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Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia.
Michele Petruzzelli, Miriam Ferrer, Martijn J Schuijs, Sam O Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J Lukey, Duncan I Jodrell, Christian Frezza, Erwin F Wagner, Ashok R Venkitaraman, Timotheus YF Halim, Tobias Janowitz
Feb 17, 2022
An elevated neutrophil-lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer...