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Results: 32
NAFLD exacerbates the effect of dietary sugar on liver fat and development of an atherogenic lipoprotein phenotype
A Margot Umpleby, Fariba Shojaee-Moradie, Barbara Fielding, Xuefei Li, Andrea Marino, Najlaa Alsini, Cheryl Isherwood, Nicola Jackson, Aryati Ahmad, Michael Stolinski, Julie A Lovegrove, Sigurd Johnsen, John Wright, Malgorzata E Wilinska, Roman Hovorka, Jimmy Bell, E Louise Thomas, Gary S Frost, Bruce A Griffin
Jul 13, 2016
Global architecture for the nutrition training of health professionals
Breanna Lepre, Helena Trigueiro, Jørgen Torgerstuen Johnsen, Ali Ahsan Khalid, Lauren Ball, Sumantra Ray
Aug 11, 2022
BACKGROUND: This paper provides an overview of capacity-building efforts in the context of nutrition education for medical and healthcare professionals. METHODS: Content analysis of eighteen reports related to nutrition...
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases
Viatcheslav Zaitsev, Ulrike Johnsen, Matthias Reher, Marius Ortjohann, Garry Taylor, Michael Danson, Peter Schönheit, Susan Crennell
Jul 03, 2018
The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner-Doudoroff pathway and a branched Entner-Doudoroff pathway, respectively. Key enzymes for these...
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases
Viatcheslav Zaitsev, Ulrike Johnsen, Matthias Reher, Marius Ortjohann, Garry Taylor, Michael Danson, Peter Schönheit, Susan Crennell
Jul 03, 2018
The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner-Doudoroff pathway and a branched Entner-Doudoroff pathway, respectively. Key enzymes for these...
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
Evangelos Prokakis, Anna Dyas, Regina Grün, Sonja Fritzsche, Upasana Bedi, Zahra B Kazerouni, Robyn L Kosinsky, Steven A Johnsen, Florian Wegwitz
Jun 11, 2021
The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called "death-from-cancer" signature predicting...
Cardiovascular risk factors and incident albuminuria in screen-detected type 2 diabetes.
DR Webb, F Zaccardi, MJ Davies, SJ Griffin, NJ Wareham, RK Simmons, GE Rutten, A Sandbaek, T Lauritzen, K Borch-Johnsen, K Khunti
Feb 03, 2017
Does training of general practitioners for intensive treatment of people with screen-detected diabetes have a spillover effect on mortality and cardiovascular morbidity in ‘at risk’ individuals with normoglycaemia? Results from the ADDITION-Denmark cluster-randomised controlled trial
Stress Corrosion Cracking in an Extruded Cu-Free Al-Zn-Mg Alloy
Stress corrosion cracking (SCC) in Cu-free Al-Zn-Mg (7xxx) aluminium alloys limits its use in many applications. In this work, we study in detail the microstructure of a peak and slightly overaged condition in an AA7003...
Adrian Lervik, John C. Walmsley, Lars Lodgaard, Calin D. Marioara, Roy Johnsen, Otto Lunder, Randi Holmestad
Sep 08, 2020
Physical activity levels in adults and elderly from triaxial and uniaxial accelerometry. The Tromsø Study.
Edvard H Sagelv, Ulf Ekelund, Sigurd Pedersen, Søren Brage, Bjørge H Hansen, Jonas Johansson, Sameline Grimsgaard, Anna Nordström, Alexander Horsch, Laila A Hopstock, Bente Morseth
Dec 19, 2019
INTRODUCTION: Surveillance of physical activity at the population level increases the knowledge on levels and trends of physical activity, which may support public health initiatives to promote physical activity. Physical...
Physical activity levels in adults and elderly from triaxial and uniaxial accelerometry. The Tromsø Study.
Edvard H Sagelv, Ulf Ekelund, Sigurd Pedersen, Søren Brage, Bjørge H Hansen, Jonas Johansson, Sameline Grimsgaard, Anna Nordström, Alexander Horsch, Laila A Hopstock, Bente Morseth
Jan 06, 2020
INTRODUCTION:Surveillance of physical activity at the population level increases the knowledge on levels and trends of physical activity, which may support public health initiatives to promote physical activity. Physical...
Humans thrived in South Africa through the Toba eruption about 74,000 years ago.
Eugene I Smith, Zenobia Jacobs, Racheal Johnsen, Minghua Ren, Erich C Fisher, Simen Oestmo, Jayne Wilkins, Jacob A Harris, Panagiotis Karkanas, Shelby Fitch, Amber Ciravolo, Deborah Keenan, Naomi Cleghorn, Christine S Lane, Thalassa Matthews, Curtis W Marean
May 25, 2018
Approximately 74 thousand years ago (ka), the Toba caldera erupted in Sumatra. Since the magnitude of this eruption was first established, its effects on climate, environment and humans have been debated. Here we describe the...
Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.
Melanie S Patzak, Vijayalakshmi Kari, Shilpa Patil, Feda H Hamdan, Robert G Goetze, Marius Brunner, Jochen Gaedcke, Julia Kitz, Duncan I Jodrell, Frances M Richards, Christian Pilarsky, Robert Gruetzmann, Petra Rümmele, Thomas Knösel, Elisabeth Hessmann, Volker Ellenrieder, Steven A Johnsen, Albrecht Neesse
Mar 19, 2019
BACKGROUND: Cytosolic 5'-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. Here, we investigate NT5C1A expression in pancreatic ductal adenocarcinoma...
Chemotherapeutic resistance Cytosolic 5′-nucleotidase 1A Gemcitabine pancreatic cancer 5'-Nucleotidase Animals Biomarkers Tumor Carcinoma Pancreatic Ductal Cell Line Tumor Deoxycytidine Disease Models Animal Drug Resistance Neoplasm Gene Expression Humans Mice Mice Transgenic Models Biological Pancreatic Neoplasms Prognosis Xenograft Model Antitumor Assays Gemcitabine
Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes
L Tao, ECF Wilson, NJ Wareham, A Sandbaek, GEHM Rutten, T Lauritzen, K Khunti, MJ Davies, K Borch-Johnsen, SJ Griffin, RK Simmons
Aug 11, 2014
Aged Cluster Analysis Cohort Studies Combined Modality Therapy Cost-Benefit Analysis Diabetes Complications Diabetes mellitus Type 2 Female Health Care Costs Humans Incidence Male Mass Screening Middle Aged Patient Education as Topic Patient-Centered Care Quality-Adjusted Life Years Risk Factors Time Factors United Kingdom
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
E Hessmann, MS Patzak, L Klein, N Chen, V Kari, I Ramu, TE Bapiro, KK Frese, A Gopinathan, FM Richards, DI Jodrell, C Verbeke, X Li, R Heuchel, JM Löhr, SA Johnsen, TM Gress, V Ellenrieder, A Neesse
Feb 15, 2017
Chemotherapy DRUG METABOLISM pancreatic cancer PANCREATIC FIBROSIS 5'-Nucleotidase Actins Animals Antimetabolites Antineoplastic Carcinoma Pancreatic Ductal Cell Line Tumor Cytidine Triphosphate Deoxycytidine FIBROBLASTS Floxuridine Humans Liver Liver Neoplasms Mice Pancreatic Neoplasms Primary Cell Culture Tumor Microenvironment Gemcitabine
On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer.
Tina Moser, Julie Waldispuehl-Geigl, Jelena Belic, Sabrina Weber, Qing Zhou, Samantha O Hasenleithner, Ricarda Graf, Jasmin Alia Terzic, Florian Posch, Heinz Sill, Sigurd Lax, Karl Kashofer, Gerald Hoefler, Helmut Schoellnast, Ellen Heitzer, Jochen B Geigl, Thomas Bauernhofer, Michael R Speicher
Nov 13, 2020
We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in patients with colorectal cancer during the 48-h application of...
Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets.
AM Umpleby, F Shojaee-Moradie, B Fielding, X Li, A Marino, N Alsini, C Isherwood, N Jackson, A Ahmad, M Stolinski, JA Lovegrove, S Johnsen, J Mendis, J Wright, ME Wilinska, R Hovorka, J Bell, LE Thomas, G Frost, BA Griffin
Feb 02, 2018
IDO1+ Paneth cells promote immune escape of colorectal cancer.
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
Jun 02, 2020
Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an...
IDO1 + Paneth cells promote immune escape of colorectal cancer
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P. Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
May 22, 2021
Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune...
IDO1 + Paneth cells promote immune escape of colorectal cancer
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P. Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
Feb 18, 2021
Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune...
Retrieving the paleoclimatic signal from the deeper part of the EPICA Dome C ice core
JL Tison, M De Angelis, G Littot, E Wolff, H Fischer, M Hansson, M Bigler, R Udisti, A Wegner, J Jouzel, B Stenni, S Johnsen, V Masson-Delmotte, A Landais, V Lipenkov, L Loulergue, JM Barnola, JR Petit, B Delmonte, G Dreyfus, D Dahl-Jensen, G Durand, B Bereiter, A Schilt, R Spahni, K Pol, R Lorrain, R Souchez, D Samyn
Sep 02, 2015
Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer.
Kirsten GM Aspros, Jodi M Carter, Tanya L Hoskin, Vera J Suman, Malayannan Subramaniam, Michael J Emch, Zhenqing Ye, Zhifu Sun, Jason P Sinnwell, Kevin J Thompson, Xiaojia Tang, Esther PB Rodman, Xiyin Wang, Adam W Nelson, Igor Chernukhin, Feda H Hamdan, Elizabeth S Bruinsma, Jason S Carroll, Martin E Fernandez-Zapico, Steven A Johnsen, Krishna R Kalari, Haojie Huang, Roberto A Leon-Ferre, Fergus J Couch, James N Ingle, Matthew P Goetz, John R Hawse
Mar 21, 2022
Triple Negative Breast Cancer (TNBC) accounts for 15-20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities. Thus, there is an urgent need to identify novel...
Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer.
Kirsten GM Aspros, Jodi M Carter, Tanya L Hoskin, Vera J Suman, Malayannan Subramaniam, Michael J Emch, Zhenqing Ye, Zhifu Sun, Jason P Sinnwell, Kevin J Thompson, Xiaojia Tang, Esther PB Rodman, Xiyin Wang, Adam W Nelson, Igor Chernukhin, Feda H Hamdan, Elizabeth S Bruinsma, Jason Carroll, Martin E Fernandez-Zapico, Steven A Johnsen, Krishna R Kalari, Haojie Huang, Roberto A Leon-Ferre, Fergus J Couch, James N Ingle, Matthew P Goetz, John R Hawse
Feb 17, 2022
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