition of the anatomical structure...
Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population
Youn Sue Lee, Yoonsu Cho, Stephen Burgess, George Davey Smith, Caroline L Relton, So-Youn Shin, Min-Jeong Shin
Aug 22, 2016
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