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Results: 20238
Coffee consumption and cancer risk
Paul Carter, Shuai Yuan, Siddhartha Kar, Mathew Vithayathil, Amy M Mason, Stephen Burgess, Susanna C Larsson
Oct 07, 2022
BACKGROUND: Coffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee...
Sleep duration and risk of overall and 22 site-specific cancers
Olga E Titova, Karl Michaëlsson, Mathew Vithayathil, Amy M Mason, Siddhartha Kar, Stephen Burgess, Susanna C Larsson
Aug 21, 2020
Studies of sleep duration in relation to the risk of site-specific cancers other than breast cancer are scarce. Furthermore, the available results are inconclusive and the causality remains unclear. We aimed to investigate the...
Mendelian randomization Cancer SINGLE-NUCLEOTIDE POLYMORPHISMS Sleep Adult Aged Biological Specimen Banks Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Neoplasms Odds Ratio Polymorphism Single Nucleotide Risk Factors Sleep Time Factors United Kingdom
Causal associations of thyroid function and dysfunction with overall, breast and thyroid cancer
Shuai Yuan, Siddhartha Kar, Mathew Vithayathil, Paul Carter, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 13, 2020
Whether thyroid dysfunction plays a causal role in the development of cancer remains inconclusive. We conducted a two-sample Mendelian randomization study to investigate the associations between genetic predisposition to thyroid...
Mendelian randomization Cancer hyperthyroidism Hypothyroidism thyroid-stimulating hormone Thyroxine Biological Specimen Banks Breast Neoplasms Female Humans hyperthyroidism Hypothyroidism Male Mendelian Randomization Analysis Polymorphism Single Nucleotide Thyroid Function Tests Thyroid Gland Thyroid Neoplasms Thyrotropin
Assessing the role of cortisol in cancer
BACKGROUND: Cortisol's immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential...
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Aug 29, 2021
Background
Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass...
Published by: PLoS Medicine
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Jul 29, 2021
Background: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index...
Smoking, alcohol consumption, and cancer
Susanna C Larsson, Paul Carter, Siddhartha Kar, Mathew Vithayathil, Amy M Mason, Karl Michaëlsson, Stephen Burgess
Aug 25, 2020
BACKGROUND: Smoking is a well-established cause of lung cancer and there is strong evidence that smoking also increases the risk of several other cancers. Alcohol consumption has been inconsistently associated with cancer risk...
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 27, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Published by: Nutrients
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Sep 13, 2021
BACKGROUND: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index...
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 30, 2021
BACKGROUND: Folate, vitamin B6 and vitamin B12 have been associated with digestive system cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. METHODS: Two, one and 14...
Adult Anemia Pernicious Case-Control Studies Digestive System Neoplasms Female Folic Acid Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Humans Male Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Sweden United Kingdom Vitamin B 12 Vitamin B 6 Vitamin B Complex Vitamin B Deficiency
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Feb 20, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M Mason, Stephen Burgess, Susanna C Larsson
Feb 27, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Mendelian randomization Cancer ferritin Iron Serum transferrin Transferrin Saturation Adult Aged Biological Specimen Banks Brain Neoplasms Female Ferritins Genetic Predisposition to Disease Genome-Wide Association Study Humans Iron Liver Neoplasms Male Mendelian Randomization Analysis Middle Aged Neoplasms Nutritional Status Odds Ratio Polymorphism Single Nucleotide Risk Factors Transferrin United Kingdom White People
Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank.
Paul Carter, Mathew Vithayathil, Siddhartha Kar, Rahul Potluri, Amy M Mason, Susanna C Larsson, Stephen Burgess
Sep 25, 2020
Laboratory studies have suggested oncogenic roles of lipids, as well as anticarcinogenic effects of statins. Here we assess the potential effect of statin therapy on cancer risk using evidence from human genetics. We obtained...
Mendelian randomization causal inference Cell Biology Cholesterol Chromosomes Gene Expression Genetic epidemiology human Lipids Statins Biological Specimen Banks genetic variation Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Mendelian Randomization Analysis Neoplasms prevalence Risk Factors United Kingdom
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study.
Shuai Yuan, Siddhartha Kar, Paul Carter, Mathew Vithayathil, Amy M Mason, Stephen Burgess, Susanna C Larsson
Apr 29, 2020
We conducted a two-sample Mendelian randomization study to investigate the causal associations of type 2 diabetes mellitus (T2DM) with risk of overall cancer and 22 site-specific cancers. Summary-level data for cancer were...
Genetically predicted circulating protein biomarkers and ovarian cancer risk.
Daniel PC Considine, Guochong Jia, Xiang Shu, Joellen M Schildkraut, Paul DP Pharoah, Wei Zheng, Siddhartha P Kar, Ovarian Cancer Association Consortium
Dec 10, 2020
OBJECTIVE: Most women with epithelial ovarian cancer (EOC) are diagnosed after the disease has metastasized and survival in this group remains poor. Circulating proteins associated with the risk of developing EOC have the...
circulating biomarkers Circulating proteins epithelial ovarian cancer Genome-Wide Association Study risk Biomarkers Tumor Carcinoma Ovarian Epithelial Case-Control Studies England Female Genetic Predisposition to Disease Genome-Wide Association Study Germ-Line Mutation Healthy Volunteers Humans Neoplasm Invasiveness Ovarian Neoplasms Polymorphism Single Nucleotide Risk Assessment
Breast cancer risk factors and their effects on survival
Maria Escala-Garcia, Anna Morra, Sander Canisius, Jenny Chang-Claude, Siddhartha Kar, Wei Zheng, Stig E. Bojesen, Doug Easton, Paul D. P. Pharoah, Marjanka K. Schmidt
Nov 17, 2020
Abstract: Background: Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to...
Serum Estradiol and 20 Site-Specific Cancers in Women
Susanna C Larsson, Siddhartha Kar, John RB Perry, Paul Carter, Mathew Vithayathil, Amy M Mason, Douglas F Easton, Stephen Burgess
Sep 28, 2021
CONTEXT: The causal role of endogenous estradiol in cancers other than breast and endometrial cancer remains unclear. OBJECTIVE: This Mendelian randomization study assessed the causal associations of endogenous 17β-estradiol...
Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer
Susanna C Larsson, Amy M Mason, Siddhartha Kar, Mathew Vithayathil, Paul Carter, John A Baron, Karl Michaëlsson, Stephen Burgess
Nov 06, 2020
BACKGROUND: Observational studies have shown that milk consumption is inversely associated with colorectal, bladder, and breast cancer risk, but positively associated with prostate cancer. However, whether the associations...
Body mass index and the association between low-density lipoprotein cholesterol as predicted by HMGCR genetic variants and breast cancer risk.
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