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Results: 81
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino, Usman Baber, Roxana Mehran, Valentin Fuster, John Danesh, Philippe Frossard, Danish Saleheen, Olle Melander, Galina K Sukhova, Donna Neuberg, Peter Libby, Sekar Kathiresan, Benjamin L Ebert
Nov 28, 2017
Early Detection of Alzheimer's Disease Using Bottleneck Transformers
Early detection of Alzheimer's disease (AD) and its prodromal state, mild cognitive impairment (MCI), is crucial for providing suitable treatment and preventing the disease from progressing. It can also aid researchers and...
Published by: IGI Global Scientific Publishing
Developing an Explainable Machine Learning-Based Thyroid Disease Prediction Model
Healthcare and medicine are key areas where machine learning algorithms are widely used. The medical decision support systems thus created are accurate enough, however, they suffer from the lack of transparency in decision...
Published by: IGI Global Scientific Publishing
Collagen fibre implant for tendon and ligament biological augmentation. In vivo study in an ovine model.
Davide Enea, Jessica Gwynne, Simon Kew, Meera Arumugam, Jennifer Shepherd, Roger Brooks, Siddhartha Ghose, Serena Best, Ruth Cameron, Neil Rushton
Apr 19, 2013
PURPOSE: Although most in vitro studies indicate that collagen is a suitable biomaterial for tendon and ligament tissue engineering, in vivo studies of implanted collagen for regeneration of these tissues are still lacking. The...
Coffee consumption and cancer risk
Paul Carter, Shuai Yuan, Siddhartha Kar, Mathew Vithayathil, Amy M Mason, Stephen Burgess, Susanna C Larsson
Oct 07, 2022
BACKGROUND: Coffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee...
Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L Seifert, Marshall W Hogarth, Davi A Mazala, Kai Ting Huang, Rita Horvath, Jyoti K Jaiswal, György Hajnóczky
Apr 21, 2020
Muscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix...
Atrophy autosomal recessive Calcium Injury membrane Mitochondria mitochondrial disease muscle disease Adolescent Adult Animals Calcium Calcium Signaling Calcium-Binding Proteins Cation Transport Proteins Cell Membrane Cytosol Female FIBROBLASTS Homeostasis Humans Male Mice Knockout Mitochondria Mitochondrial Membrane Transport Proteins Models Biological Muscle Contraction Muscle Weakness Muscle Skeletal Muscular Atrophy Sarcolemma Tetanus Wasting Syndrome
Sleep duration and risk of overall and 22 site-specific cancers
Olga E Titova, Karl Michaëlsson, Mathew Vithayathil, Amy M Mason, Siddhartha Kar, Stephen Burgess, Susanna C Larsson
Aug 21, 2020
Studies of sleep duration in relation to the risk of site-specific cancers other than breast cancer are scarce. Furthermore, the available results are inconclusive and the causality remains unclear. We aimed to investigate the...
Mendelian randomization Cancer SINGLE-NUCLEOTIDE POLYMORPHISMS Sleep Adult Aged Biological Specimen Banks Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Neoplasms Odds Ratio Polymorphism Single Nucleotide Risk Factors Sleep Time Factors United Kingdom
Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank
Paul Carter, Mathew Vithayathil, Siddhartha Kar, Rahul Potluri, Amy M Mason, Susanna C Larsson, Stephen Burgess
Oct 14, 2020
Assessing the role of cortisol in cancer
BACKGROUND: Cortisol's immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential...
Optimal Placement of Micro Distribution Generator in Micro-Grid for Loss Minimization Using PSO
The major aim of DG optimal placement is obtaining the best DGs units sizes and locations so as to have optimum operation and planning of the distribution network system while considering DG capacity constraint. This paper...
Published by: IGI Global Scientific Publishing
How Do Digital Market Platform Hosts Exercise Control Over Sellers?
High speed connectivity, smart mobile devices, social media, and rapidly-proliferating end-user applications have given rise to digital markets. This paper investigates how digital market hosts exercise control over sellers. The...
Published by: IGI Global Scientific Publishing
Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank.
Paul Carter, Mathew Vithayathil, Siddhartha Kar, Rahul Potluri, Amy M Mason, Susanna C Larsson, Stephen Burgess
Sep 25, 2020
Laboratory studies have suggested oncogenic roles of lipids, as well as anticarcinogenic effects of statins. Here we assess the potential effect of statin therapy on cancer risk using evidence from human genetics. We obtained...
Mendelian randomization causal inference Cell Biology Cholesterol Chromosomes Gene Expression Genetic epidemiology human Lipids Statins Biological Specimen Banks genetic variation Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Mendelian Randomization Analysis Neoplasms prevalence Risk Factors United Kingdom
Causal associations of thyroid function and dysfunction with overall, breast and thyroid cancer
Shuai Yuan, Siddhartha Kar, Mathew Vithayathil, Paul Carter, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 13, 2020
Whether thyroid dysfunction plays a causal role in the development of cancer remains inconclusive. We conducted a two-sample Mendelian randomization study to investigate the associations between genetic predisposition to thyroid...
Mendelian randomization Cancer hyperthyroidism Hypothyroidism thyroid-stimulating hormone Thyroxine Biological Specimen Banks Breast Neoplasms Female Humans hyperthyroidism Hypothyroidism Male Mendelian Randomization Analysis Polymorphism Single Nucleotide Thyroid Function Tests Thyroid Gland Thyroid Neoplasms Thyrotropin
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 30, 2021
BACKGROUND: Folate, vitamin B6 and vitamin B12 have been associated with digestive system cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. METHODS: Two, one and 14...
Adult Anemia Pernicious Case-Control Studies Digestive System Neoplasms Female Folic Acid Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Humans Male Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Sweden United Kingdom Vitamin B 12 Vitamin B 6 Vitamin B Complex Vitamin B Deficiency
chromMAGMA
Robbin Nameki, Anamay Shetty, Eileen Dareng, Jonathan Tyrer, Xianzhi Lin, Ovarian Cancer Association Consortium, Paul Pharoah, Rosario I Corona, Siddhartha Kar, Kate Lawrenson
Aug 01, 2022
Candidate causal risk variants from genome-wide association studies reside almost exclusively in noncoding regions of the genome and innovative approaches are necessary to understand their biological function. Multi-marker...
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Feb 20, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Jul 29, 2021
Background: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index...
Bioactive IGF-1 release from collagen-GAG scaffold to enhance cartilage repair in vitro.
Leanne M Mullen, Serena M Best, Siddhartha Ghose, John Wardale, Neil Rushton, Ruth E Cameron
Apr 13, 2015
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 27, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Published by: Nutrients
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Aug 29, 2021
Background
Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass...
Published by: PLoS Medicine
Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study.
Shuai Yuan, Siddhartha Kar, Paul Carter, Mathew Vithayathil, Amy M Mason, Stephen Burgess, Susanna C Larsson
Apr 29, 2020
We conducted a two-sample Mendelian randomization study to investigate the causal associations of type 2 diabetes mellitus (T2DM) with risk of overall cancer and 22 site-specific cancers. Summary-level data for cancer were...
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