Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Kyle J Gaulton,
Teresa Ferreira,
Yeji Lee,
Anne Raimondo,
Reedik Mägi,
Michael E Reschen,
Anubha Mahajan,
Adam Locke,
N William Rayner,
Neil Robertson,
Robert A Scott,
Inga Prokopenko,
Laura J Scott,
Todd Green,
Thomas Sparso,
Dorothee Thuillier,
Loic Yengo,
Harald Grallert,
Simone Wahl,
Mattias Frånberg,
Rona J Strawbridge,
Hans Kestler,
Himanshu Chheda,
Lewin Eisele,
Stefan Gustafsson,
Valgerdur Steinthorsdottir,
Gudmar Thorleifsson,
Lu Qi,
Lennart C Karssen,
Elisabeth M van Leeuwen,
Sara M Willems,
Man Li,
Han Chen,
Christian Fuchsberger,
Phoenix Kwan,
Clement Ma,
Michael Linderman,
Yingchang Lu,
Soren K Thomsen,
Jana K Rundle,
Nicola L Beer,
Martijn van de Bunt,
Anil Chalisey,
Hyun Min Kang,
Benjamin F Voight,
Gonçalo R Abecasis,
Peter Almgren,
Damiano Baldassarre,
Beverley Balkau,
Rafn Benediktsson,
Matthias Blüher,
Heiner Boeing,
Lori L Bonnycastle,
Erwin P Bottinger,
Noël P Burtt,
Jason Carey,
Guillaume Charpentier,
Peter S Chines,
Marilyn C Cornelis,
David J Couper,
Andrew T Crenshaw,
Rob M van Dam,
Alex SF Doney,
Mozhgan Dorkhan,
Sarah Edkins,
Johan G Eriksson,
Tonu Esko,
Elodie Eury,
João Fadista,
Jason Flannick,
Pierre Fontanillas,
Caroline Fox,
Paul W Franks,
Karl Gertow,
Christian Gieger,
Bruna Gigante,
Omri Gottesman,
George B Grant,
Niels Grarup,
Christopher J Groves,
Maija Hassinen,
Christian T Have,
Christian Herder,
Oddgeir L Holmen,
Astradur B Hreidarsson,
Steve E Humphries,
David J Hunter,
Anne U Jackson,
Anna Jonsson,
Marit E Jørgensen,
Torben Jørgensen,
Wen-Hong L Kao,
Nicola D Kerrison,
Leena Kinnunen,
Norman Klopp,
Augustine Kong,
Peter Kovacs,
Peter Kraft,
Jasmina Kravic,
Cordelia Langford,
Karin Leander,
Liming Liang,
Peter Lichtner,
Cecilia M Lindgren,
Eero Lindholm,
Allan Linneberg,
Ching-Ti Liu,
Stéphane Lobbens,
Jian'an Luan,
Valeriya Lyssenko,
Satu Männistö,
Olga McLeod,
Julia Meyer,
Evelin Mihailov,
Ghazala Mirza,
Thomas W Mühleisen,
Martina Müller-Nurasyid,
Carmen Navarro,
Markus M Nöthen,
Nikolay N Oskolkov,
Katharine R Owen,
Domenico Palli,
Sonali Pechlivanis,
Leena Peltonen,
John RB Perry,
Carl GP Platou,
Michael Roden,
Douglas Ruderfer,
Denis Rybin,
Yvonne T van der Schouw,
Bengt Sennblad,
Gunnar Sigurðsson,
Alena Stančáková,
Gerald Steinbach,
Petter Storm,
Konstantin Strauch,
Heather M Stringham,
Qi Sun,
Barbara Thorand,
Emmi Tikkanen,
Anke Tonjes,
Joseph Trakalo,
Elena Tremoli,
Tiinamaija Tuomi,
Roman Wennauer,
Steven Wiltshire,
Andrew R Wood,
Eleftheria Zeggini,
Ian Dunham,
Ewan Birney,
Lorenzo Pasquali,
Jorge Ferrer,
Ruth JF Loos,
Josée Dupuis,
Jose C Florez,
Eric Boerwinkle,
James S Pankow,
Cornelia van Duijn,
Eric Sijbrands,
James B Meigs,
Frank B Hu,
Unnur Thorsteinsdottir,
Kari Stefansson,
Timo A Lakka,
Rainer Rauramaa,
Michael Stumvoll,
Nancy L Pedersen,
Lars Lind,
Sirkka M Keinanen-Kiukaanniemi,
Eeva Korpi-Hyövälti,
Timo E Saaristo,
Juha Saltevo,
Johanna Kuusisto,
Markku Laakso,
Andres Metspalu,
Raimund Erbel,
Karl-Heinz Jöcke,
Susanne Moebus,
Samuli Ripatti,
Veikko Salomaa,
Erik Ingelsson,
Bernhard O Boehm,
Richard N Bergman,
Francis S Collins,
Karen L Mohlke,
Heikki Koistinen,
Jaakko Tuomilehto,
Kristian Hveem,
Inger Njølstad,
Panagiotis Deloukas,
Peter J Donnelly,
Timothy M Frayling,
Andrew T Hattersley,
Ulf de Faire,
Anders Hamsten,
Thomas Illig,
Annette Peters,
Stephane Cauchi,
Rob Sladek,
Philippe Froguel,
Torben Hansen,
Oluf Pedersen,
Andrew D Morris,
Collin NA Palmer,
Sekar Kathiresan,
Olle Melander,
Peter M Nilsson,
Leif C Groop,
Inês Barroso,
Claudia Langenberg,
Nicholas J Wareham,
Christopher A O'Callaghan,
Anna L Gloyn,
David Altshuler,
Michael Boehnke,
Tanya M Teslovich,
Mark I McCarthy,
Andrew P Morris,
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Jan 23, 2018
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near...