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Results: 43
Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model.
Eric Peter Thelin, Claire E Hall, Kunal Gupta, Keri LH Carpenter, Siddharthan Chandran, Peter J Hutchinson, Rickie Patani, Adel Helmy
Jun 05, 2018
Cytokine mediated inflammation likely plays an important role in secondary pathology after traumatic brain injury (TBI). The aim of this study was to elucidate secondary cytokine responses in an in vitro enriched (>80%) human...
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Oct 24, 2022
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Sep 18, 2022
Targeting patient recovery priorities in degenerative cervical myelopathy
Benjamin Davies, Oliver D Mowforth, Stefan Yordanov, Daniel Alvarez-Berdugo, Simon Bond, Marianna Nodale, Paula Kareclas, Lynne Whitehead, Jon Bishop, Siddharthan Chandran, Sarah Lamb, Mark Bacon, Marios C Papadopoulos, Michelle Starkey, Iwan Sadler, Lara Smith, Sukhvinder Kalsi-Ryan, Adrian Carpenter, Rikin A Trivedi, Martin Wilby, David Choi, Ian B Wilkinson, Michael G Fehlings, Peter John Hutchinson, Mark RN Kotter
Mar 20, 2023
Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One)
J William L Brown, Nick G Cunniffe, Ferran Prados, Baris Kanber, Joanne L Jones, Edward Needham, Zoya Georgieva, David Rog, Owen R Pearson, James Overell, David MacManus, Rebecca S Samson, Jonathan Stutters, Charles ffrench-Constant, Claudia AM Gandini Wheeler-Kingshott, Carla Moran, Paul D Flynn, Andrew W Michell, Robin Jm Franklin, Siddharthan Chandran, Daniel R Altmann, Declan T Chard, Peter Connick, Alasdair J Coles
May 31, 2021
Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis.
Simon Licht-Mayer, Graham R Campbell, Arpan R Mehta, Katie McGill, Alex Symonds, Sarah Al-Azki, Gareth Pryce, Stephanie Zandee, Chao Zhao, Markus Kipp, Kenneth J Smith, David Baker, Daniel Altmann, Stephen M Anderton, Yolanda S Kap, Jon D Laman, Bert A 't Hart, Moses Rodriguez, Robin Jm Franklin, Siddharthan Chandran, Hans Lassmann, Bruce D Trapp, Don J Mahad
Oct 10, 2022
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test
Peter Connick, Madhan Kolappan, Rickie Patani, Michael A Scott, Charles Crawley, Xiao-Ling He, Karen Richardson, Kelly Barber, Daniel J Webber, Claudia AM Wheeler-Kingshott, Daniel J Tozer, Rebecca S Samson, David L Thomas, Ming-Qing Du, Shi L Luan, Andrew W Michell, Daniel R Altmann, Alan J Thompson, David H Miller, Alastair Compston, Siddharthan Chandran
May 26, 2011
Adult Cell Proliferation Cells Cultured Disability Evaluation England Feasibility Studies Female Humans Magnetic Resonance Imaging Male Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Middle Aged Multiple Sclerosis Chronic Progressive Research Design Risk Assessment Time Factors Transplantation Autologous Treatment Outcome
Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation.
Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 Å away from the IP3-binding core (IBC). However, the precise...
Enhanced axonal response of mitochondria to demyelination offers neuroprotection
Simon Licht-Mayer, Graham R. Campbell, Marco Canizares, Arpan R. Mehta, Angus B. Gane, Katie McGill, Aniket Ghosh, Alexander Fullerton, Niels Menezes, Jasmine Dean, Jordon Dunham, Sarah Al-Azki, Gareth Pryce, Stephanie Zandee, Chao Zhao, Markus Kipp, Kenneth J. Smith, David Baker, Daniel Altmann, Stephen M. Anderton, Yolanda S. Kap, Jon D. Laman, Bert A.‘t Hart, Moses Rodriguez, Ralf Watzlawick, Jan M. Schwab, Roderick Carter, Nicholas Morton, Michele Zagnoni, Robin J. M. Franklin, Rory Mitchell, Sue Fleetwood-Walker, David A. Lyons, Siddharthan Chandran, Hans Lassmann, Bruce D. Trapp, Don J. Mahad
Jun 22, 2021
Enhanced axonal response of mitochondria to demyelination offers neuroprotection
Simon Licht-Mayer, Graham R Campbell, Marco Canizares, Arpan R Mehta, Angus B Gane, Katie McGill, Aniket Ghosh, Alexander Fullerton, Niels Menezes, Jasmine Dean, Jordon Dunham, Sarah Al-Azki, Gareth Pryce, Stephanie Zandee, Chao Zhao, Markus Kipp, Kenneth J Smith, David Baker, Daniel Altmann, Stephen M Anderton, Yolanda S Kap, Jon D Laman, Bert A 't Hart, Moses Rodriguez, Ralf Watzlawick, Jan M Schwab, Roderick Carter, Nicholas Morton, Michele Zagnoni, Robin Jm Franklin, Rory Mitchell, Sue Fleetwood-Walker, David A Lyons, Siddharthan Chandran, Hans Lassmann, Bruce D Trapp, Don J Mahad
Jun 26, 2020
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly...
Circulating maternal placental growth factor responses to low-molecular-weight heparin in pregnant patients at risk of placental dysfunction.
Kelsey McLaughlin, Sebastian R Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C Windrim, W Tony Parks, Adrian W Bowman, Ulla Sovio, Gordon C Smith, John C Kingdom
Sep 14, 2021
BACKGROUND: Patients at high risk of severe preeclampsia and fetal growth restriction have low circulating levels of placental growth factor and features of maternal vascular malperfusion placental pathology at delivery....
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors
Jake P. Mann, Paul Carter, Matthew J. Armstrong, Hesham K. Abdelaziz, Hardeep Uppal, Billal Patel, Suresh Chandran, Ranjit More, Philip N. Newsome, Rahul Potluri
Oct 27, 2020
Non-alcoholic fatty liver disease (NAFLD) is common and strongly associated with the metabolic syndrome. Though NAFLD may progress to end-stage liver disease, the top cause of mortality in NAFLD is cardiovascular disease (CVD)....
Psoriatic arthritis
Oliver FitzGerald, Alexis Ogdie, Vinod Chandran, Laura C. Coates, Arthur Kavanaugh, William Tillett, Ying Ying Leung, Maarten deWit, Jose U. Scher, Philip J. Mease
Aug 12, 2021
Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or tests available. Diagnosis is most commonly...
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Jun 21, 2021
Abstract: The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history...
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors.
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Jul 02, 2021
Abstract: The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history...
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology.
Rameen Shakur, Juan Pablo Ochoa, Alan J Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Aug 09, 2021
The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden...
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Jun 14, 2021
Abstract: The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history...
Psoriatic arthritis
Oliver FitzGerald, Alexis Ogdie, Vinod Chandran, Laura C. Coates, Arthur Kavanaugh, William Tillett, Ying Ying Leung, Maarten deWit, Jose U. Scher, Philip J. Mease
Aug 12, 2021
Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or tests available. Diagnosis is most commonly...
Enhanced axonal response of mitochondria to demyelination offers neuroprotection
Simon Licht-Mayer, Graham R. Campbell, Marco Canizares, Arpan R. Mehta, Angus B. Gane, Katie McGill, Aniket Ghosh, Alexander Fullerton, Niels Menezes, Jasmine Dean, Jordon Dunham, Sarah Al-Azki, Gareth Pryce, Stephanie Zandee, Chao Zhao, Markus Kipp, Kenneth J. Smith, David Baker, Daniel Altmann, Stephen M. Anderton, Yolanda S. Kap, Jon D. Laman, Bert A.‘t Hart, Moses Rodriguez, Ralf Watzlawick, Jan M. Schwab, Roderick Carter, Nicholas Morton, Michele Zagnoni, Robin J. M. Franklin, Rory Mitchell, Sue Fleetwood-Walker, David A. Lyons, Siddharthan Chandran, Hans Lassmann, Bruce D. Trapp, Don J. Mahad
Jul 14, 2020
Quantifying preference for social stimuli in young children using two tasks on a mobile platform.
Indu Dubey, Simon Brett, Liliana Ruta, Rahul Bishain, Sharat Chandran, Supriya Bhavnani, Matthew K Belmonte, Georgia Lockwood Estrin, Mark Johnson, Teodora Gliga, Bhismadev Chakrabarti, START consortium
Jun 07, 2022
Children typically prefer to attend to social stimuli (e.g. faces, smiles) over non-social stimuli (e.g. natural scene, household objects). This preference for social stimuli is believed to be an essential building block for...
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