Search
Results: 64
Activity-dependent compensation of cell size is vulnerable to targeted deletion of ion channels
Abstract: In many species, excitable cells preserve their physiological properties despite significant variation in physical size across time and in a population. For example, neurons in crustacean central pattern generators...
Impact of HR Practices on Organizational Effectiveness
The purpose of this paper is to identify the factors for both HR practices and organizational effectiveness along with what extent HR practices impact organizational effectiveness. The data were randomly collected from faculty...
Published by: IGI Global Scientific Publishing
Activity-dependent compensation of cell size is vulnerable to targeted deletion of ion channels.
In many species, excitable cells preserve their physiological properties despite significant variation in physical size across time and in a population. For example, neurons in crustacean central pattern generators generate...
Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K.
A potassium (K+ ) rich diet is known to have an antihypertensive effect that has been embodied by the NHLBI in the DASH diet. However, the molecular basis for this blood pressure-lowering effect has been unclear, until a recent...
Limited predictive value of blastomere angle of division in trophectoderm and inner cell mass specification.
Inner cell mass Mouse embryogenesis Pre-implantation lineage specification Time-lapse microscopy Trophectoderm Animals Animals Genetically Modified Blastocyst Blastomeres Cell Division Cell Lineage Cell Nucleus Ectoderm Embryo Mammalian Embryonic Development Female Male Mice Mice Transgenic Microscopy Confocal Morula Trophoblasts
Selective digestive decontamination in critically ill children
Background
Selective digestive decontamination of the digestive tract involves the routine administration of oral, gastric, and intravenous antibiotics to mechanically ventilated children to prevent hospital-acquired...
Negotiating Open Access
In this chapter, the authors interrogate the discursive terrain of the open access phenomenon to position the processual as well as the discourse communities that open access is inevitably enmeshed in. The essay explores the...
Information Resources Management Library and Information Science Information Resources Management Education Government and Law
Published by: IGI Global Scientific Publishing
WNK signalling pathways in blood pressure regulation.
hyperkalemia Hypertension NCC Proteasome Ubiquitin-E3 ligase complex WNK kinases Animals blood pressure Cullin Proteins Humans Hypertension Neovascularization Physiologic Protein Serine-Threonine Kinases Pseudohypoaldosteronism Receptors Drug Signal Transduction Sodium Chloride Symporters Sodium-Potassium-Chloride Symporters
A Multi-Objective Genetic Algorithm-Based Resource Scheduling in Mobile Cloud Computing
Mobile cloud computing is an emerging technology in recent years. This technology reduces battery consumption and execution time by executing mobile applications in remote cloud server. The virtual machine (VM) load balancing...
Published by: IGI Global Scientific Publishing
ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.
Cullin‐3 ROMK WNK kinases hyperkalemia Proteasome ubiquitin‐ligase complex Adaptor Proteins Signal Transducing Animals Biomarkers Cell Line Cullin Proteins Gene Knock-In Techniques Genetic Predisposition to Disease Kidney Membrane Potentials Mice Transgenic Microfilament Proteins Mutation Oocytes Phenotype Potassium Potassium Channels Inwardly Rectifying Protein Processing Post-Translational Protein Serine-Threonine Kinases Pseudohypoaldosteronism Transfection Xenopus laevis
Immune reconstitution after alemtuzumab therapy for multiple sclerosis triggering Graves' orbitopathy
Jonathan CP Roos, Carla Moran, V Krishna Chatterjee, Joanne Jones, Alasdair Coles, Rachna Murthy
Dec 20, 2018
Alemtuzumab-a monoclonal antibody targeting the CD52 glycoprotein expressed by most mature leucocytes-effectively decreases relapse rate and disability progression in early, relapsing-remitting multiple sclerosis (MS). However...
Adolescent Adult Alemtuzumab Antineoplastic Agents Immunological Autoantibodies Disease Progression Enzyme-Linked Immunosorbent Assay Female Graves Ophthalmopathy Humans Immune Reconstitution Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis Receptors Thyrotropin Recurrence Retrospective Studies Risk Factors
Midface toddler excoriation syndrome (MiTES) can be caused by autosomal recessive biallelic mutations in a gene for congenital insensitivity to pain, PRDM12.
BACKGROUND: Midface toddler excoriation syndrome (MiTES) is a condition recently reported in three unrelated children. Habitual scratching from the first year of life inflicted deep, chronic, scarring wounds around the nose and...
A New Paradigm for Blended Learning
The world has witnessed changes in teaching and learning attitudes ever since the dawn of the technological revolution. Additionally, the overwhelming propensity for technology among Indian teachers and pupils has had a great...
Published by: IGI Global Scientific Publishing
Arrhythmia Classification Based on Bi-Directional Long Short-Term Memory and Multi-Task Group Method
Early and accurate classification of arrhythmia helps the experts to select the treatment for the patient to increase the recovery rate. The deep learning method of convolution neural network (CNN) is used for classification...
Published by: IGI Global Scientific Publishing
T2-relaxation mapping and fat fraction assessment to objectively quantify clinical activity in thyroid eye disease
Imaging in thyroid eye disease (TED) is used to exclude other diagnoses, assess for apical crowding and plan surgery. But to quantify TED activity objectively, subjective clinical scoring assessments remain the norm. Magnetic...
Communicative Governance to Mitigate the COVID-19 Pandemic
Emerging democracies are handicapped by systemic weaknesses such as inadequate healthcare safety nets, weak administrative capacities, and rigidly hierarchical bureaucracies and conflicts between levels of political leadership....
Published by: IGI Global Scientific Publishing
Making technological innovation work for sustainable development.
Laura Diaz Anadon, Gabriel Chan, Alicia G Harley, Kira Matus, Suerie Moon, Sharmila L Murthy, William C Clark
Sep 20, 2018
This paper presents insights and action proposals to better harness technological innovation for sustainable development. We begin with three key insights from scholarship and practice. First, technological innovation processes...
The systematic development and pilot randomized evaluation of counselling for alcohol problems, a lay counselor-delivered psychological treatment for harmful drinking in primary care in India
Abhijit Nadkarni, Richard Velleman, Hamid Dabholkar, Sachin Shinde, Bhargav Bhat, Jim McCambridge, Pratima Murthy, Terry Wilson, Benedict Weobong, Vikram Patel
Mar 01, 2015
Background: Despite harmful drinking causing a significant burden on global health, there is a large treatment gap, especially in low- and middle-income countries. A major barrier to care is the lack of adequately skilled...
Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity
Amit Nathubhai, Teemu Haikarainen, Jarkko Koivunen, Sudarshan Murthy, Francoise Koumanov, Matthew Lloyd, Geoffrey Holman, Taina Pihlajaniemi, David Tosh, Lari Lehtio, Michael Threadgill
Jan 26, 2017
Compounds 13 and 14 were evaluated against eleven PARP isoforms to reveal that both 13 and 14 were more potent and isoform-selective towards inhibiting tankyrases (TNKSs) than the “standard” inhibitor 1 (XAV939)5, i.e. IC50 =...
Community detoxification for alcohol dependence
Abhijit Nadkarni, Paige Endsley, Urvita Bhatia, Daniela C. Fuhr, Aneesa Noorani, Aresh Naik, Pratima Murthy, Richard Velleman
May 01, 2017
Issues: Despite the potential advantages of community detoxification for alcohol dependence, in many countries the available resources are mostly focused on specialist services that are resource-intensive, and often difficult...
The systematic development and pilot randomized evaluation of counselling for alcohol problems, a lay counselor-delivered psychological treatment for harmful drinking in primary care in India
Abhijit Nadkarni, Richard Velleman, Hamid Dabholkar, Sachin Shinde, Bhargav Bhat, Jim McCambridge, Pratima Murthy, Terry Wilson, Benedict Weobong, Vikram Patel
Mar 01, 2015
Background: Despite harmful drinking causing a significant burden on global health, there is a large treatment gap, especially in low- and middle-income countries. A major barrier to care is the lack of adequately skilled...
A Systematic Review of Neurosurgical Care in Low-Income Countries.
Hannah K Weiss, Roxanna M Garcia, Jesutofunmi A Omiye, Dominique Vervoort, Robert Riestenberg, Ketan Yerneni, Nikhil Murthy, Annie B Wescott, Peter Hutchinson, Gail Rosseau
Feb 19, 2020
Objective:More than 5 billion individuals lack access to essential surgical care. Neurosurgical care is especially limited in low-income countries (LICs). Studies describing neurosurgical care in LICs are critical for...
Research Traumatic brain injury Hydrocephalus Literature review Global Health Low-income Countries TBI Traumatic Brain Injury Global neurosurgery Lcogs Lancet Commission On Global Surgery Lic Low-income Country
Published by: World neurosurgery: X
|
|< |
< |
1 |