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Results: 509
Trajectories of childhood immune development and respiratory health relevant to asthma and allergy.
Howard HF Tang, Shu Mei Teo, Danielle Cm Belgrave, Michael D Evans, Daniel J Jackson, Marta Brozynska, Merci Mh Kusel, Sebastian L Johnston, James E Gern, Robert F Lemanske, Angela Simpson, Adnan Custovic, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Dec 07, 2018
Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterogeneous and do not always result in asthma. Similarly, not all atopic individuals develop wheeze...
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2020
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk.
Howard HF Tang, Anna Lang, Shu Mei Teo, Louise M Judd, Ronald Gangnon, Michael D Evans, Kristine E Lee, Rose Vrtis, Patrick G Holt, Robert F Lemanske, Daniel J Jackson, Kathryn E Holt, Michael Inouye, James E Gern
Nov 26, 2020
BACKGROUND: Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma. OBJECTIVES: In this study, we tested whether developmental trajectories of the nasopharyngeal...
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.
Qin Qin Huang, Howard HF Tang, Shu Mei Teo, Danny Mok, Scott C Ritchie, Artika P Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J Holt, Chiea Chuen Khor, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Aug 25, 2020
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid...
Autoimmune Diseases Butyrophilins CD4-Positive T-Lymphocytes Cathepsin H Child Child Development Child Preschool Datasets as Topic Fetal Blood Gene Expression Profiling Gene Expression Regulation Developmental Gene Regulatory Networks Genetic Predisposition to Disease Genome-Wide Association Study HLA-C Antigens Humans Hypersensitivity Infant Infant Newborn Mendelian Randomization Analysis Myeloid Cells Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Prospective Studies Quantitative Trait Loci
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2021
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.
Scott C Ritchie, Samuel A Lambert, Matthew Arnold, Shu Mei Teo, Sol Lim, Petar Scepanovic, Jonathan Marten, Sohail Zahid, Mark Chaffin, Yingying Liu, Gad Abraham, Willem H Ouwehand, David J Roberts, Nicholas A Watkins, Brian G Drew, Anna C Calkin, Emanuele Di Angelantonio, Nicole Soranzo, Stephen Burgess, Michael Chapman, Sekar Kathiresan, Amit V Khera, John Danesh, Adam S Butterworth, Michael Inouye
Jan 07, 2022
Cardiometabolic diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the genome1-3. Polygenic scores (PGS) aggregate these into a metric representing an...
Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.
Shu Mei Teo, Howard HF Tang, Danny Mok, Louise M Judd, Stephen C Watts, Kym Pham, Barbara J Holt, Merci Kusel, Michael Serralha, Niamh Troy, Yury A Bochkov, Kristine Grindle, Robert F Lemanske, Sebastian L Johnston, James E Gern, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Nov 12, 2018
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the...
airway microbiota allergic sensitization Asthma lower respiratory infection Acute Disease Asthma Child Preschool Cohort Studies Disease Susceptibility Female Humans Hypersensitivity Immunoglobulin E Infant Longitudinal Studies Male Microbiota nasopharynx Prospective Studies Respiratory Sounds Respiratory Tract Infections Risk Factors
Customer Involvement Facets Stimulating Customers' Intention to Use Internet-Only Bank Services in China
In this study, the authors extended the perceived risk-value model to include customer involvement to conceptualize an adoption intention model in the context of internet-only bank services (IOBSs). Hypotheses were tested using...
Published by: IGI Global Scientific Publishing
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond CS Seet, Sue-Anne Toh
Oct 08, 2020
INTRODUCTION AND OBJECTIVE: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Use of Bayesian statistics to calculate transient heat fluxes on compressor disks
Future gas turbine engines require improved understanding of the heat transfer between compressor disks and air in compressor cavities under transient operating conditions. Calculation of transient heat fluxes from...
Use of Bayesian statistics to calculate transient heat fluxes on compressor disks
Future gas turbine engines require improved understanding of the heat transfer between compressor disks and air in compressor cavities under transient operating conditions. Calculation of transient heat fluxes from...
Some Reflections on Joseph Needham's Intellectual Heritage.
Jianjun Mei
Apr 03, 2020
In this essay, I reflect on Joseph Needham's intellectual heritage, its impact on understanding the world history of knowledge circulation, and its broad influence on generations of scholars. I present two case studies of...
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences
Jia-Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pei-Sze Ng, Mei-Yee Meng, Siti Norhidayu Hasan, Bethan Sandey, Stephen-John Sammut, Cheng-Har Yip, Pathmanathan Rajadurai, Oscar M. Rueda, Carlos Caldas, Suet-Feung Chin, Soo-Hwang Teo
Dec 22, 2020
Abstract: Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain...
Diagnosing the
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productivity slowdown
This paper explores the slowdown in labour productivity growth in the UK and other advanced economies by decomposing its growth into contributions from different sectors of the economy, looking at both within‐industry...
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond C S Seet, Sue-Anne Toh
Mar 14, 2020
INTRODUCTION AND OBJECTIVE:Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Oxidative Stress Adipocytes Inflammation mononuclear cells myotubes family history of type 2 diabetes
Published by: BMJ open diabetes research & care
An Effective Emotional Analysis Method of Consumer Comment Text Based on ALBERT-ATBiFRU-CNN
Mei Yang
Dec 21, 2022
To address the challenges of insufficient feature extraction for text sentiment analysis in the e-commerce big data environment, the author proposes a deep learning-based emotion analysis method of consumer comment text....
Published by: IGI Global Scientific Publishing
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
Stable<i> trans</i> isomer as the kinetic and theromodynamic product for the oxidative addition of MeI to cycloplatinated(II) complexes comprising isocyanide ligands
Hamid R. Shahsavari, Reza Babadi Aghakhanpour, Mojdeh Hossein-Abadi, Reza Kia, Paul R. Raithby
Apr 01, 2018
The present investigation introduces a new series of cycloplatinated(II) complexes, with the general formula Pt(O-bpy)(Me)(CN-R)] (R = benzyl, 2-naphtyl and tert-butyl), which are able to generate the stable trans-Pt(IV)...
Stable<i> trans</i> isomer as the kinetic and theromodynamic product for the oxidative addition of MeI to cycloplatinated(II) complexes comprising isocyanide ligands
Hamid R. Shahsavari, Reza Babadi Aghakhanpour, Mojdeh Hossein-Abadi, Reza Kia, Paul R. Raithby
Apr 01, 2018
The present investigation introduces a new series of cycloplatinated(II) complexes, with the general formula Pt(O-bpy)(Me)(CN-R)] (R = benzyl, 2-naphtyl and tert-butyl), which are able to generate the stable trans-Pt(IV)...
Multi-Modal Regualtion of Actin Networks
Lin Mei
Jan 01, 0001
Eukaryotic cells employ the actin cytoskeleton to maintain cell shape, support motility, and sense and respond to external mechanical stimuli. An intricate network of actin filaments constitutes the foundation of tissue...
Published by: Rockefeller University
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Würtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
Oct 04, 2019
GWAS blood cell traits cardiometabolic diseases colocalisation analysis Cytokines eQTLs metabolites Multivariate Analysis protein QTLs Adolescent Adult Aged Biomarkers Blood Proteins Cardiovascular Diseases Child Cytokines Female Follow-Up Studies Gene Regulatory Networks Genetic Pleiotropy Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Longitudinal Studies Male Middle Aged Polymorphism Single Nucleotide Prognosis Prospective Studies Quantitative Trait Loci Young Adult
Pathogenic viruses as a global commons
In light of the Covid-19 pandemic, the international community’s approach towards pathogenic viruses needs to be re-evaluated. This commentary notes that attempts to justify viral sovereignty, either under treaties or...
Tessa Sze-Myn Teo
Jun 18, 2021
Exploring the Influential Factors of Continuous Online Shopping Intention
Cheng-Mei Tung
Jan 01, 2022
This study explores consumers' continuous intention regarding online shopping in Taiwan. The technology acceptance model and expectation confirmation model are integrated to explore the influential factors in the continuous...
Published by: IGI Global Scientific Publishing
Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors DCC and Neogenin
Sze Sing Shaun Teo
Jan 01, 0001
During neurodevelopment, commissural axons are guided to the ventral midline in a remarkably precise and stereotyped way. Netrin, a secreted laminin-related protein, provides the major attractive cue for midline guidance. It is...
Published by: Rockefeller University
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