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Results: 26
Pharmacogenomic alerts
John-Paul L Carter, James Critchlow, Sarah Jackson, Sonali Sanghvi, Helene Feger, Afzal Chaudhry, Lorraine Foley, Reecha Sofat
Feb 14, 2022
Stigma towards dependent drinking and its role on caregiving burden
Introduction: Stigma towards alcohol use disorders is prevalent in India and can lead to social exclusion and hamper treatment access and outcomes. Family members of individuals with dependent drinking are often their primary...
Alcohol use disorder caregiver burden discrimination india stigma /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities name=SDG 10 - Reduced Inequalities
Design of a Parallel and Scalable Crawler for the Hidden Web
The WWW contains huge amount of information from different areas. This information may be present virtually in the form of web pages, media, articles (research journals / magazine), blogs etc. A major portion of the information...
Published by: IGI Global Scientific Publishing
‘He was trapped in his own web’—Dependent drinking as a poverty trap
Introduction and Aims: Of the Indian population, 2.7% have alcohol dependence, the most severe of alcohol use disorders. Alcohol use disorders have previously been found to be correlated with a range of negative economic...
alcohol dependence Alcohol use disorder poverty trap Qualitative /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Stigma towards dependent drinking and its role on caregiving burden
Introduction: Stigma towards alcohol use disorders is prevalent in India and can lead to social exclusion and hamper treatment access and outcomes. Family members of individuals with dependent drinking are often their primary...
Alcohol use disorder caregiver burden discrimination india stigma /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities name=SDG 10 - Reduced Inequalities
‘He was trapped in his own web’—Dependent drinking as a poverty trap
Introduction and Aims: Of the Indian population, 2.7% have alcohol dependence, the most severe of alcohol use disorders. Alcohol use disorders have previously been found to be correlated with a range of negative economic...
alcohol dependence Alcohol use disorder poverty trap Qualitative /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Iatrogenic antibody deficiency from B-cell targeted therapies in autoimmune rheumatic diseases.
B-cell targeted therapies (BCTT) are now widely used in autoimmune rheumatic diseases, including SLE, antineutrophil cytoplasmic antibody-associated vasculitis and rheumatoid arthritis. Early studies suggested that rituximab did...
An Analysis on Consumer Preference of Ayurvedic Products in Indian Market
With the growing awareness of lifestyle diseases and risk related to chemical-based products, there has been an increasing interest in green/natural products. The purpose of this study is to analyze the recent surge in the...
Published by: IGI Global Scientific Publishing
Auditing the AUDIT
Abhijit Nadkarni, Alison Garber, Sheina Costa, Sheena Wood, Sonali Kumar, Nathalie MacKinnon, Mariam Ibrahim, Richard Velleman, Urvita Bhatia, Godwin Fernandes, Benedict Weobong, Anil Rane
Sep 01, 2019
Introduction: The World Health Organization's (WHO) Alcohol Use Disorders Identification Test (AUDIT) is used extensively across the world, with cut-off scores recommended by the WHO. We reviewed the use and validity of AUDIT...
Alcohol use disorders Alcohol Use Disorders Identification Test (AUDIT) low- and middle-income countries Psychometrics Systematic review /dk/atira/pure/subjectarea/asjc/3000/3005 name=Toxicology /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2700/2736 name=Pharmacology (medical) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Association of preeclampsia with anthropometric measures and blood pressure in Indian children.
Karuna Randhir, Hemlata Pisal, Vrushali Kadam, Amrita Khaire-Ghadge, Nandini Malshe, Ruma Deshpande, Sonali Palkar, Sanjay Lalwani, Kalyanaraman Kumaran, Chittaranjan Yajnik, Clive Osmond, Caroline Fall, Sadhana Joshi
May 05, 2020
BACKGROUND AND OBJECTIVE: Birth weight and post-natal growth are important predictors of adult health. Preeclampsia (PE) is associated with low birth weight and may have long term effects on the health of the children. The...
Prospective association between handgrip strength and cardiac structure and function in UK adults.
Sebastian E Beyer, Mihir M Sanghvi, Nay Aung, Alice Hosking, Jackie A Cooper, José Miguel Paiva, Aaron M Lee, Kenneth Fung, Elena Lukaschuk, Valentina Carapella, Murray A Mittleman, Soren Brage, Stefan K Piechnik, Stefan Neubauer, Steffen E Petersen
Jul 20, 2018
BACKGROUND: Handgrip strength, a measure of muscular fitness, is associated with cardiovascular (CV) events and CV mortality but its association with cardiac structure and function is unknown. The goal of this study was to...
Auditing the AUDIT
Abhijit Nadkarni, Alison Garber, Sheina Costa, Sheena Wood, Sonali Kumar, Nathalie MacKinnon, Mariam Ibrahim, Richard Velleman, Urvita Bhatia, Godwin Fernandes, Benedict Weobong, Anil Rane
Sep 01, 2019
Introduction: The World Health Organization's (WHO) Alcohol Use Disorders Identification Test (AUDIT) is used extensively across the world, with cut-off scores recommended by the WHO. We reviewed the use and validity of AUDIT...
Alcohol use disorders Alcohol Use Disorders Identification Test (AUDIT) low- and middle-income countries Psychometrics Systematic review /dk/atira/pure/subjectarea/asjc/3000/3005 name=Toxicology /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2700/2736 name=Pharmacology (medical) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Cyber Security Solutions for Businesses in Financial Services
This paper examines the challenges that small, medium, and large businesses in the financial services industry are facing concerning data security and providing relevant tools and strategies to protect the same. A qualitative...
Published by: IGI Global Scientific Publishing
Inherent mosaicism and extensive mutation of human placentas.
Tim HH Coorens, Thomas RW Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D Young, Raheleh Rahbari, Neil Sebire, Peter J Campbell, D Stephen Charnock-Jones, Gordon CS Smith, Sam Behjati
Feb 24, 2021
Genetic and chemotherapeutic influences on germline hypermutation.
Joanna Kaplanis, Benjamin Ide, Rashesh Sanghvi, Matthew Neville, Petr Danecek, Tim Coorens, Elena Prigmore, Patrick Short, Giuseppe Gallone, Jeremy McRae, Genomics England Research Consortium, Jenny Carmichael, Angela Barnicoat, Helen Firth, Patrick O'Brien, Raheleh Rahbari, Matthew Hurles
May 18, 2022
Mutations in the germline generates all evolutionary genetic variation and is a cause of genetic disease. Parental age is the primary determinant of the number of new germline mutations in an individual's genome1,2. Here we...
Genetic and chemotherapeutic influences on germline hypermutation.
Joanna Kaplanis, Benjamin Ide, Rashesh Sanghvi, Matthew Neville, Petr Danecek, Tim Coorens, Elena Prigmore, Patrick Short, Giuseppe Gallone, Jeremy McRae, Genomics England Research Consortium, Jenny Carmichael, Angela Barnicoat, Helen Firth, Patrick O'Brien, Raheleh Rahbari, Matthew Hurles
Jun 11, 2022
Malware Threat Affecting Financial Organization Analysis Using Machine Learning Approach
Romil Rawat, Yagya Rimal, P. William, Snehil Dahima, Sonali Gupta, K. Sankaran, Sanjaya Sarangi
Jan 01, 2022
Since 2014, Emotet has been using man-in-the-browsers (MITB) attacks to target companies in the finance industry and their clients. Its key aim is to steal victims' online money-lending records and vital credentials as they go...
Published by: IGI Global Scientific Publishing
Recommendations for the management of secondary hypogammaglobulinaemia due to B cell targeted therapies in autoimmune rheumatic diseases.
Sonali Wijetilleka, David R Jayne, Chetan Mukhtyar, Aftab Ala, Philip D Bright, Hector Chinoy, Lorraine Harper, Majid A Kazmi, Sorena Kiani-Alikhan, Charles K Li, Siraj A Misbah, Louise Oni, Fiona E Price-Kuehne, Alan D Salama, Sarita Workman, David Wrench, Mohammed Yousuf Karim
Nov 27, 2019
OBJECTIVES: The association of B cell targeted therapies with development of hypogammaglobulinaemia and infection is increasingly recognized. Our aim was to develop consensus recommendations for immunoglobulin replacement...
Clonal diversification and histogenesis of malignant germ cell tumours
Thomas RW Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C Dentro, Matthew D Young, Tim HH Coorens, Hyunchul Jung, Tim Butler, Matthew DC Neville, Daniel Leongamornlert, Mathijs A Sanders, Yvette Hooks, Alex Cagan, Thomas J Mitchell, Isidro Cortes-Ciriano, Anne Y Warren, David C Wedge, Rakesh Heer, Nicholas Coleman, Matthew J Murray, Peter J Campbell, Raheleh Rahbari, Sam Behjati
Aug 11, 2022
article /631/67/1679 /631/114/739 /631/1647/514 /631/67/69 /631/67/2329 /45/23 /45/91 /45/70 /13/51 /14/63 article
Published by: Nature Publishing Group UK
Immunoglobulin replacement for secondary immunodeficiency after B-cell targeted therapies in autoimmune rheumatic disease
Sonali Wijetilleka, Chetan Mukhtyar, David Jayne, Aftab Ala, Philip Bright, Hector Chinoy, Lorraine Harper, Majid Kazmi, Sorena Kiani-Alikhan, Charles Li, Siraj Misbah, Louise Oni, Fiona Price-Kuehne, Alan Salama, Sarita Workman, David Wrench, Mohammed Yousuf Karim
Feb 24, 2020
BACKGROUND: Consensus guidelines are not available for the use of immunoglobulin replacement therapy (IGRT) in patients developing iatrogenic secondary antibody deficiency following B-cell targeted therapy (BCTT) in autoimmune...
A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.
Tatsuya Ozawa, Sonali Arora, Frank Szulzewsky, Gordana Juric-Sekhar, Yoshiteru Miyajima, Hamid Bolouri, Yoshie Yasui, Jason Barber, Robert Kupp, James Dalton, Terreia S Jones, Mitsutoshi Nakada, Toshihiro Kumabe, David W Ellison, Richard J Gilbertson, Eric C Holland
Sep 21, 2018
The majority of supratentorial ependymomas (ST-ependymomas) have few mutations but frequently display chromothripsis of chromosome 11q that generates a fusion between C11orf95 and RELA (RELAFUS). Neural stem cells transduced...
Clonal diversification and histogenesis of malignant germ cell tumours.
Thomas RW Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C Dentro, Matthew D Young, Tim HH Coorens, Hyunchul Jung, Tim Butler, Matthew DC Neville, Daniel Leongamornlert, Mathijs A Sanders, Yvette Hooks, Alex Cagan, Thomas J Mitchell, Isidro Cortes-Ciriano, Anne Y Warren, David C Wedge, Rakesh Heer, Nicholas Coleman, Matthew J Murray, Peter J Campbell, Raheleh Rahbari, Sam Behjati
Sep 11, 2022
Impact on birth weight and child growth of Participatory Learning and Action women's groups with and without transfers of food or cash during pregnancy
Naomi M Saville, Bhim P Shrestha, Sarah Style, Helen Harris-Fry, B James Beard, Aman Sen, Sonali Jha, Anjana Rai, Vikas Paudel, Raghbendra Sah, Puskar Paudel, Andrew Copas, Bishnu Bhandari, Rishi Neupane, Joanna Morrison, Lu Gram, Anni-Maria Pulkki-Brännström, Jolene Skordis-Worrall, Machhindra Basnet, Saskia de Pee, Andrew Hall, Jayne Harthan, Meelan Thondoo, Sonja Klingberg, Janice Messick, Dharma S Manandhar, David Osrin, Anthony Costello
Jul 24, 2019
BACKGROUND: Undernutrition during pregnancy leads to low birthweight, poor growth and inter-generational undernutrition. We did a non-blinded cluster-randomised controlled trial in the plains districts of Dhanusha and Mahottari...
Visual hallucinations in neurological and ophthalmological disease
John O'Brien, John Paul Taylor, Clive Ballard, Roger A Barker, Clare Bradley, Alistair Burns, Daniel Collerton, Sonali Dave, Rob Dudley, Paul Francis, Andrea Gibbons, Kate Harris, Vanessa Lawrence, Iracema Leroi, Ian McKeith, Michel Michaelides, Chaitali Naik, Claire O'Callaghan, Kirsty Olsen, Marco Onofrj, Rebecca Pinto, Gregor Russell, Peter Swann, Alan Thomas, Prabitha Urwyler, Rimona Sharon Weil, Dominic Ffytche
Feb 24, 2020
Visual hallucinations are common in older people and are especially associated with ophthalmological and neurological disorders, including dementia and Parkinson's disease. Uncertainties remain whether there is a single...
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, Michael E Reschen, Anubha Mahajan, Adam Locke, N William Rayner, Neil Robertson, Robert A Scott, Inga Prokopenko, Laura J Scott, Todd Green, Thomas Sparso, Dorothee Thuillier, Loic Yengo, Harald Grallert, Simone Wahl, Mattias Frånberg, Rona J Strawbridge, Hans Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Lu Qi, Lennart C Karssen, Elisabeth M van Leeuwen, Sara M Willems, Man Li, Han Chen, Christian Fuchsberger, Phoenix Kwan, Clement Ma, Michael Linderman, Yingchang Lu, Soren K Thomsen, Jana K Rundle, Nicola L Beer, Martijn van de Bunt, Anil Chalisey, Hyun Min Kang, Benjamin F Voight, Gonçalo R Abecasis, Peter Almgren, Damiano Baldassarre, Beverley Balkau, Rafn Benediktsson, Matthias Blüher, Heiner Boeing, Lori L Bonnycastle, Erwin P Bottinger, Noël P Burtt, Jason Carey, Guillaume Charpentier, Peter S Chines, Marilyn C Cornelis, David J Couper, Andrew T Crenshaw, Rob M van Dam, Alex SF Doney, Mozhgan Dorkhan, Sarah Edkins, Johan G Eriksson, Tonu Esko, Elodie Eury, João Fadista, Jason Flannick, Pierre Fontanillas, Caroline Fox, Paul W Franks, Karl Gertow, Christian Gieger, Bruna Gigante, Omri Gottesman, George B Grant, Niels Grarup, Christopher J Groves, Maija Hassinen, Christian T Have, Christian Herder, Oddgeir L Holmen, Astradur B Hreidarsson, Steve E Humphries, David J Hunter, Anne U Jackson, Anna Jonsson, Marit E Jørgensen, Torben Jørgensen, Wen-Hong L Kao, Nicola D Kerrison, Leena Kinnunen, Norman Klopp, Augustine Kong, Peter Kovacs, Peter Kraft, Jasmina Kravic, Cordelia Langford, Karin Leander, Liming Liang, Peter Lichtner, Cecilia M Lindgren, Eero Lindholm, Allan Linneberg, Ching-Ti Liu, Stéphane Lobbens, Jian'an Luan, Valeriya Lyssenko, Satu Männistö, Olga McLeod, Julia Meyer, Evelin Mihailov, Ghazala Mirza, Thomas W Mühleisen, Martina Müller-Nurasyid, Carmen Navarro, Markus M Nöthen, Nikolay N Oskolkov, Katharine R Owen, Domenico Palli, Sonali Pechlivanis, Leena Peltonen, John RB Perry, Carl GP Platou, Michael Roden, Douglas Ruderfer, Denis Rybin, Yvonne T van der Schouw, Bengt Sennblad, Gunnar Sigurðsson, Alena Stančáková, Gerald Steinbach, Petter Storm, Konstantin Strauch, Heather M Stringham, Qi Sun, Barbara Thorand, Emmi Tikkanen, Anke Tonjes, Joseph Trakalo, Elena Tremoli, Tiinamaija Tuomi, Roman Wennauer, Steven Wiltshire, Andrew R Wood, Eleftheria Zeggini, Ian Dunham, Ewan Birney, Lorenzo Pasquali, Jorge Ferrer, Ruth JF Loos, Josée Dupuis, Jose C Florez, Eric Boerwinkle, James S Pankow, Cornelia van Duijn, Eric Sijbrands, James B Meigs, Frank B Hu, Unnur Thorsteinsdottir, Kari Stefansson, Timo A Lakka, Rainer Rauramaa, Michael Stumvoll, Nancy L Pedersen, Lars Lind, Sirkka M Keinanen-Kiukaanniemi, Eeva Korpi-Hyövälti, Timo E Saaristo, Juha Saltevo, Johanna Kuusisto, Markku Laakso, Andres Metspalu, Raimund Erbel, Karl-Heinz Jöcke, Susanne Moebus, Samuli Ripatti, Veikko Salomaa, Erik Ingelsson, Bernhard O Boehm, Richard N Bergman, Francis S Collins, Karen L Mohlke, Heikki Koistinen, Jaakko Tuomilehto, Kristian Hveem, Inger Njølstad, Panagiotis Deloukas, Peter J Donnelly, Timothy M Frayling, Andrew T Hattersley, Ulf de Faire, Anders Hamsten, Thomas Illig, Annette Peters, Stephane Cauchi, Rob Sladek, Philippe Froguel, Torben Hansen, Oluf Pedersen, Andrew D Morris, Collin NA Palmer, Sekar Kathiresan, Olle Melander, Peter M Nilsson, Leif C Groop, Inês Barroso, Claudia Langenberg, Nicholas J Wareham, Christopher A O'Callaghan, Anna L Gloyn, David Altshuler, Michael Boehnke, Tanya M Teslovich, Mark I McCarthy, Andrew P Morris, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Jan 23, 2018
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near...
Binding Sites Case-Control Studies Chromatin Immunoprecipitation Chromosome Mapping Diabetes mellitus Type 2 Gene Expression Regulation Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genomics Hepatocyte Nuclear Factor 3-beta Humans Islets of Langerhans Liver Molecular Sequence Annotation Polymorphism Single Nucleotide Receptor Melatonin MT2
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