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FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants.
Rhys Grinter, Iain D Hay, Jiangning Song, Jiawei Wang, Don Teng, Vijay Dhanesakaran, Jonathan J Wilksch, Mark R Davies, Dene Littler, Simone A Beckham, Ian R Henderson, Richard A Strugnell, Gordon Dougan, Trevor Lithgow
Nov 21, 2018
Iron is essential for life. Accessing iron from the environment can be a limiting factor that determines success in a given environmental niche. For bacteria, access of chelated iron from the environment is often mediated by...
Vegetarian Society President Discusses Making a Lifestyle Change on World Vegetarian Day
Winthrop University
Jan 01, 0001
World Vegetarian Day is Oct. 1. October is also Vegetarian Awareness Month. Simone Mayers decided to make a lifestyle change after taking an ecological psychology course at Winthrop.
Published by: Winthrop University
American Police Officers
Over the last several years, the killing of Blacks by white police officers in America has drawn a great deal of attention from many sectors in society. A number of cases involving police murder of Blacks have been captured on...
Published by: Department of History, University of Karachi
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease.
Gabriella T Heller, Francesco A Aprile, Thomas CT Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas PJ Knowles, Christopher M Dobson, Michele Vendruscolo
Dec 14, 2020
Disordered proteins are challenging therapeutic targets, and no drug is currently in clinical use that modifies the properties of their monomeric states. Here, we identify a small molecule (10074-G5) capable of binding and...
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide
Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy
Protein biosynthesis is a vital process for all kingdoms of life. The ribosome is the massive ribonucleoprotein machinery that reads the genetic code, in the form of messenger RNA (mRNA), to produce proteins. The mechanism of...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Tuning crystal morphology of succinic acid using a polymer additive
The effect of the triblock copolymer Pluronic P123 (PP123) on the growth of succinic acid crystals from aqueous solutions is reported at two batch process scales: 10 and 350 mL. The presence of small quantities of PP123 is shown...
Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy
Protein biosynthesis is a vital process for all kingdoms of life. The ribosome is the massive ribonucleoprotein machinery that reads the genetic code, in the form of messenger RNA (mRNA), to produce proteins. The mechanism of...
Cognitive Rehabilitation With Mobile Technology and Social Support for Veterans With TBI and PTSD
Eric B Elbogen, Paul A Dennis, Elizabeth E Van Voorhees, Shannon M Blakey, Jacqueline L Johnson, Sally C Johnson, H Ryan Wagner, Robert M Hamer, Jean C Beckham, Tom Manly, Aysenil Belger
Mar 22, 2019
OBJECTIVE: To investigate effects of cognitive rehabilitation with mobile technology and social support on veterans with traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD). PARTICIPANTS: There were 112 dyads...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
A high-throughput multi-microfluidic crystal generator (MMicroCryGen) platform for facile screening of polymorphism and crystal morphology for pharmaceutical compounds
In this work, a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, offering a facile methodology for generating individual crystals for fast and easy screening of the polymorphism and crystal...
Exploring parkrun as a social context for collective health practices
Critiques of public health policies to reduce physical inactivity have led to calls for practice-led research and the need to reduce the individualising effects of health promotion discourse. The purpose of this paper is to...
embodiment exercise/activity health behaviour lifestyles medicalisation population health /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2719 name=Health Policy /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Roll-your-own cigarettes in Europe
Excise duties on roll-your-own (RYO) tobacco, which are generally based on RYO cigarettes containing 1 g of tobacco, are lower than duties on factory-made (FM) cigarettes. This provides a price incentive for smokers to switch to...
Tuning crystal morphology of succinic acid using a polymer additive
The effect of the triblock copolymer Pluronic P123 (PP123) on the growth of succinic acid crystals from aqueous solutions is reported at two batch process scales: 10 and 350 mL. The presence of small quantities of PP123 is shown...
Ion Conduction Mechanism as a Fingerprint of Potassium Channels
K+-channels are membrane proteins that regulate the selective conduction of potassium ions across cell membranes. Although the atomic mechanisms of K+ permeation have been extensively investigated, previous work focused on...
Beauvoir's Wallowing Woman: A Modern Critique of Immanence and Bad Faith in The Second Sex
Haley Zorger
Jan 01, 0001
The present paper investigates the concept of immanence in Simone de Beauvoir's The Second Sex, through a modern lens, specifically in her critique of the housewife and mother. Also utilizing Sartre's concepts of bad faith and...
feminism simone de beauvoir immanence transcendence bad faith Arts and Humanities Feminist, Gender, and Sexuality Studies Philosophy Women's Studies
Published by: Ursinus College
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Digital Gaming for Cross-Cultural Learning
Although game-based learning has gained significant attention in higher education globally, it is difficult to harness its engagement and interactions to improve student success. This paper argues that the use of digital games...
Published by: IGI Global Scientific Publishing
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
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