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Placement for Intercommunicating Virtual Machines in Autoscaling Cloud Infrastructure
Due to pay-as-you-go style adopted by cloud datacenters (DC), modern day applications having intercommunicating tasks depend on DC for their computing power. Due to unpredictability of rate at which data arrives for immediate...
Published by: IGI Global Scientific Publishing
Inter-adsorbate forces and coherent scattering in helium spin-echo experiments.
David J Ward, Arjun Raghavan, Anton Tamtögl, Andrew P Jardine, Emanuel Bahn, John Ellis, Salvador Miret-Artès, William Allison
Oct 07, 2020
In studies of dynamical systems, helium atoms scatter coherently from an ensemble of adsorbates as they diffuse on the surface. The results give information on the co-operative behaviour of interacting adsorbates and thus...
Alkali metal adsorption on metal surfaces
Arjun Raghavan, Louie Slocombe, Alexander Spreinat, David J Ward, William Allison, John Ellis, Andrew P Jardine, Marco Sacchi, Nadav Avidor
Nov 06, 2020
The adsorption of sodium on Ru(0001) is studied using 3He spin-echo spectroscopy (HeSE), molecular dynamics simulations (MD) and density functional theory (DFT). In the multi-layer regime, an analysis of helium reflectivity...
Cut-off Value of Random Blood Glucose among Asian Indians for Preliminary Screening of Persons with Prediabetes and Undetected Type 2 Diabetes Defined by the Glycosylated Haemoglobin Criteria.
Priscilla Susairaj, Chamukuttan Snehalatha, Arun Raghavan, Arun Nanditha, Ramachandran Vinitha, Krishnamoorthy Satheesh, Desmond G Johnston, Nicholas J Wareham, Ambady Ramachandran
Apr 05, 2020
AIM: The increased morbidity and mortality due to type 2 diabetes can be partly due to its delayed diagnosis. In developing countries, the cost and unavailability of conventional screening methods can be a setback. Use of random...
DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4,000 years ago.
Frederik Valeur Seersholm, Mikkel Winther Pedersen, Martin Jensen Søe, Hussein Shokry, Sarah Siu Tze Mak, Anthony Ruter, Maanasa Raghavan, William Fitzhugh, Kurt H Kjær, Eske Willerslev, Morten Meldgaard, Christian MO Kapel, Anders Johannes Hansen
Sep 08, 2018
The demographic history of Greenland is characterized by recurrent migrations and extinctions since the first humans arrived 4,500 years ago. Our current understanding of these extinct cultures relies primarily on preserved...
The B-MaP-C study
Alona Courtney, Rachel O'Connell, Tim Rattay, Baek Kim, Ramsey I Cutress, Cliona C Kirwan, Ashu Gandhi, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Rajiv V Dave
Sep 14, 2020
Introduction: Approximately 55,000 women in the United Kingdom are diagnosed with new breast cancer annually. Since emerging in December 2019, SARS-CoV-2 (coronavirus disease 2019, COVID-19) has become a global pandemic...
A pragmatic and scalable strategy using mobile technology to promote sustained lifestyle changes to prevent type 2 diabetes in India and the UK
Arun Nanditha, Hazel Thomson, Priscilla Susairaj, Weerachai Srivanichakorn, Nick Oliver, Ian F. Godsland, Azeem Majeed, Ara Darzi, Krishnamoorthy Satheesh, Mary Simon, Arun Raghavan, Ramachandran Vinitha, Chamukuttan Snehalatha, Kate Westgate, Soren Brage, Stephen J. Sharp, Nicholas J. Wareham, Desmond G. Johnston, Ambady Ramachandran
Jun 06, 2020
Abstract: Aims/hypothesis: This randomised controlled trial was performed in India and the UK in people with prediabetes to study whether mobile phone short message service (SMS) text messages can be used to motivate and educate...
A pragmatic and scalable strategy using mobile technology to promote sustained lifestyle changes to prevent type 2 diabetes in India and the UK
Arun Nanditha, Hazel Thomson, Priscilla Susairaj, Weerachai Srivanichakorn, Nick Oliver, Ian F. Godsland, Azeem Majeed, Ara Darzi, Krishnamoorthy Satheesh, Mary Simon, Arun Raghavan, Ramachandran Vinitha, Chamukuttan Snehalatha, Kate Westgate, Soren Brage, Stephen J. Sharp, Nicholas J. Wareham, Desmond G. Johnston, Ambady Ramachandran
Jan 08, 2021
Abstract: Aims/hypothesis: This randomised controlled trial was performed in India and the UK in people with prediabetes to study whether mobile phone short message service (SMS) text messages can be used to motivate and educate...
A pragmatic and scalable strategy using mobile technology to promote sustained lifestyle changes to prevent type 2 diabetes in India and the UK
Arun Nanditha, Hazel Thomson, Priscilla Susairaj, Weerachai Srivanichakorn, Nick Oliver, Ian F Godsland, Azeem Majeed, Ara Darzi, Krishnamoorthy Satheesh, Mary Simon, Arun Raghavan, Ramachandran Vinitha, Chamukuttan Snehalatha, Kate Westgate, Soren Brage, Stephen J Sharp, Nicholas J Wareham, Desmond G Johnston, Ambady Ramachandran
Nov 05, 2019
Behavioural change Diabetes prevention Glycosylated haemoglobin A1c Lifestyle modification Mobile technology Prediabetes screening Short message service Adult Aged Blood Glucose Cell Phone Diabetes mellitus Type 2 Female Glycated Hemoglobin Humans Hyperglycemia india Life Style Male Middle Aged Monitoring Physiologic Prediabetic State PREVENTIVE MEDICINE Program Evaluation Risk Reduction Behavior Sample Size Telemedicine Text Messaging United Kingdom
Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom
Dragana Milojkovic, Nicholas CP Cross, Sahra Ali, Jenny Byrne, Gavin Campbell, Fiona L Dignan, Mark Drummond, Brian Huntly, Scott Marshall, Mary Frances McMullin, Pratap Neelakantan, Manoj Raghavan, Muttuswamy Sivakumaran, Jane Tighe, Farooq Wandroo, Fenella Willis, Fiona Glen, Louise Fildes, Sarah J Collington, Jacqueline Ryan, Richard E Clark, Adam J Mead
Jul 03, 2020
Management of chronic myeloid leukaemia (CML) has recently undergone dramatic changes, prompting the European LeukemiaNet (ELN) to issue recommendations in 2013; however, it remains unclear whether real-world CML management is...
CML management chronic myeloid leukaemia molecular response real-world study Tyrosine kinase inhibitor Adult Disease Management Female Humans Imatinib Mesylate Leukemia Myelogenous Chronic BCR-ABL Positive Male Middle Aged Protein Kinase Inhibitors Retrospective Studies Treatment Outcome United Kingdom
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Peitao Wu, Denis Rybin, Lawrence F Bielak, Mary F Feitosa, Nora Franceschini, Yize Li, Yingchang Lu, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sridharan Raghavan, Lynda M Rose, Karen Schwander, Albert V Smith, Salman M Tajuddin, Dina Vojinovic, Najaf Amin, Donna K Arnett, Erwin P Bottinger, Ayse Demirkan, Jose C Florez, Mohsen Ghanbari, Tamara B Harris, Lenore J Launer, Jingmin Liu, Jun Liu, Dennis O Mook-Kanamori, Alison D Murray, Mike A Nalls, Patricia A Peyser, André G Uitterlinden, Trudy Voortman, Claude Bouchard, Daniel Chasman, Adolfo Correa, Renée de Mutsert, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Linda Kao, Sharon LR Kardia, Charles Kooperberg, Ruth JF Loos, Michael M Province, Tuomo Rankinen, Susan Redline, Paul M Ridker, Jerome I Rotter, David Siscovick, Blair H Smith, Cornelia van Duijn, Alan B Zonderman, DC Rao, James G Wilson, Josée Dupuis, James B Meigs, Ching-Ti Liu, Jason L Vassy
Jun 01, 2020
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V. Dave, Baek Kim, Alona Courtney, Rachel O’Connell, Tim Rattay, Vicky P. Taxiarchi, Jamie J. Kirkham, Elizabeth M. Camacho, Patricia Fairbrother, Nisha Sharma, Christopher W. J. Cartlidge, Kieran Horgan, Stuart A. McIntosh, Daniel R. Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E. Coles, Ramsey I. Cutress, Ashu Gandhi, Cliona C. Kirwan
May 25, 2021
Abstract: Background: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions....
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
The genetic prehistory of the New World Arctic.
Maanasa Raghavan, Michael DeGiorgio, Anders Albrechtsen, Ida Moltke, Pontus Skoglund, Thorfinn S Korneliussen, Bjarne Grønnow, Martin Appelt, Hans Christian Gulløv, T Max Friesen, William Fitzhugh, Helena Malmström, Simon Rasmussen, Jesper Olsen, Linea Melchior, Benjamin T Fuller, Simon M Fahrni, Thomas Stafford, Vaughan Grimes, MA Priscilla Renouf, Jerome Cybulski, Niels Lynnerup, Marta Mirazon Lahr, Kate Britton, Rick Knecht, Jette Arneborg, Mait Metspalu, Omar E Cornejo, Anna-Sapfo Malaspinas, Yong Wang, Morten Rasmussen, Vibha Raghavan, Thomas vO Hansen, Elza Khusnutdinova, Tracey Pierre, Kirill Dneprovsky, Claus Andreasen, Hans Lange, M Geoffrey Hayes, Joan Coltrain, Victor A Spitsyn, Anders Götherström, Ludovic Orlando, Toomas Kivisild, Richard Villems, Michael H Crawford, Finn C Nielsen, Jørgen Dissing, Jan Heinemeier, Morten Meldgaard, Carlos Bustamante, Dennis H O'Rourke, Mattias Jakobsson, M Thomas P Gilbert, Rasmus Nielsen, Eske Willerslev
Dec 17, 2014
Selected 'Starter kit' energy system modelling data for selected countries in Africa, East Asia, and South America (#CCG, 2021).
Lucy Allington, Carla Cannone, Ioannis Pappis, Karla Cervantes Barron, Will Usher, Steve Pye, Edward Brown, Mark Howells, Miriam Zachau Walker, Aniq Ahsan, Flora Charbonnier, Claire Halloran, Stephanie Hirmer, Jennifer Cronin, Constantinos Taliotis, Caroline Sundin, Vignesh Sridharan, Eunice Ramos, Maarten Brinkerink, Paul Deane, Andrii Gritsevskyi, Gustavo Moura, Arnaud Rouget, David Wogan, Edito Barcelona, Taco Niet, Holger Rogner, Franziska Bock, Jairo Quirós-Tortós, Jam Angulo-Paniagua, Satheesh Krishnamurthy, John Harrison, Long Seng To
Apr 28, 2022
Energy system modeling can be used to develop internally-consistent quantified scenarios. These provide key insights needed to mobilise finance, understand market development, infrastructure deployment and the associated role of...
Sequential screening for lung cancer in a high-risk group: randomised controlled trial: LungSEARCH
Stephen G Spiro, Pallav L Shah, Robert C Rintoul, Jeremy George, Samuel Janes, Matthew Callister, Marco Novelli, Penny Shaw, Gabrijela Kocjan, Chris Griffiths, Mary Falzon, Richard Booton, Nicholas Magee, Michael Peake, Paul Dhillon, Kishore Sridharan, Andrew G Nicholson, Simon Padley, Magali N Taylor, Asia Ahmed, Jack Allen, Yenting Ngai, Nyasha Chinyanganya, Victoria Ashford-Turner, Sarah Lewis, Dahmane Oukrif, Pamela Rabbitts, Nicholas Counsell, Allan Hackshaw
Feb 08, 2021
BACKGROUND: Low-dose computed tomography (LDCT) screening detects early-stage lung cancer and reduces mortality. We proposed a sequential approach targeted to a high-risk group as a potentially efficient screening strategy....
Adenocarcinoma of Lung Bronchoscopy Carcinoma Large Cell Carcinoma Non-Small-Cell Lung Carcinoma Small Cell Carcinoma Squamous Cell Cytological Techniques Early Detection of Cancer Female Humans Lung Neoplasms Male Middle Aged Neoplasm Staging Optical Imaging Pulmonary Disease Chronic Obstructive Risk Assessment Sensitivity and Specificity Sputum Tomography X-Ray Computed United Kingdom
A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.
Florian J Clemente, Alexia Cardona, Charlotte E Inchley, Benjamin M Peter, Guy Jacobs, Luca Pagani, Daniel J Lawson, Tiago Antão, Mário Vicente, Mario Mitt, Michael DeGiorgio, Zuzana Faltyskova, Yali Xue, Qasim Ayub, Michal Szpak, Reedik Mägi, Anders Eriksson, Andrea Manica, Maanasa Raghavan, Morten Rasmussen, Simon Rasmussen, Eske Willerslev, Antonio Vidal-Puig, Chris Tyler-Smith, Richard Villems, Rasmus Nielsen, Mait Metspalu, Boris Malyarchuk, Miroslava Derenko, Toomas Kivisild
Nov 12, 2014
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic
James C Glasbey, Dmitri Nepogodiev, Joana FF Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Pgdme, Mohammad K Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganly, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham MA Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith J Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar Mrcog, Raghavan Vidya, Aneel A Bhangu, COVIDSurg Collaborative
Sep 03, 2020
PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical...
The NeST (Neoadjuvant systemic therapy in breast cancer) study
I. Whitehead, G. W. Irwin, F. Bannon, C. E. Coles, E. Copson, R. I. Cutress, R. V. Dave, M. D. Gardiner, M. Grayson, C. Holcombe, S. Irshad, C. O’Brien, R. L. O’Connell, C. Palmieri, A. M. Shaaban, N. Sharma, J. K. Singh, S. Potter, S. A. McIntosh, Liz Clayton, Ellen Copson, Karina Cox, Tim Crook, Beatrix Elsberger, Ahmed Ghoneima, Sirwan Hadad, Anita Hargreaves, Paul Healy, Adam Heetun, Dan Henderson, Julia Henderson, Natalie Hirst, Fiona Hoar, Mike Hughes, Emma Iddles, Sheeba Irshad, Tracey Irvine, Stacey Jones, Sarantos Kaptanis, Emma MacInnes, Andrew McCanny, Linda McLaughlin, Anthony Neal, Rachel O’Connell, Neill Patani, Belinda Pearce, Mandana Pennick, Simon Pilgrim, Rene Roux, Matthew Rowland, Sunita Saha, Kavita Sharma, Jagdeep Singh, Chiara Sirianni, Brendan Skelly, Rachel Soulsby, Mark Tatterton, Rob Thomas, Medy Tsalic, Raghavan Vidya, Olivia Waker, Lisa Whisker, Ian Whitehead, Janet Woods
Jan 22, 2021
Abstract: Background: Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine...
Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.
Anna-Sapfo Malaspinas, Oscar Lao, Hannes Schroeder, Morten Rasmussen, Maanasa Raghavan, Ida Moltke, Paula F Campos, Francisca Santana Sagredo, Simon Rasmussen, Vanessa F Gonçalves, Anders Albrechtsen, Morten E Allentoft, Philip LF Johnson, Mingkun Li, Silvia Reis, Danilo V Bernardo, Michael DeGiorgio, Ana T Duggan, Murilo Bastos, Yong Wang, Jesper Stenderup, J Victor Moreno-Mayar, Søren Brunak, Thomas Sicheritz-Ponten, Emily Hodges, Gregory J Hannon, Ludovic Orlando, T Douglas Price, Jeffrey D Jensen, Rasmus Nielsen, Jan Heinemeier, Jesper Olsen, Claudia Rodrigues-Carvalho, Marta Mirazón Lahr, Walter A Neves, Manfred Kayser, Thomas Higham, Mark Stoneking, Sergio DJ Pena, Eske Willerslev
Dec 17, 2014
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.
Esther H Lips, Tapsi Kumar, Anargyros Megalios, Lindy L Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A Ahmed, Mingchu Xu, Alexandra W van den Belt-Dusebout, Wim Brugman, Anna K Casasent, Karen Clements, Helen R Davies, Liping Fu, Anita Grigoriadis, Timothy M Hardman, Lorraine M King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C Maley, Jeffrey R Marks, Brian A Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K Schmidt, Abeer M Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk FA Wessels, E Shelley Hwang, Nicholas E Navin, P Andrew Futreal, Grand Challenge PRECISION consortium, Alastair M Thompson, Jelle Wesseling, Elinor J Sawyer
Jul 10, 2022
Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is...
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer.
Esther H Lips, Tapsi Kumar, Anargyros Megalios, Lindy L Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A Ahmed, Mingchu Xu, Alexandra W van den Belt-Dusebout, Wim Brugman, Anna K Casasent, Karen Clements, Helen R Davies, Liping Fu, Anita Grigoriadis, Timothy M Hardman, Lorraine M King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C Maley, Jeffrey R Marks, Brian A Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K Schmidt, Abeer M Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk FA Wessels, E Shelley Hwang, Nicholas E Navin, P Andrew Futreal, Grand Challenge PRECISION consortium, Alastair M Thompson, Jelle Wesseling, Elinor J Sawyer
Jun 14, 2022
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