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Results: 310
Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion.
Accretion and the resulting increase in local concentration is a widespread mechanism in biology to enhance biomolecular functions (for example, in liquid-liquid demixing phases). Such macromolecular aggregation phases (e.g....
Primate prefrontal neurons signal economic risk derived from the statistics of recent reward experience.
Risk derives from the variation of rewards and governs economic decisions, yet how the brain calculates risk from the frequency of experienced events, rather than from explicit risk-descriptive cues, remains unclear. Here, we...
Controlling Neuromorphic Behavior of Organic Electrochemical Transistors by Blending Mixed and Ion Conductors
We examine the neuromorphic behavior of organic electrochemical transistors (OECTs) based on polymer blends of a mixed conductor (PEDOT:PSS) and an ion conductor (PSSNa). We show that the addition of ionic conductor into...
Interactions between callose and cellulose revealed through the analysis of biopolymer mixtures.
Radwa H Abou-Saleh, Mercedes C Hernandez-Gomez, Sam Amsbury, Candelas Paniagua, Matthieu Bourdon, Shunsuke Miyashima, Ykä Helariutta, Martin Fuller, Tatiana Budtova, Simon D Connell, Michael E Ries, Yoselin Benitez-Alfonso
Dec 18, 2018
The properties of (1,3)-β-glucans (i.e., callose) remain largely unknown despite their importance in plant development and defence. Here we use mixtures of (1,3)-β-glucan and cellulose, in ionic liquid solution and hydrogels, as...
Tryptophan-dependent auxin biosynthesis is required for HD-ZIP III-mediated xylem patterning.
Robertas Ursache, Shunsuke Miyashima, Qingguo Chen, Anne Vatén, Keiji Nakajima, Annelie Carlsbecker, Yunde Zhao, Ykä Helariutta, Jan Dettmer
Aug 08, 2019
Arabidopsis thaliana Auxin biosynthesis HD-ZIP III Metaxylem Arabidopsis Arabidopsis Proteins Body Patterning Gene Expression Regulation Developmental Gene Expression Regulation Plant Genes Plant Homeodomain Proteins Indoleacetic Acids Mutation Oxygenases Plant Roots Plants Genetically Modified Signal Transduction Tryptophan Xylem
Comparison of the Phenotype and Outcome of Granulomatosis with Polyangiitis Between UK and Japanese Cohorts.
Shunsuke Furuta, Afzal N Chaudhry, Yoshihiro Arimura, Hiroaki Dobashi, Shouichi Fujimoto, Sakae Homma, Niels Rasmussen, David R Jayne
Feb 27, 2020
OBJECTIVE: There are differences in the frequencies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis subgroups between different geographic regions, and we have reported differences in the phenotype of...
ANTINEUTROPHIL CYTOPLASMIC ANTIBODY–ASSOCIATED VASCULITIS Europe Granulomatosis with polyangiitis Japan outcome Phenotype Adult Age of Onset Aged Antibodies Antineutrophil Cytoplasmic Disease-Free Survival Female Glucocorticoids Granulomatosis with polyangiitis Humans Japan Male Middle Aged Phenotype Prognosis Recurrence Retrospective Studies Survival Rate Treatment Outcome United Kingdom
Towards a finite-time singularity of the Navier-Stokes equations Part 1. Derivation and analysis of dynamical system
© 2018 Cambridge University Press. The evolution towards a finite-time singularity of the Navier-Stokes equations for flow of an incompressible fluid of kinematic viscosity is studied, starting from a finite-energy configuration...
Mutation-specific effects in germline transmission of pathogenic mtDNA variants.
Auke BC Otten, Suzanne CEH Sallevelt, Phillippa J Carling, Joseph CFM Dreesen, Marion Drüsedau, Sabine Spierts, Aimee DC Paulussen, Christine EM de Die-Smulders, Mary Herbert, Patrick F Chinnery, David C Samuels, Patrick Lindsey, Hubert JM Smeets
Oct 04, 2018
STUDY QUESTION: Does germline selection (besides random genetic drift) play a role during the transmission of heteroplasmic pathogenic mitochondrial DNA (mtDNA) mutations in humans? SUMMARY ANSWER: We conclude that inheritance...
Simulations and spectra of water in CO matrices.
Rafael Escribano, Emilio Artacho, Akira Kouchi, Tetusya Hama, Yuki Kimura, Hiroshi Hidaka, Naoki Watanabe
Aug 17, 2017
Models for the inclusion of water molecules in carbon monoxide matrices are developed using density functional theory applied to amorphous solid systems. The models cover a large range of systems for smaller or larger CO...
AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
Ricardo S Randall, Shunsuke Miyashima, Tiina Blomster, Jing Zhang, Annakaisa Elo, Anna Karlberg, Juha Immanen, Kaisa Nieminen, Ji-Young Lee, Tatsuo Kakimoto, Karolina Blajecka, Charles W Melnyk, Annette Alcasabas, Celine Forzani, Miho Matsumoto-Kitano, Ari Pekka Mähönen, Rishikesh Bhalerao, Walter Dewitte, Ykä Helariutta, James AH Murray
Sep 29, 2018
Higher plant vasculature is characterized by two distinct developmental phases. Initially, a well-defined radial primary pattern is established. In eudicots, this is followed by secondary growth, which involves development of...
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S Kotecha, Mark N Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
Sep 30, 2022
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S Kotecha, Mark N Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
Sep 02, 2022
Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene.
Linda S Forero-Quintero, William Raymond, Tetsuya Handa, Matthew N Saxton, Tatsuya Morisaki, Hiroshi Kimura, Edouard Bertrand, Brian Munsky, Timothy J Stasevich
Jun 27, 2021
The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped with exquisite spatial resolution along the 1D genome...
Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene
Linda S. Forero-Quintero, William Raymond, Tetsuya Handa, Matthew N. Saxton, Tatsuya Morisaki, Hiroshi Kimura, Edouard Bertrand, Brian Munsky, Timothy J. Stasevich
May 26, 2021
Abstract: The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped with exquisite spatial resolution along the...
Visualizing Magnetic Structure in 3D Nanoscale Ni-Fe Gyroid Networks.
Justin Llandro, David M Love, András Kovács, Jan Caron, Kunal N Vyas, Attila Kákay, Ruslan Salikhov, Kilian Lenz, Jürgen Fassbender, Maik RJ Scherer, Christian Cimorra, Ullrich Steiner, Crispin HW Barnes, Rafal E Dunin-Borkowski, Shunsuke Fukami, Hideo Ohno
Apr 27, 2020
Arrays of interacting 2D nanomagnets display unprecedented electromagnetic properties via collective effects, demonstrated in artificial spin ices and magnonic crystals. Progress toward 3D magnetic metamaterials is hampered by...
Plant development. Arabidopsis NAC45/86 direct sieve element morphogenesis culminating in enucleation.
Kaori Miyashima Furuta, Shri Ram Yadav, Satu Lehesranta, Ilya Belevich, Shunsuke Miyashima, Jung-Ok Heo, Anne Vatén, Ove Lindgren, Bert De Rybel, Gert Van Isterdael, Panu Somervuo, Raffael Lichtenberger, Raquel Rocha, Siripong Thitamadee, Sari Tähtiharju, Petri Auvinen, Tom Beeckman, Eija Jokitalo, Ykä Helariutta
Nov 04, 2019
Photoassimilates such as sugars are transported through phloem sieve element cells in plants. Adapted for effective transport, sieve elements develop as enucleated living cells. We used electron microscope imaging and...
Genetic determinants of survival in progressive supranuclear palsy
Edwin Jabbari, Shunsuke Koga, Rebecca R Valentino, Regina H Reynolds, Raffaele Ferrari, Manuela MX Tan, James B Rowe, Clifton L Dalgard, Sonja W Scholz, Dennis W Dickson, Thomas T Warner, Tamas Revesz, Günter U Höglinger, Owen A Ross, Mina Ryten, John Hardy, Maryam Shoai, Huw R Morris, PSP Genetics Group
Jan 21, 2021
BACKGROUND: The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of survival in progressive supranuclear palsy (PSP). METHODS: In stage one...
Adult Age of Onset Aged Chromosomes Human Pair 12 Databases Genetic Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Kaplan-Meier Estimate Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Linkage Disequilibrium Male Middle Aged Polymorphism Single Nucleotide RNA Long Noncoding Supranuclear Palsy Progressive Survival Analysis White People
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.
Aled J Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D'Santos, I Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A Samarajiwa, Masashi Narita
May 23, 2018
Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. We have recently identified that NOTCH1 can drive 'lateral induction' of a unique senescence phenotype in adjacent cells by...
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