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Results: 1483
Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid.
Kathryn E Holt, Minh Duy Phan, Stephen Baker, Pham Thanh Duy, Tran Vu Thieu Nga, Satheesh Nair, A Keith Turner, Ciara Walsh, Séamus Fanning, Sinéad Farrell-Ward, Shanta Dutta, Sam Kariuki, François-Xavier Weill, Julian Parkhill, Gordon Dougan, John Wain
Sep 06, 2019
Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a serious global health concern. Since their emergence in the mid-1970s multi-drug resistant (MDR) S. Typhi now dominate drug sensitive equivalents...
Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype
Damir Varešlija, Elspeth Ward, Siobhan P. Purcell, Nicola S. Cosgrove, Sinéad Cocchiglia, Philip J. O’Halloran, Sara Charmsaz, Fiona T. Bane, Francesca M. Brett, Michael Farrell, Jane Cryan, Alan Beausang, Lance Hudson, Arran K. Turnbul, J. Michael Dixon, Arnold D. K. Hill, Nolan Priedigkeit, Steffi Oesterreich, Adrian V. Lee, Andrew H. Sims, Aisling M. Redmond, Jason S. Carroll, Leonie S. Young
Feb 18, 2021
The innovation game
Purpose: This paper seeks to present a teaching tool (the Innovation Game) which aims to demonstrate the challenges of developing an effective innovation strategy in the context of new product development. The goal of the game...
Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.
Damir Varešlija, Elspeth Ward, Siobhan P Purcell, Nicola S Cosgrove, Sinéad Cocchiglia, Philip J O'Halloran, Sara Charmsaz, Fiona T Bane, Francesca M Brett, Michael Farrell, Jane Cryan, Alan Beausang, Lance Hudson, Arran K Turnbul, J Michael Dixon, Arnold DK Hill, Nolan Priedigkeit, Steffi Oesterreich, Adrian V Lee, Andrew H Sims, Aisling M Redmond, Jason S Carroll, Leonie S Young
Jan 14, 2021
Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression. In primary breast cancer, the coactivator AIB1 promotes estrogen...
Humans Breast Neoplasms Neoplasm Metastasis Tamoxifen Histone Deacetylases Cadherins Estrogen Receptor alpha Repressor Proteins Antigens CD Prognosis Disease-Free Survival Cell Proliferation Gene Expression Regulation Neoplastic Phenotype Female Nuclear Receptor Coactivator 3 Epithelial-Mesenchymal Transition MCF-7 Cells
Excited and exotic bottomonium spectroscopy from lattice QCD
Abstract: We explore the spectrum of excited and exotic bottomonia using lattice QCD. Highly excited states are identified with masses up to 11,000 MeV, many of which can be grouped into supermultiplets matching those of the...
StephenWaddams, Sanctity of Contracts in a Secular Age: Equity, Fairness and Enrichment, Cambridge
Sinéad Agnew
Oct 29, 2021
This book reinvigorates the debate about the place of substantive fairness in contract law. Its central argument is that it is time we recognised a general judicial power to relieve against highly unreasonable contracts. The...
The innovation game
Purpose: This paper seeks to present a teaching tool (the Innovation Game) which aims to demonstrate the challenges of developing an effective innovation strategy in the context of new product development. The goal of the game...
The associations among personality, alcohol-related Protective Behavioural Strategies (PBS), alcohol consumption and sexual intercourse in Irish, female college students.
INTRODUCTION: The study presented one of the first examinations of the associations among personality, alcohol-related protective behavioural strategies (PBS), alcohol consumption, sexual intercourse and sex-related alcohol...
Lorentz- and permutation-invariants of particles
Abstract: Two theorems of Weyl tell us that the algebra of Lorentz- (and parity-) invariant polynomials in the momenta of n particles are generated by the dot products and that the redundancies which arise when n exceeds the...
Lorentz- and permutation-invariants of particles
Abstract: Two theorems of Weyl tell us that the algebra of Lorentz- (and parity-) invariant polynomials in the momenta of n particles are generated by the dot products and that the redundancies which arise when n exceeds the...
Piloting a ‘Timeline of Crisis Tool’ with service users on admission to an acute psychiatric ward
Objective: Being admitted to a psychiatric ward can be a distressing and confusing experience. Our objective was to develop and pilot a Timeline Tool as a way of supporting service users in developing a narrative of their...
Piloting a ‘Timeline of Crisis Tool’ with service users on admission to an acute psychiatric ward
Objective: Being admitted to a psychiatric ward can be a distressing and confusing experience. Our objective was to develop and pilot a Timeline Tool as a way of supporting service users in developing a narrative of their...
Birth "Out-of-Hours"
Hannah E Knight, Jan H van der Meulen, Ipek Gurol-Urganci, Gordon C Smith, Amit Kiran, Steve Thornton, David Richmond, Alan Cameron, David A Cromwell
Apr 07, 2016
BACKGROUND: Concerns have been raised that a lack of senior obstetricians ("consultants") on the labour ward outside normal hours may lead to worse outcomes among babies born during periods of reduced cover. METHODS AND...
Adult After-Hours Care Apgar Score Cesarean Section Chi-Square Distribution Clinical Competence consultants Delivery of Health Care delivery Obstetric EXTRACTION Obstetrical Female Health Care Surveys Humans Labor Obstetric Live Birth Logistic Models Multivariate Analysis Obstetric Labor Complications Odds Ratio Personnel Staffing and Scheduling Pregnancy Process Assessment Health Care Risk Factors Time Factors United Kingdom
Redefining shelter
Shelter is one of the most 'intractable problems' in humanitarian aid and yet there is little clarity on an overarching definition. Terminology for shelter and housing is often conflated, and the most prominent definition does...
adequate shelter definition of shelter Displacement emergency shelter enabled process humanitarian aid Internally displaced persons non-governmental organisation post conflict post disaster refugee self-recovery Settlements Shelter sheltering temporary housing transitional settlement transitional shelter Humans Relief Work housing
Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer.
Alacoque L Browne, Sara Charmsaz, Damir Varešlija, Ailis Fagan, Nicola Cosgrove, Sinéad Cocchiglia, Siobhan Purcell, Elspeth Ward, Fiona Bane, Lance Hudson, Arnold D Hill, Jason S Carroll, Aisling M Redmond, Leonie S Young
Feb 22, 2019
Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes which enable the cancer cell to evade therapy and...
Animals Antineoplastic Agents Hormonal Breast Neoplasms Chromatin Assembly and Disassembly Drug Resistance Neoplasm Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Humans MCF-7 Cells Mice Mice Inbred NOD Mice SCID Microarray Analysis Nuclear Receptor Coactivator 1 Transcriptional Activation Transcriptome Tumor Cells Cultured
Excited and exotic bottomonium spectroscopy from lattice QCD
Abstract: We explore the spectrum of excited and exotic bottomonia using lattice QCD. Highly excited states are identified with masses up to 11,000 MeV, many of which can be grouped into supermultiplets matching those of the...
Excited and exotic bottomonium spectroscopy from lattice QCD
Abstract
We explore the spectrum of excited and exotic bottomonia using lattice QCD. Highly excited states are identified with masses up to 11,000 MeV...
Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas.
Epigenetic modifications, such as DNA methylation or histone modifications, can be transmitted between cellular or organismal generations. However, there are no experiments measuring their role in adaptation, so here we use...
Chlamydomonas adaptive walk Carbon Dioxide epigenetic mutation experimental evolution Methylation phosphate starvation salt tolerance Adaptation Biological Adaptation Physiological Chlamydomonas Chlamydomonas reinhardtii DNA Methylation Directed Molecular Evolution Environment Epigenesis Genetic Epigenomics genetic variation Mutation Salt Tolerance
Sharing a written medical summary with patients on the post‐admission ward round
Anna L. Crucefix, Aaron P. L. Fleming, Caroline S. Lebus, Anne‐Marie Slowther, Zoë Fritz
May 07, 2021
Abstract: Rationale, Aims and Objectives: Sharing aspects of the traditional medical record with patients has been successful in primary and antenatal care, but has not been investigated in the UK inpatient setting. Our aim was...
Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability
Elise Ng-Cordell, Anna Kolesnik-Taylor, Sinéad O'Brien, Duncan Astle, Gaia Scerif, Kate Baker
Jun 09, 2022
DDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23...
Sharing a written medical summary with patients on the post-admission ward round
RATIONALE, AIMS AND OBJECTIVES: Sharing aspects of the traditional medical record with patients has been successful in primary and antenatal care, but has not been investigated in the UK inpatient setting. Our aim was to...
Gene functional networks and autism spectrum characteristics in young people with intellectual disability
BACKGROUND: The relationships between specific genetic aetiology and phenotype in neurodevelopmental disorders are complex and hotly contested. Genes associated with intellectual disability (ID) can be grouped into networks...
Predisposing and Precipitating Risk Factors for Delirium in Elderly Patients Admitted to a Cardiology Ward
Carl Moritz Zipser, Florian Freimut Hildenbrand, Bernhard Haubner, Jeremy Deuel, Jutta Ernst, Heidi Petry, Maria Schubert, Katja-Daniela Jordan, Roland Von Känel, Soenke Boettger
Oct 13, 2021
Aim: Although the risk factors for delirium in general medicine are well-established, their significance in cardiac diseases remains to be determined. Therefore, we evaluated the predisposing and precipitating risk factors in...
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