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Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.
Soon Seng Ng, Kourosh Saeb-Parsy, Samuel JI Blackford, Joe M Segal, Maria Paola Serra, Marta Horcas-Lopez, Da Yoon No, Sotiris Mastoridis, Wayel Jassem, Curtis W Frank, Nam Joon Cho, Hiromitsu Nakauchi, Jeffrey S Glenn, S Tamir Rashid
Dec 17, 2018
Generation of human organoids from induced pluripotent stem cells (iPSCs) offers exciting possibilities for developmental biology, disease modelling and cell therapy. Significant advances towards those goals have been hampered...
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications.
John Ong, Maria Paola Serra, Joe Segal, Ana-Maria Cujba, Soon Seng Ng, Richard Butler, Val Millar, Stephanie Hatch, Salman Zimri, Hiroyuki Koike, Karen Chan, Andrew Bonham, Michelle Walk, Ty Voss, Nigel Heaton, Ragai Mitry, Anil Dhawan, Daniel Ebner, Davide Danovi, Hiromitsu Nakauchi, S Tamir Rashid
Mar 17, 2020
Use of hepatocytes derived from induced pluripotent stem cells (i-Heps) is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in bridging this gap....
Mode-localized accelerometer in the nonlinear Duffing regime with 75 ng bias instability and 95 ng/√Hz noise floor.
Hemin Zhang, Milind Pandit, Guillermo Sobreviela, Madan Parajuli, Dongyang Chen, Jiangkun Sun, Chun Zhao, Ashwin A Seshia
Mar 21, 2022
Mode-localized sensors have attracted attention because of their high parametric sensitivity and first-order common-mode rejection to temperature drift. The high-fidelity detection of resonator amplitude is critical to...
Structure of the Chicken Neuron-Glia Cell Adhesion Molecule, Ng-CAM: Origin of the Polypeptides and Relation to the Ig Superfamily
Mark P Burgoon
Jan 01, 0001
The neuron-glia cell adhesion molecule, Ng-CAM, is a cell-surface glycoprotein expressed on neurons and Schwann cells in the chicken nervous system. It is expressed as a group of related components of -200 kD, 135 kD, and 80 kD...
Published by: Rockefeller University
Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein.
Lidia Ruiz-Llorente, M Cristina Vega, Francisco J Fernández, Carmen Langa, Nicholas Morrell, Paul Upton, Carmelo Bernabeu
Oct 20, 2021
Endoglin (Eng, CD105) is a type I membrane glycoprotein that functions in endothelial cells as an auxiliary receptor for transforming growth factor β (TGF-β)/bone morphogenetic protein (BMP) family members and as an integrin...
Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis.
Nicola E Owen, Graeme J Alexander, Sambit Sen, Katherine Bunclark, Gary Polwarth, Joanna Pepke-Zaba, Anthony P Davenport, Nicholas W Morrell, Paul D Upton
May 07, 2020
BACKGROUND: BMP9, originating from the liver, and BMP10 are circulating BMPs that preserve vascular endothelial integrity. We assessed BMP9, BMP10 and soluble endoglin (sEng) levels and their relationships to liver disease...
BMP10 Bone morphogenetic protein 9 cirrhosis ELISA Endoglin Adult Aged Animals Biopsy Bone Morphogenetic Proteins Case-Control Studies Cell Line Disease Models Animal Down-Regulation Endoglin Female Growth Differentiation Factor 2 Hepatopulmonary Syndrome Humans Hypertension Pulmonary Liver Cirrhosis Male Mice Mice Knockout Middle Aged Severity of Illness Index Young Adult
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.
Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J Hodson, Ming Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Oct 22, 2021
DDX3X mutation Drug Resistance Hematolymphoid malignancy Prognosis Tumour metastasis Antineoplastic Agents Biomarkers Tumor Cell Line Tumor Cyclin D1 DEAD-box RNA Helicases Disease Progression Drug Resistance Neoplasm Humans Lymphoma Large B-Cell Diffuse Lymphoma Non-Hodgkin Mitogen-Activated Protein Kinases Mutation Prognosis STAT3 Transcription Factor Exome Sequencing
Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein.
Lidia Ruiz-Llorente, M Cristina Vega, Francisco J Fernández, Carmen Langa, Nicholas W Morrell, Paul D Upton, Carmelo Bernabeu
Jan 05, 2022
Endoglin (Eng, CD105) is a type I membrane glycoprotein that functions in endothelial cells as an auxiliary receptor for transforming growth factor β (TGF-β)/bone morphogenetic protein (BMP) family members and as an integrin...
A critical examination of the recently reported crystal structures of the human SMN protein.
Manfred S Weiss, Kay Diederichs, Randy J Read, Santosh Panjikar, Gregory D Van Duyne, A Gregory Matera, Utz Fischer, Clemens Grimm
Feb 07, 2019
A recent publication by Seng et al. in this journal reports the crystallographic structure of refolded, full-length SMN protein and two disease-relevant derivatives thereof. Here, we would like to suggest that at least two of...
Pathogenic mtDNA mutations causing mitochondrial myopathy
Steven A Hardy, Emma L Blakely, Andrew I Purvis, Mariana C Rocha, Syeda Ahmed, Gavin Falkous, Joanna Poulton, Michael R Rose, Olivia O'Mahony, Niamh Bermingham, Charlotte F Dougan, Yi Shiau Ng, Rita Horvath, Doug M Turnbull, Grainne S Gorman, Robert W Taylor
Oct 01, 2019
Pathogenic mitochondrial tRNA (mt-tRNA) gene mutations represent a prominent cause of primary mitochondrial DNA (mtDNA)-related disease despite accounting for only 5%-10% of the mitochondrial genome.(1,2) Although some common...
A New Way to See a Bronchopleural Fistula
A 77-year-old man presented with five episodes of sepsis to different hospitals in the year after having a left lower lobectomy for squamous cell carcinoma. In the first two episodes, a rim-enhancing left pleural effusion was...
Technology Leadership in Malaysian Schools
Education 4.0 is the answer to the global needs for the advanced integration of humans and technology. Leading school’s technology utilization can be the way forward to support education 4.0 realization. This study aims to...
Published by: IGI Global Scientific Publishing
Levetiracetam-induced eosinophilic pneumonia.
Levetiracetam is widely regarded as a benign antiepileptic drug, compared to older antiepileptic medication. We report a case of eosinophilic pneumonia due to levetiracetam use in a non-smoking woman aged 59 years with no...
Identification of critical stacking faults in thin-film CdTe solar cells
Cadmium telluride (CdTe) is a p-type semiconductor used in thin-film solar cells. To achieve high light-to-electricity conversion, annealing in the presence of CdCl2 is essential, but the underlying mechanism is...
Elucidating the Mechanism of Fatigue Crack Acceleration Following the Occurrence of an Underload
Enrico Salvati, Tan Sui, Hongjia Zhang, Alexander J.G. Lunt, Kai Soon Fong, Xu Song, Alexander M. Korsunsky
Dec 01, 2016
Fatigue Crack Growth Rate (FCGR) is altered by a single anomalous load exceeding cyclic maximum (Overload) or compressive load below cyclic minimum (Underload). The authors study fatigue crack acceleration due to a single...
Algorithmic Fairness in Mortgage Lending
Abstract: To address the rising concern that algorithmic decision-making may reinforce discriminatory biases, researchers have proposed many notions of fairness and corresponding mathematical formalizations. Each of these...
Striking the Air
NG Hammond
Aug 13, 2018
The sounds of early modern Paris are first explored through poetic and satirical depictions of urban noise, with emphasis placed on the disruption that they present. The attempt by Louis XIV to assert his absolute power becomes...
Discover!ng women in STEM
Richard Watermeyer
Jan 01, 0001
This paper explores the role of Discover! Saturday Clubs as informal
educational spaces devised as a means of broader dissemination and
experiential learning for school-aged girls, with fledgling interests in...
educational spaces devised as a means of broader dissemination and
experiential learning for school-aged girls, with fledgling interests in...
Discover!ng women in STEM
Richard Watermeyer
Jan 01, 0001
This paper explores the role of Discover! Saturday Clubs as informal
educational spaces devised as a means of broader dissemination and
experiential learning for school-aged girls, with fledgling interests in...
educational spaces devised as a means of broader dissemination and
experiential learning for school-aged girls, with fledgling interests in...
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